Prostatic obstruction: pathogenesis and treatment
The human prostate gland, of undoubted importance in reproductive physiology, is one of the commonest causes of clinical urological problems in the male. Yet surprisingly little is known about its innervation, response to drugs and its physiological role. Its benign disorders (prostatic hyperplasia...
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London [u.a.]
Springer
1994
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Summary: | The human prostate gland, of undoubted importance in reproductive physiology, is one of the commonest causes of clinical urological problems in the male. Yet surprisingly little is known about its innervation, response to drugs and its physiological role. Its benign disorders (prostatic hyperplasia with resulting bladder outflow obstruction, bladder neck dyssynergia, prostatitis, prostatodynia), while well recognised clinically, are also poorly understood Urodynamics has only recently been routinely employed in the quantitative assessment of the lower urinary tract This book concisely and critically reviews the current "state of the art" concerning basic science data on the bladder and prostate, as well as their changed functions in benign hyperplasia. The text deals with basic science aspects, presents the reasons for prostatectomy, reviews contemporary techniques and their safety, and examines recent work on the pharmacotherapy of benign hyperplasia |
| Item Description: | Literaturangaben |
| Physical Description: | XX, 234 S. Ill., graph. Darst. |
| ISBN: | 3540196811 0387196811 |
Staff View
MARC
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| 245 | 1 | 0 | |a Prostatic obstruction |b pathogenesis and treatment |c Christopher R. Chapple (ed.) |
| 264 | 1 | |a London [u.a.] |b Springer |c 1994 | |
| 300 | |a XX, 234 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 520 | 3 | |a The human prostate gland, of undoubted importance in reproductive physiology, is one of the commonest causes of clinical urological problems in the male. Yet surprisingly little is known about its innervation, response to drugs and its physiological role. Its benign disorders (prostatic hyperplasia with resulting bladder outflow obstruction, bladder neck dyssynergia, prostatitis, prostatodynia), while well recognised clinically, are also poorly understood | |
| 520 | |a Urodynamics has only recently been routinely employed in the quantitative assessment of the lower urinary tract | ||
| 520 | |a This book concisely and critically reviews the current "state of the art" concerning basic science data on the bladder and prostate, as well as their changed functions in benign hyperplasia. The text deals with basic science aspects, presents the reasons for prostatectomy, reviews contemporary techniques and their safety, and examines recent work on the pharmacotherapy of benign hyperplasia | ||
| 650 | 7 | |a Blaas |2 gtt | |
| 650 | 7 | |a Obstructies |2 gtt | |
| 650 | 7 | |a Prostaat |2 gtt | |
| 650 | 7 | |a Therapieën |2 gtt | |
| 650 | 7 | |a Tumoren |2 gtt | |
| 650 | 4 | |a Bladder |x Obstructions | |
| 650 | 4 | |a Bladder |x Obstructions |x therapy | |
| 650 | 4 | |a Bladder |x innervation | |
| 650 | 4 | |a Prostate |x Hypertrophy | |
| 650 | 4 | |a Prostate |x Innervation | |
| 650 | 4 | |a Prostate |x Surgery | |
| 650 | 4 | |a Prostate |x innervation | |
| 650 | 4 | |a Prostatic Diseases |x physiopathology | |
| 650 | 4 | |a Prostatic Diseases |x therapy | |
| 650 | 4 | |a Urinary Bladder Neck Obstruction |x physiopathology | |
| 650 | 4 | |a Urinary Bladder Neck Obstruction |x therapy | |
| 650 | 4 | |a Urinary Bladder |x innervation | |
| 650 | 0 | 7 | |a Therapie |0 (DE-588)4059798-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pathophysiologie |0 (DE-588)4044898-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Prostatahypertrophie |0 (DE-588)4137018-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Prostatahypertrophie |0 (DE-588)4137018-1 |D s |
| 689 | 0 | 1 | |a Pathophysiologie |0 (DE-588)4044898-8 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Prostatahypertrophie |0 (DE-588)4137018-1 |D s |
| 689 | 1 | 1 | |a Therapie |0 (DE-588)4059798-2 |D s |
| 689 | 1 | |5 DE-604 | |
| 700 | 1 | |a Chapple, Christopher R. |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005862172&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-005862172 | |
Record in the Search Index
| _version_ | 1807684314594279424 |
|---|---|
| adam_text |
CONTENTS
LIST
OF
CONTRIBUTORS
.
XIX
SECTION
A:
THE
IMPORTANCE
OF
NEURAL
FACTORS
IN
THE
PRESENTATION
AND
TREATMENT
OF
PROSTATIC
OBSTRUCTION
1
INTRODUCTION:
THE
CLINICAL
PROBLEM
C.R.
CHAPPLE
.
3
HISTORICAL
REVIEW
.
3
URODYNAMIC
INVESTIGATION
.
3
PROSTATE
OBSTRUCTION
AND
DETRUSOR
INSTABILITY
.
5
THE
NEURAL
CONTROL
OF
THE
HUMAN
PROSTATE:
NEURAL
INFLUENCES
AND
BENIGN
PROSTATIC
HYPERPLASIA
.
8
2
THE
ANATOMY
AND
INNERVATION
OF
THE
BLADDER
C.R.
CHAPPLE
.
13
INTRODUCTION
.
13
HISTORICAL
ASPECTS
.
13
ANATOMY
.
14
INNERVATION
.
15
MOTOR
INNERVATION
.
16
SENSORY
INNERVATION
.
19
SUMMARY
.
21
3
THE
PHYSIOLOGY
OF
MICTURITION
C.R.
CHAPPLE
.
25
NEUROPHYSIOLOGICAL
CONTROL
OF
THE
BLADDER
.
25
LOCAL
NEURAL
PATHWAYS
.
25
REFLEXES
GOVERNING
MICTURITION
.
26
PHARMACOLOGICAL
RESPONSES
OF
THE
BLADDER
.
27
THE
ROLE
OF
THE
PARASYMPATHETIC
NERVOUS
SYSTEM
.
27
THE
ROLE
OF
THE
SYMPATHETIC
NERVOUS
SYSTEM
.
30
THE
ROLE
OF
NON-ADRENERGIC,
NON-CHOLINERGIC
NEUROTRANSMISSION
.
32
SUMMARY
.
37
XIV
CONTENTS
4
PATHOPHYSIOLOGICAL
CHANGES
IN
THE
OBSTRUCTED
BLADDER
C.R.
CHAPPLE
.
43
A
REVIEW
OF
PREVIOUS
EXPERIMENTAL
ANIMAL
STUDIES
.
43
HUMAN
STUDIES
.
47
A
CLINICAL
STUDY
OF
THE
PATHOGENESIS
OF
DETRUSOR
INSTABILITY
IN
THE
OBSTRUCTED
BLADDER
.
50
SUMMARY
.
59
5
ANATOMY
AND
INNERVATION
OF
THE
PROSTATE
GLAND
C.R.
CHAPPLE
.
65
INTRODUCTION
.
65
ANATOMY
.
65
INNERVATION
.
67
SECTION
B:
CONTEMPORARY
MANAGEMENT
OF
BLADDER
OUTFLOW
OBSTRUCTION
6
BLADDER
OUTFLOW
OBSTRUCTION
IN
THE
MALE
R.
TURNER-WARWICK
.
79
INTRODUCTION
.
79
DETRUSOR
FUNCTION
AND
DYSFUNCTION
.
79
NORMAL
BLADDER
FUNCTION
.
79
INSTABILITY
AND
MYTH
OF
"
PROSTATISM
"
.
80
DETRUSOR
RESPONSE
TO
OBSTRUCTION
.
80
RESPONSE
OF
UNSTABLE
DETRUSOR
SYMPTOMS
TO
THE
RELIEF
OF
OBSTRUCTION
.
81
THE
CAUSE
OF
UNSTABLE
DETRUSOR
BEHAVIOUR
IN
MALE
BLADDER
OUTFLOW
OBSTRUCTION
.
82
SHOULD
THE
NATURAL
AGE-RELATED
DIMINUTION
OF
THE
VOIDING
FLOW
BE
REGARDED
AS
NORMAL?
.
83
BLADDER
NECK
OBSTRUCTION
.
84
BLADDER
OUTFLOW
OBSTRUCTION
AND
"
RELATIVE
OBSTRUCTION
"
.
.
.
84
VOIDING
INEFFICIENCY
.
85
NORMAL
BLADDER
NECK
FUNCTION
.
85
BLADDER
NECK
DYSSYNERGIA
.
85
SYMPTOMS
AND
PRESENTATION
OF
DYSSYNERGIC
BLADDER
NECK
OBSTRUCTION
.
86
SECONDARY
SYMPTOMS
.
87
PROSTATITIS
AND
THE
DYSSYNERGIC
BLADDER
NECK
.
87
SYNERGIC
BLADDER
NECK
OBSTRUCTION:
DETRUSOR
DYSFUNCTION
.
88
DIAGNOSIS
OF
DYSSYNERGIC
BLADDER
NECK
OBSTRUCTION
.
89
INDICATIONS
FOR
THE
TREATMENT
OF
DYSSYNERGIC
BLADDER
NECK
OBSTRUCTION
.
91
EFFECTIVE
RELAXATION
OF
THE
DYSSYNERGIC
BLADDER
NECK
BY
ENDOSCOPIC
INCISION
.
91
CONTENTS
XV
THE
RELATIONSHIP
OF
PROSTATIC
ENLARGEMENT
TO
THE
NORMAL
BLADDER
NECK
MECHANISM
.
92
THE
RELATIONSHIP
OF
PROSTATIC
ENLARGEMENT
TO
THE
DYSSYNERGIC
BLADDER
NECK
MECHANISM
.
93
DOUBLE
OBSTRUCTION:
THE
COMBINATION
OF
PROSTATIC
AND
DYSSYNERGIC
BLADDER
NECK
OBSTRUCTION
-
THE
"
TRAPPED
PROSTATE
"
.
94
DEVELOPMENT
OF
SECONDARY
BLADDER
NECK
CONTRACTURE
AFTER
LOOP
RESECTION
OF
A
DOUBLE
OBSTRUCTION
.
96
TREATMENT
OF
DOUBLE
OBSTRUCTION
BY
COMBINED
ENDOSCOPIC
INCISION
AND
LOOP
RESECTION
.
96
CONSERVATIVE
SURGERY
OF
DOUBLE
OBSTRUCTION
.
96
THE
"
SMALL
FIBROUS
PROSTATE
"
.
.
99
SUMMARY:
THE
THREE
APPEARANCES
OF
THE
PROXIMAL
POSTERIOR
URETHRA
AND
THEIR
APPROPRIATE
TREATMENT
IN
PROVEN
OUTFLOW
OBSTRUCTION
.
100
CONCLUSION
.
101
7
THE
INVESTIGATION
OF
BENIGN
PROSTATIC
HYPERPLASIA
J.G.
NOBLE
AND
C.R.
CHAPPLE
.
103
THE
BLADDER
.
103
STANDARD
INVESTIGATIONS
.
104
UPPER
TRACT
ASSESSMENT
.
104
INVESTIGATION
OF
BLADDER
FUNCTION
.
105
FREQUENCY-VOLUME
CHART
.
106
PAD
TESTING
.
106
UROFLOWMETRY
.
107
ULTRASOUND
CYSTODYNAMOGRAM
(USCD)
.
108
CYSTOMETRY
.
108
URETHRAL
PRESSURE
PROFILE
.
110
BENIGN
OR
MALIGNANT
PROSTATIC
DISEASE?
.
ILL
8
THE
COMPLICATIONS
OF
PROSTATECTOMY
J.W.H.
EVANS
AND
N.
MACCARTNEY
.
113
INTRODUCTION
.
113
ANAESTHETIC
COMPLICATIONS
IN
THE
ELDERLY
MALE
.
114
RISKS
OF
SURGERY
AND
ANAESTHESIA
.
114
OVERALL
RISKS
OF
MORTALITY
DURING
ANAESTHESIA
AND
SURGERY
.
114
RISK
OF
CARDIAC
ARREST
DURING
SURGERY
.
115
RISK
OF
MYOCARDIAL
INFARCTION
DURING
SURGERY
.
115
RISKS
OF
GENERAL
ANAESTHESIA
IN
THE
ELDERLY
MALE
.
115
CENTRAL
NERVOUS
SYSTEM
.
116
CARDIOVASCULAR
SYSTEM
.
116
RESPIRATORY
SYSTEM
.
117
COMPLICATIONS
OF
GENERAL
ANAESTHESIA
SPECIFIC
TOTURP
.
118
XVI
CONTENTS
REGIONAL
ANAESTHESIA
.
118
CARDIOVASCULAR
EFFECTS
.
118
RESPIRATORY
SYSTEM
.
119
OTHER
COMPLICATIONS
.
119
SUMMARY
.
120
COMPLICATIONS
OF
PROSTATECTOMY
.
120
MORTALITY
OF
PROSTATECTOMY
.
120
MORTALITY
OF
OPEN
PROSTATECTOMY
.
120
MORTALITY
OF
TURP
.
121
MORBIDITY
OF
TURP
.
121
LONG-TERM
MORBIDITY
.
122
PEROPERATIVE
COMPLICATIONS
OF
TURP
.
123
TRAUMA
.
123
HAEMORRHAGE
.
124
IRRIGATION
FLUID
LOADING
AND
THE
TUR
SYNDROME
.
126
RISKS
TO
THE
SURGEON
.
133
PROPHYLACTIC
MEASURES
IN
PROSTATECTOMY
PATIENTS
.
134
THE
RECOVERY
ROOM
AND
WARD
.
134
OTHER
PHYSIOLOGICAL
DISTURBANCES
CAUSED
BY
TURP
.
135
THERMODYNAMICS,
HYPOTHERMIA
AND
TURP
.
135
ACUTE
HAEMODYNAMICS
OF
TURP
.
137
CONCLUSION
.
139
9
PROSTATE
STENTS
E.J.G.
MILROY
.
147
INTRODUCTION
.
147
PROSTATE
STENTS
.
147
TEMPORARY
STENTS
.
147
PERMANENT
STENTS
.
150
EXPERIMENTAL
WORK
.
151
CLINICAL
EXPERIENCE
.
153
PROSTATE
OBSTRUCTION
.
153
RESULTS
.
156
STENT
REMOVAL
.
157
OTHER
PERMANENT
PROSTATE
STENTS
.
159
INDICATIONS
FOR
PROSTATE
STENTS
.
160
OTHER
INDICATIONS
FOR
URETHRAL
STENTS
.
161
FUTURE
DEVELOPMENTS
.
161
CONCLUSION
.
162
10
PROSTATIC
HYPERTHERMIA
T.J.
CHRISTMAS
.
165
INTRODUCTION
.
165
LOCAL
PROSTATIC
HYPERTHERMIA
.
166
TRANSRECTAL
MICROWAVE
HYPERTHERMIA
.
166
TRANSURETHRAL
MICROWAVE
HYPERTHERMIA
.
168
CONCLUSION
.
171
CONTENTS
XVII
11
BALLOON
DILATATION
OF
THE
PROSTATE
J.
BRANTLEY
THRASHER
AND
KJ.
KREDER
.
175
INTRODUCTION
.
175
HISTORY
OF
PROSTATE
DILATATION
.
175
TECHNIQUES
.
176
PATIENT
SELECTION
.
182
MECHANISM
OF
ACTION
.
182
RESULTS
.
184
COMPLICATIONS
.
186
SUMMARY
.
186
12
IS
PHARMACOTHERAPY
A
SATISFACTORY
ALTERNATIVE
TREATMENT
FOR
BENIGN
PROSTATIC
HYPERPLASIA?
C.R.
CHAPPLE
AND
I.R.
MARSHALL
.
189
HORMONAL
THERAPY
.
191
ADRENERGIC
BLOCKADE
.
194
EXPERIMENTAL
STUDIES
.
195
FUNCTIONAL
MUSCLE
STRIP
STUDIES
.
195
RADIOLIGAND
BINDING
STUDIES:
HOMOGENATES
.
196
RADIOLIGAND
BINDING
STUDIES:
SLIDE-MOUNTED
TISSUE
SECTIONS
.
199
CONCLUSIONS
.
202
CLINICAL
STUDIES
.
202
CONCLUSIONS
.
205
THE
FUTURE
.
206
LABORATORY
STUDIES
.
206
CLINICAL
STUDIES
.
208
13
BLADDER
NECK
DYSSYNERGIA
AND
PROSTATITIS
J.G.
NOBLE
.
213
BLADDER
NECK
DYSSYNERGIA
.
213
BLADDER
NECK
FUNCTION
.
214
CLINICAL
FEATURES
.
215
INVESTIGATION
.
216
TREATMENT
.
220
SUMMARY
.
222
PROSTATITIS
.
222
PATHOGENESIS
.
223
CLINICAL
FEATURES
.
224
INVESTIGATIONS
.
224
TREATMENT
.
225
SUMMARY
.
226
SUBJECT
INDEX
.
229 |
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV008863336 |
| callnumber-first | R - Medicine |
| callnumber-label | RC899 |
| callnumber-raw | RC899 |
| callnumber-search | RC899 |
| callnumber-sort | RC 3899 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | YK 9500 |
| ctrlnum | (OCoLC)27973452 (DE-599)BVBBV008863336 |
| dewey-full | 616.6/5 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.6/5 |
| dewey-search | 616.6/5 |
| dewey-sort | 3616.6 15 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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Chapple (ed.)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">London [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">1994</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XX, 234 S.</subfield><subfield code="b">Ill., graph. 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| id | DE-604.BV008863336 |
| illustrated | Illustrated |
| indexdate | 2024-08-18T00:48:21Z |
| institution | BVB |
| isbn | 3540196811 0387196811 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-005862172 |
| oclc_num | 27973452 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-188 |
| owner_facet | DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-20 DE-188 |
| physical | XX, 234 S. Ill., graph. Darst. |
| publishDate | 1994 |
| publishDateSearch | 1994 |
| publishDateSort | 1994 |
| publisher | Springer |
| record_format | marc |
| spelling | Prostatic obstruction pathogenesis and treatment Christopher R. Chapple (ed.) London [u.a.] Springer 1994 XX, 234 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben The human prostate gland, of undoubted importance in reproductive physiology, is one of the commonest causes of clinical urological problems in the male. Yet surprisingly little is known about its innervation, response to drugs and its physiological role. Its benign disorders (prostatic hyperplasia with resulting bladder outflow obstruction, bladder neck dyssynergia, prostatitis, prostatodynia), while well recognised clinically, are also poorly understood Urodynamics has only recently been routinely employed in the quantitative assessment of the lower urinary tract This book concisely and critically reviews the current "state of the art" concerning basic science data on the bladder and prostate, as well as their changed functions in benign hyperplasia. The text deals with basic science aspects, presents the reasons for prostatectomy, reviews contemporary techniques and their safety, and examines recent work on the pharmacotherapy of benign hyperplasia Blaas gtt Obstructies gtt Prostaat gtt Therapieën gtt Tumoren gtt Bladder Obstructions Bladder Obstructions therapy Bladder innervation Prostate Hypertrophy Prostate Innervation Prostate Surgery Prostate innervation Prostatic Diseases physiopathology Prostatic Diseases therapy Urinary Bladder Neck Obstruction physiopathology Urinary Bladder Neck Obstruction therapy Urinary Bladder innervation Therapie (DE-588)4059798-2 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Prostatahypertrophie (DE-588)4137018-1 gnd rswk-swf Prostatahypertrophie (DE-588)4137018-1 s Pathophysiologie (DE-588)4044898-8 s DE-604 Therapie (DE-588)4059798-2 s Chapple, Christopher R. Sonstige oth DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005862172&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Prostatic obstruction pathogenesis and treatment Blaas gtt Obstructies gtt Prostaat gtt Therapieën gtt Tumoren gtt Bladder Obstructions Bladder Obstructions therapy Bladder innervation Prostate Hypertrophy Prostate Innervation Prostate Surgery Prostate innervation Prostatic Diseases physiopathology Prostatic Diseases therapy Urinary Bladder Neck Obstruction physiopathology Urinary Bladder Neck Obstruction therapy Urinary Bladder innervation Therapie (DE-588)4059798-2 gnd Pathophysiologie (DE-588)4044898-8 gnd Prostatahypertrophie (DE-588)4137018-1 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4044898-8 (DE-588)4137018-1 |
| title | Prostatic obstruction pathogenesis and treatment |
| title_auth | Prostatic obstruction pathogenesis and treatment |
| title_exact_search | Prostatic obstruction pathogenesis and treatment |
| title_full | Prostatic obstruction pathogenesis and treatment Christopher R. Chapple (ed.) |
| title_fullStr | Prostatic obstruction pathogenesis and treatment Christopher R. Chapple (ed.) |
| title_full_unstemmed | Prostatic obstruction pathogenesis and treatment Christopher R. Chapple (ed.) |
| title_short | Prostatic obstruction |
| title_sort | prostatic obstruction pathogenesis and treatment |
| title_sub | pathogenesis and treatment |
| topic | Blaas gtt Obstructies gtt Prostaat gtt Therapieën gtt Tumoren gtt Bladder Obstructions Bladder Obstructions therapy Bladder innervation Prostate Hypertrophy Prostate Innervation Prostate Surgery Prostate innervation Prostatic Diseases physiopathology Prostatic Diseases therapy Urinary Bladder Neck Obstruction physiopathology Urinary Bladder Neck Obstruction therapy Urinary Bladder innervation Therapie (DE-588)4059798-2 gnd Pathophysiologie (DE-588)4044898-8 gnd Prostatahypertrophie (DE-588)4137018-1 gnd |
| topic_facet | Blaas Obstructies Prostaat Therapieën Tumoren Bladder Obstructions Bladder Obstructions therapy Bladder innervation Prostate Hypertrophy Prostate Innervation Prostate Surgery Prostate innervation Prostatic Diseases physiopathology Prostatic Diseases therapy Urinary Bladder Neck Obstruction physiopathology Urinary Bladder Neck Obstruction therapy Urinary Bladder innervation Therapie Pathophysiologie Prostatahypertrophie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005862172&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT chapplechristopherr prostaticobstructionpathogenesisandtreatment |