Therapeutic applications of oligonucleotides:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York u.a.
Springer u.a.
1995
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| Series: | Medical intelligence unit
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 138 S. graph. Darst. |
| ISBN: | 3540588906 1570591903 |
Staff View
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Record in the Search Index
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| adam_text | MEDICAL INTELLIGENCE UNIT THERAPEUTIC APPLICATIONS OF OLIGONUCLEOTIDES
STANLEY T. CROOKE, M.D., PH.D. ISIS PHARMACEUTICALS, INC. CARLSBAD,
CALIFORNIA, U.S.A. SPRINGER-VERLAG NEW YORK BERLIN HEIDELBERG LONDON
PARIS R-G. L NDES COMPANY TOKYO HONG KONG BARCELONA BUDAPEST AUSTIN
CONTENTS 1. HISTORY 1 POLYNUDEOTIDES 1 THE ANTISENSE CONCEPT 2
STRATEGIES TO INDUCE TRANSCRIPTIONAL ARREST 3 RIBOZYMES AND
OLIGONUDEOTIDE-MEDIATED RNA CLEAVAGE 4 COMBINATORIAL APPROACHES TO
OLIGONUDEO TIDE THERAPEUTICS 4 THE MEDICINAL CHEMISTRY OF
OLIGONUCLEOTIDES 4 PHARMACOLOGICAL RATIONALIZATION OF THERAPEUTIC
OLIGONUCLEOTIDES 5 CONCLUSIONS 5 2. MOLECULAR MECHANISMS OF ACTION OF
OLIGONUCLEOTIDES DESIGNED TO INTERACT WITH NUCLEIC ACIDS 11 RNA
INTERMEDIARY METABOLISM 11 AFFINITY 12 SPECIFICITY FOR NUCLEIC ACID
SEQUENCES 16 THERAPEUTIC SPECIFICITY (THERAPEUTIC INDEX) 18 KINETIC
CONSIDERATIONS AFFINITY AND SPECIFICITY 18 MECHANISMS OF ACTION OF
OLIGONUCLEOTIDES INTERACTING WITH NUCLEIC ACID TARGETS 19 CONCLUSIONS 29
3. THE SELECTION OF OPTIMAL RNA RECEPTOR SITES FOR ANTISENSE EFFECTS 39
FACTORS INFLUENCING RECEPTOR SEQUENCE ACCESSIBILITY 39 THE OPTIMAL
ANTISENSE SITE VARIES AS A FUNCTION OF THE RNA SPECIES 44 THE OPTIMAL
ANTISENSE SITE VARIES AS A FUNCTION OF TERMINATING MECHANISM 47
CONCLUSIONS 48 4. FIRST GENERATION OLIGONUDEOTIDE ANALOGS OTHER THAN
PHOSPHOROTHIOATES 53 INTRODUCTION 53 METHYLPHOSPHONATES 53 SYNTHESIS AND
PURIFICATION : 54 PHYSICOCHEMICAL PROPERTIES 55 BIOCHEMICAL PROPERTIES
55 PHARMACOKINETIC PROPERTIES 55 METHYLPHOSPHONATE PHOSPHODIESTER
CHIMERS 57 CC-OLIGONUCLEOTIDES 58 PHOSPHORODITHIOATE OLIGONUCLEOTIDES 59
CONCLUSIONS 59 5. PHOSPHOROTHIOATE OLIGONUCLEOTIDES 63 INTRODUCTION 63
SYNTHESIS AND PURIFICATION 63 HYBRIDIZATION 64 INTERACTIONS WITH
PROTEINS 65 PHARMACOKINETIC PROPERTIES 67 PHARMACOLOGICAL PROPERTIES 72
TOXICOLOGICAL PROPERTIES 75 CONCLUSIONS 79 6. THE MEDICINAL CHEMISTRY OF
OLIGONUCLEOTIDES 85 INTRODUCTION 85 HETEROCYDIC MODIFICATIONS 86
OLIGONUCLEOTIDE CONJUGATES 88 SUGAR MODIFICATIONS 93 BACKBONE
MODIFICATIONS 99 7. DRUG DELIVERY ISSUES AND SYSTEMS 109 INTRODUCTION
109 IN VITRO UPTAKE ENHANCEMENT (TRANSFECTION) 110 DRUG DELIVERY IN VIVO
115 CONCLUSIONS 117 8. EXPERIMENTAL CAVEATS 123 INTRODUCTION 123 FACTORS
THAT MAY INFLUENCE EXPERIMENTAL INTERPRETATIONS 124 RECOMMENDATIONS 127
9. PROSPECTUS 131 INTRODUCTION 131 KEY NEXT STEPS 132 LONG-TERM
THERAPEUTIC POTENTIAL 134 INDEX 135
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:47:26Z |
| institution | BVB |
| isbn | 3540588906 1570591903 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006744561 |
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| owner_facet | DE-355 DE-BY-UBR DE-29T |
| physical | 138 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer u.a. |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Crooke, Stanley T. 1945- Verfasser (DE-588)115845291 aut Therapeutic applications of oligonucleotides Stanley T. Crooke New York u.a. Springer u.a. 1995 138 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Chemie Oligonucleotides Chemistry Oligonucleotides Pharmacology Oligonukleotidi Farmakologija Oligonukleotidi Kemija Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Oligonucleotide (DE-588)4133456-5 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Oligonucleotide (DE-588)4133456-5 s Pharmakotherapie (DE-588)4076066-2 s DE-604 Therapie (DE-588)4059798-2 s GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006744561&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Crooke, Stanley T. 1945- Therapeutic applications of oligonucleotides Chemie Oligonucleotides Chemistry Oligonucleotides Pharmacology Oligonukleotidi Farmakologija Oligonukleotidi Kemija Pharmakotherapie (DE-588)4076066-2 gnd Oligonucleotide (DE-588)4133456-5 gnd Therapie (DE-588)4059798-2 gnd |
| subject_GND | (DE-588)4076066-2 (DE-588)4133456-5 (DE-588)4059798-2 |
| title | Therapeutic applications of oligonucleotides |
| title_auth | Therapeutic applications of oligonucleotides |
| title_exact_search | Therapeutic applications of oligonucleotides |
| title_full | Therapeutic applications of oligonucleotides Stanley T. Crooke |
| title_fullStr | Therapeutic applications of oligonucleotides Stanley T. Crooke |
| title_full_unstemmed | Therapeutic applications of oligonucleotides Stanley T. Crooke |
| title_short | Therapeutic applications of oligonucleotides |
| title_sort | therapeutic applications of oligonucleotides |
| topic | Chemie Oligonucleotides Chemistry Oligonucleotides Pharmacology Oligonukleotidi Farmakologija Oligonukleotidi Kemija Pharmakotherapie (DE-588)4076066-2 gnd Oligonucleotide (DE-588)4133456-5 gnd Therapie (DE-588)4059798-2 gnd |
| topic_facet | Chemie Oligonucleotides Chemistry Oligonucleotides Pharmacology Oligonukleotidi Farmakologija Oligonukleotidi Kemija Pharmakotherapie Oligonucleotide Therapie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006744561&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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