A practical approach to chiral separations by liquid chromatography:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Weinheim [u.a.]
VCH
1994
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | 2. Aufl. u.d.T.: Chiral separation techniques |
| Physical Description: | XVI, 405 S. Ill. |
| ISBN: | 3527282882 |
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| 245 | 1 | 0 | |a A practical approach to chiral separations by liquid chromatography |c ed. by G. Subramanian |
| 264 | 1 | |a Weinheim [u.a.] |b VCH |c 1994 | |
| 300 | |a XVI, 405 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a 2. Aufl. u.d.T.: Chiral separation techniques | ||
| 650 | 7 | |a Chiraliteit |2 gtt | |
| 650 | 7 | |a Chiralité - Applications industrielles |2 ram | |
| 650 | 7 | |a Chromatographie en phase liquide |2 ram | |
| 650 | 7 | |a Enantiomeren |2 gtt | |
| 650 | 7 | |a Enantiomères - Séparation |2 ram | |
| 650 | 7 | |a Vloeistofchromatografie |2 gtt | |
| 650 | 4 | |a Chirality |x Industrial applications | |
| 650 | 4 | |a Enantiomers |x Separation | |
| 650 | 4 | |a Liquid chromatography | |
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Record in the Search Index
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| adam_text | A PRACTICAL APPROACH TO CHIRAL SEPARATIONS BY LIQUID CHROMATOGRAPHY
EDITED BY G. SUBRAMANIAN VCH WEINHEIM * NEW YORK BASEL * CAMBRIDGE *
TOKYO CONTENTS 1 AN INTRODUCTION TO ENANTIOSEPARATION BY LIQUID
CHROMATOGRAPHY CHARLES A. WHITE AND GANAPATHY SUBRAMANIAN 1.1
INTRODUCTION 1 1.1.1 WHAT IS CHIRALITY? 1 1.1.2 WHAT CAUSES CHIRALITY? 2
1.1.3 WHY IS CHIRALITY IMPORTANT? 4 1.2 INDUSTRIES WHICH REQUIRE
ENANTIOSEPARATIONS 4 1.2.1 PHARMACEUTICAL INDUSTRY 4 1.2.2 AGROCHEMICAL
INDUSTRY 5 1.2.3 FOOD AND DRINK INDUSTRY 6 1.2.4 PETROCHEMICAL INDUSTRY
6 1.3 CHIRAL LIQUID CHROMATOGRAPHY 7 1.3.1 TYPE I CHIRAL PHASES 8 1.3.2
TYPE II CHIRAL STATIONARY PHASES 10 1.3.3 TYPE III CHIRAL STATIONARY
PHASES 10 1.3.3.1 MICROCRYSTALLINE CELLULOSE TRIACETATE AND TRIBENZOATE
10 1.3.3.2 CYCLODEXTRINS 11 1.3.3.3 CROWN ETHERS 11 1.3.3.4 SYNTHETIC
POLYMERS *. 12 1.3.4 TYPE IV CHIRAL STATIONARY PHASES 13 1.3.5 TYPE V
CHIRAL STATIONARY PHASES 13 1.3.6 MOBILE PHASE ADDITIVES 14 1.3.6.1
METAL COMPLEXES 14 1.3.6.2 ION-PAIR FORMATION 15 1.3.6.3 UNCHARGED
CHIRAL ADDITIVES 15 1.4 THE FUTURE 16 2 MODELING ENANTIODIFFERENTIATION
IN CHIRAL CHROMATOGRAPHY KENNY B. LIPKOWITZ 2.1 INTRODUCTION 19 2.2
MODELING 19 # VIII CONTENTS 2.3 COMPUTATIONAL TOOLS 22 2.3.1 QUANTUM
MECHANICS 22 2.3.2 MOLECULAR MECHANICS 23 2.3.3 MOLECULAR DYNAMICS 24
2.3.4 MONTE CARLO SIMULATIONS 24 2.3.5 GRAPHICS 25 2.4 MODELING
ENANTIOSELECTIVE BINDING IN CHROMATOGRAPHY 26 2.4.1 TYPE I CSPS 26*
2.4.2 TYPE II CSPS 41 2.4.3 TYPE III CSPS 44 2.5 RELATED STUDIES 49 2.6
SUMMARY 50 3 REGULATORY IMPLICATIONS AND CHIRAL SEPARATIONS JEFFREY R.
BROWN 3.1 INTRODUCTION 57 3.2 LICENSING OF MEDICINAL PRODUCTS 57 3.3
IMPLICATIONS OF CHIRALITY 58 3.3.1 STEREOISOMERISM 58 3.3.2 BIOLOGICAL
SIGNIFICANCE OF STEREOISOMERISM 60 3.3.3 CHIRALITY AND MEDICINAL
PRODUCTS 63 3.4 NOMENCLATURE OF MIXTURES OF ISOMERS 64 3.5 ATTITUDES
TOWARDS CHIRALITY 64 3.6 THE FUTURE 66 4 ENANTIOMER SEPARATION USING
TAILOR-MADE PHASES PREPARED BY MOLECULAR IMPRINTING BOERJE SEILERGREN 4.1
INTRODUCTION 69 4.2 HISTORICAL DEVELOPMENT 70 4.3 CSP PREPARATION AND
EVALUATION 74 4.4 POLYMER ENANTIOSELECTIVITY-STRUCTURAL CORRELATIONS 74
4.5 POLYMER SUBSTRATE SELECTIVITY * FOR BETTER OR FOR WORSE? 78 4.5.1
EXAMPLES OF HIGH SUBSTRATE SELECTIVITY - ANTIBODY-LIKE RECOGNITION 78
4.5.2 EXAMPLES OF LOW SUBSTRATE SELECTIVITY 80 4.6 NATURE OF THE SITES
82 4.7 HOW TO INCREASE AFFINITY AND SELECTIVITY 83 4.7.1 STABILITY OF
TEMPLATE ASSEMBLIES 83 4.7.1.1 CONCENTRATION OF MAA IN MONOMER MIXTURE
83 4.7.1.2 POLYMERIZATION TEMPERATURE 84 CONTENTS IX 4.7.1.3 SOLVENT 84
4.7.2 OTHER FUNCTIONAL MONOMERS 86 4.8 STRUCTURE AND MORPHOLOGY OF
IMPRINTED POLYMERS 87 4.9 A PACKING FOR ION EXCHANGE AND ENANTIOMER
SEPARATION 87 4.10 COLUMN PERFORMANCE AND SATURATION CAPACITY 90 4.11
CONCLUSIONS AND OUTLOOK 92 5 CYCLODEXTRIN BONDED CHIRAL STATIONARY
PHASES IN ENANTIOMER SEPARATIONS APRYLL M. STALCUP 5.1 INTRODUCTION 95
5.2 MAGIC MOBILE PHASE 96 5.3 DERIVATIZED CYCLODEXTRIN-BONDED PHASES
98 5.4 HYDROXYPROPYL-/?-CD CSP 99 5.5 NORMAL PHASE CSP 103 5.6
NAPHTHYLETHYLCARBAMOYLATED SS-CT) CSP 104 5.7 APPLICATIONS TO BIOLOGICAL
SAMPLES 111 5.8 CONCLUSIONS 113 6 POLYSACCHARIDE PHASES IN
ENANTIOSEPARATIONS JULES DINGENEN 6.1 INTRODUCTION 115 6.2 CELLULOSE
TRIACETATE (CTA) 117 6.3 COATED CELLULOSE AND AMYLOSE DERIVATIVES 124
6.3.1 MOBILE PHASE EFFECTS ON RETENTION AND STEREOSELECTIVITY 127 6.3.2
EFFECT OF THE SOLUTE STRUCTURE ON STEREOSELECTIVITY 139 6.3.3 INFLUENCE
OF TEMPERATURE 147 6.3.4 QUANTITATIVE ANALYSIS 150 6.3.5 PREPARATIVE
CHROMATOGRAPHIE APPLICATIONS 155 6.3.6 MICRO-LC (JI-LC) APPLICATIONS 160
6.4 BENZOYL CELLULOSE BEADS IN THE PURE POLYMERIE FORM 163 6.5
MICROCRYSTALLINE TRIBENZOYLCELLULOSE 174 6.6 CONCLUSIONS 178 * 7
SEPARATION OF ENANTIOMERS BY PROTEIN-BASED CHIRAL PHASES STIG ALIENMARK
7.1 INTRODUCTION 183 7.1.1 EARLY OBSERVATIONS OF CHIRAL DISCRIMINATION
BY PROTEINS 183 X CONTENTS 7.1.2 AFFINITY CHROMATOGRAPHY AND THE
RECIPROCITY PRINCIPLE 185 7.1.3 IMMOBILIZED PROTEINS FOR CHIRAL
SEPARATIONS 185 7.2 VARIOUS PRINCIPLES USED FOR IMMOBILIZATION OF
PROTEINS TO LIQUID CHROMATOGRAPHY SUPPORTS 186 7.2.1 NON-CROSSLINKED
PHASES 186 7.2.1.1 PHYSICAL IMMOBILIZATION BY ADSORPTION 186 7.2.1.2
HETEROBIFUNCTIONAL REAGENTS FOR THE FUNCTIONALIZATION OF SILICA MATRICES
186 7.2.1.3 COVALENT BINDING OF PROTEINS VIA HOMOBIFUNCTIONAL REAGENTS
.... 187 7.2.2 CROSSLINKED PHASES 187 7.2.2.1 PHYSICAL IMMOBILIZATION
VIA HOMOBIFUNCTIONAL REAGENTS 187 7.2.2.2 IMMOBILIZATION BY COVALENT
BINDING AND CROSSLINKING 187 7.3 GENERAL TECHNIQUES FOR REGULATION OF
RETENTION AND RESOLUTION. MOBILE PHASE OPTIMIZATION 188 7.4 DIFFERENT
PROTEIN PHASES FOR CHIRAL REVERSED PHASE LIQUID CHROMATOGRAPHY AND THEIR
USE 190 7.4.1 SERUM ALBUMIN (BSA AND HSA) 191 7.4.2 OROSOMUCOID OR OR 1
-ACID GLYCOPROTEIN (AGP) 193 7.4.3 OVOMUCOID (OVM) 194 7.4.4
CELLOBIOHYDROLASE-I (CBH-I) 196 7.4.5 AVIDIN 198 7.4.6 CHYMOTRYPSIN (CT)
199 7.4.7 OVOTRANSFERRIN OR CONALBUMIN 200 7.5 SELECTED EXAMPLES OF
USEFUL APPLICATIONS 201 7.5.1 DETERMINATION OF REACTION STEREOCHEMISTRY
201 7.5.1.1 STEREOSELECTIVE MONITORING OF PHARMACOKINETICS 201 7.5.1.2
STEREOSELECTIVITY IN ENZYME-CATALYZED REACTIONS 205 7.5.2 DETERMINATION
OF ENANTIOMERIC PURITY 207 7.5.3 PREPARATIVE-SCALE ISOLATION OF PURE
ENANTIOMERS 209 7.5.4 STUDIES OF DRUG-ALBUMIN BINDING 209 7.6 SOME
EXPERIMENTAL OBSERVATIONS RELATED TO THE MECHANISM OF RETENTION AND
CHIRAL RECOGNITION 210 7.7 SPECIAL MICROANALYTICAL TECHNIQUES 211 7.7.1
MINIATURIZATION OF THE LIQUID CHROMATOGRAPHIE SYSTEM 211 7.7.2 CAPILLARY
ELECTROPHORESIS 212 7.8 SOME CONCLUDING REMARKS 213 8 OPTICALLY ACTIVE
POLYACRYLAMIDE/SILICA COMPOSITES AND RELATED PACKINGS AND THEIR
APPLICATION IN CHIRAL SEPARATIONS JOACHIM N. KINKEL 8.1 INTRODUCTION 217
8.2 THE CHROMATOGRAPHER S VIEW: HOW TO DEFINE THE IDEAL SUPPORT? 219
CONTENTS XI 8.3 THE SYNTHESIS OF POLYMER/SILICA COMPOSITES 223 8.3.1 THE
DEPOSITION OF PREFORMED POLYMERS ON THE SURFACE OF INORGANIC OXIDES 224
8.3.2 PREPARATION OF PREFORMED POLYMERS BY COPOLYMERIZATION OF OPTICALLY
ACTIVE MONOMERS AND COMONOMERS BEARING SILANE FUNCTIONAL GROUPS AND
SUBSEQUENT REACTION WITH THE SILICA SURFACE 232 8.3.3 COPOLYMERIZATION
OF OPTICALLY ACTIVE MONOMERS WITH VINYL- OR (METH)ACRYLOXYPROPYL
MODIFIED SILICA 233 8.3.4 GRAFT POLYMERIZATION OF OPTICALLY ACTIVE VINYL
COMPOUNDS TO SILICA AND POLAR MODIFIED SILICA 237 8.3.5 GRAFT
POLYMERIZATION OF OPTICALLY ACTIVE VINYL COMPOUNDS BY UV-RADIATION OF
PHOTOINITIATOR-MODIFIED SILICA 244 8.3.6 GRAFT POLYMERIZATION OF
OPTICALLY ACTIVE VINYL COMPOUNDS INITIATED BY CERIC NITRATE/DIOL SILICA
REDOX SYSTEMS IN DILUTED NITRIC ACID SOLUTIONS 246 8.4 CHROMATOGRAPHIE
CHARACTERIZATION OF OPTICALLY ACTIVE POLYACRYLAMIDE/SILICA COMPOSITES
247 8.4.1 COMPARISON OF BRUSH-TYPE MONOMERIC PACKINGS AND POLYMER
COMPOSITES 247 8.4.2 INFLUENCE OF THE VINYL GROUP SUBSTITUENT OF
OPTICALLY ACTIVE POLYACRYLAMIDES ON THE CHROMATOGRAPHIE RESOLUTION OF
ENANTIOMERS 250 8.4.3 INFLUENCE OF SOLVENT ON RETENTION,
ENANTIOSELECTIVITY AND RESOLUTION 255 8.4.4 STRUCTURE/ENANTIOSELECTIVITY
RELATIONSHIP OF COMPOSITES, DERIVED FROM THE EPHEDRIN SKELETON 261 8.5
CHROMATOGRAPHIE APPLICATIONS 269 9 ION-PAIR CHROMATOGRAPHY IN ENANTIOMER
SEPARATIONS CURT PETTERSSON AND EVE HELDIN 9.1 INTRODUCTION 279 9.2
ION-PAIR CHROMATOGRAPHY 279 9.2.1 BATCH EXTRACTION 279 9.2.2
LIQUID-LIQUID CHROMATOGRAPHY 281 9.2.3 LIQUID-SOLID CHROMATOGRAPHY 283
9.1 SEPARATION OF ENANTIOMERS USING A CHIRAL COUNTER ION 285 9.3.1
NORMAL PHASE CHROMATOGRAPHY 287 9.3.1.1 STRUCTURE AND ENANTIOSELECTIVITY
287 9.3.1.2 MOBILE PHASE COMPOSITION AND SEPARATION 295 9.3.1.3 SOLID
PHASE AND SEPARATION 297 9.3.2 REVERSED PHASE CHROMATOGRAPHY : 301 9.4
TARTARIC ACID DERIVATIVES - UNCHARGED CHIRAL SELECTORS 302 XII CONTENTS
9.4.1 LIQUID TARTARIC ACID ESTER AS MOBILE OR LIQUID STATIONARY PHASES
302 9.4.2 TARTARIC ACID ESTERS AS DYNAMICALLY MODIFIED STATIONARY PHASES
.. 304 9.5 MISCELLANEOUS 307 9.5.1 PROTEINS AS CHIRAL MOBILE PHASE
ADDITIVES 307 9.5.2 CROWN ETHERS AS DYNAMICALLY MODIFIED STATIONARY
PHASES 308 10 SEPARATIONS OF ENANTIOMERIC COMPOUNDS BY CHIRAL SELECTORS
IN THE MOBILE OR SOLVENT PHASE BRIAN J. CLARK 10.1 INTRODUCTION 311 10.2
NUCLEAR MAGNETIC RESONANCE (NMR) 312 10.2.1 CHIRAL SHIFT REAGENT
ADDITIVES 312 10.2.2 CHIRAL SOLVATING AGENTS 312 10.2.3 CYCLODEXTRINS
AND THEIR DERIVATIVES 313 10.3 THIN LAYER CHROMATOGRAPHY (TLC) 313
10.3.1 CHIRAL STATIONARY PHASE TLC PLATES 315 10.3.2 ENANTIOSELECTORS
ADDED TO THE DEVELOPING SOLVENT 316 10.4 CHIRAL SEPARATIONS BY CAPILLARY
ELECTROPHORESIS 316 10.4.1 CHIRAL LIGAND EXCHANGE IN CAPILLARY
ELECTROPHORESIS 317 10.4.2 CHIRAL MICELLAR SEPARATIONS BY CAPILLARY
ELECTROPHORESIS 317 10.4.3 CHIRAL SEPARATIONS WITH CYCLODEXTRINS IN
CAPILLARY ELECTROPHORESIS 319 10.5 SEPARATIONS BY MOBILE PHASE ADDITIVES
IN HPLC 322 10.5.1 MOBILE PHASE ADDITIVES IN LIGAND EXCHANGE HPLC 322
10.5.2 PROTEINS AS CHIRAL SELECTORS IN HPLC 323 10.5.3 INCLUSION
COMPLEXATION IN CHIRAL SEPARATIONS BY HPLC 324 11 CHIRAL HPLC IN THE
PHARMACEUTICAL INDUSTRY IAN M. MUTTON 11.1 INTRODUCTION 329 11.1.1
CHIRAL DRUGS: SINGLE ENANTIOMERS OR RACEMATES? 329 11.1.1.1 BACKGROUND
329 11.1.1.2 BIOLOGICAL RELEVANCE OF STEREOSPECIFITY 329 11.1.1.3
REGULATORY ISSUES 330 11.1.1.4 THE PHARMACEUTICAL INDUSTRY : 330 11.1.2
THE ANALYST S ROLE 331 11.1.3 TECHNIQUES FOR CHIRAL ANALYSIS 332
11.1.3.1 SPECTROSCOPY 332 11.1.3.2 CHIRAL CHROMATOGRAPHY 332 11.2 CHIRAL
DISCRIMINATION USING HPLC 333 11.2.1 GENERAL 333 11.2.2 RESOLUTION USING
DIASTEREOMER FORMATION 333 CONTENTS XIII 11.2.3 RESOLUTION USING CHIRAL
STATIONARY PHASES (CSPS) 335 11.2.3.1 INTRODUCTION 335 11.2.3.2 TYPE I
CSPS 335 11.2.3.3 TYPE II CSPS 337 11.2.3.4 TYPE III CSPS 340 11.2.3.5
TYPE IV CSPS 342 11.2.3.6 TYPE V CSPS 343 11.2.3.7 CUSTOMIZED CSPS 345
11.2.4 RESOLUTION USING CHIRAL MOBILE PHASE ADDITIVES (CMPAS) 346
11.2.4.1 INTRODUCTION 346 11.2.4.2 CYCLODEXTRINS AS CMPAS 346 11.2.4.3
LIGAND EXCHANGERS AS CMPAS 347 11.2.4.4 PROTEINS AS CMPAS 347 11.2.4.5
CHIRAL ION-PAIR CHROMATOGRAPHY 347 11.2.5 CHIRO-OPTICAL DETECTION 348
11.2.6 PREPARATIVE CHIRAL SEPARATIBNS 348 11.3 CURRENT AND FUTURE TRENDS
349 11.4 CONCLUSION 351 12 BIOANALYTICAL APPLICATIONS OF
ENANTIOSELECTIVE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY TERENCE A. G.
NOCTOR 12.1 INTRODUCTION 357 12.1.1 ENANTIOSELECTIVE CHROMATOGRAPHIE
BIOANALYSIS 358 12.2 ENANTIOSELECTIVE BIOANALYSIS USING CHIRAL
DERIVATIZATION 358 12.2.1 INDIRECT CHIRAL RESOLUTION OF ENANTIOMERIC
AMINES IN BIOLOGICAL FLUIDS 359 12.2.2 INDIRECT CHIRAL RESOLUTION OF
ENANTIOMERIC ALCOHOLS IN BIOLOGICAL FLUIDS * 361 12.2.3 INDIRECT CHIRAL
RESOLUTION OF ENANTIOMERIC ACIDS IN BIOLOGICAL FLUIDS 361 12.3 DIRECT
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIE SEPARATION OF ENANTIOMERS USING
CHIRAL STATIONARY PHASES 363 12.3.1 PROTEIN-BASED CSPS IN THE ANALYSIS
OF DRUG ENANTIOMERS IN BIOLOGICAL FLUIDS 364 12.3.1.1 A R ACID
GLYCOPROTEIN 366 12.3.1.2 OVOMUCOID 370 12.3.1.3 SERUM ALBUMINS 371
12.3.2 CYCLODEXTRIN-BASED CSPS 373 12.3.3 BRUSH TYPE CSPS 375 12.3.1
POLYSACCHARIDE-BASED CSPS 377 12.3.4.1 BIOANALYTICAL APPLICATIONS OF
DERIVATIZED CELLULOSE CSPS 377 12.3.4.2 BIOANALYTICAL APPLICATIONS OF
DERIVATIZED AMYLOSE CSPS 380 XIV CONTENTS 12.3.5 BIOMEDICAL SEPARATIONS
USING OTHER TYPES OF CSP 380 12.3.5.1 CSPS BASED ON SYNTHETIC POLYMERS
381 12.3.5.2 CSPS BASED ON TERNARY COMPLEXATION (LIGAND EXCHANGE
CHROMATOGRAPHY) 381 12.4 MULTIDIMENSIONAL APPROACHES TO CHIRAL ANALYSIS
BY HPLC 381 12.4.1 SEQUENTIAL ACHIRAL-CHIRAL CHROMATOGRAPHY IN
BIOANALYSIS 382 12.4.2 DETERMINATION OF ENANTIOMERS IN BIOLOGICAL
MATRICES USING SERIALLY COUPLED ACHIRAL-CHIRAL CHROMATOGRAPHY 383 12.4.3
DETERMINATION OF ENANTIOMERS IN BIOLOGICAL MATRICES USING ACHIRAL-CHIRAL
CHROMATOGRAPHIE SYSTEMS, COUPLED BY MEANS OF A SWITCHING VALVE 385 12.5
DIRECT CHROMATOGRAPHIE BIOANALYSIS OF ENANTIOMERS USING CHIRAL MOBILE
PHASE ADDITIVE 389 12.5.1 CHIRAL LIGAND EXCHANGE ADDITIVES TO THE MOBILE
PHASE 389 12.5.2 CHIRAL MOBILE PHASE ADDITIVES FORMING DIASTEREOMERIC
LON-PAIRS . 389 12.5.3 CYCLODEXTRINS AS CHIRAL MOBILE PHASE ADDITIVES
390 12.6 CONCLUSION 391 INDEX 397
|
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| id | DE-604.BV009839307 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:41:50Z |
| institution | BVB |
| isbn | 3527282882 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006515761 |
| oclc_num | 31497863 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-91G DE-BY-TUM DE-703 DE-Er8 DE-11 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-91G DE-BY-TUM DE-703 DE-Er8 DE-11 DE-188 |
| physical | XVI, 405 S. Ill. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | VCH |
| record_format | marc |
| spelling | A practical approach to chiral separations by liquid chromatography ed. by G. Subramanian Weinheim [u.a.] VCH 1994 XVI, 405 S. Ill. txt rdacontent n rdamedia nc rdacarrier 2. Aufl. u.d.T.: Chiral separation techniques Chiraliteit gtt Chiralité - Applications industrielles ram Chromatographie en phase liquide ram Enantiomeren gtt Enantiomères - Séparation ram Vloeistofchromatografie gtt Chirality Industrial applications Enantiomers Separation Liquid chromatography Chirale Verbindungen (DE-588)4348527-3 gnd rswk-swf Flüssigkeitschromatographie (DE-588)4017622-8 gnd rswk-swf Enantiomerentrennung (DE-588)4135272-5 gnd rswk-swf Flüssigkeitschromatographie (DE-588)4017622-8 s Enantiomerentrennung (DE-588)4135272-5 s DE-604 Chirale Verbindungen (DE-588)4348527-3 s Subramanian, Ganapathy Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006515761&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | A practical approach to chiral separations by liquid chromatography Chiraliteit gtt Chiralité - Applications industrielles ram Chromatographie en phase liquide ram Enantiomeren gtt Enantiomères - Séparation ram Vloeistofchromatografie gtt Chirality Industrial applications Enantiomers Separation Liquid chromatography Chirale Verbindungen (DE-588)4348527-3 gnd Flüssigkeitschromatographie (DE-588)4017622-8 gnd Enantiomerentrennung (DE-588)4135272-5 gnd |
| subject_GND | (DE-588)4348527-3 (DE-588)4017622-8 (DE-588)4135272-5 |
| title | A practical approach to chiral separations by liquid chromatography |
| title_auth | A practical approach to chiral separations by liquid chromatography |
| title_exact_search | A practical approach to chiral separations by liquid chromatography |
| title_full | A practical approach to chiral separations by liquid chromatography ed. by G. Subramanian |
| title_fullStr | A practical approach to chiral separations by liquid chromatography ed. by G. Subramanian |
| title_full_unstemmed | A practical approach to chiral separations by liquid chromatography ed. by G. Subramanian |
| title_short | A practical approach to chiral separations by liquid chromatography |
| title_sort | a practical approach to chiral separations by liquid chromatography |
| topic | Chiraliteit gtt Chiralité - Applications industrielles ram Chromatographie en phase liquide ram Enantiomeren gtt Enantiomères - Séparation ram Vloeistofchromatografie gtt Chirality Industrial applications Enantiomers Separation Liquid chromatography Chirale Verbindungen (DE-588)4348527-3 gnd Flüssigkeitschromatographie (DE-588)4017622-8 gnd Enantiomerentrennung (DE-588)4135272-5 gnd |
| topic_facet | Chiraliteit Chiralité - Applications industrielles Chromatographie en phase liquide Enantiomeren Enantiomères - Séparation Vloeistofchromatografie Chirality Industrial applications Enantiomers Separation Liquid chromatography Chirale Verbindungen Flüssigkeitschromatographie Enantiomerentrennung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006515761&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT subramanianganapathy apracticalapproachtochiralseparationsbyliquidchromatography |