Handbook of B and T lymphocytes:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
San Diego u.a.
Acad. Press
1994
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XIV, 505 S. Ill., graph. Darst. |
| ISBN: | 0126539553 |
Staff View
MARC
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| 245 | 1 | 0 | |a Handbook of B and T lymphocytes |c ed. by E. Charles Snow |
| 264 | 1 | |a San Diego u.a. |b Acad. Press |c 1994 | |
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Record in the Search Index
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| adam_text | HANDBOOKOF
B and T Lymphocytes
Edited by
E Charles Snow
Department of Microbiology and Immunology
University of Kentucky Medical Center
Lexington, Kentucky
Academic Press, Inc
A Division of Harcourt Brace amp; Company
San Diego New York Boston London Sydney Tokyo Toronto
Contents
Preface xiii
PART I
GENERAL TOPICS
1 Lymphocyte Adhesion Molecules: Role in Cell Adhesion
and Intercellular Communication
David H Adams, Stephen Shaw, and Gijs van Seventer
Introduction 4
Classification of Adhesion Molecules 4
Regulation of Adhesion ] 0
Lymphocyte Interactions with Endothelium 13
Role of Adhesion in T Cell Activation 16
Regulation of Costimulatory Adhesion Pathways with
T Cell Activation 18
T Cell/Monocyte Interactions 19
T Cell/B Cell Interactions 20
Conclusions 21
References 21
2 Signaling Mechanisms Utilized by Mammalian Cells
E Charles Snow
Introduction 27
Phosphatidylinositol Metabolism 28
Phosphatidylcholine Metabolism 48
Cyclic AMP-Dependent Signaling Pathway 49
Conclusions 53
References 53
vi Contents
3 Lymphocyte Programmed Cell Death
Jonathan D Ashwell
General Considerations 63
Definitions: Programmed Cell Death and Apoptosis 64
PCD and Lymphocyte Biology 67
PCD and the Immune System 74
Conclusion 83
References 84
4 Age-Related Decline in B and T Cell Immunity
Dorit Zharhary
Introduction 91
Intrinsic Changes in B and T Cells 92
Repertoire Expression 97
Lymphocyte Development 101
Autoimmunity in Aging 105
Concluding Remarks 109
References 110
PART IB
T LYMPHOCYTES
5 Mechanisms Responsible for the Processing and Presentation
of Antigens to T Cells
Kathleen L McCoy
Dichotomy of T Cell Recognition 118
Evidence for the MHC Class II Processing Pathway 119
Mechanism of the MHC Class II Pathway 121
Evidence for the MHC Class I Processing Pathway 128
Mechanism of the MHC Class I Pathway 129
Criss-Cross Processing Pathways 135
Future Considerations 139 s
References 139
6 Antigen-Presenting Cell Regulation of T Cell Activation
Kevin B Urdahl and Marc K Jenkins
How Do T Cells Distinguish the Harmful from the Harmless? 144
Contents
The Two-Signal Model of Lymphocyte Activation 145
Activation of CD4+ T Cells Requires Two Signals 145
Cell Surface Molecules Involved in Thl Costimulation 148
Anergy May Be Induced in More Than One Way 149
Can the Two-Signal Model Explain the Ability of T Cells to
Discriminate between Self and Non-Self? 150
Can the Two-Signal Model Explain B Cell and CTL
Peripheral Tolerance? 155
Conclusion 155
References 156
7 The Concept of Memory T Cells
Charles R Mackay
Introduction 160
Features of T Memory Responses 161
Phenotypic Identification of Memory T Cells Using CD45
and Other Markers 161
Functional Characteristics of T Cell Subsets 165
Life Span of T Cell Memory and Memory T Cells 166
Mechanisms for Maintenance of T Cell Memory 167
A Scheme for T Cell Memory 169
Migration and Localization of CD45RA+ and CD45RO
T Cells 170
Role of Memory T Cells in Autoimmunity 173
Concluding Remarks 174
References 175
8 78 T Cells
Willi Born, Katherine A Kelly, and Rebecca L O Brien
Discovery 179
78 TCR Genes 180
78 T Cell Lineage 182
Ligands for 78 T Cells 190
Potential Effector Functions of 78 T Cells 196
Involvement of 78 T Cells in Infectious Diseases 197
Involvement of 78 T Cells in Autoimmune
and Other Diseases 202
Is There a Role for 78 T Cells in the Immune Response? 207
References 208
viii Contents
9 Cytolytic T Cell Development and Function -
David J Cohen and Pierre A Henkart
Historical Perspectives 215 «•
Antigen Specificity and MHC Restriction 217
CTL Development 218
Granule Exocytosis Model for CTL Killing 222
CTL Function in Vivo 226
Concluding Remarks 231
References 232
10 T Cell Subsets and Defense against Bacteria and Viruses
Stefan H E Kaufmann and Matthias J Reddehase
Introduction 238
Division of Tasks in Acquired Immunity 238
T Cell Players in the Antimicrobial Game 239
Binary Logic of Antigen Processing and Presentation 241
Refined View on Rules and Laws of Antigen Processing 242
Engagement of T Cell Subsets Defined
by MHC Expression 244
Two Sides of a Blade: Protection versus
Immunopathogenesis 244
T Cell Subset Involvement in Antimicrobial Immunity 245
Making It All Go in Vivo 257
Epilogue 261
References 262
11 T Cell Recognition of Defined Peptides and Autoimmunity
Vipin Kumar, Vatsala Bhardwaj, and Eli Sercarz
T Cell Determinants 270
TCR and Ig Receptors Share Some Structural Features 271
Self-Reactive T Cells Utilize a Limited Set of TCR
Variable Genes 274
Competition among Self and Foreign Peptides N
for Presentation 276
Importance of Dominant and Cryptic Self Determinants in
Experimental Autoimmunity 279
T Cell Determinant-Based Autoimmune Disease Therapy 283
References 284
Contents jx
PART III
B LYMPHOCYTES
12 The B Cell Antigen Receptor: Consideration of Structure
and Function
Louis B Justement
Introduction 289
The B Cell Antigen Receptor: A Multifunctional Receptor 290
Signal Transduction via the B Cell Antigen Receptor 291
The B Cell Antigen Receptor Is Part of a Multisubunit
Complex 295
Structural Features of the B Cell Antigen Receptor
Complex 302
Functional Aspects of the Antigen Receptor Complex 308
Conclusion 315
References 316
13 RNA Processing and Expression of Immunoglobulin Genes
Martha L Peterson
Introduction 321
Heavy Chain Gene Structure and Expression 322
General Mechanisms Governing RNA Production 326
Ig mRNA Regulation—Models and Experimental
Evidence 328
Conclusions and Current Model 339
References 339
14 Thymus-Independent Antigens
Subbarao Bondada and Manju Garg
Introduction 343
Properties and Classification of TI Antigens 345
Concepts on the Signaling Role of the Ig Receptor 346
Cellular Requirements for a TI Response 350
Isotope, Affinity Maturation, and Memory 357
Anatomical Differences in TI Responses 358 s
Basis of Neonatal Unresponsiveness to TI-2 Antigens 360
TI Antigens and TI-Antigen-Protein Conjugate as
Vaccines 362
Conclusion and Perspectives 365
References 365
Contents
15 Distinctive Signaling Pathways for TI versus TD B Cell Responses
Lisa S Marshall and Randolph J Noelle
Introduction 371
Thymus-Independent and Thymus-Dependent Antigen Responses
Are Different 372
Conclusion 383
References 384
16 Regulation of B Lymphocyte Growth and Differentiation
by Soluble Mediators
William Cushley and Margaret M Harnett
Introduction 389
Soluble Antigen 390
Cytokines 392
Regulation of B Lymphocyte Function by B Cell Products 409
Conclusion and Future Perspectives 412
References 413
17 CD5+ B (B-l) Cells and Immunity
Dale L Morris and Thomas L Rothstein
Introduction 421
Tissue Localization, Phenotype, and Ontogeny 422
Functional Characteristics 424
B-l Cell-Derived Immunoglobulin 427
B-l Cells and Disease 429
Origin of B-l Cells 431
Summary and Perspectives 437
References 439
18 Complement as an Effector Mechanism of Antibodies
in Host Defense
Richard Krumdieck and John E Volanakis
Introduction 448
Overview of the Complement System 448
Biochemistry of the Complement Proteins 454
Activation of Complement by Antibodies 457
Biologic Activities of the Complement System 459
Concluding Remarks 466
References 467
Contents
19 Natural Antibodies, Immune Networks, and Autoimmunity
Dennis M Klinman
Natural Antibodies 473
Immune Networks 477 *•
Autoimmunity 483
Conclusion 487
References 487
Index 491
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| isbn | 0126539553 |
| language | English |
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| spelling | Handbook of B and T lymphocytes ed. by E. Charles Snow San Diego u.a. Acad. Press 1994 XIV, 505 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben B-lymfocyten gtt T-lymfocyten gtt B cells B-Lymphocytes immunology Lymphocytes T cells T-Lymphocytes immunology B-Lymphozyt (DE-588)4137121-5 gnd rswk-swf T-Lymphozyt (DE-588)4127387-4 gnd rswk-swf Handboeken (vorm) gtt T-Lymphozyt (DE-588)4127387-4 s DE-604 B-Lymphozyt (DE-588)4137121-5 s Snow, E. C. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006366532&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of B and T lymphocytes B-lymfocyten gtt T-lymfocyten gtt B cells B-Lymphocytes immunology Lymphocytes T cells T-Lymphocytes immunology B-Lymphozyt (DE-588)4137121-5 gnd T-Lymphozyt (DE-588)4127387-4 gnd |
| subject_GND | (DE-588)4137121-5 (DE-588)4127387-4 |
| title | Handbook of B and T lymphocytes |
| title_auth | Handbook of B and T lymphocytes |
| title_exact_search | Handbook of B and T lymphocytes |
| title_full | Handbook of B and T lymphocytes ed. by E. Charles Snow |
| title_fullStr | Handbook of B and T lymphocytes ed. by E. Charles Snow |
| title_full_unstemmed | Handbook of B and T lymphocytes ed. by E. Charles Snow |
| title_short | Handbook of B and T lymphocytes |
| title_sort | handbook of b and t lymphocytes |
| topic | B-lymfocyten gtt T-lymfocyten gtt B cells B-Lymphocytes immunology Lymphocytes T cells T-Lymphocytes immunology B-Lymphozyt (DE-588)4137121-5 gnd T-Lymphozyt (DE-588)4127387-4 gnd |
| topic_facet | B-lymfocyten T-lymfocyten B cells B-Lymphocytes immunology Lymphocytes T cells T-Lymphocytes immunology B-Lymphozyt T-Lymphozyt Handboeken (vorm) |
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