Protein multiple sequence alignment using knowledge:

Abstract: "Protein sequence alignment is an important technique for drawing phylogenic trees and predicting the structure and function of proteins. So far, many alignment systems have been developed. These systems produce alignment that is optimal or near-optimal according to an artificially de...

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Bibliographic Details
Main Authors: Hirosawa, Makoto (Author), Hoshida, Masaki (Author), Ishikawa, Masato (Author)
Format: Book
Language:English
Published: Tokyo, Japan 1992
Series:Shin-Sedai-Konpyūta-Gijutsu-Kaihatsu-Kikō <Tōkyō>: ICOT technical report 793
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Summary:Abstract: "Protein sequence alignment is an important technique for drawing phylogenic trees and predicting the structure and function of proteins. So far, many alignment systems have been developed. These systems produce alignment that is optimal or near-optimal according to an artificially defined evaluation function. However, these computationally optimal alignments don't necessarily correspond to the biologically optimal alignment that biologists desire. We interviewed experts on alignment and extracted the knowledge they use to align sequences. The alignment system we will introduce in this paper produces biologically meaningful (sometimes optimal) alignment by using the knowledge we extracted."
Physical Description:26 S.

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