Brain tumors: biology, pathology, and clinical references
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
1997
|
| Edition: | 2., rev. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XX, 695 S. zahlr. Ill., graph. Darst. |
| ISBN: | 3540616225 |
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MARC
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| 100 | 1 | |a Schiffer, Davide |d 1928- |e Verfasser |0 (DE-588)132168014 |4 aut | |
| 245 | 1 | 0 | |a Brain tumors |b biology, pathology, and clinical references |c Davide Schiffer. With the collab. of Maria Teresa Giordana ... |
| 250 | |a 2., rev. ed. | ||
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1997 | |
| 300 | |a XX, 695 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Brain Neoplasms |x pathology | |
| 650 | 4 | |a Brain |x Tumors |x Histopathology | |
| 650 | 4 | |a Brain |x Tumors |x Pathophysiology | |
| 650 | 0 | 7 | |a Hirntumor |0 (DE-588)4072521-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pathophysiologie |0 (DE-588)4044898-8 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Hirntumor |0 (DE-588)4072521-2 |D s |
| 689 | 0 | 1 | |a Pathophysiologie |0 (DE-588)4044898-8 |D s |
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| _version_ | 1807320378560741376 |
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| adam_text |
CONTENTS
1
CYTOGENESIS
OF
THE
CENTRAL
NERVOUS
SYSTEM
.
1
1.1
NEUROGENESIS
AND
GLIOGENESIS
.
1
1.2
GLIOGENESIS
IN
ADULT
ANIMALS
.
8
1.3
DEVELOPMENT
OF
THE
CEREBELLAR
CORTEX
.
10
1.4
RADIAL
GLIA
AND
EPENDYMA
.
11
1.5
GENES
CONTROLLING
NERVOUS
SYSTEM
DEVELOPMENT
.
15
2
FACTORS
OF
THE
TRANSFORMATION
PROCESS
.
18
2.1
GENETICS
AND
MOLECULAR
BIOLOGY
.
18
2.2
FAMILIAL
INCIDENCE
OF
TUMORS
.
29
2.3
CONGENITAL
TUMORS
.
29
2.4
RISK
FACTORS:
EPIDEMIOLOGICAL
DATA
.
30
2.4.1
FAMILY
CHARACTERISTICS
.
31
2.4.2
INDIVIDUAL
FACTORS
.
32
2.4.3
MULTIPLE
SCLEROSIS
.
33
2.4.4
VIRUS
.
33
2.4.5
HEAD
INJURIES
.
33
2.4.6
IRRADIATION
.
34
2.4.7
NONPROFESSIONAL
EXOGENOUS
EXPOSURES
.
35
2.4.8
PROFESSIONAL
EXOGENOUS
EXPOSURES
.
36
2.4.9
MULTIPLE
TUMORS
.
37
3
EXPERIMENTAL
TUMORS
.
39
3.1
CHEMICAL
CARCINOGENESIS
.
39
3.1.1
TOPICALLY
ACTING
CARCINOGENS
.
39
3.1.2
RESORPTIVE
CARCINOGENS
.
39
3.1.2.1
PATHOGENESIS
OF
NITROSOUREA-INDUCED
TUMORS
.
46
3.1.2.2
CELLULAR
COMPOSITION
.
48
3.1.2.3
VASCULARIZATION
OF
ENU-INDUCED
TUMORS
.
51
3.1.2.4
UTILIZATION
OF
MNU-ENU
MODELS
.
51
X
CONTENTS
3.2
VIRAL
CARCINOGENESIS
.
52
3.3
TRANSPLANTABLE ANIMAL
MODELS
.
53
3.4
GENE
TRANSFER
MODELS
OF
NEURAL
TUMORS
.
54
4
ANTIGENS
OF
PHENOTYPIC
EXPRESSION
AND
DIFFERENTIATION
MARKERS
56
4.1
BRAIN
TUMOR-ASSOCIATED
ANTIGENS
.
56
4.2
ANTIGENS
EMPLOYED
IN
THE
HISTOLOGICAL
DIAGNOSIS
OF
BRAIN
TUMORS
.
.
57
4.2.1
GLIAL
MARKERS
.
58
4.2.1.1
S-100
PROTEIN
.
58
4.2.1.2
GLIAL
FIBRILLARY
ACIDIC
PROTEIN
.
60
4.2.1.3
GLUTAMINE
SYNTHETASE
.
61
4.2.1.4
CARBONIC
ANHYDRASE
.
61
4.2.1.5
MYELIN
BASIC
PROTEIN
.
63
4.2.1.6
MYELIN-ASSOCIATED
GLYCOPROTEIN
.
63
4.2.2
NEURONAL
MARKERS
.
64
4.2.2.1
NEURONAL-SPECIFIC
ENOLASE
.
64
4.2.2.2
NEUROFILAMENTS
.
64
4.2.2.3
SYNAPTOPHYSIN
AND
CHROMOGRANIN
.
65
4.2.3
MARKERS
NONSPECIFIC
FOR
THE
NERVOUS
SYSTEM
.
65
4.2.4
VESSEL
MARKERS
.
66
4.2.5
OTHER
INTERMEDIATE
FILAMENTS
.
68
4.2.6
EPITHELIAL
MEMBRANE
ANTIGENS
.
71
4.2.7
MARKERS
FOR
CEREBRAL
METASTASES
.
71
5
PATHOLOGY
OF
THE
HOST-TUMOR
INTERACTION
.
74
5.1
PERITUMORAL
CHANGES
.
74
5.1.1
GLIAL
REACTION
.
74
5.1.2
INCLUDED
NEURONS
.
79
5.1.3
VENTRICULAR
WALLS
.
79
5.2
REGRESSIVE
EVENTS
IN
THE
TUMOR
.
80
5.3
CEREBRAL
EDEMA
.
83
5.3.1
DEFINITION
AND
PATHOGENESIS
.
83
5.3.2
MORPHOLOGICAL
CHANGES
AND
SEQUELAE
.
86
5.4
CALCIFICATIONS
.
89
5.5
IMMUNE
RESPONSE
.
92
6
CLASSIFICATION
AND
NOSOGRAPHY
OF
NEUROEPITHELIAL
TUMORS
.
96
CONTENTS
XI
7
THE
CONCEPT
OF
MALIGNANCY:
ANAPLASIA,
CELL
PROLIFERATION,
METASTASIS
.
109
7.1
GENERAL
CONSIDERATIONS
.
109
7.2
CELL
KINETICS
.
115
7.3
METASTASIS
.
122
7.4
EXPANSION
AND
INVASIVENESS
.
124
7.4.1
INVASION
MECHANISMS
.
130
8
DESCRIPTIVE
EPIDEMIOLOGY
OF
PRIMARY
NERVOUS.
SYSTEM
TUMORS
.
.
132
8.1
GENERAL
DATA
.
132
8.1.1
MORTALITY
.
132
8.1.2
INCIDENCE
.
132
8.2
EPIDEMIOLOGY
OF
INTRACRANIAL
TUMORS
.
133
8.2.1
HISTOLOGICAL
TYPE
.
134
8.2.2
AGE
.
134
8.2.3
SEX
.
136
8.2.4
RACE
.
136
8.3
EPIDEMIOLOGY
OF
INTRASPINAL
TUMORS
.
136
9
ASTROCYTIC
TUMORS
.
137
9.1
NOSOLOGICAL
PROBLEMS
.
137
9.2
ASTROCYTIC
TUMORS
OF
THE
CEREBRAL
HEMISPHERES
.
139
9.2.1
ASTROCYTOMAS
.
139
9.2.1.1
FREQUENCY,
AGE,
SITE
AND
CLINICAL
FEATURES
.
139
9.2.1.2
MACROSCOPIC APPEARANCE
AND
IMAGING
.
139
9.2.1.3
MICROSCOPIC
APPEARANCE
.
139
9.2.1.4
PILOCYTIC
ASTROCYTOMA
.
142
9.2.1.5
ANAPLASTIC
VARIANT
.
147
9.2.1.6
PROGNOSIS
AND
TREATMENT
OF
HEMISPHERIC
ASTROCYTOMAS
.
150
9.2.2
GLIOBLASTOMA
MULTIFORME
.
155
9.2.2.1
GENERAL
CONSIDERATIONS
.
155
9.2.2.2
FREQUENCY,
AGE,
SITE
AND
CLINICAL
FEATURES
.
156
9.2.2.3
MACROSCOPIC APPEARANCE
AND
IMAGING
.
157
9.2.2.4
MICROSCOPIC
APPEARANCE
.
159
9.2.2.5
TUMOR
SPREADING
.
169
9.2.2.6
DIFFERENTIAL
DIAGNOSIS
.
171
9.2.2.7
GIANT
CELL
VARIANT
.
171
9.2.2.8
GLIOSARCOMA
.
172
9.2.2.9
BLOOD
VESSEL
ARCHITECTURE
AND
ANGIOGENESIS
IN
GLIOMAS
.
178
XII
CONTENTS
9.2.2.10
CELLULAR
KINETICS
.
185
9.2.2.11
METABOLISM
.
185
9.2.2.12
PROGNOSIS
AND
TREATMENT
.
187
9.2.3
GLIOMATOSIS
CEREBRI
.
189
9.2.4
PLEOMORPHIC
XANTHOASTROCYTOMA
.
190
9.2.4.1
MACROSCOPIC
APPEARANCE
.
190
9.2.4.2
MICROSCOPIC
APPEARANCE
.
191
9.2.4.3
PROGNOSIS
.
193
9.2.5
SUBEPENDYMAL
GIANT
CELL
ASTROCYTOMA
(TUBEROUS
SCLEROSIS)
.
193
9.2.6
ASTROBLASTOMA
.
196
9.3
ASTROCYTIC
TUMORS
OF
THE
MIDLINE
.
197
9.3.1
ASTROCYTOMA
OF
THE
OPTIC
NERVE
.
198
9.3.2
ASTROCYTOMA
OF
THE
CHIASM
.
199
9.3.3
BRAIN
STEM
ASTROCYTOMAS
.
201
9.3.4
OTHER
MIDLINE
ASTROCYTOMAS
.
203
9.3.5
CEREBELLAR
ASTROCYTOMAS
.
203
9.3.5.1
NOSOGRAPHIC
CONSIDERATIONS
.
203
9.3.5.2
FREQUENCY,
AGE
.
204
9.3.5.3
MACROSCOPIC
APPEARANCE
.
204
9.3.5.4
MICROSCOPIC
APPEARANCE
.
204
9.3.5.5
ROSENTHAL
'
S
FIBERS
.
209
9.3.5.6
MALIGNANT
TRANSFORMATION,
PROGNOSIS
.
210
9.4
ASTROCYTIC
TUMORS
OF
THE
SPINAL
CORD
.
213
9.4.1
FREQUENCY,
AGE
.
213
9.4.2
MACROSCOPIC
AND
MICROSCOPIC
APPEARANCE
.
213
10
OLIGODENDROGLIAL
TBRNORS
.
214
10.1
OLIGODENDROGLIOMA
.
214
10.1.1
FREQUENCY,
AGE,
SITE
AND
CLINICAL
FEATURES
.
214
10.1.2
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
214
10.1.3
MICROSCOPIC
APPEARANCE
.
216
10.2
PRESENCE
OF
ASTROCYTES
AND
THE
PROBLEM
OF
MIXED
GLIOMAS:
OLIGOASTROCYTOMA
.
221
10.3
ANAPLASTIC
OLIGODENDROGLIOMA
AND
PROGNOSIS
.
223
11
EPENDYMAL
TUMORS
.
228
11.1
EPENDYMOMA
.
228
11.1.1
CLASSIFICATION
PROBLEMS
.
228
11.1.2
FREQUENCY,
AGE,
SEX,
SITE
AND
CLINICAL
FEATURES
.
230
11.1.3
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
231
11.1.4
MICROSCOPIC
APPEARANCE
.
233
CONTENTS
XIII
11.1.5
REGRESSIVE
EVENTS
.
237
11.1.6
IMMUNOHISTOCHEMISTRY
.
239
11.1.7
ELECTRON
MICROSCOPY
.
242
11.1.8
ANAPLASTIC
EPENDYMOMA
.
245
11.1.9
SPREAD
VIA
THE
CEREBROSPINAL
FLUID
.
248
11.1.10
TREATMENT
AND
PROGNOSIS
.
248
11.2
SUBEPENDYMOMA
.
249
11.3
EPENDYMOBLASTOMA
.
252
12
CHOROID
PLEXUS
TUMORS
.
254
12.1
PLEXUS-PAPILLOMA
.
254
12.1.1
FREQUENCY,
AGE,
SITE
AND
CLINICAL
FEATURES
.
254
12.1.2
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
255
12.1.3
MICROSCOPIC
APPEARANCE
.
256
12.1.4
TREATMENT
AND
PROGNOSIS
.
256
12.2
MALIGNANT
VARIANT
(PLEXUS
CARCINOMA)
.
259
13
TUMORS
COMPOSED
OF
NEURAL
CELLS
.
260
13.1
GANGLIOGLIOMA
(GANGLIOCYTOMA)
.
260
13.1.1
FREQUENCY,
AGE,
SITE
AND
CLINICAL
FEATURES
.
260
13.1.2
MACROSCOPIC APPEARANCE
AND
IMAGING
.
261
13.1.3
MICROSCOPIC
APPEARANCE
.
262
13.1.4
MALIGNANT
TRANSFORMATION
(MALIGNANT
GANGLIOGLIOMA)
.
264
13.1.5
PROGNOSIS
.
266
13.2
DYSPLASTIC
GANGLIOCYTOMA
OF
THE
CEREBELLUM
.
266
13.3
INFANTILE
DESMOPLASTIC
GANGLIOGLIOMA
-
DESMOPLASTIC
INFANTILE
ASTROCYTOMA
.
267
13.4
CENTRAL
NEUROCYTOMA
.
268
13.5
DYSEMBRYOPLASTIC
NEUROEPITHELIAL
TUMORS
.
270
13.6
OLFACTORY
NEUROBLASTOMA
.
272
14
PINEAL
GLAND
TUMORS
.
275
14.1
THE
PINEAL
GLAND
.
275
14.2
PINEAL
GLAND
TUMORS
.
276
14.2.1
PINEOCYTOMA
.
1T1
14.2.1.1
MACROSCOPIC
APPEARANCE
.
277
14.2.1.2
MICROSCOPIC
APPEARANCE
.
277
14.2.1.3
TREATMENT
AND
PROGNOSIS
.
281
14.2.2
PINEALOBLASTOMA
.
281
XIV
CONTENTS
14.2.2.1
MACROSCOPIC
APPEARANCE
.
281
14.2.2.2
MICROSCOPIC
APPEARANCE
.
282
14.2.2.3
PROGNOSIS
.
285
14.2.4
TRILATERAL
RETINOBLASTOMA
.
285
14.3
PINEAL
CYSTS
.
285
15
EMBRYONAL
TUMORS
.
287
15.1
MEDULLOEPITHELIOMA
.
287
15.2
MEDULLOBLASTOMA
.
289
15.2.1
FREQUENCY,
AGE
AND
CLINICAL
FEATURES
.
289
15.2.2
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
289
15.2.3
MICROSCOPIC
APPEARANCE
.
291
15.2.3.1
DESMOPLASTIC
VARIANT
.
297
15.2.3.2
MELANOTIC
MEDULLOBLASTOMA
.
.
A
.
298
15.2.3.3
MEDULLOMYOBLASTOMA
.
298
15.2.4
DNA
CONTENT
AND
PATHOLOGY
.
299
15.2.5
PROBLEM
OF
DIFFERENTIATION
.
299
15.2.6
PROGNOSIS,
RECURRENCE,
METASTASIS
.
305
15.2.7
MEDULLOBLASTOMA
OF
ADULTS
.
307
15.3
NEUROBLASTOMA
.
308
15.3.1
MACROSCOPIC
APPEARANCE
.
308
15.3.2
MICROSCOPIC
APPEARANCE
.
308
15.3.3
PROGNOSIS
.
311
15.4
POLAR
SPONGIOBLASTOMA
.
311
15.5
APPENDIX:
TUMORS
OF
THE
RETINA
.
313
15.5.1
RETINOBLASTOMA
.
315
16
GLOMUS
TUMORS,
PARAGANGLIOMAS
.
319
16.1
SITE,
AGE,
AND
CLINICAL
FEATURES
.
319
16.2
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
320
16.3
MICROSCOPIC
APPEARANCE
.
321
16.4
PROGNOSIS
.
321
17
TUMORS
OF
THE
CRANIAL
AND
SPINAL
NERVES
.
322
17.1
NEURINOMA
(SCHWANNOMA)
.
322
17.1.1
FREQUENCY,
AGE,
SEX
.
322
17.1.2
SITE
.
323
17.1.3
CLINICAL
FEATURES
.
325
CONTENTS
XV
17.1.4
MACROSCOPIC APPEARANCE
AND
IMAGING
.
326
17.1.5
MICROSCOPIC
APPEARANCE
.
327
17.1.6
CELLULAR
SCHWANNOMA
.
333
17.1.7
IN
VITRO
CULTURE
.
333
17.2
NEUROFIBROMAS
.
334
17.2.1
PLEXIFORM
NEUROFIBROMAS
.
335
17.3
GRANULAR
CELL
TUMORS
.
335
17.4
NEUROTHEKEOMA
.
336
17.5
PERINEURIOMA
.
336
17.6
PROGNOSIS,
MALIGNANCY
.
336
18
TUMORS
OF
THE
MENINGES
.
341
18.1
MENINGIOMAS
.
341
18.1.1
GENERAL
CONSIDERATIONS
AND
NOMENCLATURE
.
341
18.1.2
FREQUENCY
.
343
18.1.3
AGE
.
343
18.1.4
SEX
.
344
18.1.5
FAMILIAL
TENDENCY
.
344
18.1.6
TRAUMA
AND
IRRADIATION
.
344
18.1.7
ASSOCIATION
WITH
OTHER
TUMORS
.
345
18.1.8
SITE
.
346
18.1.9
MULTIPLE
MENINGIOMAS
.
349
18.1.10
CLINICAL
FEATURES
AND
IMAGING
.
349
18.1.11
MACROSCOPIC
APPEARANCE
.
352
18.1.12
MICROSCOPIC
APPEARANCE
.
353
18.1.12.1
ANGIOMATOUS
MENINGIOMAS
.
356
18.1.12.2
MALIGNANT
MENINGIOMA
.
359
18.1.13
METAPLASIA
IN
MENINGIOMAS
.
362
18.1.14
REGRESSIVE
CHANGES
.
.
.
367
18.1.15
CALCIFICATIONS
.
369
18.1.16
ELECTRON
MICROSCOPY
.
374
18.1.17
RECEPTORS
FOR
STEROID
HORMONES
.
375
18.1.18
IN
VITRO
CULTURE
.
376
18.1.19
GROWTH
MODALITY
.
377
18.1.20
METASTASIS
.
380
18.1.21
PROGNOSIS,
TREATMENT
.
380
18.2
OTHER
MESENCHYMAL
TUMORS
OF
THE
MENINGES
.
382
18.2.1
BENIGN
NEOPLASMS
.
382
18.2.2
MALIGNANT
NEOPLASMS
.
383
18.2.2.1
HEMANGIOPERICYTOMA
.
383
18.2.2.2
FIBROSARCOMA
.
386
18.2.2.3
MALIGNANT
FIBROUS
HISTIOCYTOMA
.
386
18.2.2.4
PRIMARY
MENINGEAL
SARCOMATOSIS
.
388
XVI
CONTENTS
18.2.2.5
PRIMITIVE
MELANOBLASTOSIS
OF
THE
LEPTOMENINGES
.
388
18.2.2.6
PRIMARY
MELANOTIC
LESIONS
.
390
18.2.2.7
MENINGIOMATOSIS
OR
MENINGOANGIOMATOSIS
.
391
18.2.2.8
MISCELLANEOUS
.
391
19
MESENCHYMAL
TUMORS
.
392
19.1
CHORDOMAS
.
392
19.1.1
GENERAL
CONSIDERATIONS
.
392
19.1.2
MACROSCOPIC
APPEARANCE
.
393
19.1.3
MICROSCOPIC
APPEARANCE
.
395
19.1.4
ELECTRON
MICROSCOPY
.
396
19.1.5
DIFFERENTIAL
DIAGNOSIS
.
396
19.1.6
PROGNOSIS
.
397
19.2
CHONDROMA
.
397
19.3
CHONDROSARCOMAS
.
398
19.4
OSTEOMAS
.
'
.
400
19.5
OSTEOSARCOMA
.
401
20
VASCULAR
TUMORS
.
402
20.1
CAPILLARY
HEMANGIOBLASTOMA
.
402
20.1.1
BIOLOGICAL
DATA
.
402
20.1.2
MACROSCOPIC
APPEARANCE
.
403
20.1.3
MICROSCOPIC
APPEARANCE
.
404
20.1.4
REGRESSIVE
EVENTS
.
409
20.1.5
ELECTRON
MICROSCOPY
STUDY
.
410
20.1.6
METASTASIS,
RECURRENCES,
PROGNOSIS
.
410
20.1.7
ASSOCIATED
POLYCYTHEMIA
.
411
20.1.8
DIFFERENTIAL
DIAGNOSIS
.
411
21
TUMORS
AND
DYSONTOGENETIC
LESIONS
.
412
21.1
GERM
CELL
TUMORS
.
412
21.1.1
FREQUENCY,
AGE,
SITES,
CLINICAL
FEATURES,
IMAGING
.
412
21.1.2
PATHOGENESIS
.
414
21.1.3
GERMINOMA
.
414
21.1.3.1
MACROSCOPIC
APPEARANCE
.
414
21.1.3.2
MICROSCOPIC
APPEARANCE
.
414
21.1.3.3
PROGNOSIS,
TREATMENT
.
416
21.1.4
EMBRYONAL
CARCINOMA
.
417
21.1.5
CHORIOCARCINOMA
.
417
21.1.6
ENDODERMAL
SINUS
TUMOR
.
417
CONTENTS
XVII
21.1.7
TERATOCARCINOMA
.
419
21.1.8
IMMUNOHISTOCHEMICAL
AND
CHEMICAL
CHARACTERIZATION
.
419
21.2
TERATOMAS
.
419
21.2.1
FREQUENCY,
AGE,
SITE
.
420
21.2.2
MACROSCOPIC APPEARANCE
.
420
21.2.3
MICROSCOPIC
APPEARANCE
.
421
21.2.4
PROGNOSIS,
RECURRENCE
.
421
21.3
TUMORS
WITH
MUSCLE
CELLS
.
424
21.3.1
MEDULLOMYOBLASTOMA
.
424
21.3.2
PRIMITIVE
CNS
RHABDOMYOSARCOMA
.
427
21.3.3
OTHER
TUMORS
.
429
21.3.4
RHABDOID
TUMORS
.
429
21.4
DERMO-EPIDERMOID
CYSTS
.
430
21.4.1
NOSOGRAPHY,
PATHOGENESIS
.
430
21.4.2
FREQUENCY,
AGE,
SITE
AND
CLINICAL
FEATURES
.
430
21.4.3
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
431
21.4.4
MICROSCOPIC
APPEARANCE
.
433
21.4.5
PROGNOSIS,
SEQUELAE
.
435
21.5
CRANIOPHARYNGIOMA
AND
EPITHELIAL
CYSTS
.
435
21.5.1
EMBRYOGENETIC
ASPECTS
.
435
21.5.2
INCIDENCE
.
437
21.5.3
SITE
.
438
21.5.3.1
INTRAVENTRICULAR
TUMORS
.
439
21.5.4
CLINICAL
ASPECTS
.
439
21.5.5
MACROSCOPIC
APPEARANCE
.
440
21.5.6
MICROSCOPIC
APPEARANCE
.
443
21.5.6.1
ELECTRON
MICROSCOPY
AND
IMMUNOHISTOCHEMISTRY
.
447
21.5.6.2
CALCIFICATION
.
450
21.5.6.3
CYSTIC
COMPONENT
.
451
21.5.7
ADJACENT
TISSUE
.
454
21.5.8
RELATIONSHIPS
OF
CRANIOPHARYNGIOMAS
WITH
RATHKE
'
S
FISSURE
CYSTS
.
454
21.5.9
PROGNOSIS,
TREATMENT
.
458
21.6
NEUROEPITHELIAL
AND
NON-NEUROEPITHELIAL
CYSTS
.
459
21.6.1
COLLOID
CYSTS
OF
THE
THIRD
VENTRICLE
.
459
21.6.1.1
FREQUENCY,
AGE,
SITE
.
460
21.6.1.2
MACROSCOPIC
APPEARANCE
.
460
21.6.1.3
MICROSCOPIC
APPEARANCE
.
460
21.6.2
SPINAL
ENTEROGENOUS
CYSTS
.
462
21.6.3
ARACHNOID
CYSTS
.
462
21.7
LIPOMAS
.
462
21.7.1
FREQUENCY,
AGE,
SITE
.
463
21.7.2
MACROSCOPIC
APPEARANCE
.
464
21.7.3
MICROSCOPIC
APPEARANCE
.
464
21.7.4
PROGNOSIS,
TREATMENT
.
464
XVIII
CONTENTS
21.8
HAMARTOMAS,
ECTOPIAS,
AND
ECTOPIC
TUMORS
.
465
21.8.1
HAMARTOMA
OF
THE
HYPOTHALAMUS
.
465
21.8.2
GRANULE
CELL
TUMORS
.
465
21.8.3
MENINGEAL
GLIOMAS
.
467
21.8.4
ECTOPIC
GLIOMAS
AND
NEURAL
HAMARTOMAS
.
468
21.9
HAMARTOMAS
OR
VASCULAR
MALFORMATIONS
.
468
21.9.1
CLINICAL
FEATURES
.
469
21.9.2
CAPILLARY
TELEANGECTASIAS
.
469
21.9.3
CAVERNOUS
ANGIOMA
.
470
21.9.4
ARTERIOVENOUS
MALFORMATION
.
472
21.9.4.1
DURAL
ARTERIOVENOUS
MALFORMATIONS
.
473
21.9.5
VENOUS
MALFORMATIONS
.
473
22
PHAKOMATOSIS
AND
DYSGENETIC
SYNDROMES
.
475
22.1
TUBEROUS
SCLEROSIS
(BOURNEVILLE
'
S
DISEASE).
.
475
22.2
NEUROFIBROMATOSIS
.
477
22.2.1
NEUROFIBROMATOSIS
1
OR
VON
RECKLINGHAUSEN
'
S
DISEASE
.
479
22.2.1.1
CLINICAL
COURSE
.
480
22.2.2
NEUROFIBROMATOSIS-2
.
480
22.2.3
ASSOCIATED
LESIONS
OF
A
DYSPLASTIC
NATURE
.
481
22.3
VON
HIPPEL-LINDAU
SYNDROME
.
481
22.4
STURGE-WEBER
SYNDROME
.
482
22.5
OTHER
DYSGENETIC
SYNDROMES
.
483
23
PRIMARY
CENTRAL
NERVOUS
SYSTEM
LYMPHOMAS
.
484
23.1
FREQUENCY,
AGE,
SITE,
AND
CLINICAL
FEATURES
.
486
23.2
MACROSCOPIC
ASPECT
AND
IMAGING
.
486
23.3
MICROSCOPIC
APPEARANCE
.
487
23.4
EPIDURAL
LYMPHOMAS
.
496
23.5
LYMPHOMAS
IN
AIDS
.
496
23.6
PROGNOSIS,
TREATMENT
.
496
24
METASTASES
.
498
24.1
FREQUENCY
.
498
24.2
SEX
.
499
24.3
AGE
.
499
24.4
METASTATIC
PATHWAYS
.
499
24.5
MACROSCOPIC
APPEARANCE
AND
IMAGING
.
500
24.6
MICROSCOPIC
APPEARANCE
.
502
CONTENTS
XIX
24.7
DIFFERENTIAL
DIAGNOSIS
.
503
24.8
PROGNOSIS
AND
THERAPY
.
503
24.9
CARCINOMATOUS
MENINGITIS
.
505
24.10
SPINAL
METASTASES
.
505
25
BIOLOGICAL
BASIS
OF
THERAPIES
.
506
25.1
RADIOTHERAPY
.
506
25.1.1
CELLULAR
RESPONSE
TO
IONIZING
RADIATION
.
506
25.1.2
THERAPEUTIC
STUDIES
WITH
LOW
LINEAR
ENERGY
TRANSFER
RADIATION
ON
EXPERIMENTAL
BRAIN
TUMORS
.
508
25.1.3
METHODS
OF
IMPROVING
THE
THERAPEUTIC
RATIO
IN
RADIOTHERAPY
OF
BRAIN
TUMORS
.
509
25.1.3.1
ALTERED
FRACTIONATION
.
509
25.1.3.2
BRACHYTHERAPY
.
509
25.1.3.3
ASSOCIATION
WITH
CHEMOTHERAPEUTIC
AGENTS
.
510
25.1.3.4
RADIOSENSITIZERS
.
510
25.1.3.5
HYPERTHERMIA
.
511
25.1.3.6
PHOTORADIATION
THERAPY
.
512
25.1.3.7
HIGH
LINEAR
ENERGY
TRANSFER
RADIATION
.
512
25.1.3.8
RADIOPROTECTORS
.
512
25.2
CHEMOTHERAPY
.
513
25.2.1
GENERAL
CONCEPTS
.
513
25.2.2
CHEMOSENSITIVITY
AND
CHEMORESISTANCE
IN
BRAIN
TUMORS
.
513
25.2.3
DRUG
DELIVERY
TO
BRAIN
TUMORS
.
516
25.2.3.1
INTRA-CEREBROSPINAL
FLUID
AND
INTERSTITIAL
CHEMOTHERAPY
.
517
25.2.3.2
TRANSIENT
AND
REVERSIBLE
BLOOD-BRAIN
BARRIER
MODIFICATION
.
518
25.2.3.3
CARRIER
SYSTEMS
AND
LIPOSOMES
.
518
25.3
IMMUNOTHERAPY
.
519
25.4
BIOLOGIC
THERAPIES
.
'
.
.
520
26
EFFECTS
OF
TREATMENT
ON
BRAIN
TUMORS
AND
NORMAL
NERVOUS
TISSUE
.
522
26.1
EFFECTS
OF
RADIOTHERAPY
AND/OR
CHEMOTHERAPY
ON
HUMAN
BRAIN TUMORS
.
522
26.2
EFFECTS
OF
EXTERNAL
RADIOTHERAPY
ON
THE
HUMAN
BRAIN
.
523
26.3
EFFECTS
OF
BRACHYTHERAPY
ON
THE
HUMAN
BRAIN
.
531
26.4
EFFECTS
OF
EXTERNAL
RADIOTHERAPY
ON
THE
HUMAN
SPINAL
CORD
AND/OR
NERVE
ROOTS
.
531
26.5
PATHOGENESIS
OF
ADVERSE
EFFECTS
OF
RADIOTHERAPY
ON
THE
NORMAL
NERVOUS
TISSUE
.
532
26.6
EFFECTS
OF
CHEMOTHERAPY
ON
THE
HUMAN
BRAIN
AND
SPINAL
CORD
.
534
XX
CONTENTS
26.7
EFFECTS
OF
TREATMENT
ON
NORMAL
NERVOUS
TISSUE
IN
ACUTE
LYMPHOCYTIC
LEUKEMIA
OF
CHILDHOOD
.
534
26.8
SECOND
MALIGNANCIES
.
535
REFERENCES
.
536
SUBJECT
INDEX
.
689 |
| any_adam_object | 1 |
| author | Schiffer, Davide 1928- |
| author_GND | (DE-588)132168014 |
| author_facet | Schiffer, Davide 1928- |
| author_role | aut |
| author_sort | Schiffer, Davide 1928- |
| author_variant | d s ds |
| building | Verbundindex |
| bvnumber | BV011068031 |
| callnumber-first | R - Medicine |
| callnumber-label | RC280 |
| callnumber-raw | RC280.B7 |
| callnumber-search | RC280.B7 |
| callnumber-sort | RC 3280 B7 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | XH 8563 |
| ctrlnum | (OCoLC)35331335 (DE-599)BVBBV011068031 |
| dewey-full | 616.99/281 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/281 |
| dewey-search | 616.99/281 |
| dewey-sort | 3616.99 3281 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 2., rev. ed. |
| format | Book |
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| id | DE-604.BV011068031 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T00:23:44Z |
| institution | BVB |
| isbn | 3540616225 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007413507 |
| oclc_num | 35331335 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-20 |
| physical | XX, 695 S. zahlr. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Springer |
| record_format | marc |
| spelling | Schiffer, Davide 1928- Verfasser (DE-588)132168014 aut Brain tumors biology, pathology, and clinical references Davide Schiffer. With the collab. of Maria Teresa Giordana ... 2., rev. ed. Berlin [u.a.] Springer 1997 XX, 695 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Brain Neoplasms pathology Brain Tumors Histopathology Brain Tumors Pathophysiology Hirntumor (DE-588)4072521-2 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Hirntumor (DE-588)4072521-2 s Pathophysiologie (DE-588)4044898-8 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007413507&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schiffer, Davide 1928- Brain tumors biology, pathology, and clinical references Brain Neoplasms pathology Brain Tumors Histopathology Brain Tumors Pathophysiology Hirntumor (DE-588)4072521-2 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| subject_GND | (DE-588)4072521-2 (DE-588)4044898-8 |
| title | Brain tumors biology, pathology, and clinical references |
| title_auth | Brain tumors biology, pathology, and clinical references |
| title_exact_search | Brain tumors biology, pathology, and clinical references |
| title_full | Brain tumors biology, pathology, and clinical references Davide Schiffer. With the collab. of Maria Teresa Giordana ... |
| title_fullStr | Brain tumors biology, pathology, and clinical references Davide Schiffer. With the collab. of Maria Teresa Giordana ... |
| title_full_unstemmed | Brain tumors biology, pathology, and clinical references Davide Schiffer. With the collab. of Maria Teresa Giordana ... |
| title_short | Brain tumors |
| title_sort | brain tumors biology pathology and clinical references |
| title_sub | biology, pathology, and clinical references |
| topic | Brain Neoplasms pathology Brain Tumors Histopathology Brain Tumors Pathophysiology Hirntumor (DE-588)4072521-2 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Brain Neoplasms pathology Brain Tumors Histopathology Brain Tumors Pathophysiology Hirntumor Pathophysiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007413507&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schifferdavide braintumorsbiologypathologyandclinicalreferences |