Dehydroepiandrosterone (DHEA) and aging: [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC]
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York, NY
New York Acad. of Sciences
1995
|
| Series: | Annals of the New York Academy of Sciences
774 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 350 S. Ill., graph. Darst. |
| ISBN: | 1573310042 1573310050 |
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MARC
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| adam_text | ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 774
December 29, 1995
DEHYDROEPIANDROSTERONE
(DHEA) AND AGING
Editors and Conference Organizers
Francis L. Bellino, Raymond A. Daynes, Peter J. Hornsby,
David H. Lavrin, and John E. Nestler
CONTENTS
Introduction. DHEA: A Coming of Age. By John E. Nestler ix
Current Challenges for DHEA Research. By Peter J. Hornsby xiii
Historical Overview. Abbreviated Account of Some Aspects of the
Biochemistry of DHEA, 1934 1995. By Seymour Lieberman 1
Part I. Age Dependent Changes in Circulating DHEA and DHEA
Biosynthesis
DHEA and Peripheral Androgen and Estrogen Formation: Intracrinology.
By Fernand Labrie, Alain Belanger, Jacques Simard, Van Luu
The, and Claude Labrie 16
Biosynthesis of DHEAS by the Human Adrenal Cortex and Its Age Related
Decline. By Peter J. Hornsby 29
Adrenal Androgen Biosynthesis with Special Attention to P450cl7. By J. Ian
Mason, Ian M. Bird, and William E. Rainey 47
Human Dehydroepiandrosterone Sulfotransferase. Purification, Molecular
Cloning, and Characterization. By Charles N. Falany, Kathleen
A. Comer, Thomas P. Dooley, and Hansruedi Glatt 59
Regulation of Human Dehydroepiandrosterone Metabolism by Insulin. By
John E. Nestler 73
Part II. DHEA and Neurologic Function
Dehydroepiandrosterone (DHEA) Is a Neuroactive Neurosteroid. By Paul
Robel and Etienne Emile Baulieu 82
Neuronal Actions of Dehydroepiandrosterone. Possible Roles in Brain
Development, Aging, Memory, and Affect. By Maria Dorota
Majewska Ill
This volume is the result of a conference entitled Dehydroepiandrosteronc (DHEA) and
Aging which was sponsored by the New York Academy of Sciences and held on June 17 19,
1995 in Washington, DC.
2 ANNALS NEW YORK ACADEMY OF SCIENCES
Part III. Physiology of DHEA Metabolism
Dehydroepiandrosterone Sulfate and Aging. By A. Vermeulen 121
Replacement of DHEA in Aging Men and Women. Potential Remedial
Effects. By S. S. C. Yen, A. J. Morales, and O. Khorram 128
Metabolism of Dehydroepiandrosterone. By Christopher Longcope 143
Pleotropic Effects of Dietary DHEA. By Leon Milewich, Fernando
Catalina, and Michael Bennett 149
Part FV. Biochemical Modes of Action for DHEA and
Selected Metabolic Actions
Induction of Thermogenic Enzymes by DHEA and Its Metabolites. By
Henry Lardy, Nancy Kneer, Monica Bellei, and Valentina
Bobyleva 171
Mechanism of Cancer Preventive Action of DHEA. Role of Glucose 6
Phosphate Dehydrogenase. By Arthur G. Schwartz and Laura L.
Pashko 180
Regulation of Cytochromes P450 by DHEA and Its Anticarcinogenic Action.
By R. A. Prough, X. D. Lei, G. H. Xiao, H. Q. Wu, T. E. Geoghegan,
and S. J. Webb 187
Part V. DHEA, Immunology, and Aging
Does DHEAS Restore Immune Competence in Aged Animals through Its
Capacity to Function as a Natural Modulator of Peroxisome Activities?
By Nina F. L. Spencer, Matthew E. Poynter, Jon D. Hennebold,
Hong Hua Mu, and Raymond A. Daynes 200
Adaptation to Chronic Stress in Military Trainees. Adrenal Androgens,
Testosterone, Glucocorticoids, IGF 1, and Immune Function. By
Edward Bernton, David Hoover, Richard Galloway, and
KathrynPopp 217
DHEAS as an Effective Vaccine Adjuvant in Elderly Humans. Proof of
Principle Studies. By Barbara Araneo, Tad Dowell, Marion
L. Woods, Raymond Daynes, Michael Judd, and Thomas Evans 232
Relationship between Humoral Immunoaugmenting Properties of DHEAS
and IgD Receptor Expression in Young and Aged Mice. By Christina
D. Swenson, Susan R. S. Gottesman, Donald V. Belsito, Karen
M. Samanich, Joanne Edington, and G. Jeanette Thorbecke 249
Part VI. DHEA and the Atherosclerosis of Aging
The Epidemiology of DHEAS and Cardiovascular Disease. By Elizabeth
Barrett Connor and Deborah Goodman Gruen 259
Dehydroepiandrosterone and Coronary Atherosclerosis. By David
M. Herrington 271
Dehydroepiandrosterone Inhibits Human Platelet Aggregation in Vitro and in
Vivo. By Robert L. Jesse, Kathy Loesser, David M. Eich, Yong
Zhen Oian, Michael L. Hess, and John E. Nestler 281
3
Poster Papers
Dehydroepiandrosterone Attenuates Study Induced Declines in Insulin
Sensitivity in Postmenopausal Women. By G. Wright Bates, Jr.,
Robert S. Egerman, Edward S. Umstot, John E. Buster, and Peter
R. Casson 291
Cloning and Expression of Hamster Adrenal Cytochrome P450cl7 cDNA. By
Mario Cloutier, Alain Fleury, Jean Courtemanche, Lyne
Ducharme, J. Ian Mason, and Jean Guy Lehoux 294
Dehydroepiandrosterone Enhances Influenza Immunization in Aged Mice.
By H. D. Danenberg, A. Ben Yehuda, Z. Zakay Rones, and G.
Friedman 297
Dehydroepiandrosterone Augments Ml Muscarinic Receptor Stimulated
Amyloid Precursor Protein Secretion in Desensitized PC12M1 Cells. By
H. D. Danenberg, R. Haring, E. Heldman, D. Gurwitz, D.
Ben Nathan, Z. Pittel, A, Zuckerman, and A. Fisher 300
Effects of Dehydroepiandrosterone Sulfate and Stress on Hippocampal
Electrophysiological Plasticity. By David M. Diamond, Berrilyn J.
Branch, Monika Fleshner, and Gregory M. Rose 304
Sex Differences in Dehydroepiandrosterone Metabolism in Rodents. By
Gerhard Hobe, Renate Schon, Kathrin Undisz, Lutz Blei, and
HANS GEORG HlLLESHEIM 308
Effect of Dehydroepiandrosterone on Cyclic Guanosine Monophosphate in
Men of Advancing Age. By Daniela Jakubowicz, Nusen Beer, and
Rufino Rengifo 312
7a Hydroxylation of the Adrenal Androgens Dehydroepiandrosterone and
Androst 5 ene 3p, 17f5 Diol Predominates in Differentiating Human
Adipose Stromal Cells. By M. W. Khalil, B. Strutt, and D. W.
Killinger 316
Effects of Aging and Long Term Calorie Restriction on DHEA and DHEA
Sulfate in Rhesus Monkeys. By Mark A. Lane, Donald K. Ingram, and
GeorgeS. Roth 319
Steroid Hormone Regulation of a Polyclonal TH2 Immune Response. By
David A. Padgett, John F. Sheridan, and Roger M. Loria 323
Effect of TGF (3 on Dehydroepiandrosterone Sulfotransferase in Cultured
Human Fetal Adrenal Cells. By C. R. Parker, Jr., A. K. Stankovic,
C. N. Falany, and W. E. Grizzle 326
DHEA Diminishes Fat Food Intake in Lean and Obese Zucker Rats. By J. R.
Porter and F. Svec 329
Synergistic Anorectic Effect of Dehydroepiandrosterone and Fenfluramine
on Zucker Rat Food Intake and Selection. The Obesity Research
Program. By Frank Svec and Johnny R. Porter 332
Effect of Dehydroepiandrosterone on Rat Thyroxine Binding Globulin, a
Protein Upregulated during Aging. By Roger Vranckx, Patricia
Mechighel, and Lia Savu 335
4 ANNALS NEW YORK ACADEMY OF SCIENCES
Antidepressant and Cognition Enhancing Effects of DHEA in Major
Depression. By O. M. Wolkowitz, V. I. Reus, E. Roberts,
F. Manfredi, T. Chan, S. Ormiston, R. Johnson, J. Canick,
L. Brizendine, and H. Weingartner 337
Effects of Dehydroepiandrosterone on MNU Induced Breast Cancer in
Sprague Dawley Rats. By R. A. Lubet, D. M. McCormick, G. M.
Gordon, C. Grubbs, X. D. Lei, R. A. Prough, V. E. Steele, G. J.
Keixoff, C. F. Thomas, and R. D. Moon 340
Subject Index 342
Index of Contributors 349
Financial assistance was received from:
Major Funder
• National Institutes of Health
NIA
NIAMS
NCI
Contributors
• DIAGNOSTIC SYSTEMS LABORATORIES, INC.
• GLAXO WELLCOME INC.
• GLENN FOUNDATION FOR MEDICAL RESEARCH
• HENRY AND LUCY MOSES FUND, INC.
• MERCK RESEARCH LABORATORIES
• PARADIGM BIOSCIENCES, INC.
• PFIZER CENTRAL RESEARCH
• WYETH AYERST RESEARCH
The New York Academy of Sciences believes it has a responsibility to provide an open
forum for discussion of scientific questions. The positions taken by the participants in
the reported conferences are their own and not necessarily those of the Academy. The
Academy has no intent to influence legislation by providing such forums.
|
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| genre_facet | Konferenzschrift 1995 Washington DC |
| id | DE-604.BV010695688 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:57:21Z |
| institution | BVB |
| isbn | 1573310042 1573310050 |
| language | English |
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| spelling | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] ed. by Francis L. Bellino ... New York, NY New York Acad. of Sciences 1995 XIV, 350 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Annals of the New York Academy of Sciences 774 Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Dehydroepiandrosteron (DE-588)4243776-3 gnd rswk-swf Prävention (DE-588)4076308-0 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf Arteriosklerose (DE-588)4068866-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1995 Washington DC gnd-content Dehydroepiandrosteron (DE-588)4243776-3 s Physiologische Chemie (DE-588)4076124-1 s DE-604 Pharmakologie (DE-588)4045687-0 s Arteriosklerose (DE-588)4068866-5 s Prävention (DE-588)4076308-0 s Altern (DE-588)4068596-2 s Bellino, Francis L. Sonstige oth Annals of the New York Academy of Sciences 774 (DE-604)BV002532608 774 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007139233&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] Annals of the New York Academy of Sciences Physiologische Chemie (DE-588)4076124-1 gnd Pharmakologie (DE-588)4045687-0 gnd Dehydroepiandrosteron (DE-588)4243776-3 gnd Prävention (DE-588)4076308-0 gnd Altern (DE-588)4068596-2 gnd Arteriosklerose (DE-588)4068866-5 gnd |
| subject_GND | (DE-588)4076124-1 (DE-588)4045687-0 (DE-588)4243776-3 (DE-588)4076308-0 (DE-588)4068596-2 (DE-588)4068866-5 (DE-588)1071861417 |
| title | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] |
| title_auth | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] |
| title_exact_search | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] |
| title_full | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] ed. by Francis L. Bellino ... |
| title_fullStr | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] ed. by Francis L. Bellino ... |
| title_full_unstemmed | Dehydroepiandrosterone (DHEA) and aging [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] ed. by Francis L. Bellino ... |
| title_short | Dehydroepiandrosterone (DHEA) and aging |
| title_sort | dehydroepiandrosterone dhea and aging this volume is the result of a conference held on june 17 19 1995 in washington dc |
| title_sub | [this volume is the result of a conference ... held on June 17 - 19, 1995 in Washington, DC] |
| topic | Physiologische Chemie (DE-588)4076124-1 gnd Pharmakologie (DE-588)4045687-0 gnd Dehydroepiandrosteron (DE-588)4243776-3 gnd Prävention (DE-588)4076308-0 gnd Altern (DE-588)4068596-2 gnd Arteriosklerose (DE-588)4068866-5 gnd |
| topic_facet | Physiologische Chemie Pharmakologie Dehydroepiandrosteron Prävention Altern Arteriosklerose Konferenzschrift 1995 Washington DC |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007139233&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002532608 |
| work_keys_str_mv | AT bellinofrancisl dehydroepiandrosteronedheaandagingthisvolumeistheresultofaconferenceheldonjune17191995inwashingtondc |