Cellular adhesion: molecular definition to therapeutic potential
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Plenum Press
1994
|
| Schriftenreihe: | New horizons in therapeutics
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 318 S. Ill., graph. Darst. |
| ISBN: | 0306446855 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | CELLULAR ADHESION MOLECULAR DEFINITION TO THERAPEUTIC POTENTIAL EDITED
BY BRIAN W. METCALF BARBARA J. DALTON AND GEORGE POSTE SMITHKHNE BEECHAM
PHARMACEUTICALS PHILADELPHIA, PENNSYLVANIA TECHNICAL EDITOR: JUDYSCHATZ
PLENUM PRESS * NEW YORK AND LONDON CONTENTS PART I. MOLECULAR
DEFINITION*ADHESION MOLECULE STRUCTURE AND FUNCTION CHAPTER 1 THE
BIOLOGICAL FUNCTION OF (33 INTEGRINS AND OTHER VITRONECTIN RECEPTORS
DAVID A. CHERESH 1. INTRODUCTION 3 2. MATERIALS AND METHODS 4 2.1. CELLS
AND CELL CULTURE 4 2.2. ANTIBODIES 4 2.3. ADHESIVE LIGANDS 5 2.4. CDNA
TRANSFECTION OF FG CELLS 5 2.5. CELL SURFACE LABELING AND
IMMUNOPRECIPITATION 5 2.6. ADHESION ASSAY 5 2.7. INDIRECT
IMMUNOFLUORESCENCE 6 2.8. CELL MIGRATION ASSAY 6 3. RESULTS 7 3.1.
INTEGRINS AVP5 AND AVP3 ARE BOTH INVOLVED IN ADHESION OF M21 MELANOMA
AND H2981 CARCINOMA CELLS TO VITRONECTIN ... 7 3.2. INTEGRINS AV(33 AND
AVP5 EXHIBIT A DISTINCT DISTRIBUTION ON THE SURFACE OF M21 OR H2981
CELLS ATTACHED TO VITRONECTIN 7 3.3. TRANSFECTION OF FG CELLS WITH (33
CDNA RESULTS IN THE EXPRESSION OF INTEGRIN AVP3 :. 11 3.4. EXPRESSION OF
P3 IN FG CELLS ALTERS THEIR BIOLOGICAL RESPONSE TO VITRONECTIN AND
FIBRINOGEN 13 3.5. FG CELLS TRANSFECTED WITH A P3/P5 CHIMERA FAIL TO
SPREAD ON VITRONECTIN 17 4. DISCUSSION 18 REFERENCES 23 XIV CONTENTS
CHAPTER 2 INTEGRIN MODULATING FACTOR AND THE REGULATION OF LEUKOCYTE
INTEGRINS SAMUEL D. WRIGHT 1. INTRODUCTION 25 2. THE LEUKOCYTE INTEGRINS
25 3. THE LEUKOCYTE INTEGRINS PARTICIPATE IN THE MOVEMENT OF CELLS OUT
OF THE VASCULATURE 26 4. THE BINDING ACTIVITY OF LEUKOCYTE INTEGRINS IS
REGULATED 27 5. ADHESION MOLECULES MAY FUNCTION SEQUENTIALLY IN A
CASCADE 28 6. THE MECHANISM OF REGULATION OF THE BINDING ACTIVITY OF
CD18 MOLECULES 29 7. INTEGRIN MODULATING FACTOR (IMF-1) 30 7.1.
SPECIFICITY 31 7.2. STRUCTURE 32 REFERENCES 32 CHAPTER 3
STRUCTURE*FUNCTION ASPECTS OF SELECTIN*CARBOHYDRATE INTERACTIONS
LAURENCE A. LASKY, LEONARD G. PRESTA, AND DAVID V. ERBE 1. INTRODUCTION
37 2. SELECTIN CARBOHYDRATE LIGANDS 38 3. STRUCTURE-FUNCTION ANALYSIS OF
E-SELECTIN BY MUTAGENESIS 42 4. STRUCTURE-FUNCTION ANALYSIS OF
P-SELECTIN: CONSERVATION OF A CARBOHYDRATE RECOGNITION SITE 46 5.
CONCLUSIONS 51 REFERENCES 52 CHAPTER 4 RECOGNITION OF CELL SURFACE
CARBOHYDRATES BY C-TYPE ANIMAL LECTINS WILLIAM I. WEIS 1. INTRODUCTION
55 1.1. CARBOHYDRATES AS INFORMATIONAL MOLECULES 55 1.2. LECTINS AS
RECOGNITION MOLECULES 56 CONTENTS XV 2. C-TYPE LECTINS 57 2.1.
DEFINITION, FUNCTIONS, AND PRIMARY STRUCTURES 57 2.2. MANNOSE-BHIDING
PROTEINS 59 2.3. STRUCTURE OF A MANNOSE-BINDING-PROTEIN
CARBOHYDRATE-RECOGNITION DOMAIN 61 3. CARBOHYDRATE BINDING BY C-TYPE
LECTINS 65 3.1. STRUCTURE OF A C-TYPE CARBOHYDRATE-RECOGNITION
DOMAIN-OLIGOSACCHARIDE COMPLEX 65 3.2. MODULATION OF ACTIVITY BY PH 67
3.3. SPECIFICITY OF MANNOSE-BINDING PROTEINS AND OTHER C-TYPE LECTINS 68
4. MULTIVALENT BINDING 70 4.1. OLIGOSACCHARIDE MULTIVALENCY 70 4.2.
OLIGOMERIC STRUCTURE OF LECTINS 71 5. FUTURE DIRECTIONS 72 REFERENCES 73
CHAPTER 5 THE UVOMORULIN-CATENIN COMPLEX: INSIGHTS INTO THE STRUCTURE
AND FUNCTION OF CADHERINS MARTIN RINGWALD 1. INTRODUCTION 77 2.
UVOMORULIN-MEDIATED CELL ADHESION*A MULTISTEP PROCESS 78 3.
STRUCTURE-FUNCTION ANALYSIS 79 3.1. THE EXTRACELLULAR PROTEIN DOMAIN 79
3.2. THE CYTOPLASMIC PROTEIN DOMAIN 82 4. THE UVOMORULIN-CATENIN
COMPLEX: STRUCTURE AND FUNCTION OF CATENINS 83 5. MULTIPLE
CADHERIN-CATENIN COMPLEXES 87 6. CONCLUSION 88 REFERENCES 89 CHAPTER 6
CYTOTACTIN: A SUBSTRATE ADHESION MOLECULE WITH AMPHITROPIC FUNCTIONS IN
MORPHOGENESIS KATHRYN L. CROSSIN AND ANNE L. PRIETO 1. INTRODUCTION 93
2. CYTOTACTIN/TENASCIN: IDENTIFICATION AND BIOCHEMISTRY 94 XVI CONTENTS
3. CYTOTACTIN IN DEVELOPMENTAL PATTERNING AND CELL MIGRATION 96 4.
CONTROL OF CYTOTACTIN GENE EXPRESSION 98 5. EFFECTS OF CYTOTACTIN ON
CELL MORPHOLOGY AND PHYSIOLOGY 99 6. STRUCTURE-FUNCTION ANALYSIS OF
CYTOTACTIN DOMAINS -.-.-:-. - - 99 7. COMPLEX EFFECTS OF CYTOTACTIN ON
NEURITE OUTGROWTH 100 8. PERSPECTIVES 102 REFERENCES 102 CHAPTER 7
ADHESION MOLECULES AND BONE REMODELING DONALD R. BERTOLINI AND K. B. TAN
1. INTRODUCTION 107 2. BONE BIOLOGY 107 2.1. METABOLISM 107 2.2. CELL
BIOLOGY 108 2.3. BONE MATRIX ILL 3. ADHESION AND BONE REMODELING 112
3.1. THE REMODELING CYCLE 112 3.2. ADHESION MOLECULES AND THE OSTEOBLAST
113 3.3. ADHESION MOLECULES AND THE OSTEOCLAST 117 4. SUMMARY 128
REFERENCES 129 PART II. BIOLOGICAL CONSEQUENCES OF CELLULAR ADHESION
CHAPTER 8 EFFECTS OF SHEAR STRESS ON LEUKOCYTE ADHESION OMID ABBASSI,
DAVID JONES, MICHELE MARISCALCO, RODGER MCEVER, L. V. MCLNTIRE, AND C.
WAYNE SMITH 1. NEUTROPHIL ADHESION UNDER CONDITIONS OF FLOW: CD18
INTEGRINS ARE INSUFFICIENT 135 2. SELECTINS AND NEUTROPHIL ADHESION
UNDER CONDITIONS OF FLOW 137 2.1. INVESTIGATIONS OF NEUTROPHIL
L-SELECTIN IN VITRO 137 2.2. INVESTIGATIONS OF NEUTROPHIL L-SELECTIN IN
VIVO 139 2.3. INVESTIGATIONS OF E-SELECTIN IN VITRO 140 CONTENTS XVII
2.4. DOES E-SELECTIN BIND TO NEUTROPHIL L-SELECTIN UNDER CONDITIONS OF
FLOW? 142 2.5. INVESTIGATIONS OF E-SELECTIN IN VIVO 144 2.6. P-SELECTIN
ALSO SUPPORTS NEUTROPHIL ROLLING UNDER CONDITIONS OF FLOW 145 3.
THREE-STEP MODEL OF NEUTROPHIL EXTRAVASATION 146 4. SUMMARY 147
REFERENCES 147 CHAPTER 9 BLOCKADE OF LEUKOCYTE ADHESION IN IN VIVO
MODELS OF INFLAMMATION LYNNE FLAHERTY, JOHN M. HARLAN, AND ROBERT K.
WINN 1. INTRODUCTION 153 2. CHEMICAL INFLAMMATION 156 2.1. PERITONEAL
STIMULI 157 2.2. INTRAVITAL MICROSCOPY 158 3. BACTERIAL INFLAMMATION 159
4. ISCHEMIA-REPERFUSION 161 5. CONCLUSION 164 REFERENCES 164 CHAPTER 10
PROADHESIVE CYTOKINE IMMOBILIZED ON ENDOTHELIAL PROTEOGLYCAN: A NEW
PARADIGM FOR RECRUITMENT OF T CELLS YOSHIYA TANAKA, DAVID H. ADAMS, AND
STEPHEN SHAW 1. INTRODUCTION 167 2. RESULTS AND DISCUSSION 168 3.
CONCLUSIONS 171 REFERENCES 171 CHAPTER 11 LUNG INFLAMMATION AND ADHESION
MOLECULES MICHAEL S. MULLIGAN AND PETER A. WARD 1. INTRODUCTION 173 2.
IGG IMMUNE COMPLEX-INDUCED LUNG INJURY 175 XVIII CONTENTS 3. IGA IMMUNE
COMPLEX MODEL OF LUNG INJURY 179 4. LUNG INJURY FOLLOWING SYSTEMIC
ACTIVATION OF COMPLEMENT 182 5. DIFFERING TISSUE REQUIREMENTS FOR TNFA
AND IL-1 IN IGG IMMUNE COMPLEX-INDUCED INJURY -. - 183 REFERENCES 185
CHAPTER 12 ADHESION MOLECULE-DEPENDENT CARDIOVASCULAR INJURY GILBERT L.
KUKIELKA AND MARK L. ENTMAN 1. INTRODUCTION: REACTION TO INJURY IN
ISCHEMIA AND REPERFUSION 187 2. ISCHEMIA-REPERFUSION INJURY AND ITS
ETIOLOGY 189 2.1. PATHOPHYSIOLOGIC PARADIGM 189 2.2. THE EFFECT OF
ANTINEUTROPHIL THERAPY ON ISCHEMIA-REPERFUSION INJURY 190 3. FACTORS
CONTRIBUTING TO NEUTROPHIL LOCALIZATION IN ISCHEMIC AND REPERFUSED
HEARTS 192 3.1. TRAPPING OF LEUKOCYTES IN THE MICRO VESSELS 192 3.2.
INTERCELLULAR ADHESION AND INFLAMMATORY INJURY* CD18 AND THE LEUKOCYTE P
2 INTEGRINS 193 3.3. ADHESION-DEPENDENT CYTOTOXICITY*MAC-1 ADHESION TO
PARENCHYMAL-MYOCYTE ICAM-1 194 3.4. THE SELECTIN FAMILY OF ADHESION
LIGANDS* A POTENTIAL ROLE IN ISCHEMIA 197 4. CHEMOTACTIC FACTORS*SIGNALS
THAT INITIATE INFLAMMATION IN ISCHEMIA-REPERFUSION INJURY 197 4.1.
COMPLEMENT ACTIVATION 197 4.2. LIPID-DERIVED AUTACOIDS 199 4.3. REACTIVE
OXYGEN SPECIES AS CHEMOTACTIC ACTIVATORS 200 5. POTENTIAL MECHANISMS OF
NEUTROPHIL-INDUCED PARENCHYMAL INJURY ... 201 6. THE CELL BIOLOGY OF
INFLAMMATORY INJURY IN ISCHEMIA REPERFUSION: A WORKING HYPOTHESIS 202
6.1. STEP ONE: CHEMOTAXIS 203 6.2. STEP TWO: NEUTROPHIL ADHESION TO
ENDOTHELIUM 203 6.3. STEP THREE: CYTOKINE INDUCTION OF ADHESION MOLECULE
EXPRESSION 204 6.4. STEP FOUR: CYTOTOXICITY OF NEUTROPHILS 205 7.
THERAPEUTIC INTERVENTION INTO THE REACTION TO INJURY: A CELL BIOLOGICAL
APPROACH 205 7.1. ANTICOMPLEMENT STRATEGIES 206 7.2. ANTIADHESION
APPROACHES 206 CONTENTS XIX 8. SUMMARY 207 REFERENCES 207 CHAPTER 13
GPIIBLHIA ANTAGONISTS AS NOVEL ANTITHROMBOTIC DRUGS: POTENTIAL
THERAPEUTIC APPLICATIONS ANDREW J. NICHOLS, JANICE A. VASKO, PAUL F.
KOSTER, RICHARD E. VALOCIK, AND JAMES M. SAMANEN 1. INTRODUCTION 213 2.
GPIIB/IIIA, PLATELETS AND THROMBOSIS 214 2.1. PLATELET AGGREGATION AND
THROMBOSIS 214 2.2. THE ROLE OF GPIIB/IIIA IN PLATELET AGGREGATION 215
3. RGD, FROM ADHESION MOTIF TO GPIIB/IIIA ANTAGONISTS 217 3.1. RGD AS AN
ADHESION MOTIF 217 3.2. RGD ANALOGUES AS GPIIB/IIIA ANTAGONISTS 218 4.
THE PHARMACOLOGY AND THERAPEUTIC APPLICATIONS OF GPIIB/IIIA ANTAGONISTS
221 4.1. UNSTABLE ANGINA 221 4.2. PREVENTION OF ACUTE MYOCARDIAL
INFARCTION 226 4.3. ADJUVANTS TO THROMBOLYSIS 229 4.4. TRANSIENT
ISCHEMIC ATTACKS AND STROKE 231 5. WILL SELECTIVE GPIIB/IIIA ANTAGONISTS
CAUSE BLEEDING? 232 6. CONCLUSIONS 233 REFERENCES 234 PART III.
TARGETING ADHESION MOLECULES*THERAPEUTIC POTENTIAL CHAPTER 14 THE
PATHOLOGICAL CONSEQUENCES OF BACTERIAL ADHESION TO MEDICAL DEVICES: A
PRACTICAL SOLUTION TO THE PROBLEM OF DEVICE-RELATED INFECTIONS J. W.
COSTERTON 1. INTRODUCTION 241 2. THE PREDOMINANCE OF BACTERIAL BIOFILMS
IN CHRONIC BACTERIAL INFECTIONS 245 XX CONTENTS 3. THE INHERENT
RESISTANCE OF BIOFILM BACTERIA TO ANTIMICROBIAL AGENTS 250 4. THE
BIOELECTRIC INITIATIVE 254 REFERENCES 256 CHAPTER 15 PEPTIDE MIMETICS AS
ADHESION MOLECULE ANTAGONISTS JAMES SAMANEN, FADIA AH, JOHN BEAN, JAMES
CALLAHAN, WILLIAM HUFFMAN, KENNETH KOPPLE, CATHERINE PEISHOFF, AND
ANDREW NICHOLS 1. INTRODUCTION: PEPTIDE AND PROTEIN PLATELET FIBRINOGEN
RECEPTOR ANTAGONISTS 259 1.1. THE SEARCH FOR ADHESION MOLECULE
ANTAGONISTS WITH ORAL ACTIVITY IN THE AREA OF PLATELET FIBRINOGEN
RECEPTOR ANTAGONISTS 259 1.2. PEPTIDE AND PROTEIN PLATELET FIBRINOGEN
RECEPTOR ANTAGONISTS 260 2. THE DEVELOPMENT OF AN RGD PEPTIDE
PHARMACOPHORE MODEL FOR THE DESIGN OF PEPTIDE MIMETIC LIGANDS 270 2.1.
THE DEVELOPMENT OF AN RGD PEPTIDE PHARMACOPHORE MODEL THROUGH THE
EVALUATION OF CONFORMATIONALLY CONSTRAINED PEPTIDES 272 2.2. SUPPORT FOR
AN RGD PEPTIDE PHARMACOPHORE MODEL FROM A PEPTIDE MIMETIC FOR GPIIB/IIIA
281 3. SEMIPEPTIDE AND NONPEPTIDE MIMETICS OF RGD AS CANDIDATES FOR ORAL
ANTITHROMBOTIC AGENTS 284 4. CONCLUSION 285 REFERENCES 287 CHAPTER 16
DERIVATION OF THERAPEUTICALLY ACTIVE HUMANIZED AND VENEERED ANTI-CD18
ANTIBODIES GEORGE E. MARK III, MELVIN SILBERKLANG, D. EUAN MACLNTYRE,
IRWIN I. SINGER, AND EDUARDO A. PADLAN 1. INTRODUCTION 291 2.
RECOMBINANT METHODOLOGY OF CDR TRANSFER 293 2.1. PCR-MEDIATED
CONSTRUCTION OF HUMANIZED V-REGIONS 293 2.2. HUMANIZATION OF MIB4 298
CONTENTS XXI 3. ANTIBODY RESHAPING . 301 4. MANUFACTURING RECOMBINANT
ANTIBODIES 301 4.1. SELECTION OF CELL LINE FOR MANUFACTURING 301 4.2.
NS/0 PROCESS DEVELOPMENT 304 5. VENEERING 305 6. IMMUNOGENICITY 308 7.
CONCLUSION 310 REFERENCES 310 INDEX 313
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| indexdate | 2024-07-09T17:51:29Z |
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| record_format | marc |
| series2 | New horizons in therapeutics |
| spelling | Cellular adhesion molecular definition to therapeutic potential ed. by Brian W. Metcalf ... New York [u.a.] Plenum Press 1994 XXI, 318 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New horizons in therapeutics Cell Adhesion Molecules physiology Cell Adhesion physiology Cell adhesion Cell adhesion molecules Physiological effect Cell adhesion molecules Therapeutic use Integrins physiology Integrine (DE-588)4278201-6 gnd rswk-swf Zelladhäsion (DE-588)4314136-5 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift gnd-content Zelladhäsion (DE-588)4314136-5 s Physiologie (DE-588)4045981-0 s DE-604 Integrine (DE-588)4278201-6 s Metcalf, Brian W. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006910423&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cellular adhesion molecular definition to therapeutic potential Cell Adhesion Molecules physiology Cell Adhesion physiology Cell adhesion Cell adhesion molecules Physiological effect Cell adhesion molecules Therapeutic use Integrins physiology Integrine (DE-588)4278201-6 gnd Zelladhäsion (DE-588)4314136-5 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4278201-6 (DE-588)4314136-5 (DE-588)4045981-0 (DE-588)1071861417 |
| title | Cellular adhesion molecular definition to therapeutic potential |
| title_auth | Cellular adhesion molecular definition to therapeutic potential |
| title_exact_search | Cellular adhesion molecular definition to therapeutic potential |
| title_full | Cellular adhesion molecular definition to therapeutic potential ed. by Brian W. Metcalf ... |
| title_fullStr | Cellular adhesion molecular definition to therapeutic potential ed. by Brian W. Metcalf ... |
| title_full_unstemmed | Cellular adhesion molecular definition to therapeutic potential ed. by Brian W. Metcalf ... |
| title_short | Cellular adhesion |
| title_sort | cellular adhesion molecular definition to therapeutic potential |
| title_sub | molecular definition to therapeutic potential |
| topic | Cell Adhesion Molecules physiology Cell Adhesion physiology Cell adhesion Cell adhesion molecules Physiological effect Cell adhesion molecules Therapeutic use Integrins physiology Integrine (DE-588)4278201-6 gnd Zelladhäsion (DE-588)4314136-5 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Cell Adhesion Molecules physiology Cell Adhesion physiology Cell adhesion Cell adhesion molecules Physiological effect Cell adhesion molecules Therapeutic use Integrins physiology Integrine Zelladhäsion Physiologie Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006910423&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT metcalfbrianw cellularadhesionmoleculardefinitiontotherapeuticpotential |