The lac operon: a short history of a genetic paradigm
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
<<de>> Gruyter
1996
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 207 S. Ill., graph. Darst. |
| ISBN: | 3110148307 |
Staff View
MARC
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| 100 | 1 | |a Müller-Hill, Benno |d 1933-2018 |e Verfasser |0 (DE-588)12118286X |4 aut | |
| 245 | 1 | 0 | |a The lac operon |b a short history of a genetic paradigm |c Benno Müller-Hill |
| 264 | 1 | |a Berlin [u.a.] |b <<de>> Gruyter |c 1996 | |
| 300 | |a IX, 207 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Genetica |2 larpcal | |
| 650 | 4 | |a Opéron lactose - Recherche - Histoire | |
| 650 | 4 | |a Geschichte | |
| 650 | 4 | |a Lac Operon | |
| 650 | 4 | |a Lac operon |x Research |x History | |
| 650 | 0 | 7 | |a Lactose-Operon |0 (DE-588)4238892-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Entdeckung |0 (DE-588)4014841-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Forschung |0 (DE-588)4017894-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Geschichte |0 (DE-588)4020517-4 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Lactose-Operon |0 (DE-588)4238892-2 |D s |
| 689 | 0 | 1 | |a Entdeckung |0 (DE-588)4014841-5 |D s |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-007287799 | |
Record in the Search Index
| _version_ | 1807502023705231360 |
|---|---|
| adam_text |
CONTENTS
INTRODUCTION
.
1
PART
1:
A
SHORT
HISTORY
OF
THE
LAC
SYSTEM
FROM
ITS
BEGINNING
TO
1978
.
3
1.1
FROM
NOAH
TO
PASTEUR:
ADAPTATION
IN
YEAST
.
5
1.2
ADAPTATION
IN
BACILLUS
SUBTILIS
AND
ESCHERICHIA
COLI
.
7
1.3
MUTANTS
IN
THE
LAC
SYSTEM
OF
ESCHERICHIA
COLI
.
11
1.4
INDUCERS
OF
THE
LAC
SYSTEM
AND THE
DISCOVERY
OF
PERMEASE
.
16
1.5
NEGATIVE
CONTROL
THROUGH
REPRESSOR
.
24
1.6
FURTHER
EVIDENCE
FOR
NEGATIVE
CONTROL
THROUGH
REPRESSOR
.
29
1.7
THE
TRIUMPH
OF
THE
JACOB-MONOD
THEORY
.
31
1.8
MINOR
DEFECTS
IN
THE
JACOB-MONOD
THEORY
.
34
1.9
ISOLATION
OF
THE
LAC
AND
X
CI
REPRESSORS
.
37
1.10
PUTTING
THE
LAC
GENES
ON
PHAGE
| 80
OR
X
.
41
1.11
LAC
AND
X
CI
REPRESSORS
BIND
TO
THEIR
OPERATOR
DNAS
.
44
1.12
MAKING
GRAMS
OF
LAC
REPRESSOR
TO
DETERMINE
ITS
SEQUENCE
.
47
1.13
MUTATIONS
IN
LAD
SUGGEST
A
MODULAR
STRUCTURE
OF
REPRESSOR
.
50
1.14
MILLER
'
S
ANALYSIS
OF
THE
I
GENE:
CLIMBING
MOUNT
EVEREST
.
54
1.15
POSITIVE
CONTROL
THROUGH
THE
CAP
PROTEIN
.
56
1.16
ISOLATION
AND
SEQUENCE
OF
LAC
OPERATOR
.
59
1.17
CHEMICAL
DNA
SEQUENCING
.
61
1.18
STERIC
HINDRANCE
IS
THE
MECHANISM
OF
REPRESSION
.
66
1.19
CHEMICAL
SYNTHESIS
OF
LAC
OPERATOR
DNA
.
70
1.20
LAC
REPRESSOR-OPERATOR
COMPLEX
BINDS
TO
NITROCELLULOSE
.
72
1.21
POLYACRYLAMIDE
GEL
ELECTROPHORESIS
OF
PROTEIN-DNA
COMPLEXES
74
1.22
FUSION
OF
AND
COMPLEMENTATION
WITHIN THE
LACZ
GENE
.
76
1.23
ISOLATION
OF
LAC
PERMEASE
.
78
1.24
THE
END
OF
AN
ERA
.
79
PART
2:
MISINTERPRETATION
.
81
2.1
THE
INTERPRETATION
OF
EXPERIMENTS
IS
SOMETIMES
WRONG
.
83
2.2
ADAPTATION
EXPLAINED
BY
SELF-REPLICATING
GENES
.
85
2.3
THE
KINETICS
OF
ADAPTATION
.
87
VIII
CONTENTS
2.4
LAC
REPRESSOR
IS
RNA
.
89
2.5
OPERATOR
IS
RNA
OR
PROTEIN
.
91
2.6
ISOLATION
OF
LAC
REPRESSOR
.
93
2.7
ISOLATION
OF
LAC
PERMEASE
AND
ARG
REPRESSOR
.
95
2.8
GENETIC
PROOF
THAT
LAC
OPERATOR
IS
DYADIC
.
97
2.9
THE
CORE
OF
LAC
REPRESSOR
BINDS
TO
LAC
OPERATOR
.
99
2.10
LAC
REPRESSOR
USES
(3-SHEET
TO
RECOGNIZE
LAC
OPERATOR
.
102
2.11
A
N-HELIX
BINDS
TO
A
HAIRPIN
LOOP
OF
LAC
OPERATOR
.
105
2.12
PREDICTION
OF
THE
SEQUENCE
OF
LAC
OPERATOR
.
107
2.13
THE
KINETICS
OF
LAC
REPRESSOR-OPERATOR
INTERACTION
.
109
2.14
LAC
REPRESSOR
BOUND
TO
02
ACTS
AS
AN
EFFICIENT
ROAD
BLOCK
.
ILL
2.15
AUXILIARY
OPERATORS
CAN
BE
DISREGARDED
IN
REPRESSION
.
113
2.16
CAP ACTIVATES
TRANSCRIPTION
LIKE
A,
CI
REPRESSOR
.
114
2.17
IN
THE
PITFALL
OF
SYMMETRY
.
116
2.18
THE
CAP-DNA
COMPLEX:
TWO
PROPOSITIONS
.
117
2.19
THE
ADENINE
OF
CYCLIC
AMP
BINDS
TO
DNA
.
118
2.20
THE
STRUCTURE
OF
P-GALACTOSIDASE
.
119
2.21
FROM
LAMARCK
TO
CAIRNS
.
120
2.22
DNA
SEQUENCE
ANALYSIS:
NOT
IN
THIS
CENTURY!
.
124
2.23
PROTEIN
SPLICING
.
125
2.24
O1
-REPRESSOR-O2
LOOPS
.
127
PART
3:
THE
LAC
OPERON,
A
PARADIGM
OF
BEAUTY
AND
EFFICIENCY
.
129
3.1
THE
NEW
PERSPECTIVE
.
131
3.2
SOME
NUMBERS
AND
CONCEPTS
.
134
3.3
ACTIVATION
OF
THE
LAC
PROMOTER
BY
CAP
PROTEIN
.
137
3.3.1
THE
MODULAR
STRUCTURE
OF
CAP
PROTEIN
.
137
3.3.2
MUTATIONAL
ANALYSIS
OF
THE
LAC
PROMOTER
AND
THE
CAP
SITE
.
142
3.3.3
MUTATIONAL
ANALYSIS
OF
THE
CAP
PROTEIN
.
145
3.3.3.1
MUTATIONS
OF
CAP
WHICH RELIEVE
CAMP
REQUIREMENT
FOR
ACTIVATION
.
146
3.3.3.2
MUTANTS
OF
CAP
WHICH
CHANGE
THE
SPECIFICITY
OF
DNA
TARGET
RECOGNITION
.
147
3.3.3.3
MUTANTS
OF
CAP
WHICH
ABOLISH
ACTIVATION
WITHOUT
IMPAIRING
DNA BINDING
OR
BENDING
.
148
3.3.4
RNA POLYMERASE,
A
PARTNER
OF
CAP
.
151
3.3.5
CAP
IN
OTHER
SYSTEMS
.
154
CONTENTS
IX
3.4
REPRESSION
OF
THE
LAC
PROMOTER
BY
LAC
REPRESSOR
.
158
3.4.1
THE
MODULAR
STRUCTURE
OF
LAC
REPRESSOR
.
158
3.4.2
MUTATIONAL
ANALYSIS
OF
THE
LAC
OPERATORS
01,
02
AND
03
.
164
3.4.3
MUTATIONAL
ANALYSIS
OF
LAC
REPRESSOR
.
170
3.4.3.1
GENERAL
MUTANT
ANALYSIS:
NONSENSE
AND
MISSENSE
MUTANTS
OF
THE
LAD
GENE
.
170
3.4.3.2
SPECIAL
MUTANT
ANALYSIS:
SPECIFIC
PROTEIN-DNA
RECOGNITION
.
170
3.4.3.3
SPECIAL
MUTANT
ANALYSIS:
SPECIFIC
PROTEIN-INDUCER
INTERACTION
.
173
3.4.3.4
SPECIAL
MUTANT
ANALYSIS:
ALTERED
ALLOSTERIC
PROPERTIES
.
175
3.4.3.5
SPECIAL
MUTANT
ANALYSIS:
ALTERED
DIMERIZATION
AND
TETRAMERIZATION
.
176
3.4.4
RNA
POLYMERASE,
A
PARTNER
OF
LAC
REPRESSOR
.
179
3.5
P-GALACTOSIDASE,
LAC
PERMEASE
AND
TRANSACETYLASE
.
181
3.5.1
P-GALACTOSIDASE
.
181
3.5.2
LAC
PERMEASE
.
182
3.5.3
THIOGALACTOSIDE
TRANSACETYLASE
.
183
3.6
THE
LAC
SYSTEM
AS
A
TOOL
.
185
3.6.1
P-GALACTOSIDASE
FUSIONS
AND
LAC
REPRESSOR
FUSIONS
.
185
3.6.2
A-COMPLEMENTATION
.
186
3.6.3
THE
LAD
GENE
AS
AN
INDICATOR
OF
MUTAGENESIS
.
186
3.6.4
LAC
CONTROL
NOT
IN
E.
COLI
.
187
3.6.5
PEPTIDE
LIBRARIES
DISPLAYED
ON
DIMERIC
LAC
REPRESSOR
.
187
3.7
WHAT
LESSON
CAN
BE
LEARNED
FROM THE
LAC
SYSTEM?
.
191
3.8
OUTLOOK
.
195
AUTHORS
INDEX
.
199
SUBJECT
INDEX
.
203 |
| any_adam_object | 1 |
| author | Müller-Hill, Benno 1933-2018 |
| author_GND | (DE-588)12118286X |
| author_facet | Müller-Hill, Benno 1933-2018 |
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| building | Verbundindex |
| bvnumber | BV010897038 |
| callnumber-first | Q - Science |
| callnumber-label | QH434 |
| callnumber-raw | QH434 |
| callnumber-search | QH434 |
| callnumber-sort | QH 3434 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | WB 2415 WD 4150 WG 1920 WG 1940 WG 2000 |
| ctrlnum | (OCoLC)34742385 (DE-599)BVBBV010897038 |
| dewey-full | 589.9/5 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 589 - [Unassigned] |
| dewey-raw | 589.9/5 |
| dewey-search | 589.9/5 |
| dewey-sort | 3589.9 15 |
| dewey-tens | 580 - Plants |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV010897038 |
| illustrated | Illustrated |
| indexdate | 2024-08-16T00:30:54Z |
| institution | BVB |
| isbn | 3110148307 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007287799 |
| oclc_num | 34742385 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29T DE-20 DE-12 DE-11 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-29T DE-20 DE-12 DE-11 DE-188 |
| physical | IX, 207 S. Ill., graph. Darst. |
| publishDate | 1996 |
| publishDateSearch | 1996 |
| publishDateSort | 1996 |
| publisher | <<de>> Gruyter |
| record_format | marc |
| spelling | Müller-Hill, Benno 1933-2018 Verfasser (DE-588)12118286X aut The lac operon a short history of a genetic paradigm Benno Müller-Hill Berlin [u.a.] <<de>> Gruyter 1996 IX, 207 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetica larpcal Opéron lactose - Recherche - Histoire Geschichte Lac Operon Lac operon Research History Lactose-Operon (DE-588)4238892-2 gnd rswk-swf Entdeckung (DE-588)4014841-5 gnd rswk-swf Forschung (DE-588)4017894-8 gnd rswk-swf Geschichte (DE-588)4020517-4 gnd rswk-swf Lactose-Operon (DE-588)4238892-2 s Entdeckung (DE-588)4014841-5 s DE-604 Forschung (DE-588)4017894-8 s Geschichte (DE-588)4020517-4 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007287799&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Müller-Hill, Benno 1933-2018 The lac operon a short history of a genetic paradigm Genetica larpcal Opéron lactose - Recherche - Histoire Geschichte Lac Operon Lac operon Research History Lactose-Operon (DE-588)4238892-2 gnd Entdeckung (DE-588)4014841-5 gnd Forschung (DE-588)4017894-8 gnd Geschichte (DE-588)4020517-4 gnd |
| subject_GND | (DE-588)4238892-2 (DE-588)4014841-5 (DE-588)4017894-8 (DE-588)4020517-4 |
| title | The lac operon a short history of a genetic paradigm |
| title_auth | The lac operon a short history of a genetic paradigm |
| title_exact_search | The lac operon a short history of a genetic paradigm |
| title_full | The lac operon a short history of a genetic paradigm Benno Müller-Hill |
| title_fullStr | The lac operon a short history of a genetic paradigm Benno Müller-Hill |
| title_full_unstemmed | The lac operon a short history of a genetic paradigm Benno Müller-Hill |
| title_short | The lac operon |
| title_sort | the lac operon a short history of a genetic paradigm |
| title_sub | a short history of a genetic paradigm |
| topic | Genetica larpcal Opéron lactose - Recherche - Histoire Geschichte Lac Operon Lac operon Research History Lactose-Operon (DE-588)4238892-2 gnd Entdeckung (DE-588)4014841-5 gnd Forschung (DE-588)4017894-8 gnd Geschichte (DE-588)4020517-4 gnd |
| topic_facet | Genetica Opéron lactose - Recherche - Histoire Geschichte Lac Operon Lac operon Research History Lactose-Operon Entdeckung Forschung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007287799&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mullerhillbenno thelacoperonashorthistoryofageneticparadigm |