Methods to assess DNA damage and repair: interspecies comparisons
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester u.a.
Wiley
1994
|
| Schriftenreihe: | International Programme on Chemical Safety: IPCS joint activity
19 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 257 S. Ill. |
| ISBN: | 0471942561 |
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| adam_text | SCOPE 52
IPCS JOINT ACTIVITY 19
|G0MSEC8
Methods to Assess
DNA Damage
and Repair:
Interspecies Comparisons
Edited by
ROBERT G TARDIFF
EA Engineering, Science, amp; Technology, Inc , Silver Spring, Maryland,
USA
PAUL H M LOHMAN
Leiden University, The Netherlands
GERALD N WOGAN
Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Prepared by
Scientific Group on Methodologies for the Safety Evaluation of Chemicals
(SGOMSEC)
Published on behalf of the Scientific Committee on the Problems of the Environment (SCOPE) -
of the International Council of Scientific Unions (ICSU), and the International Programme on
Chemical Safety (IPCS) of the World Health Organization (WHO), the United Nations
Environment Programme (UNEP), the the International Labour Organization (ILO)
by
JOHN WILEY amp; SONS
Chichester • New York • Brisbane • Toronto • Singapore
Contents
Foreword Michel J Mercier xiii
Preface Philippe Bourdeau and Bernard D Goldstein xv
Acknowledgements xvii
Scientific Group on Methodologies for the Safety Evaluation of
Chemicals xix
Participants of the Workshop xxi
PART 1 JOINT REPORT
1 Introduction, General Conclusions, and Recommendations 3
1 1 Introduction 3
1 2 Carcinogenesis as a MultiStep Process 4
1 3 Reaction Kinetics and Adduct Monitoring 5
1 4 General Recommendations 6
1 5 References 8
2 DNA Damage 9
2 1 Molecular Dosimetry 9
211 Absorption and Distribution 9
212 Bioactivation and Detoxification 10
213 Methods for Molecular Dosimetry 11
214 Examples of Carcinogen Dosimetry in Humans 12
2 2 Cross-Species Sensitivity in Carcinogenic Response 15
2 3 Approaches to Predict Cancer Activity and Potency 15
231 Structure-Activity Relationships 16
2311 Fragmentation of the Chemistry 16
2312 Fragmentation of Biological Parameters 17
2 4 Genotoxicity Profiles in Eukaryotes 18
3 DNA Repair and Mutagenesis 19
3 1 State of Knowledge 19
3 2 Impacts of Preferential Repair 20
3 3 Mechanisms of Mutagenesis 21
viii CONTENTS
4 DNA Repair, Mutagenesis, and Risk Assessment 23
4 1 Introduction 23
4 2 Monitoring of Human Populations 24
PART 2 CONTRIBUTED CHAPTERS
5 DNA Adducts and Their Consequences 29
F A Beland and M C Poirier
5 1 Introduction 29
5 2 W-Nitrosamines 30
5 3 Aflatoxins 33
5 4 Aromatic Amines 35
5 5 Polycyclic Aromatic Hydrocarbons 39
5 6 Summary 42
5 7 References 44
6 Nucleotide Excision-Repair Among Species 57
JHJ Hoeijmakers and A R Lehman
6 1 Introduction 57
6 2 Excision-Repair in Escherichia coli 57
6 3 Excision-Repair in Saccharomyces cerevisiae 59
631 Yeast as a Model System 59
632 Repair Mutants in S cerevisiae 60
6321 The RAD3 Epistasis Group 60
6 4 Drosophila 63
641 Drosophila as a Model System 63
642 Repair-Deficient Mutants 63
643 Interaction of Excision-Repair Enzymes with Other Processes 65
6431 DNA Replication on Damaged Templates 65
6432 Recombination 65
6 5 Mammalian Cells 65
651 Cellular Biochemistry 65
652 Repair-Deficient Mutants 66
6521 Human Mutants 66
6522 Rodent Cell Mutants 68
6523 Repair of (6-4) Photoproducts 69
6524 Cloning of Human Repair Genes 70
6 6 Relationship between Repair Systems of Different Organisms 74
661 Prokaryotes and Eukaryotes 74
662 Yeast and Humans 76
6 6 References 77
CONTENTS ix
7 Interspecies Determinants:
Bioactivation and Inactivation of Carcinogens 83
G J Mulder
7 1 Introduction 83
7 2 Exposure and Pharmacokinetic Scaling 84
7 3 Activation of Carcinogens 85
731 Reactive Intermediates: Rate of Formation 85
732 Bioactivation Mechanisms: Identification of
Ultimate Carcinogens 87
7 4 Prediction of Metabolite Pattern 88
7 5 Protective Systems 91
7 6 Extrapolation from Laboratory Animals to Humans 91
7 7 References 92
8 Monitoring Cytogenetic Damage In Vivo 95
A T Natarajan, J D Tucker, and M S Sasaki
8 1 Introduction 95
8 2 Chromosomal Aberrations 96
8 3 Sister Chromatid Exchanges 98
8 4 Micronuclei 99
841 Erythrocytes 99
8411 Bone Marrow 99
8412 Peripheral Blood 100
8413 Automation 101
842 Nucleated Cells 101
8421 Application of the CB Procedure In Vitro 102
8422 Application of the CB Procedure In Vivo 102
8423 Automation 103
8424 Aneuploidy 104
8 5 Sperm Cytogenetics 106
8 6 Interspecies Comparisons 108
8 7 Conclusions 108
8 8 References • 109
9 In Vivo Somatic Cell Gene Mutations in Humans 117
R J Albertini, J A Nicklas, S H Rebison, and J P O Neill
9 1 Introduction 117
911 Rationale 117
912 Historical Context 117
913 Current Era 118
9 2 Current Assays for Human In Vivo Somatic Cell Mutations 118
921 RBC Assays 118
922 Hemoglobin Mutants 119
923 Glycophorin A (GPA) Loss Mutants 120
x CONTENTS
924 Lymphocyte Assays
9241 hpri Mutants
9 3 Other Measures of In Vivo Somatic Cell Gene Mutation
9 4 Conclusions
9 5 References
10 DNA Repair in Specific Sequences and Genomic Regions 141
L F Mullenders and C A Smith
10 1 Introduction 141
10 2 Repair of UV-Induced Lesions 142
10 2 1 Cyclobutane Pyrimidine Dimers 142
10 211 Rodent Cells 142
10 212 Human Cells 144
10 213 Drosophila melanogaster 145
10 214 Yeast 145
10 215E coli 146
10 2 2 (6-4) Photoproducts 146
10 2 3 Repair Heterogeneity Determined from Repair Synthesis 147
10 3 Alterable Repair of UV Damage in Mammalian Genes 150
10 4 Repair of Other Types of Damage 151
10 4 1 Aflatoxin B, Adducts 152
10 4 2 Acetylaminofluorene Adducts 152
10 4 3 Psoralen Adducts 153
10 4 4 Adducts of Simple Alkylating Agents 154
10 5 Conclusions 155
10 6 References 156
11 Molecular Analysis of Mutations in Endogenous Genes 161
H Vrieling and A A van Zeeland
11 1 Introduction 161
11 2 Factors Influencing Mutation Spectra 161
11 2 1 DNA Lesions 161
11 2 2 DNA Structure and Sequence 162
11 2 3 DNA Repair 163
11 3 Target Genes for Analysis of Mutation Spectra 164
11 3 1 Introduction 164
11 3 2 Chromosomal Target Genes for Mutation Studies 164
11 3 3 Spontaneously Occurring Mutations 165
11 3 4 Alkylating Agents 166
11 3 5 Cross-linking Agents 168
11 4 Conclusions 170
11 5 References 170
CONTENTS xi
12 Molecular Analysis of Mutations in Shuttle Vectors and Transgenic
Animals 179
M L Wood, S B Verghis, and J M Essigman
12 1 Introduction 179
12 2 Operational Features of Shuttle Vector and Transgenic
Animal Assays for Mutagenesis 180
12 2 1 Transiently Replicating, Episomal Shuttle Vectors 180
12 2 2 Stably Replicating Episomal Vectors 181
12 2 3 Chromosomally Integrated Shuttle Vectors 181
12 3 Mutational Specificity of Ultraviolet Light 182
12 4 Mutational Specificity of DNA Alkylating Agents 184
12 4 1 Conventional Shuttle Vector Systems 185
12 4 2 Transgenic Animal Models 185
12 4 3 Site-Specific Mutagenesis by Individual Alkyl-DNA Adducts 186
12 5 Mutational Specificity of Aromatic Amines, Amides, and
Nitro Compounds 187
12 5 1 2-AminofIuorene Derivatives 187
12 5 2 Nitropyrene Derivatives 188
12 5 3 N-methyl-4-Aminoazobenzene Derivatives 189
12 6 Mutational Specificity of Polycyclic Aromatic Hydrocarbons 189
12 6 1 BenzoMpyrene 189
12 6 2 Benzo[c]phenanthrene 190
12 7 Mutational Specificity of Other DNA Damaging Agents 190
12 7 1 Iron(m)/Hydrogen Peroxide/EDTA 190
12 7 2 Safrole 191
12 7 3 8-Methoxypsoralen (8-MOP) 191
12 8 Conclusions 192
12 9 References 193
13 Structure-Activity Relationships (SAR): Computerized Systems 201
M D Waters, A M Richards, J R Rabinowitz, H F Stack,
PHM Lohman, and H S Rosenkranz
13 1 Introduction 201
13 2 SAR as a Process 202
13 3 Correlative and Mechanistic Approaches 204
13 4 Correlative SAR Techniques 205
13 4 1 The Case System 207
13 4 2 Chemical Classification and Representation 208
13 4 3 Sar Modeling of Genotoxicity and Carcinogenesis 209
13 5 Genetic Toxicology Databases: the Gene-Tox and
NTP Databases 211
13 5 1 Genetic Activity Profiles 212
13 5 2 Problems with Some Existing Data Bases 213
13 6 Integration of Structural Concepts with Database Evaluation 215
xii • CONTENTS
13 7 SAR Estimations 215
13 7 1 Profile Matching 217
13 8 Weight-of-Evidence Scoring System 220
13 9 Summary and Discussion 222
13 10 References 226
14 Structure-Activity Relationships: Experimental Approaches 231
E W Vogel and J Ashby
14 1 Introduction 231
14 2 Early Approaches 231
14 3 Criteria and Methods for Interspecies Comparisons 234
14 3 1 Genotoxic Effectiveness 235
14 3 2 Genotoxic Efficiency 235
14 3 3 Relative Genotoxic Efficiency 235
14 331 Relative Carcinogenic Potency 235
14 332 Altered DNA Repair 239
14 333 Biological Dosimetry 241
14 4 Molecular Genetic Spectra of Procarcinogens 245
14 5 SAR Among Carcinogens/Mutagens in General 246
14 6 Conclusions and Perspectives 248
14 7 References 250
Index 255
r
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| spelling | Methods to assess DNA damage and repair interspecies comparisons ed. by Robert G. Tardiff ... Chichester u.a. Wiley 1994 XXIV, 257 S. Ill. txt rdacontent n rdamedia nc rdacarrier International Council of Scientific Unions / Scientific Committee on Problems of the Environment: SCOPE 52 International Programme on Chemical Safety: IPCS joint activity 19 International Council of Scientific Unions / Scientific Group on Methodologies for the Safety Evaluation of Chemicals: SGOMSEC 8 Beschadigingen gtt DNA gtt Reparaties gtt Carcinogens toxicity DNA Damage DNA Repair DNA damage DNA repair Environmental Exposure Genetic toxicology Mutagens toxicity Physiology, Comparative DNS-Reparatur (DE-588)4150347-8 gnd rswk-swf DNS-Schädigung (DE-588)4150350-8 gnd rswk-swf DNS-Schädigung (DE-588)4150350-8 s DNS-Reparatur (DE-588)4150347-8 s DE-604 Tardiff, Robert G. Sonstige oth Scientific Committee on Problems of the Environment: SCOPE International Council of Scientific Unions 52 (DE-604)BV000007237 52 Scientific Group on Methodologies for the Safety Evaluation of Chemicals: SGOMSEC International Council of Scientific Unions 8 (DE-604)BV000014780 8 International Programme on Chemical Safety: IPCS joint activity 19 (DE-604)BV009813756 19 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006495849&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Methods to assess DNA damage and repair interspecies comparisons International Programme on Chemical Safety: IPCS joint activity Beschadigingen gtt DNA gtt Reparaties gtt Carcinogens toxicity DNA Damage DNA Repair DNA damage DNA repair Environmental Exposure Genetic toxicology Mutagens toxicity Physiology, Comparative DNS-Reparatur (DE-588)4150347-8 gnd DNS-Schädigung (DE-588)4150350-8 gnd |
| subject_GND | (DE-588)4150347-8 (DE-588)4150350-8 |
| title | Methods to assess DNA damage and repair interspecies comparisons |
| title_auth | Methods to assess DNA damage and repair interspecies comparisons |
| title_exact_search | Methods to assess DNA damage and repair interspecies comparisons |
| title_full | Methods to assess DNA damage and repair interspecies comparisons ed. by Robert G. Tardiff ... |
| title_fullStr | Methods to assess DNA damage and repair interspecies comparisons ed. by Robert G. Tardiff ... |
| title_full_unstemmed | Methods to assess DNA damage and repair interspecies comparisons ed. by Robert G. Tardiff ... |
| title_short | Methods to assess DNA damage and repair |
| title_sort | methods to assess dna damage and repair interspecies comparisons |
| title_sub | interspecies comparisons |
| topic | Beschadigingen gtt DNA gtt Reparaties gtt Carcinogens toxicity DNA Damage DNA Repair DNA damage DNA repair Environmental Exposure Genetic toxicology Mutagens toxicity Physiology, Comparative DNS-Reparatur (DE-588)4150347-8 gnd DNS-Schädigung (DE-588)4150350-8 gnd |
| topic_facet | Beschadigingen DNA Reparaties Carcinogens toxicity DNA Damage DNA Repair DNA damage DNA repair Environmental Exposure Genetic toxicology Mutagens toxicity Physiology, Comparative DNS-Reparatur DNS-Schädigung |
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