Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie: = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
1993
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 142 Bl. graph. Darst. |
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MARC
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| 245 | 1 | 0 | |a Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie |b = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |c von Chezian Somasundaram |
| 246 | 1 | 1 | |a Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| 264 | 1 | |c 1993 | |
| 300 | |a IX, 142 Bl. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Karlsruhe, Univ., Diss. | ||
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| 650 | 0 | 7 | |a Diagnose |0 (DE-588)4012040-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Monoklonaler bispezifischer Antikörper |0 (DE-588)4326199-1 |2 gnd |9 rswk-swf |
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Record in the Search Index
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| adam_text |
V
TABLE OF CONTENTS
ACKNOWLEDGEMENTS.
ZUSAMMENFASSUNG.
SUMMARY-.
PUBLICATIONS.
TABLE OF CONTENTS.
.
ABBREVIATIONS.
PARTI: TARGETING GALLIUM-67 CHELATE TO HUMAN MELANOMAS
1 SURVEY OF LITERATURE.1
1.1 BISPECIFIC ANTIBODIES: AN INTRODUCTION.
1
1.2 PRODUCTION OF BISPECIFIC ANTIBODIES.
3
1.2.1 BIOLOGICAL PRODUCTION-.
3
1.2.2 CHEMICAL PRODUCTION.
7
1.2.3 RECOMBINANT DNA TECHNOLOGY-.
9
1.3 APPLICATIONS OF BISPECIFIC ANTIBODIES.10
1.3.1 PRETARGETED RADIOIMMUNOSCINTIGRAPHY-.10
1.3.2 DRUG TARGETING-.
11
1.3.3 REDIRECTING EFFECTOR CELL TUMOUR CYTOTOXICITY-.12
1.3.4 IMMUNOCYTOCHEMISTRY & ENZYME IMMUNOASSAY-.14
1.4 AIM OF STUDY-.16
2 MATERIALS & METHODS.17
2.1 CELL CULTURE.
17
2.1.1 HUMAN MELANOMA CELLS.
17
2.1.2 HYBRIDOMAS.
17
2.1.3 MONOCLONAL ANTIBODY PRODUCTION-.
18
2.1.4 CIYOPRESERVATION & RECOVERY OF CELLS.
18
2.1.5 CLONING OF CELLS.
19
2.1.6 MYCOPLASMA SCREENING & DECONTAMINATION.
19
2.2 PRODUCTION OF HYBRID HYBRIDOMAS.20
2.3 BIOCHEMICAL TECHNIQUES.22
2.3.1 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-. 22
2.3.1.1 AFFINITY CHROMATOGRAPHY-.22
2.3.1.2 ION EXCHANGE CHROMATOGRAPHY-.24
2.3.1.3 GEL FILTRATION CHROMATOGRAPHY-.24
BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/941577562
TABLE OF CONTENTS
VI
2.3.2
2.3.3
2.4
2.4.1
2.4.2
2.4.3
2.4.4
2.4.5
2.4.6
2.5
SDS-PAGE.
ISOELECTRIC FOCUSING-.
IMMUNOLOGICAL TECHNIQUES-.
IMMUNOGLOBULIN ELISA-.
CELL ELISA-.
AMMONIUM SULPHATE PRECIPITATION TECHNIQUE
IMMUNOREACTIVITY ASSAY.
RADIOLABELLING OF IMMUNOGLOBULINS.
TCA PRECIPITATION.
IN VIVO STUDIES.
24
-26
-26
YY 26
-27
-27
-28
-28
YY 29
29
3
3.1
3.1.1
3.2
3.2.1
3.3
3.4
3.5
3.6
RESULTS-.
SCREENING OF CULTURED CELL LINES FOR MYCOPLASMA CONTAMINATION.
DECONTAMINATION OF MYCOPLASMA-INFECTED CELL CULTURES.
SELECTION OF HYBRIDOMAS.
CHARACTERISATION OF ANTIBODIES BY IEF & SDS-PAGE.
TRIAL STUDIES IN THE CHROMATOGRAPHIC SEPARATION OF MABS 3-9 & HDMEL3
GENERATION OF HYBRID
HYBRIDOMAS.
PURIFICATION & CHARACTERISATION OF BISPECIFIC ANTIBODIES.
IN VIVO EXPERIMENTS.
32
YY32
YY32
33
33
34
36
36
55
4
4.1
4.2
4.3
4.4
4.5
4.6
4.7
DISCUSSION-.
SELECTION OF HYBRIDOMAS.
CHARACTERISATION & PURIFICATION OF PARENTAL ANTIBODIES
MYCOPLASMA SCREENING &
DECONTAMINATION.
GENERATION OF HYBRID
HYBRIDOMAS.
PURIFICATION & CHARACTERISATION OF BISPECIFIC ANTIBODIES
IN VIVO EXPERIMENTS.
CONCLUSION-.
60
60
YY60
YY62
63
YY63
67
69
PART II: REDIRECTING MACROPHAGE-MEDIATED TUMOUR CYTOTOXICITY
5
5.1
5.2
5.2.1
5.2.2
5.2.2.1
SURVEY OF LITERATURE.
INTRODUCTION.
REDIRECTING EFFECTOR CELL-MEDIATED TUMOUR CYTOTOXICITY.
T LYMPHOCYTES.
MYELOID CELLS.
MACROPHAGES IN TUMOUR BIOLOGY-.
-70
70
71
71
73
73
TABLE OF CONTENTS
5
.
1
.
2.2
5
.
2.23
5.3
6
6.1
6
.
1.1
6
.
1.2
6.1.3
6.2
6
.
2.1
6
.
2.2
6.3
6.3.1
6.3.2
6.3.3
6.3.4
6.4
6.5
6.6
6
.
6.1
6
.
6.2
6.7
6.7.1
6.7.2
6.8
6.9
6.9.1
6.10
6.11
7
7.1
7.2
7.3
7.3.1
7.3.2
7.3.3
CYTOTOXIC TRIGGER MOLECULES.
TARGETING MYELOID CELLS TO TUMOURS USING BSMABS
AIM OF STUDY-.
MATERIALS & METHODS.
CELL CULTURE.
TUMOUR TARGET CELLS.
MACROPHAGE EFFECTOR CELLS.
HYBRIDOMAS.
CHARACTERIZATION OF TARGET & EFFECTOR CELLS.
FLUORESCENT-ACTIVATED CELL SORTING-.
ANTIGEN DENSITY DETERMINATION.
CONSTRUCTION OF BISPECIFIC ANTIBODY FRAGMENTS.
DIGESTION OF INTACT ANTIBODY TO F(AB02 FRAGMENTS.
REDUCTION OF F(AB02 TO FAB' FRAGMENTS.
COUPLING OF FAB' FRAGMENTS.
SDS-PAGE ANALYSIS.
COMPETITION ASSAY-.
IMMUNOREACTIVITY ASSAY-.
CROSS-LINKING CAPACITY OF BISPECIFIC F(AB02 FRAGMENTS.
PHASE CONTAST MICROSCOPY-.
FLUORESCENT MICROSCOPY-.
IN VITRO CYTOTOXICITY ASSAYS.
51CR-RELEASE ASSAY.
3
H-THYMIDINE UPTAKE INHIBITION ASSAY-.
IN VIVO
STUDY-.
ACTIVATION STUDIES.
MEASUREMENT OF RNI PRODUCTION-.
EFFECT OF TUMOUR CELL CULTURE SUPERNATANT ON M$ ACTIVATION
EFFECT OF PERITONEAL M | SUPERNATANT ON TUMOUR GROWTH.
RESULTS-.
CHARACTERISATION OF RAT M ) EFFECTOR CELLS.
CHARACTERISATION OF TUMOUR TARGET CELLS.
CONSTRUCTION OF BISPECIFIC ANTIBODY FRAGMENTS.
ENZYMATIC DIGESTION OF MAB 0X42 TO F(AB')2.
ENZYMATIC DIGESTION OF MAB 1.1ASML TO FFAB')*-
PURIFICATION OF FFAB'TE FRAGMENTS.
VLL
74
76
77
-79
YY79
YY 79
-79
-80
-80
-80
-80
-81
-81
-81
-82
-82
-82
-82
-83
-83
-83
-83
-83
84
-84
84
85
YY 85
-85
87
YY87
90
90
91
92
92
TABLE OF CONTENTS
7.3.4
7.3.5
7.3.6
7.4
7.4.1
7.4.2
7.5
7.6
7.6.1
7.6.2
7.7
7.8
7.9
8
8.1
8.2
8.3
8.4
8.5
REDUCTION OF F(AB')
2 FRAGMENTS TO THE FAB'PRODUCT.
PURIFICAT;ON OF FAB' FRAGMENTS-.
COUPLING OF FAB' FRAGMENTS.
CHARACTERISATION OF BISPECIFIC F(AB')2 FRAGMENTS.
COMPETITION ASSAYS.
IMMUNOREACTIVITY ASSAYS.
CROSS-LINKING CAPACITY OF BISPECIFIC ANTIBODY FHTKNENTS.
IN VITRO CYTOTOXICITY ASSAYS.YY .
SHORT-TERM ^CR-RELEASE ASSAYS.
LONG-TERM 3
H-THYMIDINE INCORPORATION INHIBITION ASSAYS'~~1
IN VIVO EXPERIMENTS.
ACTIVATION STUDY-.
EFFECT OF CELL-FREE SUPERNATANTS ON M* ACTIVATION
& TUMOUR MIL GROWTH.
VM
93
93
94
.95
95
.96
98
-
101
YY
101
-102
105
105
YY 106
DISCUSSION-.
SELECTION OF PARENTAL ANTIBODIES.
CONSTRUCTION & CHARACTERISATION OF BAF-.
CROSS-LINKING CAPACITY OF BAF-.
REDIRECTING MF-MEDIATED TUMOUR CYTOTOXICITY USING BAF-
CONCLUSION.
108
108
108
109
-110
113
APPENDIX 1-
REFERENCES-
114
-117 |
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| author | Somasundaram, Chezian |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV009752783 |
| illustrated | Illustrated |
| indexdate | 2024-10-09T16:21:08Z |
| institution | BVB |
| language | German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006450486 |
| oclc_num | 70877406 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-355 DE-BY-UBR DE-11 DE-188 |
| owner_facet | DE-91 DE-BY-TUM DE-355 DE-BY-UBR DE-11 DE-188 |
| physical | IX, 142 Bl. graph. Darst. |
| publishDate | 1993 |
| publishDateSearch | 1993 |
| publishDateSort | 1993 |
| record_format | marc |
| spelling | Somasundaram, Chezian Verfasser aut Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy von Chezian Somasundaram Production and evaluation of bispecific monoclonal antibodies for tumour and therapy 1993 IX, 142 Bl. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Karlsruhe, Univ., Diss. Therapie (DE-588)4059798-2 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Diagnose (DE-588)4012040-5 gnd rswk-swf Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Krebs Medizin (DE-588)4073781-0 s Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 s Therapie (DE-588)4059798-2 s DE-604 Diagnose (DE-588)4012040-5 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006450486&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Somasundaram, Chezian Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy Therapie (DE-588)4059798-2 gnd Krebs Medizin (DE-588)4073781-0 gnd Diagnose (DE-588)4012040-5 gnd Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4073781-0 (DE-588)4012040-5 (DE-588)4326199-1 (DE-588)4113937-9 |
| title | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| title_alt | Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| title_auth | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| title_exact_search | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| title_full | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy von Chezian Somasundaram |
| title_fullStr | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy von Chezian Somasundaram |
| title_full_unstemmed | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy von Chezian Somasundaram |
| title_short | Herstellung und Evaluierung bispezifischer monoklonaler Antikörper zur Tumordiagnostik und Therapie |
| title_sort | herstellung und evaluierung bispezifischer monoklonaler antikorper zur tumordiagnostik und therapie production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| title_sub | = Production and evaluation of bispecific monoclonal antibodies for tumour and therapy |
| topic | Therapie (DE-588)4059798-2 gnd Krebs Medizin (DE-588)4073781-0 gnd Diagnose (DE-588)4012040-5 gnd Monoklonaler bispezifischer Antikörper (DE-588)4326199-1 gnd |
| topic_facet | Therapie Krebs Medizin Diagnose Monoklonaler bispezifischer Antikörper Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006450486&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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