Pharmacokinetic analysis: a practical approach
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Lancaster, Pa. [u.a.]
Technomic Publ.
1996
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 548 S. graph. Darst. |
| ISBN: | 1566764254 |
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MARC
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| 245 | 1 | 0 | |a Pharmacokinetic analysis |b a practical approach |c Peter I. D. Lee ; Gordon L. Amidon |
| 264 | 1 | |a Lancaster, Pa. [u.a.] |b Technomic Publ. |c 1996 | |
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Record in the Search Index
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| adam_text | TABLE OF CONTENTS
Preface xi
SECTION I: BASICS AND METHODS
Chapter 1. Introduction 3
Solving the Pharmacokinetic Puzzle 7
Characterizing Concentration Profiles by
the Time Constant Approach 10
Chapter 2. Time Constant Approach 15
Time Constants and Mean Residence Times 15
Physiological Meanings and Clinical Applications
of Time Constants 22
Mathematical Definitions of Time Constants and
Mean Residence Time 24
Derivation of Mean Residence Time from
Input and Output Times 28
A Simple Example 33
Time Constant Plot 34
The Relationship of Rate Limiting Time
Constants to the Concentration Profile 36
Model Building in Time Constant Approach 39
An Example Comparing Time Constant Approach
and Compartmental Modeling 44
Compartmental Modeling 47
Drug Defined Models 51
Model Independent Estimation of Time Constants 53
References 57
v
I
Vi Table of Contents
Chapter 3. Evaluation of Time Constants by
Visual Inspection of Concentration Time Profiles 61
Not All the Time Constants Can Be Observed 61
Time Constants Appear on the Concentration Time
Profile According to the Order of Magnitude 63
Flip Flop and Dominant Time Constant of
Terminal Phase 64
Indistinguishable Time Constants with
Overlapping Time Windows 66
Time Constant Windows Interrupted by
Peak Concentration 67
Observation Time Scale and Identification of
Time Constant 69
Superposition Principle and Time Shifting 69
Pharmacokinetic and Pharmacodynamic Links—
Isolated Multi Compartment Model 73
Chapter 4. Scaling of Time Constants among
Different Animal Species 77
Pharmacokinetic Time Constants and
Physiological Time Scales 77
Interspecies Scaling of Time Constants 80
References 87
SECTION II: FORMULATION FACTORS
Chapter 5. Influence of Administration Route on
Pharmacokinetics—Bioavailability 93
Introduction 93
Pharmacokinetic Models 95
Case Studies 104
Examples 112
References 118
Chapter 6. Influence of Formulation on
Pharmacokinetics—Bioequivalence 121
Introduction 121
Pharmacokinetic Models 123
Case Studies 128
Examples 137
References 140
Table of Contents VM
Chapter 7. Influence of Dosage on
Pharmacokinetics—Dose Proportionality 143
Introduction 143
Pharmacokinetic Models 144
Case Studies 147
Examples 157
References 164
Chapter 8. Pharmacokinetics of Sustained
Release and Immediate Release Formulations 167
Introduction 167
Pharmacokinetic Models 168
Case Studies 172
Examples 181
References 187
SECTION in: ABSORPTION, DISTRIBUTION,
METABOLISM, AND PHARMACODYNAMICS
Chapter 9. Absorption of Drugs in the
Gastrointestinal Tract 191
Introduction 191
Pharmacokinetic Models 192
Case Studies 196
Examples 206
References 211
Chapter 10. Drug Distribution into Tissue
Tissue Penetration 213
Introduction 213
Pharmacokinetic Models 214
Case Studies 219
Examples 228
References 235
Chapter 11. Pharmacokinetics of Metabolites 237
Introduction 237
Pharmacokinetic Models 239
Case Studies 247
Examples 262
References 271
Viii Table of Contents
Chapter 12. Relationship between Pharmacokinetics
and Pharmacodynamics 273
Introduction 273
Pharmacokinetic Models 274
Case Studies 283
Examples 298
References 310
SECTION IV: INTERACTIONS
Chapter 13. Influence of Food on Pharmacokinetics 315
Introduction 315
Pharmacokinetic Models 316
Case Studies 322
Examples 331
References 342
Chapter 14. Effects of Drug Interactions
on Pharmacokinetics 345
Introduction 345
Pharmacokinetic Models 346
Case Studies 350
Examples 356
References 365
SECTION V: SPECIAL POPULATIONS
Chapter 15. Influence of Age on Pharmacokinetics 369
Introduction 369
Pharmacokinetic Models 371
Case Studies 376
Examples 383
References 389
Chapter 16. Difference in Pharmacokinetics
between Genders 393
Introduction 393
Pharmacokinetic Model 394
Case Study 397
Examples 400
References 405
Table of Contents ix
Chapter 17. Special Pharmacokinetic Considerations
in Renal Impairment 407
Introduction 407
Pharmacokinetic Models 408
Case Studies 413
Examples 425
References 436
Chapter 18. Special Pharmacokinetic Considerations
in Hepatic Impairment 439
Introduction 439
Pharmacokinetic Models 440
Case Studies 447
Examples 456
References 464
Chapter 19. Special Pharmacokinetic Considerations
in Other Diseases 467
Introduction 467
Pharmacokinetic Models 468
Case Studies 474
Examples 484
References 497
Appendix 1: Evaluation of Mean Residence Times from
Input and Output Times 499
Appendix 2: Derivation of AUC and AUMC
Using Laplace Transformation 505
Appendix 3: Derivation of AUC and AUMC 509
Index 543
|
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| author | Lee, Peter I. D. Amidon, Gordon L. |
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| id | DE-604.BV011022483 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:02:44Z |
| institution | BVB |
| isbn | 1566764254 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007379512 |
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| physical | XIII, 548 S. graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Technomic Publ. |
| record_format | marc |
| spelling | Lee, Peter I. D. Verfasser aut Pharmacokinetic analysis a practical approach Peter I. D. Lee ; Gordon L. Amidon Lancaster, Pa. [u.a.] Technomic Publ. 1996 XIII, 548 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmacocinétique Pharmacokinetics Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 s DE-604 Amidon, Gordon L. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007379512&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lee, Peter I. D. Amidon, Gordon L. Pharmacokinetic analysis a practical approach Pharmacocinétique Pharmacokinetics Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4115557-9 |
| title | Pharmacokinetic analysis a practical approach |
| title_auth | Pharmacokinetic analysis a practical approach |
| title_exact_search | Pharmacokinetic analysis a practical approach |
| title_full | Pharmacokinetic analysis a practical approach Peter I. D. Lee ; Gordon L. Amidon |
| title_fullStr | Pharmacokinetic analysis a practical approach Peter I. D. Lee ; Gordon L. Amidon |
| title_full_unstemmed | Pharmacokinetic analysis a practical approach Peter I. D. Lee ; Gordon L. Amidon |
| title_short | Pharmacokinetic analysis |
| title_sort | pharmacokinetic analysis a practical approach |
| title_sub | a practical approach |
| topic | Pharmacocinétique Pharmacokinetics Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Pharmacocinétique Pharmacokinetics Pharmakokinetik |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007379512&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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