Regulation of gene expression in Escherichia coli:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Chapman & Hall [u.a.]
1996
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 592 S. Ill., graph. Darst. |
| ISBN: | 0412102919 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
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| 245 | 1 | 0 | |a Regulation of gene expression in Escherichia coli |c E. C. C. Lin ... |
| 264 | 1 | |a New York [u.a.] |b Chapman & Hall [u.a.] |c 1996 | |
| 300 | |a 592 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Escherichia coli - Génétique |2 ram | |
| 650 | 7 | |a Génétique bactérienne |2 ram | |
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| 700 | 1 | |a Lin, Edmund C. |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-007428920 | ||
Datensatz im Suchindex
| _version_ | 1804125579702697984 |
|---|---|
| adam_text | REGULATION OF
GENE EXPRESSION
IN ESCHERICHIA COLI
ECC Lin, Ph D
A Simon Lynch, Ph D
Harvard Medical School
Boston, Massachusetts, U S A
E3
CHAPMAN amp; HALL
!®P An International Thomson Publishing Company
New York • Atoany • Bom • Boston • Cincinnati • Detroit • London • Madrid • Melbourne •
Mexico City • Padflc Grove • Paris • San Francisco • Singapore • Tokyo • Toronto • Washington
R G LANDES COMPANY
AUSTIN
1 Introduction: From Physiology to DNA and Back 1
Jon Beckwith
2 RNA Chain Initiation and Promoter Escape by RNA Polymerase 7
Michael J Chamberlin and Lilian M Hsu
Promoter Function is Regulated at Two Distinct Phases of Transcription:
Promoter Binding and RNA Chain Initiation 7
The Biochemistry of the RNA Chain Initiation Phase of Transcription 8
Parameters That Describe the RNA Chain Initiation Reaction at Different Promoters 11
Factors That Affect the Initiation Reaction: Intrinsic Factors 13
Factors That Affect the Initiation Reaction: Extrinsic Factors 15
Models for the Mechanism of RNA Chain Initiation:
Some Simple Models Do Not Account for What Is Known 15
Models for the Mechanism of RNA Chain Initiation-Models Based on Recent
Models for RNA Chain Elongation 16
3 Transcription Termination and Its Control 27
Jeffrey W Roberts
Termination 27
Antitermination 34
4 Codon Context, Translational Step-Times and Attenuation 47
G Wesley Hatfield
Overview 47
Attenuation 48
Codon Context and Translational Efficiency 52
Effects of Codon Pair Bias on Translational Step-Times 54
Discussion 60
5 Control by Antisense RNA 67
Brian N Zeiler and Robert W Simons
Introduction 67
Antisense RNAs Control Diverse Biological Functions 67
Antisense RNAs Control Gene Expression at Many Different
Post-Transcriptional Levels 71
Antisense RNAs Pair to Their Target RNAs by Defined Mechanisms 76
Overview 78
6 Translational Control of Gene Expression in E Coli and Bacteriophage 85
Mathias Springer
Introduction 85
Translation Initiation 88
Translational Operators 89
Translational Repressors 98
Mechanisms of Control 102
Translational Control and mRNA Processing and/or Degradation 108
The Role of Translational Control in Growth Rate Regulation 112
Conclusions and Perspectives 113
7 Effects of DNA Supercoiling on Gene Expression 127
James C Wang and A Simon Lynch
Synopsis 127
Introduction 128
The Dependence of Transcription on the Cellular Level of DNA Gyrase
and DNA Topoisomerase 1 129
Mechanistic Considerations 130
Supercoiling of the DNA Template by Transcription 136
Concluding Remarks 139
8 The HU and IHF Proteins:
Accessory Factors for Complex Protein-DNA Assemblies 149
Howard A Nash
Perspective 149
Structure 150
Interaction with Nucleic Acids 152
Control of Intracellular Concentration and Activity 156
Participation of IHF and HU in Well-Characterized Biochemical Processes 158
Unfinished Business 166
9 The lac and gal Operons Today 181
SankarAdhya
Introduction 181
The lac and gal Operons Encode Enzymes of a Continuous Biochemical Pathway 182
The Regulatory Circuits and Their Components 182
Modulation of Promoters by cAMP*CRP 187
Control of P2 by UTP in gal 191
Natural Polarity 191
Negative Control by Repressor-Operator Interactions 192
Epilogue 7 7 194
10 The Maltose System 201
Winjried Boos, RalfPeist, Katja Decker and Eva Zdych
Introduction and Scope 201
The Positive Transcriptional Activator MalT 203
The Maltose/Maltodextrin Transport System 206
The Enzymes of the Maltose System 209
Nonclassical Regulatory Phenomena 212
Perspectives 219
11 The Phosphoenolpyruvate-Dependent Carbohydrate:
Phosphotransferase System (PTS) and Control of Carbon Source Utilization 231
Joseph W Lengeler
Introduction 231
Regulatory Phenomena Related to Carbon Source Utilization 232
Bacterial Transport Systems and Global Regulatory Networks Form a Unit 234
The Bacterial PTS Is a Transport and Signal Transduction System 237
IIAGlc of the PTS Is Central to Carbon Catabolite Repression 239
IIAGlc, the Regulation of Adenylate Cyclase Activity and of Intracellular cAMP Levels 241
Not Only cAMP Levels, but Also CRP Levels Are Essential in Catabolite Repression 242
IIAGk and Inducer Exclusion 243
Catabolite Repression and Inducer Exclusion Act in Concert 244
Carbon Catabolite Repression through PTS-Control Is Part of a Stimulon 245
Concluding Remarks 247
12 The Cap Modulon 255
Stephen Busby and Annie Kolb
The Long History of CAP 255
Cyclic AMP and Gene Expression 255
CAP as a Global Regulator: The CAP Modulon 256
CAP Binding at Target Promoters and Structural Studies 259
Activation by CAP at Simple Promoters 265
Activation by CAP at Complex Promoters 266
CAP as a Repressor and a Co-Repressor 269
CAP: Paradigm or Artifact? 270
13 Regulation of Nitrogen Assimilation 281
Boris Magasanik
The glnALG(glnA ntrBC) Operon 282
The o54-Dependent Promoter 282
Transcriptional Enhancers 283
Phosphorylation ofNRI 283
NR/NRH as Two-Component Paradigm 284
Activation of Transcription 285
Response to Nitrogen Availability 287
14 History of the Pho System 291
Annamaria Torriani-Gorini
15 Are the Multiple Signal Transduction Pathways of the Pho Regulon
Due to Cross Talk or Cross Regulation? 297
Barry L Wanner, Weihong Jiang, Soo-Ki Kim, Sayaka Yamagata, Andreas Haldimann
and Larry L Daniels
Introduction 297
Genes for P; Control of the Pho Regulon 299
Transmembrane Signaling by Environmental P; 300
Genes for P; Independent Controls of the Pho Regulon 303
Activation by CreC and Acetyl Phosphate 306
Cross Talk, Cross Regulation and a Hypothesis 308
Is There Evidence for Cross Regulation? 309
Overview and Prospects for Future Studies 311
16 The FNR Modulon and FNR-Regulated Gene Expression 317
John R Guest, Jeffrey Green, Alistair S Irvine and Stephen Spiro
Introduction 317
The Metabolic Arena 318
The FNR Modulon 321
The FNR Protein and Relationships with CAP 323
The DNA-Binding Specificity of FNR 324
In Vitro Transcription Activation and Repression 326
Transcriptional Organization of Representative Promoters 327
Potential FNR Contacts with RNA Polymerase and DNA-Bending 330
The Mystery of Redox-Sensing 331
Structural and Functional Homologs of FNR 335
Concluding Remarks 337
17 The NAR Modulon Systems:
Nitrate and Nitrite Regulation of Anaerobic Gene Expression 343
Andrew J Darwin and Valley Stewart
Introduction 343
Anaerobic Respiration 344
The Characterization of the Nar Regulatory System 345
Dual Two-Component Regulatory Systems 346
The Role of Nitrite in the Nar Regulatory System 347
The Sensor Proteins 347
The Response Regulators 349
Indirect Nitrate Regulation of Gene Expression 353
Concluding Remarks 354
18 Regulation of Aerobic and Anaerobic Metabolism by the Arc System 361
A Simon Lynch and Edmund C C Lin
Introduction 361
Identification of the arc Genes 361
In Vivo Studies of arc Mutants 365
In Vitro Phosphorylation Studies 366
The Arc Modulon 368
ArcA DNA Binding 370
The Arc Stimulus 372
Future Studies 373
19 The Porin Regulon: A Paradigm for the Two-Component Regulatory Systems 383
James M Slauch and Thomas J Silhavy
Introduction 383
Background 384
The History of Porin Regulation 385
The Structure of the ompB Locus 389
The Structure of the ompF and ompC Genes 390
The Roles of OmpR and EnvZ 393
Phosphorylation and Signal Transduction 397
Summary and Conclusions 404
20 The Leucine Lrp Regulon 419
Elaine B Newman and Rongtuan Lin
Introduction 419
The Leucine-Responsive Regulatory Protein 420
Regulation of Lrp Synthesis 420
Target Operons of Lrp and Mutant Phenotypes 421
Lrp as a Chromosome Organizer 424
Molecular Aspects of Lrp Interactions at Individual Promoters 425
Appendix 428
21 Adaptive responses to Oxidative Stress: The soxRS and oxyR Regulons 435
Elena Hidalgo and Bruce Demple
Reactive Oxygen Species 435
Antioxidant Defenses 436
Oxidative Stress 436
Global Responses to Oxidative Stress 437
The soxRS Regulon 437
The oxyR Regulon 442
Control of Antibiotic Resistance Genes 445
22 The SOS Regulatory System 453
John W Little
Introduction and Current Regulatory Model 453
Development of the SOS Model 454
Recent Developments 458
Behavior of the SOS Gene Regulatory Circuitry 469
Future Prospects 474
23 Heat Shock Regulation 481
Dominique Missiakas, Satish Raina and Costa Georgopoulos
Introduction 481
Properties of Important Heat Shock Proteins 482
Regulation of the o32-Promoted Heat Shock Response 487
A Second Heat Shock Regulon 491
The o54-Promoted Stress Response 495
Heat Shoclcor Stress Responses in Other Eubacteria 495
24 Roles for Energy-Dependent Proteases in Regulatory Cascades 503
Susan Gottesman
Introduction 503
The Proteases and Their Targets 504
Summary and General Conclusions 513
25 Control of rRNA and Ribosome Synthesis 521
Richard L Gourse and Wilma Ross
Introduction 521
rRNA Gene Organization 522
High Activity of rRNA Synthesis Rates 523
Stringent Control 530
Growth Rate Dependent Control 531
Additional Considerations 535
Conclusion and Future Prospects 536
26 Cell Division 547
Lawrence I Roth fie Id and Jorge Garcia-Lara
Introduction 547
The Cell Division Process 548
Essential Cell Division Genes 548
Transcriptional Regulation of Cell Division Genes 552
Translational Control 558
Division Inhibitors 558
Cell Division Inhibition by Mutations in Genes That Do Not Code
for Cell Division Proteins 561
Past, Present and Future 562
27 Regulation of Gene Expression in Stationary Phase 571
Heidi Goodrich-Blair, Maria Uria-Nickelsen and Roberto Kolter
Introduction 571
The o5 Regulon 573
RpoS Regulation 575
Index 585
|
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| indexdate | 2024-07-09T18:03:48Z |
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| isbn | 0412102919 |
| language | English |
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| spelling | Regulation of gene expression in Escherichia coli E. C. C. Lin ... New York [u.a.] Chapman & Hall [u.a.] 1996 592 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Escherichia coli - Génétique ram Génétique bactérienne ram Régulation génétique ram Genregulation (DE-588)4122166-7 gnd rswk-swf Escherichia coli (DE-588)4070959-0 gnd rswk-swf Escherichia coli (DE-588)4070959-0 s Genregulation (DE-588)4122166-7 s DE-604 Lin, Edmund C. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007428920&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Regulation of gene expression in Escherichia coli Escherichia coli - Génétique ram Génétique bactérienne ram Régulation génétique ram Genregulation (DE-588)4122166-7 gnd Escherichia coli (DE-588)4070959-0 gnd |
| subject_GND | (DE-588)4122166-7 (DE-588)4070959-0 |
| title | Regulation of gene expression in Escherichia coli |
| title_auth | Regulation of gene expression in Escherichia coli |
| title_exact_search | Regulation of gene expression in Escherichia coli |
| title_full | Regulation of gene expression in Escherichia coli E. C. C. Lin ... |
| title_fullStr | Regulation of gene expression in Escherichia coli E. C. C. Lin ... |
| title_full_unstemmed | Regulation of gene expression in Escherichia coli E. C. C. Lin ... |
| title_short | Regulation of gene expression in Escherichia coli |
| title_sort | regulation of gene expression in escherichia coli |
| topic | Escherichia coli - Génétique ram Génétique bactérienne ram Régulation génétique ram Genregulation (DE-588)4122166-7 gnd Escherichia coli (DE-588)4070959-0 gnd |
| topic_facet | Escherichia coli - Génétique Génétique bactérienne Régulation génétique Genregulation Escherichia coli |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007428920&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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