Cancer chemotherapeutic agents:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Washington, DC
American Chemical Society
1995
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| Series: | ACS professional reference book
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xx, 698 Seiten Illustrationen, Diagramme |
| ISBN: | 0841229201 0841232164 |
Staff View
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| 245 | 1 | 0 | |a Cancer chemotherapeutic agents |c William O. Foye, editor (Massachusetts College of Pharmacy and Allied Health Sciences) |
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Record in the Search Index
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CANCER CHEMOTHERAPEUTK AGENTS WILLIAM O. FOYE, EDITOR MASSACHUSETTS
COLLEGE OF PHARMACY AND ALLIED HEALTH SCIENCES ACS PROFESSIONAL
REFERENCE BOOK AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC 1995 CONTENTS
CONTRIBUTORS XVII PREFACE XIX 1. INTRODUCTION AND HISTORICAL BACKGROUND
1 SAUL A. SCHEPARTZ SUMMARY 5 REFERENCES 6 2. PREDICTION OF BIOCHEMICAL
MECHANISM OF ACTION FROM THE IN VITRO ANTITUMOR SCREEN OF THE NATIONAL
CANCER INSTITUTE 9 KENNETH D. PAULL, ERNEST HARNEL, AND LOUIS MALSPEIS
SCREENING PROCEDURES 10 SPECIAL CONCENTRATION PARAMETERS GI 50 , TGI,
AND LC 50 10 THE MEAN"GRAPH 11 QUESTION OF IN VITRO BIOCHEMICAL
MECHANISM OF ACTION 12 STANDARD AGENTS AND THE STANDARD AGENT DATABASE
12 EXAMPLES OF COMPARE USED WITH THE STANDARD AGENT DATABASE 13
APPLICATIONS OF COMPARE 21 APPLICATIONS COMPLETED OR IN PROGRESS 29
CONCLUSION 30 FUTURE DIRECTIONS 30 APPENDIX A: THE COMPARE ALGORITHM 31
APPENDIX B: MEAN GRAPHS 33 APPENDIX C: STANDARD AGENT NSC NUMBERS AND
COMMON NAMES 40 REFERENCES 42 3. ANTIMETABOLITES 47 GENERAL INTRODUCTION
TO CHAPTERS 3 AND 4 47 J. A. MONTGOMERY GENERAL DESCRIPTION OF
ANTIMETABOLITES 48 J. A. MONTGOMERY IX FLUOROPYRIMIDINES 49 S. ANANTHAN
5-FLUOROURACIL AND 5-FLUORO-2'-DEOXYURIDINE 49 CHEMISTRY 50 MECHANISM OF
ACTION 50 ROUTE OF ADMINISTRATION, ABSORPTION, FATE, AND EXCRETION 52
TOXICITY AND SIDE EFFECTS 53 DEVELOPMENT OF RESISTANCE 53 PRODRUGS AND
OTHER FLUORINATED PYRIMIDINES 54 BIOCHEMICAL MODULATION BY OTHER DRUGS
AND COMBINATION CHEMOTHERAPY 55 REFERENCES 56 THIOPURINES 58 REFERENCES
INHIBITORS OF NUCLEOSIDE DIPHOSPHATE REDUCTASE J. A. MONTGOMERY 62 66 W.
B. PARKER HYDROXYUREA 67 DEOXYADENOSINE ANALOGUES 68 OTHER INHIBITORS OF
NDPR 68 REFERENCES 69 2'-DEOXYRIBONUCLEOSIDE ANALOGUES 71 J. A. SECRIST
III CYTARABINE 71 FLUDARABINE 73 OTHER AGENTS 75 REFERENCES 77 OTHER
NUCLEOSIDES 82 J. A. MONTGOMERY 2'-DEOXYCOFORMYCIN 82 TIAZOFURIN 83
CYCLOPENTENYLCYTOSINE 84 REFERENCES 85 FOLIC ACID ANALOGUES 86 C. G.
TEMPLE, JR. HOMOFOLATES 86 A^-PROPARGYL-5,8-DIDEAZAFOLIC ACID 89
5,10-DIDEAZA-5,6,7,8-TETRAHYDROFOLIC ACID 91 REFERENCES 93 METHOTREXATE
AND RELATED DIAMINOHETEROCYCLES 96 J. R. PIPER CLASSICAL ANTIFOLATES 97
LIPOPHILIC ANTIFOLATES 101 REFERENCES - 103 6-DIAZO-5-OXO-L-NORLEUCINE
105 REFERENCES L-ASPARAGINASE REFERENCES N-(PHOSPHONOACETYL)-L-ASPARTIC
ACID REFERENCES 4. AGENTS THAT REACT WITH DNA INTRODUCTION NITROGEN
MUSTARD AND RELATED STRUCTURES MECHLORETHAMINE CHLORAMBUCIL MELPHALAN
CYDOPHOSPHAMIDE AND RELATED STRUCTURES ESTRAMUSTINE REFERENCES PLATINUM
COMPLEXES CHEMISTRY' MECHANISM OF ACTION PHARMACOLOGY TOXICITY AND
CARCINOGENICITY ANTITUMOR ACTIVITY DEVELOPMENT OF RESISTANCE MODULATION
OF ANTITUMOR ACTIVITY AND COMBINATION THERAPY REFERENCES NITROSOUREAS
L,3-BIS(2-CHLOROETHYL)-L-NITROSOUREA
L-(2-CHLOROETHYL)-3-CYDOHEXYL-L-NITROSOUREA STREPTOZOTOCIN OTHER AGENTS
OF CLINICAL INTEREST SYNTHESIS MECHANISMS OF ACTIVITY TOXICITY MUTAGENIC
AND CARCINOGENIC EFFECTS FACTORS AFFECTING SENSITIVITY AND RESISTANCE OF
TUMOR CELLS TO REFERENCES J. A. MONTGOMERY 106 107 J. A. MONTGOMERY 108
108 J. A. MONTGOMERY 108 111 111 J. A. MONTGOMERY 112 ROBERT F. STRUCK
112 113 113 114 117 120 121 WILLIAM R. WAUD 122 122 124 125 126 127 128
129 133 ROBERT D. ELLIOTT 134 135 136 136 138 138 141 142 NITROSOUREAS
143 143 ALLEY! SULFONATES 149 Y. FULMER SHEALY BUSULFAN AND RELATED
BIFIINCTIONAL SULFONIC ACID ESTERS 150 CLOMESONE AND RELATED COMPOUNDS
153 REFERENCES 156 TRIAZENYLIMIDAZOLES, OTHER TRIAZENES, AND
LMIDAZO[5,L-C/]- L 1 5 9 Y. FULMER SHEALY TRIAZENYLIMIDAZOLES AND
RELATED TRIAZENES 160 MITOZOLOMIDE AND TEMOZOLOMIDE 174 PREVIOUS REVIEWS
179 REFERENCES 179 AZIRIDINES 186 ROBERT C. REYNOLDS
TRIS(L-AZIRIDINYL)PHOSPHINE SULFIDE 187 OTHER 1-AZIRIDINYLPHOSPHINES 189
3,6-DIAZIRIDINYL-2,5-BIS(CARBOETHOXYAMINO)-1,4-BENZOQUINONE (DIAZIQUONE)
189 OTHER AZQ_ANALOGUES 192 REFERENCES 194 PROCARBAZINE 197 JOSEPH A.
MADDRY CHEMISTRY 198 METABOLISM AND MECHANISM OF ACTION 198 TOXICITY 200
REFERENCES """ 200 HEXAMETHYIMELAMINE 201 JOSEPH A. MADDRY CHEMISTRY 201
METABOLISM, MECHANISM OF ACTION, AND OTHER BIOCHEMICAL INTERACTIONS 202
TOXICITY AND RESISTANCE 203 OTHER MELAMINE DERIVATIVES 203 REFERENCES
203 5. TOPOISOMERASE II INHIBITORS 205 INHIBITORS OF DNA TOPOISOMERASES
205 SISIR K. SENGUPTA INHIBITORY AGENTS OF DNA TOPOISOMERASE II 205
PROBABLE MODES OF TUMOR CELL DAMAGE BY MAMMALIAN TOPOISOMERASE POISONS
209 INHIBITORS OF DNA TOPOISOMERASE I: CAMPTOTHECINS 210 ANTHRACYCLINES
210 ACKNOWLEDGMENTS 217 REFERENCES 217 ROLE OF INTERCALATION AND DNA
BINDING IN THE ACTIVITY OF ACRIDINES AND RELATED TRICYCLIC
DNA-INTERCALATING AGENTS 218 --. DEVELOPMENT OF DNA-INTERCALATING
LIGANDS AS ANTICANCER DRUGS WILLIAM A. DENNY I 218 MECHANISM OF
INHIBITION OF TOPOISOMERASE II BY DNA-INTERCALATING AGENTS 220
CHARACTERISTICS OF DNA BINDING IMPORTANT FOR ACTIVITY AMSACRINE CI-921
L'-CARBAMATE ANALOGUES OF AMSACRINE: TARGETING TOPOISOMERASE
9-AMINOACRIDINE-4-CARBOXAMIDES ACRIDINECARBOXAMIDE OTHER TRICYCLIC
CARBOXAMIDES: "MINIMAL INTERCALATOR" CONCEPT 1 -NITROACRIDINES OTHER
ACRIDINE DERIVATIVES DIACRIDINES AS BISINTERCALATING AGENTS
POLYINTERCALATING TRIACRIDINES ACKNOWLEDGMENTS REFERENCES 220 223 224 UP
225 226 227 228 230 230 231 233 234 234 EPIPODOPHYLLOTOXINS,
AMINOANTHRAQUINONES, ELLIPHCINE, MERBARONE, BENZISOQUINOLINEDIONES, AND
RELATED COMPOUNDS 239 THE EPIPODOPHYLLOTOXINS: ETOPOSIDE AND TENIPOSIDE
AMINOANTHRAQUINONES ELLIPTICINE AND RELATED COMPOUNDS MERBARONE
BENZISOQUINOLINEDIONES MISCELLANEOUS TOPOISOMERASE II INHIBITORS
ACKNOWLEDGMENTS REFERENCES 6. INHIBITORS OF DNA-TRANSCRIBING ENZYMES
DNA*DRUG INTERACTION VIA INTERCALATION TRANSCRIPTION OF DNA
TRANSCRIPTION AND REPLICATION OF RNA AND DNA IN VIRUSES INHIBITORS OF
TRANSCRIPTION INHIBITORS OF PROKARYOTIC RNA POLYMERASE INHIBITORS OF
EUKARYOTIC RNA POLYMERASE RIFAMYCINS ACTINOMYCINS REFERENCES C. C. CHENG
241 243 246 250 251 253 254 254 261 SISIR K. SENGUPTA 261 266 267 267
268 268 268 270 288 7. CAMPTOTHECIN AND ANALOGUES: SYNTHESIS, BIOLOGICAL
IN VITRO AND IN VIVO ACTIVITIES, AND CLINICAL POSSIBILITIES 293 MONROE
E. WALL AND MANSUKH C. WANI STRUCTURAL FEATURES OF CPT 293 INITIAL SAR
STUDIES 295 ANALOGUE SYNTHESIS AND EFFECT OF SUBSTITUENTS ON BIOLOGICAL
ACTIVITIES 296 EFFECT OF CPT AND ANALOGUES ON T-L 305 CLINICAL PROSPECTS
307 ACKNOWLEDGMENTS . 308 REFERENCES 308 8. DNA MINOR-GROOVE BINDING
COMPOUNDS AS ANTITUMOR AGENTS 311 MICHAEL CORY BIOPHYSICAL
CHARACTERIZATION OF MINOR-GROOVE BINDING MOLECULES: DISTAMYCIN AND
NETROPSIN AS PROTOTYPES 313 FACTORS INFLUENCING DNA MINOR-GROOVE BINDING
320 HOECHST 33258 320 MITOMYCIN 324 CC-1065 326 MITHRAMYCIN,
CHROMOMYCIN, AND OLIVOMYCIN 330 PHTHALANILIDES AND QUATERNARY
HETEROCYDICS 332 ANTHRAMYCINS 335 CONCLUSIONS 337 REFERENCES 337 9.
ANTIMITOTIC AGENTS 345 10. 11. TUBULIN AND MICROTUBULES DRUGS ACTING AT
THE VINBLASTINE SITE DRUGS ACTING AT THE COLCHICINE SITE CONCLUSIONS AND
FUTURE PERSPECTIVES REFERENCES BLEOMYCIN-GROUP ANTITUMOR AGENTS
NATURALLY OCCURRING BLM-GROUP ANTIBIOTICS SEMISYNTHETIC AND SYNTHETIC
BLMS BLM MODELS BLM AS AN ANTITUMOR AGENT BLM-MEDIATED DNA STRAND
SCISSION RNA STRAND SCISSION BY FE-BLM ACKNOWLEDGMENTS REFERENCES DRUGS
THAT BLOCK STEROID HORMONE ACTION MATTHIAS C. LU 347 350 355 361 362 369
SIDNEY M. HECHT 370 372 375 375 378 382 384 384 FOR THE TREATMENT OF
BREAST AND PROSTATE CANCER 389 CHRISTOPHER J. KENDRICK-PARKER AN BREAST
CANCER PROSTATE CANCER FUTURE POTENTIAL REFERENCES D V. CRAIG JORDAN 391
410 416 418 12. PHOTOCHEMICALLY ACTIVATED ANTICANCER AGENTS 429 THOMAS
J. DOUGHERTY PHOTODYNAMIC THERAPY 430 CLINICAL EXPERIENCE WITH PORFIMER
IN PDT 433 MECHANISTIC ASPECTS OF PDT 436 OTHER PHOTOSENSITIZERS 440
STRUCTURE-ACTIVITY RELATIONSHIPS 446 OTHER APPLICATIONS OF
PHOTOACTIVATED DRUGS 449 SUMMARY 451 REFERENCES 452 13. IMMUNE-MODIFYING
AGENTS 457 MICHEL AWWAD, HELENA R. AXELROD, AND STEVEN C. GILMAN
OVERVIEW OF THE IMMUNE SYSTEM 458 IMMUNE-MODIFYING AGENTS 468 SUMMARY
AND CONCLUSION 476 REFERENCES 476 14. HYPOXIA-SELECTIVE CYTOTOXINS 483
15. 16. WILLIAM THE PHENOMENON OF TUMOR HYPOXIA REASONS FOR RESISTANCE
OF HYPOXIC CELLS TO CONVENTIONAL CHEMOTHERAPY HYPOXIC CELLS AS A TARGET
FOR CHEMOTHERAPY DESIGN REQUIREMENTS FOR BIOREDUCTIVELY ACTIVATED HSCS
MITOMYCIN C AND OTHER AZIRIDOQUINONES NITRO AROMATICS THAT UNDERGO
INTERNAL REARRANGEMENT "DUAL-FUNCTION" NITRO AROMATICS NITRO AROMATIC
DEACTIVATED MUSTARDS IV-OXIDES"' METAL COMPLEXES OTHER TRIGGERING
FUNCTIONS BISBIOREDUCTIVE COMPOUNDS FUTURE DEVELOPMENTS IN HSC DESIGN
ACKNOWLEDGMENTS REFERENCES CHEMICAL RADIATION SENSITIZERS AND PROTECTORS
A. DENNY 484 484 484 485 486 488 490 491 493 494 495 495 496 497 497 501
BEVERLY A. TEICHER AND ENRIQUE ALVAREZ SOTOMAYOR RADIATION SENSITIZERS
RADIATION PROTECTORS REFERENCES OLIGONUCLEORIDES AND POLYNUCLEOTIDES AS
POTENTIAL CANCER CHEMOTHERAPEUTIC AGENTS ARVELA R. HEIDER AND THOMAS
SYNTHETIC METHODS THE ANTITEMPLATE APPROACH 501 516 520 529 J. BARDOS
532 536 THE ANTISENSE APPROACH 539 THE ANTIGENE APPROACH 548 ODN
CONJUGATES 551 RIBOZYMES 553 STABILITY AND CELLULAR UPTAKE 554
PHARMACOKINETICS 557 CHEMOTHERAPY STUDIES 558 DOUBLE-STRANDED RNA 560
CONCLUSION 562 GLOSSARY 563 ACKNOWLEDGMENTS 565 REFERENCES 565 17.
ANTITUMOR ANTIBIOTICS 577 WILLIAM A. REMERS AND BHASHYAM S. LYENGAR
CLINICALLY USED ANTITUMOR ANTIBIOTICS NOT COVERED IN OTHER CHAPTERS 578
OTHER ANTITUMOR ANTIBIOTICS OF INTEREST 594 ADDENDUM 651 REFERENCES 657
INDEX 681 |
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| id | DE-604.BV010449137 |
| illustrated | Illustrated |
| indexdate | 2025-02-09T19:00:28Z |
| institution | BVB |
| isbn | 0841229201 0841232164 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006962731 |
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| physical | xx, 698 Seiten Illustrationen, Diagramme |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | American Chemical Society |
| record_format | marc |
| series2 | ACS professional reference book |
| spelling | Cancer chemotherapeutic agents William O. Foye, editor (Massachusetts College of Pharmacy and Allied Health Sciences) Washington, DC American Chemical Society 1995 xx, 698 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier ACS professional reference book Oncolytica gtt Antineoplastic Agents therapeutic use Antineoplastic agents Neoplasms drug therapy Cytostatikum (DE-588)4068347-3 gnd rswk-swf Cytostatikum (DE-588)4068347-3 s DE-604 Foye, William O. 1923-2014 (DE-588)1222168812 edt GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006962731&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cancer chemotherapeutic agents Oncolytica gtt Antineoplastic Agents therapeutic use Antineoplastic agents Neoplasms drug therapy Cytostatikum (DE-588)4068347-3 gnd |
| subject_GND | (DE-588)4068347-3 |
| title | Cancer chemotherapeutic agents |
| title_auth | Cancer chemotherapeutic agents |
| title_exact_search | Cancer chemotherapeutic agents |
| title_full | Cancer chemotherapeutic agents William O. Foye, editor (Massachusetts College of Pharmacy and Allied Health Sciences) |
| title_fullStr | Cancer chemotherapeutic agents William O. Foye, editor (Massachusetts College of Pharmacy and Allied Health Sciences) |
| title_full_unstemmed | Cancer chemotherapeutic agents William O. Foye, editor (Massachusetts College of Pharmacy and Allied Health Sciences) |
| title_short | Cancer chemotherapeutic agents |
| title_sort | cancer chemotherapeutic agents |
| topic | Oncolytica gtt Antineoplastic Agents therapeutic use Antineoplastic agents Neoplasms drug therapy Cytostatikum (DE-588)4068347-3 gnd |
| topic_facet | Oncolytica Antineoplastic Agents therapeutic use Antineoplastic agents Neoplasms drug therapy Cytostatikum |
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