Interleukin-10:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Springer u.a.
1995
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 162 S. Ill., graph. Darst. |
| ISBN: | 3540589007 1570590923 |
Staff View
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| 245 | 1 | 0 | |a Interleukin-10 |c Jan E. DeVries ... |
| 264 | 1 | |a New York u.a. |b Springer u.a. |c 1995 | |
| 300 | |a 162 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 650 | 2 | |a Interleukine-10 | |
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| 650 | 0 | 7 | |a Interleukin 10 |0 (DE-588)4337389-6 |2 gnd |9 rswk-swf |
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Record in the Search Index
| _version_ | 1808046642642812928 |
|---|---|
| adam_text |
CONTENTS
1.
MOLECULAR
BIOLOGY
OF
INTERLEUKIN
10
AND
ITS
RECEPTOR
.
1
KEVIN
W.
MOORE,
ALICE
S.-Y.
HO
ANDJIANGCHUN
XU-AMANO
INTRODUCTION
.
1
IL
10
CDNA
CLONES
AND
PROTEIN
.
1
THE
IL
10
GENE
AND
ITS
EXPRESSION
.
2
VIRAL
HOMOLOGS
OF
IL-10
.
2
IL
10
RECEPTORS
.
4
CONCLUDING
REMARKS
.
6
2.
PHYSICOCHEMICAL
AND
STRUCTURAL
PROPERTIES
OF
INTERLEUKIN
10
.
11
PAUL
P.
TROTTA
AND
WILLIAM
T
WINDSOR
INTRODUCTION
.
11
PREDICTED
PHYSICOCHEMICAL
AND
STRUCTURAL
PROPERTIES
.
11
PHYSICOCHEMICAL
PROPERTIES
.
13
STABILITY
PROPERTIES
.
14
STRUCTURAL
PROPERTIES
.
14
CRYSTALLIZATION
.
17
FUTURE
DIRECTIONS
.
17
3.
IL-10
AND
HUMAN
T
CELLS
.
19
HANS
YSSEL
AND
RENI
DE
WAAL
MALEFYT
INTRODUCTION
.
19
PRODUCTION
OF
IL
10
.
20
PRODUCTION
OF
IL
10
BY
HUMAN
PERIPHERAL
BLOOD
AND
CORD
BLOOD
T
CELLS
.
20
IL
10
PRODUCTION
BY
HUMAN
T-CELL
CLONES
.
21
KINETICS
AND
CONDITIONS
OF
IL
10
PRODUCTION
.
21
IL
10
PRODUCTION
IN
DISEASE
.
22
DIRECT
EFFECTS
OF
IL
10
ON
HUMAN
T
CELLS
.
23
CONCLUDING
REMARKS
.
24
4.
INTERLEUKIN
10
AND
B
LYMPHOCYTES
.
29
FRANCINE
BRIIRE
ANDJACQUES
BANCHEREAU
INTRODUCTION
.
29
IL
10
PRODUCING
CELLS
.
29
IL
10
IN
BIOLOGICAL
FLUIDS
AND
NATURAL
ANTI-IL-10
ANTIBODIES
.
30
IL-10
AND
B-CELL
SURVIVAL
.
30
IL
10
INDUCES
B-CELL
PROLIFERATION
.
31
IL
10
INDUCES
B-CELL
DIFFERENTIATION
.
32
IL
10
IN
B-CELL
IMMUNODEFICIENCIES
.
33
CONCLUDING
REMARKS
.
34
5.
REGULATION
OF
HUMAN
MONOCYTE
FUNCTIONS
BY
INTERLEUKIN
10
.
37
RENT
DE
WAALMALEFYT,
CARL
G.
FIGDOR
ANDJAN
E.
DE
VRIES
INTRODUCTION
.
37
EFFECTS
OF
IL
10
ON
MONOCYTE
MORPHOLOGY
.
37
IL
10
MODULATES
CLASS
II
MHC
EXPRESSION
ON
MONOCYTES
.
39
IL
10
MODULATES
THE
EXPRESSION
OF
ADHESION
AND
CO-STIMULATORY
MOLECULES
ON
MONOCYTES
.
40
IL
10
MODULATES
MONOCYTE
FC
RECEPTOR
EXPRESSION
.
41
IL-10
INHIBITS
NO
PRODUCTION
BY
MONOCYTES/MACROPHAGES
.
41
IL
10
INHIBITS
THE
PRODUCTION
OF
CYTOKINES
AND
CHEMOKINES
BY
MONOCYTES
AND
NEUTROPHILS
.
42
HUMAN
MONOCYTES
ARE
ABLE
TO
PRODUCE
IL
10
WHICH
HAS
AUTOREGULATORY
ACTIVITIES
.
43
IL
10
INHIBITS
ANTIGEN-PRESENTING
FUCTIONS
OF
MONOCYTES
.
44
IL
10
IS
A
POTENT
ANTIINFLAMMATORY
CYTOKINE
.
46
6.
INTERLEUKIN-10:
AN
INHIBITOR
OF
MACROPHAGE-DEPENDENT
STIMULATION
OF
THL
CELLS
.
53
ANNE
O
'
GARRA
INTRODUCTION
.
53
IL
10
INHIBITS
MACROPHAGE
BUT
NOT
B-CELL
ANTIGEN
PRESENTING
FUNCTION
FOR
THL
CLONES
.
53
DIFFERENTIAL
EFFECT
OF
IL
10
ON
DENDRITIC
CELL-INDUCED
T-CELL
PROLIFERATION
AND
IFN-Y
PRODUCTION
.
54
IL
10
INHIBITS
THE
DEVELOPMENT
OF
THL
CELLS
PRODUCING
HIGH
LEVELS
OF
IFN-Y
.
54
MECHANISM
OF
ACTION
OF
IL
10
FOR
INHIBITION
OF
MACROPHAGE
APC
FUNCTION
.
55
7.
IL
10
AND
BONE
FORMATION/HEMATOPOIESIS
.
59
PETER
VAN
VLASSELAER
INTRODUCTION
.
59
IL
10
AND
BONE
FORMATION
.
59
IL
10
REGULATES
BONE
PROTEIN
SYNTHESIS
AND
EXTRACELLULAR
MATRIX
FORMATION
.
60
THE
"
IL-10
-
TGF-P
1
LOOP
"
.
62
IL
10
AND
HEMATOPOIESIS
.
62
8.
REGULATORY
FUNCTION
OF
IL
10
IN
EXPERIMENTAL
PARASITIC
INFECTIONS
.
69
STEVEN
G.
REED
AND
ALAN
SHER
INTRODUCTION
.
69
REGULATION
BY
IL
10
OF
T
CROZRLNFECTION
.
69
THE
ROLE
OF
IL
10
IN
EXPERIMENTAL
SCHISTOSOMIASIS
.
73
CONCLUDING
REMARKS
.
75
9.
IL
10
IN
MYCOBACTERIAL
INFECTION
.
79
PETER
A.
SIELING
AND
ROBERT
L.
MODLIN
INTRODUCTION
.
79
DISTRIBUTION
OF
THL
AND
TH2
CYTOKINES
IN
MYCOBACTERIAL
DISEASE
.
80
CELLULAR
SOURCE
OF
IL
10
IN
MYCOBACTERIAL
INFECTION
AND
THE
ANTIGENS
RESPONSIBLE
FOR
STIMULATING
ITS
PRODUCTION
.
80
BIOLOGIC
FUNCTION
OF
IL
10
IN
MYCOBACTERIAL
DISEASE
.
81
M.
LEPRAEANDUCED
IL
10
SECRETION
SUPPRESSES
CYTOKINE
RELEASE
.
83
IL
10
INHIBITS
IL
12
PRODUCTION
.
84
IL
10
INHIBITS
CD1
EXPRESSION
AND
SUBSEQUENT
M.
LEPRAE-SPECIFIC
PROLIFERATION
OF
AP
T-CELL
RECEPTOR
CD4,
CD8
DOUBLE
NEGATIVE
T-CELLS
.
85
CONCLUDING
REMARKS
.
87
10.
IL-10
IN
HUMAN
LEISHMANIASIS
.
91
EDGAR
M.
CARVALHO
INTRODUCTION
.
91
IL
10
IN
VISCERAL
LEISHMANIASIS
.
93
IL
10
IN
DIFFUSE
CUTANEOUS
LEISHMANIASIS
.95
IL
10
IN
CUTANEOUS
AND
MUCOSAL
LEISHMANIASIS
.
96
11.
IL-10
AND
HIV-1
REPLICATION
.
101
HANNEKE
SCHUITEMAKER,
NEELTJEA.
KOOTSTRA,
AND
FRANK
MIEDEMA
INTRODUCTION
.
101
12.
INTERLEUKIN
10
AND
TRANSPLANTATION
TOLERANCE
.113
MARIA-GRAZIA
RONCAROLO
INTRODUCTION
.
113
EFFECTS
OF
IL
10
ON
ALLOGENEIC
RESPONSES
IN
VITRO
.
114
ROLE
OF
IL-10
IN
TRANSPLANTED
PATIENTS
.
115
ROLE
OF
IL
10
IN
ANIMAL MODELS
OF
TRANSPLANTATION
.
117
CONCLUDING
REMARKS
.
118
13.
EFFECTS
OF
IL
10
IN
LIPOPOLYSACCHARIDE
AND
SUPERANTIGEN-INDUCED
LETHAL
SHOCK
IN
VIVO
.
121
ALBERT
ZLOTNIK
AND
RACHEL
A.
FREIBERG
INTRODUCTION
.
121
IL-10
PREVENTS
THE
TOXIC
EFFECTS
OF
LPS
IN
VIVO
.
121
IL
10
INHIBITS
T-CELL
ACTIVATION
IN
VIVO
.
122
CONCLUDING
REMARKS
.
124
14.
INHIBITION
OF
CELL-MEDIATED
IMMUNE
RESPONSES
IN
VIVO
BY
RECOMBINANT
IL-10
.
127
FIONA
POWRIE
AND
ROBERT
L.
COFFMAN
INTRODUCTION
.
127
PRODUCTION
OF
IL-4
AND
IL
10
IN
RESPONSE
TO
L.
MAJOR
ANTIGENS
IN
VITRO
INHIBITS
IFN-Y
PRODUCTION
.
128
IL-4
AND
IL
10
SYNERGIZE
TO
INHIBIT
SECONDARY
THL
RESPONSES
IN
VIVO
.
128
INHIBITION
OF
INFLAMMATORY
BOWEL
DISEASE
IN
MICE
BY
ADMINISTRATION
OF
RIL-10
.
129
15.
IL-10
TRANSGENIC
MICE
.
135
MYUNG-SHIK
LEE
AND
NORA
SARVETNICK
INTRODUCTION
.
135
PHENOTYPE
OF
INS-IL-10
TRANSGENIC
MICE
.
135
FUNCTIONAL
ASPECTS
OF
TRANSGENIC
EXPRESSION
OF
IL-10
.
136
CONCLUDING
REMARKS
.
138
16.
INTERLEUKIN
10
DEFICIENT
MICE
.
141
DONNA
RENNICK,
DAN
BERG,
RALF
KUHN
AND
WERNER
MULLER
INTRODUCTION
.
141
POTENTIAL
MECHANISMS
LEADING
TO
CHRONIC
INFLAMMATORY
BOWEL
DISEASE
IN
IL
10
DEFICIENT
MICE
.
142
IMMUNOHISTOLOGICAL
ANALYSES
OF
COLONIC
LYMPHOCYTES
.
142
IL
10
DEFICIENT
MICE
EXHIBIT
ABERRANT
CYTOKINE
PRODUCTION
.
143
IL
10
DEFICIENT
MICE
EXHIBIT
OTHER
ABNORMAL
IMMUNE-INFLAMMATORY
REACTIONS
.
144
CONCLUDING
REMARKS
.
145
17.
A
PHASE
I
STUDY
OF
INTERLEUKIN
10
IN
HEALTHY
HUMANS:
SAFETY
AND
EFFECTS
ON
CYTOKINE
PRODUCTION
.
149
AMY
E.
CHEMOFF,
ERIC
V.
GRANOWITZ,
LELAND
SHAPIRO,
EDOUARD
VANNIER,
GERHARD
LONNEMANN,
JONATHAN
B.
ANGEL,
SCOTT
F.
ORENCOLE,
JEFFREY
S.
KENNEDY,
XI-XIAN
ZHANG,
HEI-DE
WEN,
ELLEN
C.
DONALDSON,
ELAINE
RADWANSKI,
DAVID
L.
CUTLER,
SHELDON
M.
WOLFF,
AND
CHARLES
A.
DINAREUO
INTRODUCTION
.
149
MATERIALS
AND
METHODS
.
150
RESULTS
.
152
DISCUSSION
.
155
INDEX
.
159 |
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| id | DE-604.BV010153228 |
| illustrated | Illustrated |
| indexdate | 2024-08-22T00:47:23Z |
| institution | BVB |
| isbn | 3540589007 1570590923 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006744578 |
| oclc_num | 31378398 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-20 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-20 |
| physical | 162 S. Ill., graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer u.a. |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Interleukin-10 Jan E. DeVries ... New York u.a. Springer u.a. 1995 162 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Interleukine-10 Interleukin-10 Interleukin 10 (DE-588)4337389-6 gnd rswk-swf Interleukin 10 (DE-588)4337389-6 s DE-604 De Vries, Jan E. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006744578&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Interleukin-10 Interleukine-10 Interleukin-10 Interleukin 10 (DE-588)4337389-6 gnd |
| subject_GND | (DE-588)4337389-6 |
| title | Interleukin-10 |
| title_auth | Interleukin-10 |
| title_exact_search | Interleukin-10 |
| title_full | Interleukin-10 Jan E. DeVries ... |
| title_fullStr | Interleukin-10 Jan E. DeVries ... |
| title_full_unstemmed | Interleukin-10 Jan E. DeVries ... |
| title_short | Interleukin-10 |
| title_sort | interleukin 10 |
| topic | Interleukine-10 Interleukin-10 Interleukin 10 (DE-588)4337389-6 gnd |
| topic_facet | Interleukine-10 Interleukin-10 Interleukin 10 |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006744578&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT devriesjane interleukin10 |