The role of proteoglycans and glycosaminoglycans in aging:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Basel ; München u.a.
Karger
1994
|
| Series: | Interdisciplinary topics in gerontology
28 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 140 S. Ill., graph. Darst. |
| ISBN: | 3805559259 |
Staff View
MARC
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| 100 | 1 | |a Sames, Klaus |d 1939- |e Verfasser |0 (DE-588)121895106 |4 aut | |
| 245 | 1 | 0 | |a The role of proteoglycans and glycosaminoglycans in aging |c Klaus Sames |
| 264 | 1 | |a Basel ; München u.a. |b Karger |c 1994 | |
| 300 | |a XIII, 140 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Interdisciplinary topics in gerontology |v 28 | |
| 650 | 2 | |a Glycosaminoglycanes - Métabolisme | |
| 650 | 7 | |a Glycosaminoglycanes - Métabolisme |2 ram | |
| 650 | 2 | |a Protéoglycanes - Métabolisme | |
| 650 | 7 | |a Protéoglycanes - Métabolisme |2 ram | |
| 650 | 2 | |a Vieillissement - Physiologie | |
| 650 | 7 | |a Vieillissement |2 ram | |
| 650 | 0 | 7 | |a Alter |0 (DE-588)4001446-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Glykosaminoglykane |0 (DE-588)4157746-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Proteoglykane |0 (DE-588)4176001-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Altern |0 (DE-588)4068596-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Proteoglykane |0 (DE-588)4176001-3 |D s |
| 689 | 0 | 1 | |a Altern |0 (DE-588)4068596-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Glykosaminoglykane |0 (DE-588)4157746-2 |D s |
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| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Alter |0 (DE-588)4001446-0 |D s |
| 689 | 2 | 1 | |a Proteoglykane |0 (DE-588)4176001-3 |D s |
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| 689 | 3 | 0 | |a Alter |0 (DE-588)4001446-0 |D s |
| 689 | 3 | 1 | |a Glykosaminoglykane |0 (DE-588)4157746-2 |D s |
| 689 | 3 | |5 DE-604 | |
| 830 | 0 | |a Interdisciplinary topics in gerontology |v 28 |w (DE-604)BV000005627 |9 28 | |
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Record in the Search Index
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| adam_text |
CONTENTS
ABBREVIATIONS
.
XI
FOREWORD
.
XII
PREFACE
.
XIII
1
INTRODUCTION:
BIOCHEMISTRY
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
1.1.
STRUCTURE
OF
PROTEOGLYCAN
MOLECULES
.
1
1.2.
METABOLISM
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
.
7
1.3.
LOCALIZATION
AND
DISTRIBUTION
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
.
9
1.4.
FUNCTIONS
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
.
11
1.5.
METHODS
OF
PROTEOGLYCAN
ISOLATION
AND
CHARACTERIZATION
.
15
2
AGE-RELATED
CHANGES
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
IN
TISSUES
AND
ORGANS
2.1.
CARTILAGE
.
18
2.1.1.
HYALINE
CARTILAGE
.
18
2.1.1.1.
ARTICULAR
CARTILAGE
.
18
2.1.1.1.1.
HUMAN
ARTICULAR
CARTILAGE
.
18
2.1.1.1.1.1.
AGE-RELATED
CHANGES
OF
TOTAL
GLYCOSAMINOGLYCAN
CONTENT
.
18
2.1.1.1.1.2.
DIFFERENTIATED
DETERMINA
TION
OF
TOTAL
AMOUNTS
OF
ISOLATED
GLYCOSAMINOGLYCAN
TYPES
.
19
2.1.1.1.1.3.
CHANGES
IN
PROTEOGLYCAN
EXTRACTS
AND
AGGREGATES
.
19
2.1.1.1.1.4.
CHANGES
IN
ISOLATED
PROTEOGLYCAN
MONOMERS
.
20
2.1.1.1.1.5.
VARIOUS
CHANGES
IN
PROTEOGLYCANS
AND
AGGREGATES
.
22
2.1.1.1.1.6.
HISTOCHEMISTRY
.
24
2.1.1.1.2.
ARTICULAR
CARTILAGE
OF
OTHER
SPECIES
.
25
2.1.1.1.2.1.
PRIMATES
.
25
2.1.1.1.2.2.
RATS
AND
MICE
.
25
2.1.1.1.2.3.
DOGS
.
26
2.1.1.1.2.4.
PIGS
.
26
2.1.1.1.2.5.
CATTLE
.
27
2.1.1.1.2.6.
SHEEP
.
27
2.1.1.1.2.7.
SUMMARY
AND
CONCLUSIONS
.
27
2.1.1.2.
COSTAL
CARTILAGE
AND
XIPHOID
CARTILAGE
.
28
2.1.1.2.1.
HUMAN
COSTAL
CARTILAGE
.
28
2.1.1.2.1.1.
GLYCOSAMINOGLYCANS
.
28
2.1.1.2.1.2.
PROTEOGLYCANS
.
29
2.1.1.2.1.3.
METABOLISM
.
31
2.1.1.2.1.4.
TOPOCHEMISTRY
AND
HISTOCHEMISTRY
.
31
2.1.1.2.1.5.
SUMMARY
AND
CONCLUSION
.
37
VII
2.1.1.2.2.
OTHER
SPECIES
.
3§
2.1.1.2.2.1,
RAT
.
\
.
.
38
2.I.I.2.2.2.
RABBIT
.
\
39
2.1.1.3.
TRACHEAL
AND
BRONCHIAL
CARTILAGE
.
39
2.1.1.4.
NASAL
CARTILAGE
.
40
2.1.2.
ELASTIC
CARTILAGE
.
4
Q
2.1.3.
FIBROUS
CARTILAGE
.
42
2.1.3.1.
INTERVERTEBRAL
DISC
.
42
2.1.3.1.1.
GLYCOSAMINOGLYCANS
.
42
2.1.3.1.2.
PROTEOGLYCANS
.
42
2.1.3.1.3.
DOGS
.
43
2.1.3.1.4.
RABBIT
.
43
2.1.3.2.
MENISCUS
.
43
2.1.3.3.
CONCLUSION
.
43
2.2.
OTHER
TISSUES
AND
ORGANS
.
44
2.2.1.
BONE
.
44
2.2.2.
TENDON
.
44
2.2.3.
SYNOVIAL
FLUID
.
45
2.2.4.
TEETH,
PERIODONTAL
MEMBRANE,
AND
ORAL
MUCOSA
.
45
2.2.5.
CORNEA
AND
OTHER
EYE
TISSUES
.
46
2.2.6.
BLOODVESSELS
.
49
2.2.6.1.
PROTEOGLYCANS
.
50
2.2.6.2.
METABOLISM
.
50
2.2.6.3.
VEINS
.
53
2.2.6.4.
SMALL
VESSELS
.
53
2.2.7.
HEART
IN
GENERAL
AND
HEART
CONNECTIVE
TISSUE
.
53
2.2.7.1.
HEART
VALVES
.
53
2.2.8.
SKIN
AND
SUBCUTIS
.
54
2.2.9.
LUNG
.
56
2.2.10.
KIDNEY
.
57
2.2.11.
SPLEEN
.
5G
2.2.12.
BONE
MARROW
.
59
2.2.13.
LIVER
.
5$
2.2.14.
INTESTINAL
TRACT
.
60
2.2.14.1.
MOUTH
AND
ESOPHAGUS
.
60
2.2.14.2.
STOMACH
.
60
2.2.15.
UTERUS
.
60
2.2.16.
OVARIES
.
61
2.2.17.
TESTES
.
61
2.2.18.
HYPOPHYSIS
.
62
2.2.19.
ADRENAL
GLANDS
.
62
2.2.20.
MYOCARDIUM
AND
SKELETAL
MUSCLE
.
62
2.2.21.
BRAIN
AND
CENTRAL
NERVOUS
SYSTEM
.
63
2.2.22.
BODY
FLUIDS
.
63
2.2.22.1.
URINE
.
64
2.2.22.2.
SERUM
AND
PLASMA
.
64
2.2.23.
INVERTEBRATES
.
64
CONTENTS
VIII
3
CHANGES
IN
SUBCELLULAR
AND
SUPRAMOLECULAR
STRUCTURES
3.1.
SUBCELLULAR
AND
EXTRACELLULAR
COMPARTMENTS
.
65
3.1.1.
COLLAGEN-PROTEOGLYCAN
INTERACTION
.
65
3.1.2.
LYSOSOMAL
MEMBRANE
.
65
3.1.3.
BASEMENT
MEMBRANES,
PERICELLULAR
MATRIX
AND
CELL
MEMBRANES
.
65
3.1.4.
CELL
NUCLEI
.
67
3.2.
CONCLUSION
TO
CHAPTERS
2
AND
3
.
67
4
CHANGES
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
DURING
IN
VITRO
AGING
4.1.
HUMAN
DIPLOID
EMBRYONIC
LUNG
FIBROBLASTS
.
69
4.1.1.
GLYCOSAMINOGLYCANS
OF
IN
VITRO
AGING
HUMAN
LUNG
FIBROBLASTS
.
69
4.1.2.
INFLUENCES
ON
THE
GLYCOSAMINOGLYCAN/PROTEOGLYCAN
METABOLISM
OF
EMBRYONIC
HUMAN
LUNG
FIBROBLASTS
IN
VITRO
.
75
4.1.3.
CHANGES
AT
THE
PROTEOGLYCAN
LEVEL
.
77
4.2.
OTHER
TYPES
OF
FIBROBLASTS
AND
FIBROBLAST-LIKE
CELLS
.
79
4.2.1.
SKIN
FIBROBLASTS
AND
RAT
EMBRYO
FIBROBLASTS
.
79
4.2.2.
KERATOCYTES
.
79
4.2.3.
SYNOVIAL
CELLS
.
80
4.3.
ENDOTHELIAL
CELLS
.
80
4.3.1.
DIFFERENT
INFLUENCES
ON
ENDOTHELIAL
CELL
AGING
.
81
4.4.
SMOOTH
MUSCLE
CELLS
.
83
4.5.
CHONDROCYTES
.
83
4.6.
IN
VITRO
'
AGING
'
OF
TISSUE
EXPLANTS
.
83
4.7.
IN
VITRO
TESTS
OF
IN
VIVO
AGING
.
84
4.7.1.
CELLS
AGED
IN
VIVO
.
84
4.7.2.
IN
VIVO
AGED
TISSUE
EXPLANTS
.
85
4.8.
EXPERIMENTS
COMPARING
IN
VITRO
WITH
IN
VIVO
AGING
.
86
4.9.
CONCLUSIONS
.
88
5
CHANGES
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
IN
DISEASES
OF
HIGH
AGE
AND
WERNER
'
S
SYNDROME
5.1.
OSTEOARTHROSIS
.
89
5.2.
OSTEOPHYTES
.
90
5.3.
DEGENERATION
OF
THE
DISC
.
90
5.4.
PHOTOAGING
.
90
5.5.
DIABETES
.
90
5.6.
CHRONIC
GASTRITIS
.
90
5.7.
ATHEROSCLEROSIS
.
91
5.8.
DEGENERATIVE
DISEASES
OF
THE
CENTRAL
NERVOUS
SYSTEM
.
92
5.9.
AMYLOIDOSIS
AND
HYALINOSIS
.
93
5.10.
WERNER
'
S
SYNDROME
.
93
CONTENTS
IX
6
INFLUENCES
ON
GLYCOSAMINOGLYCANS
AND
PROTEOGLYCANS
AND
PHARMACOLOGICAL
EFFECTS
OF
GLYCOSAMINOGLYCANS
AND
PROTEOGLYCANS
6.1.
INFLUENCES
.
94
6.2.
PHARMACOLOGICAL
EFFECTS
.
95
7
CAUSES
AND
MECHANISMS
OF
AGE-RELATED
CHANGES
AND
CONCLUSIONS
FROM
THE
FOREGOING
(ORGAN-SPECIFIC)
CHAPTERS
7.1.
MECHANISMS
OF
AGE-RELATED
CHANGES
OF
PROTEOGLYCANS
AND
GLYCOSAMINOGLYCANS
.
96
7.1.1.
CHANGES
IN
CARTILAGE
.
96
7.1.2.
CHANGES
IN
DIFFERENT
TISSUES
AND
TISSUE
STRUCTURES
.
99
7.2.
PROTEOGLYCAN
AND
GLYCOSAMINOGLYCAN
AGE-RELATED
CHANGES
AND
THE
CAUSES
OF
AGING
.
99
7.3.
FINAL
CONCLUSIONS
.
103
REFERENCES
.
.
SUBJECT
INDEX
.
.
CONTENTS
X |
| any_adam_object | 1 |
| author | Sames, Klaus 1939- |
| author_GND | (DE-588)121895106 |
| author_facet | Sames, Klaus 1939- |
| author_role | aut |
| author_sort | Sames, Klaus 1939- |
| author_variant | k s ks |
| building | Verbundindex |
| bvnumber | BV009788567 |
| classification_rvk | WX 7504 |
| ctrlnum | (OCoLC)463897700 (DE-599)BVBBV009788567 |
| discipline | Biologie |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV009788567 |
| illustrated | Illustrated |
| indexdate | 2024-07-20T03:28:32Z |
| institution | BVB |
| isbn | 3805559259 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006476036 |
| oclc_num | 463897700 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-12 DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XIII, 140 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Karger |
| record_format | marc |
| series | Interdisciplinary topics in gerontology |
| series2 | Interdisciplinary topics in gerontology |
| spelling | Sames, Klaus 1939- Verfasser (DE-588)121895106 aut The role of proteoglycans and glycosaminoglycans in aging Klaus Sames Basel ; München u.a. Karger 1994 XIII, 140 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Interdisciplinary topics in gerontology 28 Glycosaminoglycanes - Métabolisme Glycosaminoglycanes - Métabolisme ram Protéoglycanes - Métabolisme Protéoglycanes - Métabolisme ram Vieillissement - Physiologie Vieillissement ram Alter (DE-588)4001446-0 gnd rswk-swf Glykosaminoglykane (DE-588)4157746-2 gnd rswk-swf Proteoglykane (DE-588)4176001-3 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteoglykane (DE-588)4176001-3 s Altern (DE-588)4068596-2 s DE-604 Glykosaminoglykane (DE-588)4157746-2 s Alter (DE-588)4001446-0 s Interdisciplinary topics in gerontology 28 (DE-604)BV000005627 28 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006476036&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sames, Klaus 1939- The role of proteoglycans and glycosaminoglycans in aging Interdisciplinary topics in gerontology Glycosaminoglycanes - Métabolisme Glycosaminoglycanes - Métabolisme ram Protéoglycanes - Métabolisme Protéoglycanes - Métabolisme ram Vieillissement - Physiologie Vieillissement ram Alter (DE-588)4001446-0 gnd Glykosaminoglykane (DE-588)4157746-2 gnd Proteoglykane (DE-588)4176001-3 gnd Altern (DE-588)4068596-2 gnd |
| subject_GND | (DE-588)4001446-0 (DE-588)4157746-2 (DE-588)4176001-3 (DE-588)4068596-2 (DE-588)4143413-4 |
| title | The role of proteoglycans and glycosaminoglycans in aging |
| title_auth | The role of proteoglycans and glycosaminoglycans in aging |
| title_exact_search | The role of proteoglycans and glycosaminoglycans in aging |
| title_full | The role of proteoglycans and glycosaminoglycans in aging Klaus Sames |
| title_fullStr | The role of proteoglycans and glycosaminoglycans in aging Klaus Sames |
| title_full_unstemmed | The role of proteoglycans and glycosaminoglycans in aging Klaus Sames |
| title_short | The role of proteoglycans and glycosaminoglycans in aging |
| title_sort | the role of proteoglycans and glycosaminoglycans in aging |
| topic | Glycosaminoglycanes - Métabolisme Glycosaminoglycanes - Métabolisme ram Protéoglycanes - Métabolisme Protéoglycanes - Métabolisme ram Vieillissement - Physiologie Vieillissement ram Alter (DE-588)4001446-0 gnd Glykosaminoglykane (DE-588)4157746-2 gnd Proteoglykane (DE-588)4176001-3 gnd Altern (DE-588)4068596-2 gnd |
| topic_facet | Glycosaminoglycanes - Métabolisme Protéoglycanes - Métabolisme Vieillissement - Physiologie Vieillissement Alter Glykosaminoglykane Proteoglykane Altern Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006476036&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000005627 |
| work_keys_str_mv | AT samesklaus theroleofproteoglycansandglycosaminoglycansinaging |