Inhaled glucocorticoids in asthma: mechanisms and clinical actions
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York [u.a.]
Dekker
1997
|
| Series: | Lung biology in health and disease
97 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXVI, 773 S. Ill., graph. Darst. |
| ISBN: | 0824797302 |
Staff View
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Record in the Search Index
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| adam_text | INHALED GLUCOCORTICOIDS IN ASTHMA MECHANISMS AND CLINICAL ACTIONS EDITED
BY ROBERT P. SCHLEIMER THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE
BALTIMORE, MARYLAND WILLIAM W. BUSSE UNIVERSITY OF WISCONSIN MEDICAL
SCHOOL MADISON, WISCONSIN PAUL M. O BYRNE MCMASTER UNIVERSITY HAMILTON,
ONTARIO, CANADA MARCEL DEKKER, INC. NEW YORK* BASEL * HONG KONG CONTENTS
INTRODUCTION CLAUDE LENFANT HI PREFACE VII CONTRIBUTORS XI PART ONE
SUBCELLULAR ACTIONS OF GLUCOCORTICOIDS 1. GLUCOCORTICOID RECEPTOR
STRUCTURE AND FUNCTION 3 ROGER L. MIESFELD AND JOHN W. BLOOM I.
INTRODUCTION 3 II. BIOCHEMICAL ANALYSES OF GR FUNCTIONS 4 III.
GR-MEDIATED CONTROL OF GENE EXPRESSION 12 IV. SUMMARY AND PERSPECTIVES
17 DISCUSSION 18 REFERENCES 20 XVU XVIII CONTENTS 2. NEGATIVE
TRANSCRIPTIONAL REGULATION BY THE GLUCOCORTICOID RECEPTOR IS RESPONSIBLE
FOR THE ANTI-INFLAMMATORY ACTIVITY OF GLUCOCORTICOIDS 29 MICHAEL KARIN
AND FAHRI SAATCIOGLU I. INTRODUCTION 29 II. NUCLEAR RECEPTOR SUPERFAMILY
30 III. PHYSIOLOGICAL IMPLICATIONS 38 IV. SUMMARY 42 DISCUSSION 43
REFERENCES 46 3. GLUCOCORTICOIDS ATTENUATE INDUCTION OF TWO PRIMARY
RESPONSE/ IMMEDIATE EARLY GENES, PROSTAGLANDIN SYNTHASE 2 AND INDUCIBLE
NITRIC OXIDE SYNTHASE, WHOSE PRODUCTS MEDIATE PARACRINE CELL
COMMUNICATION 53 HARVEY HERSCHMAN, REBECCA GILBERT, SRINIVASA REDDY,
BRADLEY FLETCHER, WEILIN XIE, JEFFREY SMITH, AND DEAN KUJUBU I. PRIMARY
RESPONSE/IMMEDIATE EARLY GENES 53 II. THE TIS10 GENE ENCODES A SECOND
PROSTAGLANDIN SYNTHASE/ CYCLOOXYGENASE 54 III. PGS2 EXPRESSION IS
INDUCED IN FIBROBLASTS BY MITOGENS AND IN MACROPHAGES BY
ENDOTOXIN/LIPOPOLYSACCHARIDE 55 IV. GLUCOCORTICOIDS INHIBIT BOTH THE
PRODUCTION OF PROSTAGLANDINS AND THE INDUCTION OF PGS2 57 V.
GLUCOCORTICOIDS INHIBIT MITOGEN-STIMULATED ACCUMULATION OF PGS2 MRNA 61
VI. GLUCOCORTICOIDS TONICALLY REGULATE PGS2 EXPRESSION IN VIVO 66 VII.
LIGAND-INDUCED PROSTAGLANDIN SYNTHESIS REQUIRES PGS2 GENE EXPRESSION IN
FIBROBLASTS AND MACROPHAGES 67 VIII. MACROPHAGE NITRIC OXIDE SYNTHASE
IS ALSO A GLUCOCORTI- COID-INHIBITED PRIMARY RESPONSE/IMMEDIATE EARLY
GENE 71 IX. GLUCOCORTICOID ATTENUATION DEFINES A SUBCLASS OF IMMEDIATE
EARLY GENES WHOSE PRODUCTS MEDIATE PARACRINE CELL COMMUNICATION 73
DISCUSSION 76 REFERENCES 78 CONTENTS XIX 4. GLUCOCORTICOIDS AND
APOPTOSIS OF HEMATOPOIETIC CELLS: TRANSCRIPTIONAL AND
POSTTRANSCRIPTIONAL CONTROL 81 E. BRAD THOMPSON I. INTRODUCTION 81 II.
MECHANISMS OF REGULATION OF GENE EXPRESSION BY GLUCOCORTICOIDS,
TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL 82 III. GLUCOCORTICOIDS CAUSE
APOPTOSIS OF CELL TYPES IMPORTANT IN ASTHMA 86 IV. APOPTOSIS IN CEM
CELLS 91 V. GENE REGULATION BY GLUCOCORTICOIDS IN CLONED CEM CELLS:
DOWNREGULATION OF C-MYC APPEARS TO BE A CRITICAL STEP IN APOPTOSIS 96
DISCUSSION 97 REFERENCES 100 5. LYMPHOCYTE ACTIVATION: THE INTERPLAY AND
SYNERGY OF IMMUNOSUPPRESSANTS 107 ISABELLA GRAEF, NEIL CLIPSTONE,
STEFFAN N. HO, LUIKA A. TIMMERMAN, JEFFREY NORTHROP, AND GERALD R.
CRABTREE I. CONTINGENT GENETIC REGULATORY EVENTS DURING T-LYMPHOCYTE
ACTIVATION 107 II. SIGNAL TRANSDUCTION AND TRANSCRIPTIONAL PATHWAYS
INITIATING T-LYMPHOCYTE ACTIVATION 110 III. CALCINEURIN AND RAS AS
ESSENTIAL SIGNALING INTERMEDIATES IN T-CELL ACTIVATION 110 IV. THE RAS-
AP-L PATHWAY 111 V. MECHANISM OF ACTION OF THE MAJOR IMMUNOSUPPRESSANTS
113 VI. INTERPLAY AND POSSIBLE SYNERGY BETWEEN IMMUNOSUPPRESSANTS 114
DISCUSSION 114 REFERENCES 116 PART TWO EFFECTS ON AIRWAY MUCOSA AND
SUBMUCOSA 6. AIRWAY ULTRASTRUCTURE IN ASTHMA 121 LAURI A. LAITINEN AND
ANNIKA LAITINEN I. INTRODUCTION 121 II. STRUCTURAL EPITHELIAL CHANGES IN
ASTHMA 121 III. EXTRACELLULAR MATRIX AND THE BASEMENT MEMBRANE 124 XX
CONTENTS IV. EFFECT OF TREATMENT ON AIRWAY STRUCTURE IN ASTHMA 125 V.
CONCLUSION 126 VI. SUMMARY 126 DISCUSSION 128 REFERENCES 131 7. SPUTUM
INDICES OF INFLAMMATION IN ASTHMA 133 FREDERICK E. HARGREAVE, EMILIO
PIZZICHINI, MARCIA PIZZICHINI, ANN EFTHIMIADIS, JERRY DOLOVICH, AND PAUL
M. O BYRNE I. INTRODUCTION 133 II. METHODS OF EXAMINATION OF SPUTUM 134
III. INDICES OF AIRWAY INFLAMMATION IN ASTHMA 137 IV. THE EFFECT OF
CORTICOSTEROIDS ON INFLAMMATORY INDICES 140 V. CONCLUSIONS 143
DISCUSSION 144 REFERENCES . 147 8. TISSUE REMODELING AND FIBROBLAST
HETEROGENEITY IN ASTHMA AND OTHER CHRONIC AIRWAYS INFLAMMATORY DISEASES
151 JACK GAULDIE, PATRICIA J. SIME, GUY M. TREMBLAY, DIANE TORRY, MANEL
JORDANA, AND BENGT SARNSTRAND I. INTRODUCTION 151 II. MATRIX METABOLISM
152 III. EFFECTOR FUNCTION OF AIRWAYS FIBROBLASTS 153 IV. FIBROBLAST
HETEROGENEITY 156 V. SUMMARY 159 DISCUSSION 161 REFERENCES 163 9. AIRWAY
MICROCIRCULATION, EPITHELIUM, AND GLUCOCORTICOIDS 167 CARL G. A. PERSSON
I. INTRODUCTION 167 II. TREATMENT OF ASTHMA BY ORAL INTAKE OF DESICCATED
ADRENALS 169 III. FOCUS ON IN VIVO FUNCTIONS 171 IV. EXUDATION OF PLASMA
AS AN AIRWAY END-ORGAN RESPONSE 172 V. EXUDATION PATHWAYS 176 VI. ACUTE
CHALLENGE-INDUCED EXUDATION 179 VII. MICROVASCULAR-EPITHELIAL EXUDATION
OF PLASMA IN LATE-PHASE RESPONSES 181 CONTENTS XXI VIII. IX. X. XI. XII.
PLASMA EXUDATION IN DISEASE ROLES OF EXUDED PLASMA THE IMPORTANCE OF
REDUCING IN ASTHMA AIRWAY EPITHELIAL RESTITUTION SUMMARY DISCUSSION
REFERENCES AIRWAY MUCOSAL PERVIOUSNESS IN VIVO 182 184 186 187 191 193
197 10. INHIBITION OF INFLAMMATORY CELL RECRUITMENT BY GLUCOCORTICOIDS:
CYTOKINES AS PRIMARY TARGETS 203 ROBERT P. SCHLEIMER, LISA A. BECK, LISA
A. SCHWIEBERT, CRISTIANA STELLATO, KELLY DAVENPECK, AND BRUCE S. BOCHNER
I. INTRODUCTION 203 II. INHIBITION OF THE ACTIVATION OF GENES OF
INFLAMMATION: A MAJOR MECHANISM OF GLUCOCORTICOID ACTION 204 III.
EFFECTS OF GLUCOCORTICOIDS ON LEUKOCYTE ACCUMULATION IN ALLERGIC
DISEASES AND EXPERIMENTAL ALLERGEN CHALLENGE MODEL SYSTEMS 205 IV.
SUMMARY 218 DISCUSSION 219 REFERENCES 223 11. AIRWAY LYMPHOCYTES 239
STEPHEN R. DURHAM, CHRIS J. CORRIGAN, DOUGLAS S. ROBINSON, QUTAYBA
HAMID, AND A. B. KAY I. INTRODUCTION 239 II. T LYMPHOCYTES AND ASTHMA
240 III. CORTICOSTEROIDS AND T LYMPHOCYTES IN ASTHMA 243 IV. SUMMARY 246
DISCUSSION 248 REFERENCES 252 12. EFFECTS OF CORTICOSTEROIDS ON
BASOPHILS AND MAST CELLS 259 JUDAH A. DENBURG I. INTRODUCTION 259 II.
BASIC BIOLOGY: IN VITRO STUDIES 260 III. APPLIED BIOLOGY: EX VIVO AND IN
VIVO STUDIES 263 XXII CONTENTS IV. SUMMARY 267 DISCUSSION 268 REFERENCES
271 13. GLUCOCORTICOID EFFECTS ON HUMAN EOSINOPHILS 279 GERALD J.
GLEICH, LOREN W. HUNT, BRUCE S. BOCHNER, AND ROBERT P. SCHLEIMER I.
INTRODUCTION II. IN VITRO STUDIES III. IN VIVO STUDIES IV. LIDOCAINE AS
A GLUCOCORTICOMIMETIC AGENT V. SUMMARY DISCUSSION REFERENCES 279 280 287
290 292 292 295 14. CYTOKINES AND GROWTH FACTORS IN ASTHMA 309 STEPHEN
J. LANE, DAVID J. COUSINS, ANA R. SOUSA, DONTCHO Z. STAYNOV, AND TAK H.
LEE I. INTRODUCTION 309 II. WHAT ARE CYTOKINES AND GROWTH FACTORS? 310
III. CRITERIA FOR CYTOKINE INVOLVEMENT IN ASTHMA 310 IV. SPECIFIC
CYTOKINE INVOLVEMENT IN ASTHMA 310 V. T-HELPER CYTOKINE PROFILE IN
ASTHMA 314 VI. IN VIVO EVIDENCE FOR CYTOKINE INVOLVEMENT IN ASTHMA 315
VII. FAILURE TO RESPOND TO CORTICOSTEROID THERAPY IN ASTHMA: RELEVANCE
TO CYTOKINE NETWORKS 319 VIII. MOLECULAR REGULATION OF CYTOKINES IN
BRONCHIAL ASTHMA 323 IX. SUMMARY 329 DISCUSSION 330 REFERENCES 334 PART
THREE GLUCOCORTICOID ACTIVITY AND SELECTIVITY AT THE AIRWAY LEVEL 15.
BASIS OF AIRWAY SELECTIVITY OF INHALED GLUCOCORTICOIDS 351 RALPH
BRATTSAND AND BENGT I. AXELSSON I. DEVELOPMENT OF CURRENT
GLUCOCORTICOIDS WITH AIRWAY SELECTIVITY 351 II. BASIS OF AIRWAY
SELECTIVITY 357 III. TOPICAL UPTAKE AND BINDING IN AIRWAY-LUNG TISSUE
360 CONTENTS XXIII IV. EFFICIENT HEPATIC FIRST-PASS METABOLISM 364 V.
PROSPECTS FOR A FURTHER IMPROVEMENT OF AIRWAY SELECTIVITY 365 VI.
SUMMARY 370 DISCUSSION 372 REFERENCES 375 16. GLUCOCORTICOID
PHARMACOKINETICS: PRINCIPLES AND CLINICAL APPLICATIONS 381 STAFFAN
EDSBDCKER AND STANLEY J. SZEFLER I. INTRODUCTION 381 II. OVERALL
CONDITIONS INFLUENCING RESPONSE TO GLUCOCORTICOIDS: BENEFICIAL AND
ADVERSE 382 III. STRUCTURE-ACTIVITY RELATIONSHIPS 383 IV.
PHARMACOKINETICS 386 V. INFLUENCE OF PHARMACOKINETICS ON
PHARMACODYNAMICS 410 VI. CLINICAL APPLICATIONS OF PHARMACOKINETICS:
OPTIMIZING EFFICACY, OVERCOMING APPARENT STEROID RESISTANCE, AND
MINIMIZING THE RISK OF ADVERSE EFFECTS 419 VII. FUTURE DIRECTIONS 421
DISCUSSION 422 REFERENCES 425 17. DETERMINANTS OF DOSE AND RESPONSE TO
INHALED THERAPEUTIC AGENTS IN ASTHMA 447 GERALD C. SMALDONE I. II. III.
IV. V. VI. INTRODUCTION THE AEROSOL DOSE TO THE PATIENT REGIONAL DOSE
RESPONSE TO THERAPY SUMMARY DISCUSSION REFERENCES PART FOUR CLINICAL
ASPECTS 447 448 458 465 468 472 474 475 18. A COMPARISON OF INHALED
VERSUS ORAL CORTICOSTEROIDS AS MAINTENANCE THERAPY IN ASTHMA 481 WILLIAM
W. BUSSE I. INTRODUCTION 481 II. COMPARISON OF ORAL AND INHALED
CORTICOSTEROIDS 482 XXIV CONTENTS III. EFFECT OF ORAL VERSUS INHALED
CORTICOSTEROIDS IN PREVENTING INFECTIOUS EXACERBATIONS OF ASTHMA 486 IV.
EFFECTS OF PREDNISONE OR INHALED CORTICOSTEROIDS ON AIRWAY
RESPONSIVENESS 488 V. SUMMARY 489 DISCUSSION 489 REFERENCES 492 19.
INHALED CORTICOSTEROIDS IN ASTHMA: IMPORTANCE OF EARLY INTERVENTION 493
PAUL M. O BYRNE I. INTRODUCTION 493 II. OBJECTIVES OF ASTHMA MANAGEMENT
494 III. REASONS FOR EARLY INTERVENTION WITH INHALED CORTICOSTEROIDS 495
IV. EFFICACY OF EARLY INTERVENTION WITH INHALED CORTICOSTEROIDS 495 V.
EFFECTS OF INHALED CORTICOSTEROIDS ON LUNG FUNCTION OVER TIME 497 VI.
SAFETY OF EARLY INTERVENTION WITH INHALED CORTICOSTEROIDS 498 VII.
COST-BENEFIT OF INHALED CORTICOSTEROIDS 500 VIII. SUMMARY 500 DISCUSSION
501 REFERENCES 502 20. ROLE OF GLUCOCORTICOIDS IN THE THERAPY OF ACUTE
ASTHMA 507 E. R. MCFADDEN, JR. I. INTRODUCTION II. GENERAL
CONSIDERATIONS III. MECHANISMS OF ACTION IV. INFLUENCE OF
GLUCOCORTICOIDS IN THE RESOLUTION OF ACUTE ASTHMA V. DOSE-RESPONSE
RELATIONSHIPS VI. TIMING OF ADMINISTRATION VII. PREVENTION OF
RECURRENCES VIII. SUMMARY DISCUSSION REFERENCES 507 508 508 509 511 512
513 514 514 517 21. CORTICOSTEROIDS IN THE TREATMENT OF ALLERGIC
RHINITIS 521 PETER H. HOWARTH I. INTRODUCTION 521 CONTENTS XXV II. III.
IV. V. VI. VII. MUCOSAL INFLAMMATION AND RHINITIS INFLAMMATORY MODEL OF
RHINITIS INFLUENCE OF CORTICOSTEROID THERAPY ON NASAL INFLAMMATION
CLINICAL EFFECT OF CORTICOSTEROIDS IN RHINITIS ADVERSE EFFECTS
CONCLUSION DISCUSSION REFERENCES 522 528 529 531 535 535 536 539 22.
EFFICACY AND SAFETY OF INHALED CORTICOSTEROIDS IN CHILDREN 551 SOREN E.
PEDERSEN I. INTRODUCTION II. PHARMACODYNAMICS III. EFFECT ON
INFLAMMATION AND HYPERREACTIVITY IV. CLINICAL TRIALS V. PHARMACOKINETICS
VI. DELIVERY SYSTEMS VII. SYSTEMIC EFFECTS VIII. BONE TURNOVER IX.
GROWTH X. CATARACTS XI. METABOLIC EFFECTS XII. CENTRAL NERVOUS SYSTEM
EFFECTS XIII. ORAL CANDIDIASIS XIV. DYSPHONIA XV. OTHER LOCAL SIDE
EFFECTS XVI. SUMMARY DISCUSSION REFERENCES 551 552 554 555 559 559 563
567 573 584 585 586 586 587 587 587 588 591 23. EFFECTS OF INHALED
STEROID THERAPY FOR ASTHMA ON SKELETAL METABOLISM 607 JOHN H. TOOGOOD I.
INTRODUCTION 607 II. PATHOGENESIS OF GLUCOCORTICOID-INDUCED OSTEOPOROSIS
607 III. METABOLIC INDICES 608 IV. DATA AVAILABLE FOR INHALED STEROID
608 V. EFFECTS OF BUDESONIDE ON MINERAL METABOLISM 609 VI. EFFECTS OF
BUDESONIDE ON BONE TURNOVER 610 VII. COMPARISONS OF BUDESONIDE VERSUS
PREDNISONE 611 XXVI CONTENTS VIII. COMPARISONS OF BUDESONIDE VERSUS
BECLOMETHASONE 612 IX. CLINICAL OUTCOMES 614 X. EFFECTS OF INHALED
STEROID THERAPY ON BONE DENSITY 614 XI. EFFECTS ON OCCURRENCE OF
FRACTURES 618 XII. SUMMARY 618 XIII. CAVEATS 619 DISCUSSION 619
REFERENCES 623 24. STEROID-RESISTANT ASTHMA 627 DONALD Y. M: LEUNG I.
INTRODUCTION 627 II. CONTROL OF AIRWAY INFLAMMATION BY GLUCOCORTICOIDS
628 III. DEFINITION OF STEROID-RESISTANT ASTHMA 629 IV. CELLULAR
RESPONSES TO GLUCOCORTICOIDS 630 V. MECHANISMS OF GLUCOCORTICOID
RESISTANCE 634 VI. SUMMARY AND IMPLICATIONS FOR THERAPY 641 DISCUSSION
642 REFERENCES 645 PART FIVE PROSPECTS 25. INHALED GLUCOCORTICOIDS IN
ASTHMA: CURRENT UNDERSTANDING AND FUTURE DIRECTIONS 651 PETER J. BARNES
I. INTRODUCTION 651 II. CELLULAR TARGETS FOR INHALED GLUCOCORTICOIDS 652
III. KEY GENE TARGETS OF INHALED GLUCOCORTICOIDS 656 IV. MOLECULAR
MECHANISMS OF ANTI-INFLAMMATORY ACTIONS 661 V. GLUCOCORTICOID
RESPONSIVENESS 663 VI. FUTURE CLINICAL USE OF INHALED GLUCOCORTICOIDS
667 VII. FUTURE DEVELOPMENTS 671 DISCUSSION 673 REFERENCES 675 AUTHOR
INDEX 687 SUBJECT INDEX 753
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV010958528 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:01:41Z |
| institution | BVB |
| isbn | 0824797302 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007330408 |
| oclc_num | 35128178 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-12 |
| owner_facet | DE-355 DE-BY-UBR DE-12 |
| physical | XXVI, 773 S. Ill., graph. Darst. |
| publishDate | 1997 |
| publishDateSearch | 1997 |
| publishDateSort | 1997 |
| publisher | Dekker |
| record_format | marc |
| series | Lung biology in health and disease |
| series2 | Lung biology in health and disease |
| spelling | Inhaled glucocorticoids in asthma mechanisms and clinical actions ed. by Robert P. Schleimer ... New York [u.a.] Dekker 1997 XXVI, 773 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Lung biology in health and disease 97 Astma gtt Glucocorticoïden gtt Inhalatie gtt Asthma Hormone therapy Asthma drug therapy Glucocorticoids Therapeutic use Glucocorticoids pharmacology Bronchialasthma (DE-588)4069674-1 gnd rswk-swf Inhalationstherapie (DE-588)4161728-9 gnd rswk-swf Corticosteroide (DE-588)4070120-7 gnd rswk-swf Glucocorticosteroide (DE-588)4021338-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Bronchialasthma (DE-588)4069674-1 s Inhalationstherapie (DE-588)4161728-9 s Glucocorticosteroide (DE-588)4021338-9 s DE-604 Corticosteroide (DE-588)4070120-7 s Schleimer, Robert P. Sonstige oth Lung biology in health and disease 97 (DE-604)BV000008326 97 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007330408&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Inhaled glucocorticoids in asthma mechanisms and clinical actions Lung biology in health and disease Astma gtt Glucocorticoïden gtt Inhalatie gtt Asthma Hormone therapy Asthma drug therapy Glucocorticoids Therapeutic use Glucocorticoids pharmacology Bronchialasthma (DE-588)4069674-1 gnd Inhalationstherapie (DE-588)4161728-9 gnd Corticosteroide (DE-588)4070120-7 gnd Glucocorticosteroide (DE-588)4021338-9 gnd |
| subject_GND | (DE-588)4069674-1 (DE-588)4161728-9 (DE-588)4070120-7 (DE-588)4021338-9 (DE-588)4143413-4 |
| title | Inhaled glucocorticoids in asthma mechanisms and clinical actions |
| title_auth | Inhaled glucocorticoids in asthma mechanisms and clinical actions |
| title_exact_search | Inhaled glucocorticoids in asthma mechanisms and clinical actions |
| title_full | Inhaled glucocorticoids in asthma mechanisms and clinical actions ed. by Robert P. Schleimer ... |
| title_fullStr | Inhaled glucocorticoids in asthma mechanisms and clinical actions ed. by Robert P. Schleimer ... |
| title_full_unstemmed | Inhaled glucocorticoids in asthma mechanisms and clinical actions ed. by Robert P. Schleimer ... |
| title_short | Inhaled glucocorticoids in asthma |
| title_sort | inhaled glucocorticoids in asthma mechanisms and clinical actions |
| title_sub | mechanisms and clinical actions |
| topic | Astma gtt Glucocorticoïden gtt Inhalatie gtt Asthma Hormone therapy Asthma drug therapy Glucocorticoids Therapeutic use Glucocorticoids pharmacology Bronchialasthma (DE-588)4069674-1 gnd Inhalationstherapie (DE-588)4161728-9 gnd Corticosteroide (DE-588)4070120-7 gnd Glucocorticosteroide (DE-588)4021338-9 gnd |
| topic_facet | Astma Glucocorticoïden Inhalatie Asthma Hormone therapy Asthma drug therapy Glucocorticoids Therapeutic use Glucocorticoids pharmacology Bronchialasthma Inhalationstherapie Corticosteroide Glucocorticosteroide Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007330408&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000008326 |
| work_keys_str_mv | AT schleimerrobertp inhaledglucocorticoidsinasthmamechanismsandclinicalactions |