Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization: with 15 tables
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Stuttgart ; Jena ; Lübeck ; Ulm
Fischer
1996
|
| Series: | Progress in histochemistry and cytochemistry
31,3 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 137 S. Ill., graph. Darst. |
| ISBN: | 3437210467 1560814527 |
Staff View
MARC
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Record in the Search Index
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| adam_text | Contents
1 Introduction
1.1 General introduction 1
1.2 Interphase and metaphase chromosome structure 1
1.2.1 The organization of DNA in the nucleus 1
1.2.2 Eu and heterochromatin 3
1.2.3 Chromosome banding and nomenclature 3
1.3 Karyotypic analysis of chromosomes 4
1.3.1 Changes in ploidy and numerical chromosomal aberrations 4
1.3.2 Structural chromosomal aberrations 5
1.4 Tools in molecular genetics 7
1.5 Non radioactive in situ hybridization 9
1.5.1 The development of non isotopic in situ hybridization 9
1.5.2 The sensitivity and application of ISH 10
1.5.3 Novel methods in ISH: Comparative genomic hybridization 13
2 Methodological aspects of in situ hybridization 14
2.1 Isolated nuclei vs tissue sections 14
2.2 Types of DNA probes 16
2.2.1 Repetitive DNA probes 16
2.2.2 Library DNA probes 19
2.2.3 Unique regional DNA probes : 20
2.3 Types of labels for DNA probes 20
2.4 Pretreatment of the specimen 21
2.4.1 Fixation of the tissue 21
2.4.2 Slide preparation 23
2.4.3 Permeabilizing treatments 23
2.5 Denaturation and hybridization 24
2.6 Visualization of hybridization signals 25
2.7 Evaluation of ISH signals 27
2.7.1 Evaluation of ISH signals 27
2.7.2 Statistical analysis 31
3 Cytogenetic aberrations in solid tumors 31
3.1 General aspects 31
3.1.1 Cytogenetic changes in human cancer 31
3.1.2 Oncogenes and tumor suppressor genes 32
3.1.3 Cytogenetic analysis of solid tumors 33
3.2 Urinary system 34
3.2.1 Kidney cancer 34
3.2.2 Bladder cancer 35
3.3 Gastrointestinal system 39
VI ¦ Contents
3.3.1 Esophageal cancer 39
3.3.2 Gastric cancer 41
3.3.3 Colorectal cancer 41
3.4 Hepatobiliary system and pancreas 45
3.4.1 Liver cancer 45
3.4.2 Pancreatic cancer 47
3.5 Endocrine system 47
3.5.1 The MEN1 syndrome 47
3.5.2 The MEN2a, MEN2b, and FMTC syndrome 48
3.5.3 Thyroid gland cancer 50
3.6 Male reproductive system 51
3.6.1 Testicular cancer 51
3.6.2 Prostatic cancer 53
3.7 Female reproductive system and breast 56
3.7.1 Ovarian cancer 56
3.7.2 Cervical cancer 57
3.7.3 Endometrial cancer 59
3.7.4 Breast cancer 60
3.8 Nervous system 63
3.8.1 Gliomas 64
3.8.2 Meningiomas 66
3.8.3 Neurofibromas/schwannomas 67
3.9 Respiratory system 68
3.9.1 Lung cancer 68
3.9.2 Malignant mesothehomas 71
3.10 Skin 71
3.10.1 Basal cell carcinomas 71
3.10.2 Squamous cell carcinomas 72
3.10.3 Melanomas 72
3.11 Head and neck 74
3.11.1 Upper aerodigestive tract cancer 74
3.11.2 Salivary gland cancer 75
3.11.3 Nasopharyngeal cancer 76
3.12 Skeletal and soft tissues 76
3.12.1 Osteosarcomas 76
3.12.2 Ewing sarcomas 77
3.12.3 Chondrosarcomas 78
3.12.4 Rhabdomyosarcomas 78
3.12.5 Smooth muscle tumors 79
3.12.6 Synovial sarcomas 79
3.12.7 Fat cell tumors 80
Contents ¦ VII
3.13 Pediatric tumors 80
3.13.1 Tumors of the central nervous system 80
3.13.2 Neuroblastomas 81
3.13.3 Retinoblastomas 82
3.13.4 Pediatric tumors of the kidney 82
3.14 Lymphoid system 83
3.14.1 Hodgkin s lymphomas 83
3.14.2 Non Hodgkin s lymphomas 84
4 Concluding remarks 85
4.1 The utility of interphase cytogenetics 85
4.2 Prospects in interphase cytogenetics 86
4.2.1 Developments in DNA probe technology 86
4.2.2 Developments in visualization histochemistry 87
4.2.3 Developments in computer assisted evaluation 87
References 90
Subject index 135
|
| any_adam_object | 1 |
| author | Alers, Janneke C. Dekken, Herman van |
| author_facet | Alers, Janneke C. Dekken, Herman van |
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| author_sort | Alers, Janneke C. |
| author_variant | j c a jc jca h v d hv hvd |
| building | Verbundindex |
| bvnumber | BV010967149 |
| classification_rvk | WE 6000 |
| ctrlnum | (OCoLC)260218557 (DE-599)BVBBV010967149 |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV010967149 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:01:49Z |
| institution | BVB |
| isbn | 3437210467 1560814527 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007337728 |
| oclc_num | 260218557 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 |
| physical | IX, 137 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | Fischer |
| record_format | marc |
| series | Progress in histochemistry and cytochemistry |
| series2 | Progress in histochemistry and cytochemistry |
| spelling | Alers, Janneke C. Verfasser aut Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables J. C. Alers ; H. van Dekken Stuttgart ; Jena ; Lübeck ; Ulm Fischer 1996 IX, 137 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in histochemistry and cytochemistry 31,3 In-situ-Hybridisierung (DE-588)4215968-4 gnd rswk-swf Chromosomenanalyse (DE-588)4147988-9 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Interphase (DE-588)4343297-9 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Chromosomenanalyse (DE-588)4147988-9 s Interphase (DE-588)4343297-9 s In-situ-Hybridisierung (DE-588)4215968-4 s DE-604 Dekken, Herman van Verfasser aut Progress in histochemistry and cytochemistry 31,3 (DE-604)BV000005277 31,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007337728&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Alers, Janneke C. Dekken, Herman van Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables Progress in histochemistry and cytochemistry In-situ-Hybridisierung (DE-588)4215968-4 gnd Chromosomenanalyse (DE-588)4147988-9 gnd Krebs Medizin (DE-588)4073781-0 gnd Interphase (DE-588)4343297-9 gnd |
| subject_GND | (DE-588)4215968-4 (DE-588)4147988-9 (DE-588)4073781-0 (DE-588)4343297-9 |
| title | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables |
| title_auth | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables |
| title_exact_search | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables |
| title_full | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables J. C. Alers ; H. van Dekken |
| title_fullStr | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables J. C. Alers ; H. van Dekken |
| title_full_unstemmed | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization with 15 tables J. C. Alers ; H. van Dekken |
| title_short | Interphase cytogenetic analysis of solid tumors by non-isotopic DNA in situ hybridization |
| title_sort | interphase cytogenetic analysis of solid tumors by non isotopic dna in situ hybridization with 15 tables |
| title_sub | with 15 tables |
| topic | In-situ-Hybridisierung (DE-588)4215968-4 gnd Chromosomenanalyse (DE-588)4147988-9 gnd Krebs Medizin (DE-588)4073781-0 gnd Interphase (DE-588)4343297-9 gnd |
| topic_facet | In-situ-Hybridisierung Chromosomenanalyse Krebs Medizin Interphase |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007337728&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000005277 |
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