Molecular bioinformatics: algorithms and applications
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | German |
| Published: |
Berlin ; New York
<<de>> Gruyter
1996
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 300 S. Ill., graph. Darst. |
| ISBN: | 3110141132 |
Staff View
MARC
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| 650 | 4 | |a Algorithms | |
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Record in the Search Index
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| adam_text | TABLE OF CONTENTS
PREFACE VII
1. INTRODUCTION 1
1.1. METHODOLOGIES 3
1.2. APPLICATION AREAS 8
2. ARTIFICIAL INTELLIGENCE & EXPERT SYSTEMS 13
2.1. METHODOLOGY 13
2.1.1. SYMBOLIC COMPUTATION 14
2.1.2. KNOWLEDGE REPRESENTATION 18
2.1.3. KNOWLEDGE PROCESSING 29
2.2. APPLICATIONS 34
2.2.1. COMPUTER AIDED REASONING IN MOLECULAR BIOLOGY 34
2.2.2. KNOWLEDGE BASED REPRESENTATION OF MATERIALS AND METHODS 40
2.2.3. KNOWLEDGE BASED EXPLORATION IN MOLECULAR PATHOLOGY 44
2.2.4. PLANNING CLONING EXPERIMENTS WITH MOLGEN 46
2.2.5. EXPERT SYSTEMS FOR PROTEIN PURIFICATION 62
2.2.6. KNOWLEDGE BASED PREDICTION OF GENE STRUCTURE 87
2.2.7. ARTIFICIAL INTELLIGENCE FOR INTERPRETATION OF NMR SPECTRA 94
2.2.7.1. NUCLEAR MAGNETIC RESONANCE 94
2.2.7.2. PROTEAN 104
2.2.7.3. PROTEIN NMR ASSISTANT 108
3. PREDICATE LOGIC, PROLOG & PROTEIN STRUCTURE ILL
3.1. METHODOLOGY ILL
3.1.1. SYNTAX ILL
3.1.2. CONNECTIVES 112
3.1.3. QUANTIFICATION AND INFERENCE 113
3.1.4. UNIFICATION 114
3.1.5. RESOLUTION 116
3.1.6. REASONING BY ANALOGY 117
3.2. APPLICATIONS 122
3.2.1. EXAMPLE : MOLECULAR REGULATION OF X- VIRUS IN PROLOG 122
3.2.2. KNOWLEDGE BASED ENCODING OF PROTEIN TOPOLOGY IN PROLOG 126
3.2.3. PROTEIN TOPOLOGY PREDICTION THROUGH CONSTRAINT SATISFACTION 133
3.2.4. INDUCTIVE LOGIC PROGRAMMING IN MOLECULAR BIOINFORMATICS 142
3.2A.I. TRIMETHOPRIM ANALOGUES 147
3.2.4.2. DRUG DESIGN OF THERMOLYSIN INHIBITORS 149
3.2.4.3. OC-HELIX PREDICTION 150
4. MACHINE LEARNING OF CONCEPTS IN MOLECULAR BIOLOGY 152
4.1. METHODOLOGY 152
4.1.1. LEARNING HIERARCHICAL CLASSIFICATIONS: COBWEB/3 152
4.1.2. LEARNING PARTITIONAL CLASSIFICATIONS: AUTOCLASS III 159
4.2. APPLICATIONS 162
4.2.1. INDUCTIVE ANALYSIS OF PROTEIN SUPER-SECONDARY STRUCTURE 162
4.2.1.1. PROPERTIES OF SECONDARY STRUCTURES 164
4.2.1.2. PRL DATABASE 168
4.2.1.3. A-HELIXAX-HELIX PAIRS 175
4.2.1.4. HELIX/SS-STRAND PAIRS 187
4.2.2. SYMBOLIC INDUCTION ON PROTEIN AND DNA SEQUENCES 197
4.2.2.1. DECISION TREES OVER REGULAR PATTERNS 200
4.2.2.2. SEARCHING SIGNAL PEPTIDE PATTERNS IN PREDICATE LOGIC HYPOTHESIS
SPACE 205
5. EVOLUTIONARY COMPUTATION 211
5.1. METHODOLOGY 212
5.1.1. GENETIC ALGORITHMS 212
5.1.2. EVOLUTION STRATEGY 219
5.1.3. GENETIC PROGRAMMING 220
5.1.4. SIMULATED ANNEALING 230
5.2. APPLICATIONS 236
5.2.1. 2-D PROTEIN MODEL FOR CONFORMATION SEARCH 236
5.2.2. PROTEIN FOLDING SIMULATION BY FORCE FIELD OPTIMISATION 246
5.2.2.1. REPRESENTATION FORMALISM 247
5.2.2.2. FITNESS FUNCTION 249
5.2.2.3. CONFORMATIONAL ENERGY 250
5.2.2.4. GENETIC OPERATORS 251
5.2.2.5. AB INITIO PREDICTION RESULTS 252
5.2.2.6. SIDE CHAIN PLACEMENT 256
5.2.3. MULTI-CRITERIA OPTIMISATION OF PROTEIN CONFORMATIONS 256
5.2.3.1. VECTOR FITNESS FUNCTION 258
5.2.3.2. SPECIALISED GENETIC OPERATORS 260
5.2.3.3. RESULTS 262
5.2.4. PROTEIN - SUBSTRATE DOCKING 267
5.2A.I. DISTANCE CONSTRAINT DOCKING 268
5.2.4.2. ENERGY DRIVEN DOCKING 270
6. ARTIFICIAL NEURAL NETWORKS 272
6.1. METHODOLOGY 272
6.1.1. PERCEPTRON AND BACKPROPAGATION NETWORK 273
6.1.2. KOHONEN NETWORK 276
6.2. APPLICATIONS 279
6.2.1. EXON-INTRON BOUNDARY RECOGNITION 280
6.2.2. SECONDARY STRUCTURE PREDICTION 284
6.2.3. I TY TORSION ANGLE PREDICTION 286
6.2.4. SUPER-SECONDARY STRUCTURE DETECTION 288
7. SUMMARY, CONCLUSION & PROSPECTS 291
8. APPENDIX 293
8.1. INTERNET ENTRY POINTS FOR BIOCOMPUTING 293
8.1.1. INFORMATION, LITERATURE, REFERENCES 293
8.1.2. INSTITUTIONS DEALING WITH MOLECULAR BIOINFORMATICS 294
8.1.3. DATABASES 294
8.1.4. SEARCH TOOLS FOR WORLD WIDE WEB AND FTP SITES 295
8.1.5. SOFTWARE RESOURCES 296
INDEX 297
|
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| isbn | 3110141132 |
| language | German |
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| physical | XV, 300 S. Ill., graph. Darst. |
| publishDate | 1996 |
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| publisher | <<de>> Gruyter |
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| spelling | Schulze-Kremer, Steffen Verfasser aut Molecular bioinformatics algorithms and applications Steffen Schulze-Kremer Berlin ; New York <<de>> Gruyter 1996 XV, 300 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Algorithms Computer Simulation Information Systems Molecular Biology Molecular biology Computer simulation Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Molekulare Bioinformatik (DE-588)4531334-9 gnd rswk-swf Computersimulation (DE-588)4148259-1 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 s Computersimulation (DE-588)4148259-1 s DE-604 Molekulare Bioinformatik (DE-588)4531334-9 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006904697&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schulze-Kremer, Steffen Molecular bioinformatics algorithms and applications Algorithms Computer Simulation Information Systems Molecular Biology Molecular biology Computer simulation Molekularbiologie (DE-588)4039983-7 gnd Molekulare Bioinformatik (DE-588)4531334-9 gnd Computersimulation (DE-588)4148259-1 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4531334-9 (DE-588)4148259-1 |
| title | Molecular bioinformatics algorithms and applications |
| title_auth | Molecular bioinformatics algorithms and applications |
| title_exact_search | Molecular bioinformatics algorithms and applications |
| title_full | Molecular bioinformatics algorithms and applications Steffen Schulze-Kremer |
| title_fullStr | Molecular bioinformatics algorithms and applications Steffen Schulze-Kremer |
| title_full_unstemmed | Molecular bioinformatics algorithms and applications Steffen Schulze-Kremer |
| title_short | Molecular bioinformatics |
| title_sort | molecular bioinformatics algorithms and applications |
| title_sub | algorithms and applications |
| topic | Algorithms Computer Simulation Information Systems Molecular Biology Molecular biology Computer simulation Molekularbiologie (DE-588)4039983-7 gnd Molekulare Bioinformatik (DE-588)4531334-9 gnd Computersimulation (DE-588)4148259-1 gnd |
| topic_facet | Algorithms Computer Simulation Information Systems Molecular Biology Molecular biology Computer simulation Molekularbiologie Molekulare Bioinformatik Computersimulation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006904697&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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