Free radical damage and its control:
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier
1994
|
| Series: | New comprehensive biochemistry
28 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XVI, 392 S. Ill., graph. Darst. |
| ISBN: | 044489716X |
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| 245 | 1 | 0 | |a Free radical damage and its control |c ed. Catherine A. Rice-Evans ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 1994 | |
| 300 | |a XVI, 392 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a New comprehensive biochemistry |v 28 | |
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| adam_text | IMAGE 1
PREFACE V
LIST OF CONTRIBUTORS VII
PART I - CHEMICAL AND BIOCHEMICAL ASPECTS
CHAPTER I. CHEMISTRY OF IRON AND COPPER IN RADICAL REACTIONS W.H.
KOPPENOL 3
ABBREVIATIONS 3
1. INTRODUCTION 3
2. AUTOXIDATION REACTIONS 6
2.1. OXYGEN 6
2.2. THERMODYNAMICS 7
2.3. KINETICS AND MECHANISMS 9
3. FENTON REACTIONS 11
3.1. INTRODUCTION 11
3.2. THERMODYNAMICS 12
3.3. KINETICS 13
3.4. INTERMEDIATES 13
4. SPECIATION AND EFFECTIVENESS IN PROMOTING OXYRADICAL DAMAGE 18
ACKNOWLEDGEMENT 20
REFERENCES 20
CHAPTER 2. SOME CHEMICAL AND BIOCHEMICAL CONSTRAINTS OF OXIDATIVE STRESS
IN LIVING CELLS JEAN CHAUDIERE 25
ABBREVIATIONS 25
1. THE BIRTH OF THE CONCEPT 25
2. THE BASIC PROPERTIES OF OXYGEN AND THE CONCEPT OF OXYGEN ACTIVATION
27
3. THE PUZZLING TOXICITY OF SUPEROXIDE 34
4. TOXICITY OF HYDROPEROXIDES AND THEIR RADICAL BY-PRODUCTS 39
4.1. HYDROGEN PEROXIDE 39
4.2. ORGANIC HYDROPEROXIDES 40
4.3. SODIUM AND CALCIUM HOMEOSTASIS 43
IMAGE 2
4.4. SIGNAL TRANSDUCTION 44
5. IRON TRANSPORT AND THE IRON-TRANSIT POOL 45
6. PROTECTIVE PATHWAYS OF MAMMALIAN CELLS AND TISSUES 46
6.1. HYDROPHOBIC PROTECTIVE SYSTEMS 46
6.2. HYDROPHILIC PROTECTIVE SYSTEMS 48
6.3. REGULATION OF ANTIOXIDANT ENZYMES 52
7. PROTEIN S-THIOLATION: SIGNAL OR DAMAGE? 54
8. CONCLUSION 57
REFERENCES 58
CHAPTER 3. FERRYL IRON AND PROTEIN FREE RADICALS C.E. COOPER 67
ABBREVIATIONS 67
1. INTRODUCTION 67
2. CHEMICAL STRUCTURE OF FE V 70
3. ENZYME CATALYSIS BY FERRYL ION AND FREE RADICALS 72
3.1. HAEM PROTEINS 72
3.1.1. PEROXIDASES AND CATALASES 72
3.1.1.1. PLANT/FUNGAL/BACTERIAL PEROXIDASES 75
3.1.1.2. MAMMALIAN PEROXIDASES 76
3.1.1.3. CATALASES 77
3.1.2. OXIDASES/OXYGENASES 78
3.1.2.1. CYTOCHROME OXIDASES 78
3.1.2.2. CYTOCHROME P-450 80
3.2. NON-HAEM PROTEINS 80
3.2.1. BINUCLEAR IRON CENTRES 80
3.2.2. MONONUCLEAR IRON CENTRES 82
4. METHODS FOR DETECTING FERRYL IRON AND PROTEIN FREE RADICALS 83
4.1. X-RAY CRYSTALLOGRAPHY 83
4.2. X-RAY ABSORPTION TECHNIQUES 85
4.3. MAGNETIC SUSCEPTIBILITY 86
4.4. EPR/ENDOR SPECTROSCOPY 87
4.5. OPTICAL SPECTROSCOPY 90
4.6. MAGNETIC CIRCULAR DICHROISM 93
4.7. MOSSBAUER SPECTROSCOPY 94
4.8. NUCLEAR MAGNETIC RESONANCE 97
4.9. RESONANCE RAMAN SPECTROSCOPY 98
5. RADICALS AND DISEASE - FERRYL GONE WRONG 100
5.1. ENZYMES UTILISING FERRYL INTERMEDIATES 100
5.2. ACCIDENTAL FERRYL STATES IN PROTEINS 101
5.3. NON-PROTEIN CATALYSED FERRYL PRODUCTION 103
ACKNOWLEDGEMENTS 103
REFERENCES 104
CHAPTER 4. ANTIOXIDANTS AND FREE RADICAL SCAVENGERS A. T. DIPLOCK 113
1. INTRODUCTION 113
1.1. DEFINITIONS OF ANTIOXIDANTS 113
IMAGE 3
1.2. MECHANISMS IN VIVO 1 ] 3
2. ENZYMATIC MECHANISMS OF PROTECTION 114
2.1. SUPEROXIDE DISMUTASES 114
2.2. CATALASE AND GLUTATHIONE PEROXIDASE 116
2.2.1. CATALASE 116
2.2.2. GLUTATHIONE PEROXIDASE 117
2.3. MINERALS AND NUTRITIONAL DEFICIENCY 119
3. CONTROL OF SECONDARY RADICALS 119
3.1. VITAMINE (A-TOCOPHEROL) 120
3.2. VITAMIN C (ASCORBIC ACID) 122
3.3. CAROTENOIDS 124
3.4. UBIQUINONE (COCNZYMCQ) 126
4. REMOVAL OF LIPID HYDROPEROXIDES 126
5. OTHER ANTIOXIDANT MECHANISMS 127
REFERENCES 128
CHAPTER 5. FORMATION OF FREE RADICALS AND MECHANISMS OF ACTION IN
NORMAL BIOCHEMICAL PROCESSES AND PATHOLOGICAL STATES C.A. RICE-EVANS 131
1. FREE RADICAL-GENERATING SYSTEMS IN NORMAL PROCESSES IN VIVO 131
2. FREE RADICAL-MEDIATED TISSUE DAMAGE 133
2.1. FACTORS CONTROLLING THE RELEASE OF FREE RADICALS IN DISEASE STATES
133
2.2. PEROXIDATION OF POLYUNSATURATED FATTY ACID SIDECHAINS 135
2.3. OXIDATION OF PROTEIN SUBSTITUENTS 137
2.4. CARBOHYDRATE OXIDATION AND CONSEQUENCES FOR PROTEIN FUNCTION 139
3. HAEM PROTEINS AND THE POTENTIAL FOR THE FORMATION OF REACTIVE RADICAL
SPECIES IN PATHOLOGICAL STATES 141
3.1. INTRODUCTION 141
3.2. MYOGLOBIN-DERIVED FREE RADICALS 143
3.3. HAEMOGLOBIN AS A PROMOTER OF OXIDATIVE PROCESSES 145
3.4. HAEMOGLOBIN AS A PROTECTIVE DEVICE 148
ACKNOWLEDGEMENTS 151
REFERENCES 151
CHAPTER 6. FREE RADICALS AND CELL PROLIFERATION R.H. BURDON 155
1. INTRODUCTION 155
2. PROLIFERATION OF MAMMALIAN CELLS 155
2.1. THE CELL DIVISION CYCLE AND ITS CONTROL 155
2.2. THE INFLUENCE OF THE EXTRACELLULAR ENVIRONMENT 157
3. OXIDATIVE STRESS AND CELL PROLIFERATION 158
3.1. OXYGEN TOXICITY 158
3.2. LIPID PEROXIDATION 159
3.3. EFFECTS OF A-TOCOPHEROL 159
3.4. SERUM DEPRIVATION AND LIPID PEROXIDATION 159
3.5. POLYUNSATURATED FATTY ACIDS 160
3.6. LIPID PEROXIDATION AND SIGNAL TRANSDUCTION 161
4. OXYGEN RADICALS, AND RELATED SPECIES THAT STIMULATE CELL
PROLIFERATION 163
IMAGE 4
5. CELLULAR RELEASE OF SUPEROXIDE AND HYDROGEN PEROXIDE 164
6. INTRACELLULAR GENERATION OF SUPEROXIDE 165
7. SUPEROXIDE AND HYDROGEN PEROXIDE AS CELLULAR MESSENGERS 166
8. MECHANISMS WHEREBY SUPEROXIDC AND HYDROGEN PEROXIDE PROMOTE CELL
GROWTH OR GROWTH RESPONSES 168
8.1. REDOX REGULATORY PARADIGM 170
8.2. OXIDATIVE INAETIVATION OF EXTRACELLULAR PROTEASE INHIBITORS 171
8.3. REDOX MECHANISMS AND THE SOURCE OF ACTIVE OXYGEN SPECIES 173
9. ACTIVE OXYGEN SPECIES AND NORMAL CELL PROLIFERATION 174
10. ACTIVE OXYGEN SPECIES AND CARCINOGENESIS 175
10.1. INITIATION 175
10.2. FREE RADICALS AND PROMOTION 175
10.3. PROGRESSION 177
10.4. GROWTH PROMOTION AND THE TUMOUR PHENOTYPE 177
10.5. THERAPEUTIC INTERVENTION 177
11. RADICALS AND THE ROLE OF RIBONUCLEOTIDC REDUCTASE 179
12. AN OVERVIEW 179
REFERENCES 180
PART II - PATHOLOGICAL ASPECTS
CHAPTER 7. THERAPEUTIC IRON-CHELATING AGENTS S. SINGH AND R.C. HIDER 189
1. INTRODUCTION 189
1.1. IRON ABSORPTION 190
1.2. IRON TRANSPORT 190
1.3. IRON STORAGE 191
2. IRON OVERLOAD 191
2.1. TRANSFUSIONAL SIDEROSIS 191
2.2. HYPERABSORPTION OF IRON 193
3. BIDENTATE AND HEXADENTATE IRON CHELATORS 193
4. CHELATION THERAPY 194
5. REQUIREMENTS FOR SELECTIVE IRON CHELATION 195
5.1. ABSORPTION AND SELECTIVE DISTRIBUTION 195
5.2. MINIMAL REDISTRIBUTION OF IRON 196
5.3. NEGATIVE IRON BALANCE 197
5.4. LACK OF ACUTE AND LONG-TERM TOXICITY 197
5.5. METABOLISM AND PHARMACOKINETIC PROPERTIES OF CHELATING AGENTS 198
6. DESIGN OF ORALLY ACTIVE CHELATING AGENTS 199
6.1. AMINOCARBOXYLATE LIGANDS 199
6.2. HYDROXYPYRIDINONE LIGANDS 200
6.3. DESFERRITHIOCIN LIGANDS 201
7. LOCALISED AND TEMPORARY ELEVATION OF IRON LEVELS 201
7.1. ISCHAEMIC TISSUE 201
7.2. BRAIN 205
8. SELECTIVE INHIBITION OF NON-HAEM-CONTAINING ENZYMES 207
8.1. RIBONUCLEOTIDE REDUCTASE 208
IMAGE 5
8.1.1. SYNCHRONISATION OF CELL CYCLING 208
8.1.2. ANTI-MALARIAL ACTIVITY 211
8.2. LIPOXYGENASE ENZYMES 211
9. TREATMENT OF ANAEMIA WITH IRON COMPLEXES 212
10. CONCLUSION 213
REFERENCES 213
CHAPTER 8. FREE RADICALS IN CENTRAL NERVOUS SYSTEM INJURY E.D. HALL 217
1. INTRODUCTION 217
2. OXYGEN RADICALS IN SPINAL CORD INJURY 218
2.1. ROLE IN POST-TRAUMATIC HYPOPERFUSION (SECONDARY ISCHEMIA) 218
2.2. ROLE IN POST-TRAUMATIC AXONAL DEGENERATION 223
2.3. ROLE IN POST-TRAUMATIC CONDUCTION FAILURE IN SURVIVING AXONS 224
2.4. SIMILARITY OF PEROXIDATIVE AND MECHANICAL SPINAL INJURIES 226
2.5. EFFECTS OF ANTI-OXIDANTS ON POST-TRAUMATIC NEUROLOGICAL RECOVERY
226 3. OXYGEN RADICALS IN HEAD INJURY 228
3.1. ROLE IN POST-TRAUMATIC MICROVASCULAR DAMAGE 228
3.2. ROLE IN POST-TRAUMATIC EDEMA 229
3.3. EFFECTS OF ANTIOXIDANTS ON POST-TRAUMATIC NEUROLOGICAL RECOVERY AND
SURVIVAL .. 231 4. CLINICAL EVIDENCE OF THE IMPORTANCE OF OXYGEN
RADICALS IN CNS INJURY 232
4.1. HIGH-DOSE METHYLPREDNISOLONE IN SPINAL-CORD INJURY 232
4.2. HIGH-DOSE METHYLPREDNISOLONE IN SEVERE HEAD INJURY 233
4.3. PEG-SOD IN SEVERE HEAD INJURY 233
5. SUMMARY 233
REFERENCES 234
CHAPTER 9. ULTRAVIOLET RADIATION (UVA, UVB) AND SKIN ANTIOXIDANTS L.
PACKER 239
1. INTRODUCTION 239
2. STUDIES ON EXCISED HAIRLESS MOUSE SKIN 240
2.1. UVA IRRADIATION 240
2.2. UVB IRRADIATION 240
2.3. CONCLUSIONS FROM STUDIES ON EXCISED SKIN 242
3. IN VIVO IRRADIATION OF HAIRLESS MOUSE SKIN 245
3.1. DOSE-RESPONSE FOR LIPOPHILIC ANTIOXIDANTS 246
3.2. LIPID HYDROPEROXIDES AND EFFECTS OF VITAMIN E SUPPLEMENTATION 247
3.2.1. EXPERIMENT 1: IRRADIATION WITHOUT SUPPLEMENTATION 248
3.2.2. EXPERIMENT 2: IRRADIATION WITH SUPPLEMENTATION 251
4. CONCLUSIONS 252
ACKNOWLEDGEMENTS 253
REFERENCES 253
CHAPTER 10. FREE RADICALS AND ATHEROSCLEROSIS J. C. FRUCHART AND P.
DURIEZ 257
1. INTRODUCTION 257
2. ARTERIAL WALL AND OXYRADICALS 257
IMAGE 6
3. OXIDISED LOW-DENSITY LIPOPROTEINS (OX-LDL) 259
3.1. INTRODUCTION 259
3.2. CHEMISTRY OF OX-LDL 260
3.3. BIOLOGY OF OX-LDL AND DEVELOPMENT OF THE FATTY STREAK. TRANSITION
TO MORE ADVANCED LESIONS 260
3.3.1. INFILTRATION OF OX-LDL ACROSS VASCULAR ENDOTHELIUM AND THE
FORMATION OF THE FATTY STREAK 260
3.3.2. EVIDENCE FOR THE IN VIVO PRESENCE OF OX-LDL 261
3.3.3. THE FATTY STREAK AND TRANSITION TO MORE ADVANCED LESION 263
3.3.4. LESION PROGRESSION 263
3.3.5. THE MATURE ATHEROSCLEROTIC PLAQUE (FIBROUS PLAQUE) 265
3.3.6. THE ROLE OF MURAL THROMBOSIS IN PLAQUE GROWTH 266
3.3.7. ARTERIAL OCCLUSION 266
3.3.8. PLAQUE REGRESSION 266
3.4. ANTIOXIDANTS AND OX-LDL 267
3.5. EFFECT OF MONOUNSATURATED AND POLYUNSATURATED FATTY ACIDS ON THE
SUSCEPTIBILITY OF PLASMA LDL TO OXIDATIVE MODIFICATION 268
3.6. SMOKING AND CORONARY HEART DISEASE 268
4. THE MACROPHAGE SCAVENGER RECEPTORS (FIG. 1) 270
5. OX-LDL AND VASOCONSTRICTION 273
6. ARRHYTHMOGENIC EFFECTS OF OX-LDL 275
7. CONCLUSION 275
REFERENCES 276
CHAPTER 11. CHEMICAL ASPECTS OF FREE RADICAL REACTIONS IN CONNECTIVE
TIS- SUE B.J. PARSONS 281
1. INTRODUCTION 281
2. REACTIONS OF FREE RADICALS WITH HYALURONIC ACID IN SIMPLE SOLUTIONS
285
2.1. OXYGEN-FREE SOLUTIONS 286
2.2. OXYGEN-CONTAINING SOLUTIONS 290
2.3. DEPOLYMERISATION OF HYALURONIC ACID INDUCED BY CU(LL) AND HYDROGEN
PEROXIDE IN SOLUTION 295
2.4. FACTORS AFFECTING THE EFFICIENCY OF HYDROXYL-RADICAL PRODUCTION IN
SOLUTIONS OF SUPEROXIDE RADICALS AND TRANSITION-METAL IONS 295
REFERENCES 298
CHAPTER 12. FREE RADICALS AND CONNECTIVE TISSUE DAMAGE M.S. BAKER 301
1. INTRODUCTION 301
2. THE RELEASE OF REACTIVE OXYGEN INTERMEDIATES (ROIS) DURING
INFLAMMATION 301 3. COMPOSITION AND ORGANIZATION OF CONNECTIVE TISSUES
(WITH SPECIAL REFERENCE TO ARTICULAR CARTILAGE) 302
4. CONNECTIVE TISSUE INJURY BY OXIDANTS 305
4.1. DIRECT CONNECTIVE TISSUE MACROMOLECULE DEGRADATION BY OXIDANTS 305
4.1.1. HYALURONIC ACID 306
4.1.2. PROTEOGLYCAN 307
4.1.3. OTHER CONNECTIVE TISSUE MACROMOLECULCS 308
IMAGE 7
4.2. CELLULAR OXIDATIVE INJURY 309
4.2.1. DECREASED BIOSYNTHESIS 309
4.2.2. ALTERED MACROMOLECULAR BIOSYNTHESIS 311
4.3. INDIRECT ACTIONS OF OXIDANTS WHICH AFFECT STRUCTURE AND FUNCTION OF
CONNECTIVE TISSUE 312
4.3.1. ACTIVATION OF PROTEASES VIA THE CYSTEINE SWITCH 312
4.3.2. INACTIVATION OF PROTEOLYTIC INHIBITORS 314
REFERENCES 316
CHAPTER 13. FREE RADICALS IN TOXICOLOGY WITH AN EMPHASIS ON ELECTRON
SPIN RESONANCE INVESTIGATIONS R.P. MASON AND C.F. CHIGNELL 319
1. INTRODUCTION 319
2. DETECTION AND IDENTIFICATION OF FREE RADICALS IN BIOLOGICAL SYSTEMS
320
3. CRITERIA FOR FREE RADICAL TOXICITY 321
4. FORMATION OF FREE RADICALS IN BIOLOGICAL SYSTEMS 322
4.1. ONE-ELECTRON ENZYMATIC OXIDATION 322
4.2. ONE-ELECTRON ENZYMATIC REDUCTION 324
4.3. LIGHT-DEPENDENT RADICAL FORMATION 325
5. SPIN TRAPPING 327
5.1. ESR SPECTRUM OF THE RADICAL ADDUCT OF CCB 328
5.2. CHLORPROMAZINE 328
6. CONCLUSIONS 330
REFERENCES 330
CHAPTER 14. RADICAL GENERATION AND DETECTION IN MYOCARDIAL INJURY B.
KALYANARAMAN, E.A. KONOREV, J. JOSEPH AND J.E. BAKER 333
1. FREE RADICALS IN MYOCARDIAL INJURY 333
2. INDIRECT EVIDENCE FOR THE ROLE OF THE OXY RADICALS 334
2.1. CELLULAR SOURCES OF OXY RADICAL AND ISOLATED HEART MODELS 334
2.2. INTERACTION OF CALCIUM AND OXY RADICALS 335
3. COMPARTMENTALIZATION OF RADICAL REACTIONS IN THE HEART 335
4. DETECTION OF OXYGEN-DERIVED FREE RADICALS 338
4.1. ESR TECHNOLOGY 338
4.2. ARTIFACTUAL GENERATION OF FREE RADICAL SIGNALS IN MYOCARDIAL TISSUE
339
4.3. AN ALTERNATIVE TISSUE PROCESSING TECHNIQUE 340
5. SPIN TRAPS IN MYOCARDIAL ISCHEMIA AND REPERFUSION INJURY 342
5.1. VASODILATORY ACTIVITY OF SPIN TRAPS 343
5.2. SPIN TRAPPING USING DMPO 345
5.3. PBN AS THE SPIN TRAP OF CHOICE IN ISCHEMIA AND REPERFUSION STUDIES
347
5.4. TRAPPING OF FREE RADICALS WITH PBN DURING MYOCARDIAL ISCHEMIA AND
REPERFUSION 347 5.5. DETECTION OF PBN ADDUCT IN CORONARY EFFLUENTS
DURING REPERFUSION 348 5.6. DETECTION OF PBN-OH ADDUCT FORMED IN A
FENTON SYSTEM 348
5.7. SOLVENT EFFECTS ON ESR PARAMETERS OF PBN/ OH 348
5.8. ESR PARAMETERS OF PBN ADDUCTS FORMED DURING MYOCARDIAL ISCHEMIA AND
REPERFUSION 349
5.9. GC-MS OF DERIVATIZED PBN ADDUCTS 352
5.10. PROTECTIVE EFFECT OF PBN ON ISCHEMIC-REPERFUSED MYOCARDIUM 353
IMAGE 8
6. FUTURE PROSPECTS 354
ACKNOWLEDGMENTS 355
REFERENCES 355
CHAPTER 15. FREE RADICAL PATHWAYS IN THE INFLAMMATORY RESPONSE EG.
WINYARD, C.J. MORRIS, V.R. WINROW, M. ZAIDI AND DR. BLAKE 1 . .. 361
1. INTRODUCTION 361
2. THE GENERATION OF FREE RADICALS IN INFLAMMATORY DISEASES 361
2.1. ACTIVATION OF NADPH OXIDASE AND MYCLOPEROXIDASC SYSTEMS 362
2.2. UNCOUPLING OF THE XANTHINE DEHYDROGENASE SYSTEM 362
2.3. UNCOUPLING OF MITOCHONDRIAL AND ENDOPLASMIC RETICULUM
ELECTRON-TRANSPORT CHAINS 364 2.4. NON-ENZYMATIC REACTIONS 365
3. INHIBITION OF FREE RADICAL PATHWAYS IN INFLAMMATION 365
3.1. ENZYMATIC REMOVAL OF OXYGEN RADICALS 365
3.2. CHELATION OF CATALYTIC IRON AND FREE RADICAL SCAVENGERS 366
4. PATHWAYS INVOLVING FREE RADICALS AS SECOND MESSENGERS IN INFLAMMATION
- SOME TOPICAL EXAMPLES 367
4.1. VASODILATION 367
4.2. FIBROSIS 367
4.3. GENE TRANSCRIPTION 369
4.3.1. NUCLEAR FACTOR K,B (NFKB) 369
4.3.2. ACTIVATOR PROTEIN I (AP-1) 370
4.3.3. HAEM OXYGENASE 370
4.3.4. TYROSINE PHOSPHATASE 371
4.3.5. COLLAGEN 371
5. FREE RADICAL PATHWAYS OF MACROMOLCCULAR DAMAGE AND TISSUE DESTRUCTION
- SOME TOPICAL EXAMPLES 372
5.1. INACTIVATION OF SERPINS AND ACTIVATION OF LATENT METALLOPROTCINASES
IN PULMONARY EMPHYSEMA AND RHEUMATOID ARTHRITIS 372
5.2. BONE RESORPTION 374
5.3. OXIDATIVE MODIFICATION OF LOW-DENSITY LIPOPROTEIN IN
ATHEROSCLEROSIS AND RHEUMATOID ARTHRITIS 375
5.4. OXIDATIVE DNA DAMAGE AS A CAUSE OF AGEING, CANCER AND AUTOIMMUNITY
376 ACKNOWLEDGEMENTS 379
REFERENCES 379
INDEX 385
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| discipline | Biologie Chemie Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV009526983 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:36:32Z |
| institution | BVB |
| isbn | 044489716X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006290521 |
| oclc_num | 260160776 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-29 DE-12 DE-703 DE-20 DE-526 DE-83 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-29 DE-12 DE-703 DE-20 DE-526 DE-83 DE-188 |
| physical | XVI, 392 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Elsevier |
| record_format | marc |
| series | New comprehensive biochemistry |
| series2 | New comprehensive biochemistry |
| spelling | Free radical damage and its control ed. Catherine A. Rice-Evans ... Amsterdam [u.a.] Elsevier 1994 XVI, 392 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New comprehensive biochemistry 28 Literaturangaben Pathobiochemie (DE-588)4044888-5 gnd rswk-swf Antioxidans (DE-588)4142729-4 gnd rswk-swf Freies Radikal (DE-588)4137149-5 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Sauerstoffradikal (DE-588)4179211-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Sauerstoffradikal (DE-588)4179211-7 s Pathophysiologie (DE-588)4044898-8 s DE-604 Freies Radikal (DE-588)4137149-5 s Pathobiochemie (DE-588)4044888-5 s Antioxidans (DE-588)4142729-4 s Rice-Evans, Catherine Sonstige (DE-588)172330831 oth New comprehensive biochemistry 28 (DE-604)BV000003914 28 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006290521&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Free radical damage and its control New comprehensive biochemistry Pathobiochemie (DE-588)4044888-5 gnd Antioxidans (DE-588)4142729-4 gnd Freies Radikal (DE-588)4137149-5 gnd Pathophysiologie (DE-588)4044898-8 gnd Sauerstoffradikal (DE-588)4179211-7 gnd |
| subject_GND | (DE-588)4044888-5 (DE-588)4142729-4 (DE-588)4137149-5 (DE-588)4044898-8 (DE-588)4179211-7 (DE-588)4143413-4 |
| title | Free radical damage and its control |
| title_auth | Free radical damage and its control |
| title_exact_search | Free radical damage and its control |
| title_full | Free radical damage and its control ed. Catherine A. Rice-Evans ... |
| title_fullStr | Free radical damage and its control ed. Catherine A. Rice-Evans ... |
| title_full_unstemmed | Free radical damage and its control ed. Catherine A. Rice-Evans ... |
| title_short | Free radical damage and its control |
| title_sort | free radical damage and its control |
| topic | Pathobiochemie (DE-588)4044888-5 gnd Antioxidans (DE-588)4142729-4 gnd Freies Radikal (DE-588)4137149-5 gnd Pathophysiologie (DE-588)4044898-8 gnd Sauerstoffradikal (DE-588)4179211-7 gnd |
| topic_facet | Pathobiochemie Antioxidans Freies Radikal Pathophysiologie Sauerstoffradikal Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006290521&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003914 |
| work_keys_str_mv | AT riceevanscatherine freeradicaldamageanditscontrol |