Pharmacological aspects of malaria chemotherapy: interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
1994
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 122 S. Ill., graph. Darst., Kt. |
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Datensatz im Suchindex
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| adam_text | PHARMACOLOGICAL ASPECTS OF MALARIA CHEMOTHERAPY INTERACTIONS OF THE
ANTIMALARIAL DRUG HALOFANTRINE WITH HUMAN BLOOD CELLS, SERUM PROTEINS
AND PLASMODIUM FALCIPARUM PARASITISED RED BLOOD CELLS
INAUGURALDISSERTATION ZUR ERLANGUNG DER WURDE EINES DOKTORS DER
PHILOSOPHIC VORGELEGT DER PHILOSOPHISCH-NATURWISSENSCHAFTLICHEN FAKULTAT
DER UNIVERSITAT BASEL VON BRUNO CENNI AUS BINNINGEN UND ROCCASTRADA (I)
BASEL, 1994 BLSLBLS BASLER - SCHNELLDRUCK V^BERNHARD SCHLATTMANN
ICATIJURASTRASSE 55 * TELEFON 061 361 37 37 * 4053 BASEL TABLE OF
CONTENTS ABBREVIATIONS 1 SUMMARY 3 ZUSAMMENFASSUNG 5 CHAPTER 1: GENERAL
INTRODUCTION 7 THE MALARIAL PARASITE 11 DISTRIBUTION AND INCIDENCE OF
MALARIA 13 CLINICAL ASPECTS OF MALARIA 15 CHEMOTHERAPY AND DRUG
RESISTANCE IN MALARIA 18 HALOFANTRINE * 23 AIMS OF THE PRESENT THESIS
25 REFERENCES 26 CHAPTER 2: THE DETERMINATION OF HALOFANTRINE IN
BIOLOGICAL SAMPLES BY HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY 31
ABSTRACT 33 INTRODUCTION 33 MATERIALS AND METHODS 34 SAMPLE PREPARATION
BY LIQUID-LIQUID EXTRACTION 34 SAMPLE PREPARATION BY SOLID PHASE
EXTRACTION 35 THIN LAYER CHROMATOGRAPHY 35 RESULTS AND DISCUSSION 36
REFERENCES 40 CHAPTER 3: THE IN VITRO DISPOSITION OF HALOFANTRINE IN
HUMAN BLOOD AND PLASMODIUMFALCIPARUM PARASITISED RED BLOOD CELLS IS
MAINLY DETERMINED BY ITS AFFINITY TO PLASMA 41 ABSTRACT 43 INTRODUCTION
44 MATERIALS AND METHODS 45 CHEMICALS 45 BLOOD PLASMA PARTITIONING 45
BLOOD CELL ISOLATION 45 [ 14 C] HALOFANTRINE MEASUREMENT IN ISOLATED
BLOOD FRACTIONS 46 PARASITE STRAIN AND CULTURE SYSTEM 46 HALOFANTRINE
UPTAKE BY PARASITISED RED BLOOD CELLS (PRBC) 47 PARASITE VIABILITY 47
RESULTS 48 CELL-PLASMA PARTITIONING 48 BLOOD PARTITIONING 48 DRUG UPTAKE
IN PARASITISED RED BLOOD CELLS (PRBC) 51 STAGE DEPENDENCE OF DRUG UPTAKE
52 SERUM INFLUENCE ON DRUG UPTAKE 53 DISCUSSION . 53 REFERENCES 56
CHAPTER 4: THE ANTIMALARIAL DRUG HALOFANTRINE IS HIGHLY BOUND TO SERUM
PROTEINS: ESTIMATION OF AFFINITY PARAMETERS AND BLOOD DISTRIBUTION . .
59 ABSTRACT 61 INTRODUCTION 61 MATERIALS AND METHODS 63 CHEMICALS. . 63
BLOOD FRACTIONS 63 SIZE EXCLUSION CHROMATOGRAPHY 64 SDS-PAGE AND WESTERN
BLOT ANALYSIS 64 ERYTHROCYTE PARTITIONING METHOD 65 CALCULATIONS 66
SIMULATIONS OF BLOOD DISTRIBUTION 67 RESULTS 67 HALOFANTRINE-BINDING TO
SERUM PROTEINS 67 ESTIMATION OF BINDING TO SERUM PROTEINS 71 ESTIMATION
OF BINDING TO ERYTHROCYTES 74 MATHEMATICAL SIMULATION OF BLOOD
DISTRIBUTION 74 DISCUSSION 76 REFERENCES 79 CHAPTER 5: PLASMODIUM
FALCIPARUM: CHARACTERISTICS OF HALOFANTRINE ACCUMULATION IN VITRO IN
PARASITISED RED BLOOD CELLS 83 ABSTRACT 85 INTRODUCTION 85 MATERIALS AND
METHODS 87 CHEMICALS 87 PARASITES 87 DRUG UPTAKE MEASUREMENT 88 [ 14 C]
HALOFANTRINE MEASUREMENT 89 RESULTS 89 DISCUSSION 93 REFERENCES 97
CHAPTER 6: CONCLUSIONS AND OUTLOOK 101 CONCLUSIONS 103 GENERAL ASPECTS
107 OUTLOOK * 109 REFERENCES P 112 THE BALLAD OF THE PLASMODIUM 117
ACKNOWLEDGEMENTS 119 CURRICULUM VITAE 121
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| spelling | Cenni, Bruno Verfasser aut Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells von Bruno Cenni 1994 122 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Basel, Univ., Diss., 1994 Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Malaria (DE-588)4037197-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Malaria (DE-588)4037197-9 s Pharmakotherapie (DE-588)4076066-2 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006500191&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cenni, Bruno Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells Pharmakotherapie (DE-588)4076066-2 gnd Malaria (DE-588)4037197-9 gnd |
| subject_GND | (DE-588)4076066-2 (DE-588)4037197-9 (DE-588)4113937-9 |
| title | Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells |
| title_auth | Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells |
| title_exact_search | Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells |
| title_full | Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells von Bruno Cenni |
| title_fullStr | Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells von Bruno Cenni |
| title_full_unstemmed | Pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells von Bruno Cenni |
| title_short | Pharmacological aspects of malaria chemotherapy |
| title_sort | pharmacological aspects of malaria chemotherapy interactions of the antimalarial drug halofantrine with human blood cells serum proteins and plasmodium falciparum parasitised red blood cells |
| title_sub | interactions of the antimalarial drug halofantrine with human blood cells, serum proteins and Plasmodium falciparum parasitised red blood cells |
| topic | Pharmakotherapie (DE-588)4076066-2 gnd Malaria (DE-588)4037197-9 gnd |
| topic_facet | Pharmakotherapie Malaria Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006500191&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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