Mouse genetics: concepts and applications
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Oxford Univ. Press
1995
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 362 S. graph. Darst. |
| ISBN: | 0195075544 |
Internformat
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| 650 | 4 | |a Mice |x Genetics | |
| 650 | 4 | |a Mice |x genetics | |
| 650 | 4 | |a Mice, Transgenic |x genetics | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Mouse Genetics
Concepts and Applications
Lee M Silver
L—•
New York Oxford
OXFORD UNIVERSITY PRESS
Contents
1 An Introduction to Mice 3
1 1 Of mice, men,- and a woman 3
1 2 The origin of mice in genetic research 7
1 3 The new biology and the mouse model 11
2 Town Mouse, Country Mouse 15
2 1 What are mice? 15
2 2 Where do mice come from? 18
2 3 Systematics of the Mus species group, the house mouse,
and the classical inbred strains 22
2 4 Lifestyles and adaptability of wild house mice 30
3 Laboratory Mice 32
3 1 Sources of laboratory mice 32
3 2 Mouse crosses and standard strains 34
3 3 Coisogenics, congenics, and other specialized strains 43
3 4 Standardized nomenclature 52
3 5 Strategies for record-keeping 57
4 Reproduction and Breeding 62
4 1 Reproductive performance: comparison of inbred strains 62
4 2 Germ cell differentiation and sexual maturation 63
4 3 Mating and pregnancy 65
4 4 The postnatal period 70
4 5 Assisted reproduction for the infertile cross 73
5 The Mouse Genome 76
5 1 Quantifying the genome 76
5 2 Karyotypes, chromosomes, and translocations 83
5 3 Genomic elements, genome evolution, and gene families 92
5 4 Repetitive non-functional DNA families 105
5 5 Genomic imprinting 110
viii CONTENTS
6 Mutagenesis and Transgenesis 114
6 1 Classical mutagenesis 114
6 2 Embryo manipulation: genetic considerations 118
6 3 Transgenic mice formed by nuclear injection 123
6 4 Targeted mutagenesis and gene replacement 127
6 5 Further uses of transgenic technologies 130
7 Mapping in the Mouse: An Overview 133
7 1 Genetic maps come in various forms 133
7 2 Mendel s genetics, linkage, and the mouse 137
7 3 General strategies for mapping mouse loci 150
7 4 The final chapter of genetics 155
8 Genetic Markers 159
8 1 Genotypic and phenotypic variation 159
8 2 Restriction fragment length polymorphisms 160
8 3 Polymorphisms detected by PCR 171
8 4 Region-specific panels of DNA markers 191
9 Classical Linkage Analysis and Mapping Panels 195
9 1 Demonstration of linkage and statistical analysis 195
9 2 Recombinant inbred strains 207
9 3 Interspecific mapping panels 227
9 4 Starting from scratch with a new mapping project 233
9 5 Quantitative traits and polygenic analysis 253
10 Non-breeding Mapping Strategies 264
10 1 Linkage maps without breeding 264
10 2 Chromosomal mapping tools 266
10 3 Physical maps and positional cloning 271
10 4 The Human Genome Project and the ultimate map 283
Appendix A: Suppliers of Mice 285
Al Major suppliers of common inbred and outbred strains 285
A2 Other commercial sources of mice 285
Appendix B: Computational Tools and Electronic Databases 286
B1 On-line electronic databases 286
B2 Mouse genetics community bulletin board 289
B3 Computer programs 289
Appendix C: Source Materials for Further Reading 291
Cl Selected monographs and books 291
C2 Selected journals and serials of particular interest 292
CONTENTS ix
Appendix D: Statistics 294
Dl Confidence limits and median estimates of linkage distance 294
D2 Quantitative differences in expression between two strains 305
Appendix E: Glossary of Terms 307
Notes 317
References 327
Index 353
|
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| dewey-sort | 3599.32 233 |
| dewey-tens | 590 - Animals |
| discipline | Biologie |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:53:33Z |
| institution | BVB |
| isbn | 0195075544 |
| language | English |
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| physical | XIII, 362 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
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| publisher | Oxford Univ. Press |
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| spelling | Silver, Lee M. 1925- Verfasser (DE-588)120023113 aut Mouse genetics concepts and applications Lee M. Silver New York [u.a.] Oxford Univ. Press 1995 XIII, 362 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Muizen gtt Gene Expression genetics Mice as laboratory animals Mice Breeding Mice Genetics Mice genetics Mice, Transgenic genetics Mutation genetics Genetik (DE-588)4071711-2 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Genexpression (DE-588)4020136-3 gnd rswk-swf Maus (DE-588)4169148-9 s Genexpression (DE-588)4020136-3 s DE-604 Genetik (DE-588)4071711-2 s HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006997608&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Silver, Lee M. 1925- Mouse genetics concepts and applications Muizen gtt Gene Expression genetics Mice as laboratory animals Mice Breeding Mice Genetics Mice genetics Mice, Transgenic genetics Mutation genetics Genetik (DE-588)4071711-2 gnd Maus (DE-588)4169148-9 gnd Genexpression (DE-588)4020136-3 gnd |
| subject_GND | (DE-588)4071711-2 (DE-588)4169148-9 (DE-588)4020136-3 |
| title | Mouse genetics concepts and applications |
| title_auth | Mouse genetics concepts and applications |
| title_exact_search | Mouse genetics concepts and applications |
| title_full | Mouse genetics concepts and applications Lee M. Silver |
| title_fullStr | Mouse genetics concepts and applications Lee M. Silver |
| title_full_unstemmed | Mouse genetics concepts and applications Lee M. Silver |
| title_short | Mouse genetics |
| title_sort | mouse genetics concepts and applications |
| title_sub | concepts and applications |
| topic | Muizen gtt Gene Expression genetics Mice as laboratory animals Mice Breeding Mice Genetics Mice genetics Mice, Transgenic genetics Mutation genetics Genetik (DE-588)4071711-2 gnd Maus (DE-588)4169148-9 gnd Genexpression (DE-588)4020136-3 gnd |
| topic_facet | Muizen Gene Expression genetics Mice as laboratory animals Mice Breeding Mice Genetics Mice genetics Mice, Transgenic genetics Mutation genetics Genetik Maus Genexpression |
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