Gene structure and expression:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge [u.a.]
Cambridge Univ. Press
1996
|
| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 212 S. Ill., graph. Darst. |
| ISBN: | 0521568668 052139855X |
Staff View
MARC
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| 100 | 1 | |a Hawkins, John D. |e Verfasser |0 (DE-588)129030333 |4 aut | |
| 245 | 1 | 0 | |a Gene structure and expression |c John D. Hawkins |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Cambridge [u.a.] |b Cambridge Univ. Press |c 1996 | |
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| 650 | 2 | |a Biologie moléculaire | |
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| 650 | 4 | |a Expressivité génétique | |
| 650 | 4 | |a Génétique moléculaire | |
| 650 | 2 | |a Régulation de l'expression des gènes | |
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Record in the Search Index
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| adam_text |
Gene structure and expression
THIRD EDITION
John D Hawkins
| CAMBRIDGE
UNIVERSITY PRESS
Contents
Introduction to the third edition page xi
Introduction to the second edition xii
Introduction to the first edition xiii
List of abbreviations xv
1 Deoxyribonucleic acid (DNA) 1
1 1 The genetic material 1
1 2 DNA is a polar helical molecule 1
1 3 DNA molecules are very long but can be twisted into compact forms 5
1 4 Replication of DNA is semi-conservative 8
1 5 The gene or cistron is the functional unit of DNA 9
1 6 Proteins bind to DNA 11
1 7 DNA can be damaged and repaired 14
2 Ribonucleic acid (RNA) 19
2 1 Expression of the information in DNA is mediated by RNA 19
2 2 Transcription is a major stage of gene expression 20
2 3 The four major classes of RNA 21
2 4 The genetic code 28
2 5 RNA editing 30
2 6 Translation is a later stage of gene expression 31
3 Methodology 37
3 1 Preparation of DNA samples for investigation 37
viii Contents
3 2 Vectors used in work with recombinant DNA 39
3 3 Electrophoresis of nucleic acids 41
3 4 Footprinting 42
3 5 Reverse transcriptase 44
3 6 Site-directed mutagenesis 46
3 7 Restriction endonucleases 47
3 8 Reporter genes 50
3 9 Restriction fragment length polymorphisms 51
3 10 Hybridisation of nucleic acids 52
3 11 The determination of base sequence in DNA 54
4 Prokaryotic DNA replication and gene expression 58
4 1 Replication 58
4 2 Transcription 63
4 3 Some RNAs are processed after transcription 67
4 4 Transposable genetic elements 68
5 The operon concept 70
5 1 Genes for sets of metabolically related enzymes are transcribed as one long
message 70
5 2 The/aroperon 74
5 3 The^a/operon 75
5 4 The ara operons 77
5 5 The/wa/regulon 77
5 6 The trp operon; control by attenuation 78
5 7 Arginine biosynthesis 81
5 8 Ribosomal proteins 82
5 9 The stringent response 84
6 Eukaryotic gene organisation and replication 86
6 1 DNA is in the nucleus in discrete linear chromosomes, associated with proteins 86
6 2 Histones associate in a regular fashion with DNA to form nucleosomes 88
6 3 Eukaryotic replication 90
6 4 Some genes can be amplified 93
7 Eukaryotic transcription 95
7 1 RNA polymerase I transcribes ribosomal RNA genes 95
Contents ix
7, 2 RNA polymerase HI transcribes the genes of small RNAs 97
#3 RNA polymerase II transcribes genes encoding proteins and some small RNAs 98
7 4 Transcriptional control 101
7 5 Transcriptional control in yeast 105
7 6 Methylation of some cytosine residues may control transcription 106
7 7 Enhancers 109
8 Post-transcriptional processing of RNA 110
8 1 Termination of transcription 110
8 2 mRNA molecules have a cap added after transcription 112
8 3 The coding sequence of many genes is interrupted by non-coding sequences 113
8 4 Introns are transcribed into mRNA and then removed 116
8 5 Some pre-mRNAs can be spliced in different ways 118
8 6 Self-splicing of introns 120
8 7 Stabilityof mRNA 121
8 8 Post-translational modifications may be needed to produce functional
proteins 122
9 Oncogenes 125
9 1 Retroviruses can be oncogenic, causing cancer 125
9 2 Oncogenes affect the growth of cells 127
9 3 Chromosomal alterations in cancer 130
10 Haemoglobin 133
10 1 Genes for globins are found in two clusters 133
10 2 Thalassaemias - 136
10 3 Other mutations 139
10 4 Prenatal diagnosis of anaemias 140
11 Proteins of the immune system 141
11 1 Immunoglobulins consist of Hand L chains 141
11 2 The variability of immunoglobulins is due to genomic rearrangements 143
11 3 L chain genes 144
11 4 H chain genes 144
11 5 DNA processing is employed during the course of the immune response 146
11 6 Transcriptional control of Ig genes 148
11 7 Allelic exclusion * 149
x Contents
11 8 T-cell receptors 150
11 9 The major histocompatibility complex 151
11 10 Class I genes are highly polymorphic 155
11 11 Class II genes 156
11 12 Ig superfamily 156
11 13 Complement genes 157
12 Some gene families 159
12 1 Collagen 159
12 2 CytochromeP450 160
12 3 Serine hydrolases 162
12 4 Lipoproteins 165
12 5 G-protein-coupled receptors 165
12 6 Growth hormone family 166
12 7 Glycoprotein hormones 167
12 8 Polyproteins are proteolyrically processed to yield the active hormones 168
13 Mitochondrial and chloroplast genomes 172
13 1 Yeast mitochondrial genome 172
13 2 Animal mitochondrial genomes 177
13 3 Plant mitochondrial genomes 179
13 4 Chloroplast genomes 180
14 Different and evolving genomes 183
14 1 The structures of prokaryotic and eukaryotic genes are different 183
14 2 Control mechanisms in prokaryotes and eukaryotes 184
14 3 Repeated sequences occur widely in many genomes 187
14 4 The plasticity of the genome 189
14 5 Evolution 190
14 6 Future developments 193
Glossary 197
Reading lists 201
Index 208 |
| any_adam_object | 1 |
| author | Hawkins, John D. |
| author_GND | (DE-588)129030333 |
| author_facet | Hawkins, John D. |
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| callnumber-label | QH450 H393G 1996 |
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| dewey-full | 572.8 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.8 |
| dewey-search | 572.8 |
| dewey-sort | 3572.8 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 3. ed. |
| format | Book |
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| language | English |
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| spelling | Hawkins, John D. Verfasser (DE-588)129030333 aut Gene structure and expression John D. Hawkins 3. ed. Cambridge [u.a.] Cambridge Univ. Press 1996 XIV, 212 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologie moléculaire Expression génique ram Expressivité génétique Génétique moléculaire Régulation de l'expression des gènes Régulation génétique ram Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Gen (DE-588)4128987-0 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf Genexpression (DE-588)4020136-3 s DE-604 Genregulation (DE-588)4122166-7 s Gen (DE-588)4128987-0 s Molekulargenetik (DE-588)4039987-4 s 1\p DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007530440&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Hawkins, John D. Gene structure and expression Biologie moléculaire Expression génique ram Expressivité génétique Génétique moléculaire Régulation de l'expression des gènes Régulation génétique ram Molekulargenetik (DE-588)4039987-4 gnd Genregulation (DE-588)4122166-7 gnd Gen (DE-588)4128987-0 gnd Genexpression (DE-588)4020136-3 gnd |
| subject_GND | (DE-588)4039987-4 (DE-588)4122166-7 (DE-588)4128987-0 (DE-588)4020136-3 |
| title | Gene structure and expression |
| title_auth | Gene structure and expression |
| title_exact_search | Gene structure and expression |
| title_full | Gene structure and expression John D. Hawkins |
| title_fullStr | Gene structure and expression John D. Hawkins |
| title_full_unstemmed | Gene structure and expression John D. Hawkins |
| title_short | Gene structure and expression |
| title_sort | gene structure and expression |
| topic | Biologie moléculaire Expression génique ram Expressivité génétique Génétique moléculaire Régulation de l'expression des gènes Régulation génétique ram Molekulargenetik (DE-588)4039987-4 gnd Genregulation (DE-588)4122166-7 gnd Gen (DE-588)4128987-0 gnd Genexpression (DE-588)4020136-3 gnd |
| topic_facet | Biologie moléculaire Expression génique Expressivité génétique Génétique moléculaire Régulation de l'expression des gènes Régulation génétique Molekulargenetik Genregulation Gen Genexpression |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007530440&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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