Regulation of chromatin structure and function:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Austin
Landes
1994
|
| Series: | Molecular biology intelligence unit
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 137 S. Ill., graph. Darst. |
| ISBN: | 157059175X |
Staff View
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Record in the Search Index
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| adam_text | MOLECULAR
BIOLOGY
INTELLIGENCE
UNIT
REGULATION OF CHROMATIN
STRUCTURE AND FUNCTION
Alan E Wolffe, Ph D
National Institutes of Health
Bethesda, Maryland
U S A
R G IANDES COMPANY
AUSTIN
CONTENTS
Preface
1 Nucleosomal Anatomy 1
DNA Structure in the Nucleosome 2
The Organization of the Histone Octamer 8
The Interaction of DNA with the Histone Octamer 9
Linker Histones, the Nucleosome, and the Chromatin Fiber 12
Nucleosome Construction and Disruption 17
Histone Modifications, Variants and Mutants—
Potential Impact on Nucleosome Structure and Function 18
Summary 24
2 Nucleosome Structure and Transcriptional Control 33
Transcription Factor Access to DNA
in the Nucleosome 33
Nucleosome Positioning Facilitates Transcriptional
Regulation 37
Nucleosome Positioning Facilitates Transcriptional
Activation 39
Nucleosome Construction and Transcription Factor Access
to DNA 41
Reconstruction of Chromatin Mediated Effects on
Transcription In Vitro 44
Summary 47
3 Assembly of the Nucleus and Higher Order Structures 53
In Vitro Systems 54
Nuclear Reconstitution and Chromatin Assembly 55
Nuclear Formation 56
Chromatin~Assembly 59
Nuclear Replication 62
Summary 66
4 Chromosomal Domains, Histones and
Transcriptional Control 73
Genetic Evidence for Histone and Chromosomal Domain
Function in Saccharomyces Cerevisiae 74
Genetic Evidence for Histone and
Chromatin Domain Function in Drosophila 76
Chromosomal Domains As Compartments for
Gene Regulation 77
Summary 80
5 Epigenetic Inheritance 85
The Active State of a Eukaryotic Gene 85
Local and Long-Range Position Effects 85
Long-Range Position Effect 87
The Fate ofNucleoprotein Complexes Conferring Active and
Repressed States During Replication 88
Nucleosome and Transcription Complex Assembly on
Replicating DNA 89
Hypotheses to Explain the Inheritance
of Chromatin States 90
Testing the Hypotheses with Experiment:
The Case of the X Chromosome 94
Summary 94
6 Developmental Regulation of Chromatin Composition 99
Core Histone Variants During Development 99
Linker Histone Variants During Development 102
Modifications of Chromatin Components
During Development 105
Summary : 107
7 Developmental Regulation of a Simple Gene Family 113
The Oocyte and Somatic 5S RNA Gene Families 113
Transcription Factors and the Transcription Complex 114
Differential Transcription Complex Assembly on Oocyte
and Somatic 5S RNA Genes 116
Chromatin Assembly, DNA Replication and 5S RNA Gene
Transcription^ 117
Histone HI and the Repression
of Oocyte 5S RNA Genes 120
The Relative Roles of Transcription Factors and Chromatin
Structure In 5S RNA Gene Regulation 122
Alternative Models 123
Future Prospects 124
Summary 124
8 Perspective 131
Index 135
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:54:26Z |
| institution | BVB |
| isbn | 157059175X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-007013650 |
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| physical | 137 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Landes |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Wolffe, Alan P. Verfasser aut Regulation of chromatin structure and function Alan P. Wolffe Austin Landes 1994 137 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Chromatin Chromatin genetics Chromatin physiology Gene Expression Regulation Genetic transcription Regulation Histones Histones genetics Histones physiology Chromatin (DE-588)4010152-6 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Chromatin (DE-588)4010152-6 s Genregulation (DE-588)4122166-7 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007013650&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wolffe, Alan P. Regulation of chromatin structure and function Chromatin Chromatin genetics Chromatin physiology Gene Expression Regulation Genetic transcription Regulation Histones Histones genetics Histones physiology Chromatin (DE-588)4010152-6 gnd Genregulation (DE-588)4122166-7 gnd |
| subject_GND | (DE-588)4010152-6 (DE-588)4122166-7 |
| title | Regulation of chromatin structure and function |
| title_auth | Regulation of chromatin structure and function |
| title_exact_search | Regulation of chromatin structure and function |
| title_full | Regulation of chromatin structure and function Alan P. Wolffe |
| title_fullStr | Regulation of chromatin structure and function Alan P. Wolffe |
| title_full_unstemmed | Regulation of chromatin structure and function Alan P. Wolffe |
| title_short | Regulation of chromatin structure and function |
| title_sort | regulation of chromatin structure and function |
| topic | Chromatin Chromatin genetics Chromatin physiology Gene Expression Regulation Genetic transcription Regulation Histones Histones genetics Histones physiology Chromatin (DE-588)4010152-6 gnd Genregulation (DE-588)4122166-7 gnd |
| topic_facet | Chromatin Chromatin genetics Chromatin physiology Gene Expression Regulation Genetic transcription Regulation Histones Histones genetics Histones physiology Genregulation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=007013650&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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