Bispecific antibodies:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Springer
1995
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 151 S. graph. Darst. |
| ISBN: | 354058885X 1570591660 |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
CONTRIBUTORS VII
INTRODUCTION IX
1. THE PRODUCTION OF BISPECIFIC ANTIBODIES 1
ROBERT F. GRAZIANO, CHEZIAN SOMASUNDARAM, JOEL GOLDSTEIN
INTRODUCTION 1
CHEMICAL PRODUCTION 1
BIOLOGICAL PRODUCTION 10
GENETIC ENGINEERING 12
CONCLUSION 20
2. T CELL-TARGETED CYTOTOXICITY 27
DAVID M. SEGAL, TIBOR BAKACS, CAROLINA R. JOST,
ISTVAN KURUCZ, GIUSEPPE SCONOCCHIA, JULIE A. TITUS
INTRODUCTION 27
IN VITRO STUDIES 27
ANIMAL MODELS 32
CLINICAL STUDIES 34
3. MYELOID CELL-TARGETED CYTOTOXICITY OF TUMOR CELLS 43
PAULK. WALLACE, FRANK H. VALONE, MICHAEL W. FANGER
THE PROPERTIES OF MONONUCLEAR PHAGOCYTES 44
MONONUCLEAR PHAGOCYTE MEDIATED CYTOTOXICITY 52
BSAB MEDIATED CYTOTOXICITY OF TUMORS 57
SUMMARY 66
4. NATURAL KILLER CELL-DIRECTED BISPECIFIC ANTIBODIES 77
JOSEPH I. CLARK, R. KATHERINE ALPAUGH, LOUIS M. WEINER
BSAB IN THE TREATMENT OF CANCER 77
BSAB DIRECTED NK CELL-TARGETED CYTOTOXICITY
OF TUMOR CELLS 79
BSAB DIRECTED NK CELL CYTOTOXICITY OF INFECTIOUS AGENTS
OR INFECTED CELLS 82
FUTURE DIRECTIONS 82
SUMMARY 83
5. TARGETED CYTOTOXICITY OF INFECTIOUS AGENTS
AND INFECTED CELLS 89
ALEXANDRA L. HOWELL, MICHAEL W. FANGER
INTERACTION OF INFECTIOUS AGENTS WITH THE IMMUNE SYSTEM 89
DENGUE VIRUS 91
TOXOPLASMA GONDII (T. GONDII) 91
HERPES SIMPLEX AND INFLUENZA VIRUSES 92
HIV AS A MODEL SYSTEM TO EXPLORE TARGETING WITH BSAB 92
ANTIBODY-DEPENDENT ENHANCEMENT (ADE) OF HIV INFECTION ... 93
RECOMBINANT SOLUBLE CD4 CONSTRUCTS THAT INTERFERE
WITH HIV INFECTION 94
TARGETING HIV-1 TO CYTOTOXIC T CELLS 96
BISPECIFIC ANTIBODIES FOR THE TARGETING OF HIV
TO MYELOID CELLS 98
OPTIMAL DESIGN OF BSAB FOR TARGETING OF HIV 100
PROPOSED CLINICAL TRIAL OF BISPECIFIC ANTIBODIES
IN HIV/AIDS INFECTION 101
BSAB TARGETING OF OTHER PATHOGENS
IN IMMUNOCOMPROMISED PATIENTS 102
FUTURE DIRECTIONS 102
6. TARGETING DRUGS, TOXINS AND RADIONUCLIDES
WITH BISPECIFIC ANTIBODIES 107
MARTIN J. GLENNIE, RUTH R. FRENCH
INTRODUCTION 107
DELIVERY OF CHEMOTHERAPEUTIC DRUGS 108
DELIVERY OF RIBOSOME-INACTIVATING PROTEINS (RIPS) 109
CLINICAL TRIALS OF BSAB WHICH TARGET RIPS 114
DELIVERY OF RADIONUCLIDES ,.... 115
CONCLUSIONS 116
7. TARGETING IMMUNE COMPLEXES AND ENZYMES
TO CELL SURFACE RECEPTORS 121
PETER M. MORGANELLI
TARGETING LIPOPROTEINS TO FCYR 121
COMPLEMENT RECEPTOR TARGETING 123
TARGETING ENZYMES FOR CANCER THERAPEUTICS 125
TARGETING ENZYMES TO BLOOD CLOTS 126
BSAB IN ENZYME IMMUNOASSAYS 128
SUMMARY 130
8. ANTIGEN TARGETING 133
CHUNLEI LIU, PAULM. GUYRE
INTRODUCTION 133
INDUCTION OF AN IMMUNE RESPONSE 134
TARGETING TO SPECIFIC ANTIGEN-PRESENTING CELLS 136
ALTERNATIVE METHODS TO TARGET AG 141
SUMMARY 143
INDEX 147
|
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV010162834 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:47:34Z |
| institution | BVB |
| isbn | 354058885X 1570591660 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006749183 |
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| owner_facet | DE-355 DE-BY-UBR DE-29 DE-11 DE-188 |
| physical | 151 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Bispecific antibodies Michael W. Fanger New York u.a. Springer 1995 151 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Antibody-drug conjugates Antibody-toxin conjugates Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 s DE-604 Fanger, Michael W. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006749183&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bispecific antibodies Antibody-drug conjugates Antibody-toxin conjugates Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 gnd |
| subject_GND | (DE-588)4326199-1 (DE-588)4143413-4 |
| title | Bispecific antibodies |
| title_auth | Bispecific antibodies |
| title_exact_search | Bispecific antibodies |
| title_full | Bispecific antibodies Michael W. Fanger |
| title_fullStr | Bispecific antibodies Michael W. Fanger |
| title_full_unstemmed | Bispecific antibodies Michael W. Fanger |
| title_short | Bispecific antibodies |
| title_sort | bispecific antibodies |
| topic | Antibody-drug conjugates Antibody-toxin conjugates Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 gnd |
| topic_facet | Antibody-drug conjugates Antibody-toxin conjugates Monoklonaler bispezifischer Antikörper Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006749183&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT fangermichaelw bispecificantibodies |