Cellular and molecular biology of bone:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
San Diego u.a.
Acad. Press
1993
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 567 S. Ill., graph. Darst. |
| ISBN: | 0125202253 |
Staff View
MARC
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| 245 | 1 | 0 | |a Cellular and molecular biology of bone |c ed. by Masaki Noda |
| 264 | 1 | |a San Diego u.a. |b Acad. Press |c 1993 | |
| 300 | |a XXI, 567 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Biologie moléculaire | |
| 650 | 7 | |a Histologia geral |2 larpcal | |
| 650 | 7 | |a Os - Anatomie |2 ram | |
| 650 | 7 | |a Os - Histologie |2 ram | |
| 650 | 7 | |a Os - Métabolisme |2 ram | |
| 650 | 2 | |a Os et tissu osseux | |
| 650 | 7 | |a Ossos (sistema locomotor) |2 larpcal | |
| 650 | 7 | |a Ostéoblastes - Cytologie |2 ram | |
| 650 | 7 | |a Ostéoclastes - Cytologie |2 ram | |
| 650 | 4 | |a Bone Development | |
| 650 | 4 | |a Bone and Bones |x anatomy & histology | |
| 650 | 4 | |a Bone and Bones |x metabolism | |
| 650 | 4 | |a Bone cells | |
| 650 | 4 | |a Bones |x Molecular aspects | |
| 650 | 4 | |a Osteoblasts |x cytology | |
| 650 | 4 | |a Osteoclasts |x cytology | |
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| 650 | 0 | 7 | |a Osteozyt |0 (DE-588)4275595-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Molekularbiologie |0 (DE-588)4039983-7 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Noda, Masaki |e Sonstige |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-005549185 | ||
Record in the Search Index
| _version_ | 1804122791167918080 |
|---|---|
| adam_text | CELLULAR AND
MOLECULAR
BIOLOGY
OF BONE
Edited by
Masaki Noda
Department of Molecular Pharmacology
Division of Functional Disorder Research
Medical Research Institute
Tokyo Medical and Dental University
Tokyo, Japan
ACADEMIC PRESS, INC
A Division of Harcourt Brace amp; Company
San Diego New York Boston London Sydney Tokyo Toronto
CONTENTS
Contributors xvii
Preface xxi
1 OSTEOBLASTIC CELL LINEAGE
Jane E Aubin, Kursad Turksen, and Johan N M Heersche
I Introduction 2
II Cells of the Osteoblast Lineage 2
A General Morphological and
Histological Definition 2
B Osteoblast Phenotypic Expression and
Osteoblast Markers 4
III Origin and Lineage of the Osteoblast 10
A Mesenchymal Stem Cells and
Multipotential and Restricted Progenitors 10
B Osteo-Chondroprogenitors 15
IV Osteoblast Heterogeneity: Subpopulations,
Stages of Differentiation, or Aberrant
Expression in Vitro? 16
V Indirect Identification of the Osteoprogenitor Cell 19
A Bone Formation in Vitro 19
B A Colony Assay for the Quantification of
Osteoprogenitor Cells and Assessment
of Their Proliferative and Self-Renewal
Capacity 22
C Regulation of the Osteoprogenitors 23
VI Monoclonal Antibodies for Identification of Cells
in the Osteoblast Lineage 25
vi Contents
VII Concluding Remarks 28
References 29
2 MOLECULAR MECHANISMS MEDIATING
DEVELOPMENTAL AND HORMONE-REGULATED
EXPRESSION OF GENES IN OSTEOBLASTS:
An Integrated Relationship of Cell Growth
and Differentiation
Gary S Stein and Jane B Lian
I Introduction 48
II The Osteoblast Developmental Sequence: A
Functionally Coupled, Integrated Relationship
between Expression of Cell Growth and Osteo-
blast-Related Genes 49
A The Ordered Expression of Genes during
Development of the Osteoblast Phenotype 50
B Two Transition-Restriction Points during
Development of the Osteoblast Phenotype
Characterize the Proliferation-
Differentiation Relationship 55
III Hormone Modifications on Development of the
Osteoblast Phenotype 59
IV Molecular Mechanisms Operative in Developmental
Expression of a Cell Growth and Bone-Specific
Gene during Osteoblast Differentiation 64
A Histone Gene Regulation at the Proliferation-
Differentiation Transition Point 64
B Transcriptional Control of the Osteocalcin
Gene Expression at Multiple Levels at
the Extracellular Matrix Mineralization
Transition Point 68
C Involvement of Chromatin Structure and
Nucleosome Organization in the Three-
Dimensional Properties of the Histone
and Osteocalcin Gene Promoters That
Integrate Activities at Basal and Enhancer
Regulatory Elements 76
V Consequence of the Abrogation of Growth Control
on Deregulation of Differentiation Genes in
Tumor Growth Cells 80
A Abrogation of Growth Control: Deregulation
of Histone H4 Transcription 80
Contents vii •
B Relaxation of Transcriptional Regulation of the
Osteocalcin Gene in Tumor Cell Lines 83
References 85
CELLULAR AND MOLECULAR BIOLOGY OF
TRANSFORMING GROWTH FACTOR 0
Seong-Jin Kim and R Tracy Ballock
I Introduction 98
II Chemistry of Transforming Growth Factor (3 98
III Multiple Actions of Transforming Growth Factor p 100
IV Transforming Growth Factor p in the Regulation of
Bone Formation and Repair 103
A Transforming Growth Factor p Is Present at
Sites of Bone Formation and Repair 104
B Osteoblasts Synthesize and Respond to
Transforming Growth Factor p in Vitro 104
C Transforming Growth Factor p Is a Potential
Coupling Factor Linking Bone Formation
and Resorption 107
D Transforming Growth Factor p Induces Bone
and Cartilage Formation in Vivo 107
V Transcriptional Control of Expression of
Transforming Growth Factor ps 108
A In Vivo and in Vitro Regulation of
Transcription of Transforming
Growth Factors ps 108
B Expression of Transforming Growth Factor p
in Bone Culture by Ostedtropic Hormones 111
VI Characterization of the Promoters for Transforming
Growth Factors pi, p2, and P3 - 112
A Characterization of the Promoter Regions of
the Transforming Growth Factor pi Gene 112
B Characterization of Human Transforming
Growth Factor P2 Promoter 117
C Characterization of the Transforming Growth
Factor P3 Promoter 118
VII Post-transcriptional Regulation of Transforming
Growth Factor p Isoforms 120
VIII Conclusion 121
References 122
viii Contents
BONE MORPHOGENETIC PROTEINS AND THEIR
GENE EXPRESSION
John M Wozney
I Introduction
II Bone Morphogenetic Protein Family
A Structure of BMP-2 through BMP-7
B Relationship to the Transforming
Growth Factor p Superfamily
C BMP-1
D BMP Genes
E BMPmRNAs
III In Vivo Activities
A Sources and Assay Systems
B Ectopic Bone Induction
C Matrix Interactions
D Animal Models of Bone Replacement
E Clinical Use
IV Mechanisms of Action
A Activities on Bone and Cartilage
Cells in Vitro
B Activities on Other Cell Types in Vitro
C Receptors
D Role in Embryonic Development
References
OUR UNDERSTANDING OF INHERITED SKELETAL
FRAGILITY AND WHAT THIS HAS TAUGHT US
ABOUT BONE STRUCTURE AND FUNCTION
Jeffrey Bonadio and Steven A Goldstein
I Introduction 170
II Mapping the Osteogenesis Imperfecta Locus 170
III Clinical Classification 171
IV Evidence of Genetic and Biochemical
Heterogeneity 172
V Characterization of the First Molecular Defect in a
Collagen Gene 173
VI Mapping Single Amino Acid Substitutions: The
Predominant Structural Mutation Associated
with Osteogenesis Imperfecta Types II-IV 175
VII Inheritance 179
A Pathogenesis I: Structural Mutations 180
B Pathogenesis II: Null Mutations 184
Contents ix •
VIII Summary 186
References 186
6 MOLECULAR AND CELLULAR BIOLOGY OF THE
MAJOR NONCOLLAGENOUS PROTEINS IN BONE
Marian F Young, Kyomi Ibaraki, Janet M Kerr,
and Anne-Marie Heegaard
I Introduction 192
II Osteonectin/SPARC/BM-40 193
A Osteonectin: An Extracellular Matrix Com-
ponent Identical to SPARC, the 43-kDa
Culture Shock Protein, and BM-40 193
B Osteonectin: Highly Conserved Structural
Domains during Evolution 196
C Osteonectin Binds to Ca2+, Hydroxyapatite,
Collagens, Thrombospondin, and Other
Matrix Components 200
D Osteonectin: Produced by Other Tissues and
Predominantly Expressed in Bone 201
E Osteonectin Expression: Potentially
Controlled by Multiple cis- and
trans-Acting Factors 202
III Osteopontin and Bone Sialoprotein 205
A Osteopontin Promoter: Potential Activator
Protein-1 Regulation and an Unusual
Vitamin D-Responsive Element 207
B Bone Sialoprotein Gene: An AC-Rich
Structure in Intron 1 Composed
Exclusively of Type 0 Intron-
Exon Junctions 209
C Distribution, Structure, and Potential
Functions of Osteopontin and
Bone Sialoprotein - 209
D Osteopontin and Bone Sialoprotein in Bone
Disease and Immune Function 213
IV Biglycan and Decorin 214
A Decorin and Biglycan: A Sequence Motif
Rich in Leucine 215
B Biglycan and Decorin Gene Structure 217
C Expression of Biglycan and Decorin mRNA
and Protein in Developing Human Tissues 217
D Possible Functions of Biglycan and Decorin
Include Cell-Matrix Interactions and
Control of Cell Proliferation 218
x Contents
V Conclusion 221
References 222
THE OSTEOCALCIN GENE AS A MOLECULAR MODEL
FOR TISSUE-SPECIFIC EXPRESSION AND 1,25-
DIHYDROXYVITAMIN D3 REGULATION
J Wesley Pike, Teruki Sone, Keiichi Ozono,
Robert A Kesterson, and Sandra A Kerner
I Introduction • 236
II Osteocalcin Gene Transcription Unit 236
III Functional Activity of the Osteocalcin Promoter 237
A Basal Activity of the Osteocalcin Promoter
in Vitro 237
B Bone-Specific Expression of a Reporter Gene
in Transgenic Mice 238
C Hormonal Responsiveness of the
Osteocalcin Promoter 239
D Mapping the Vitamin D- and Retinoic Acid-
Responsive Elements 240
E Structural Organization of the Vitamin
D-Responsive Elements 241
F The Activator Protein-1 Site within
the Human Osteocalcin Promoter
Synergizes with the Vitamin D-
Responsive Element 242
IV Steroid Receptor Superfamily 243
A Structural Aspects of the Steroid
Receptor Family 243
B Cloning and Structure of the
Vitamin D Receptor 245
V Role of the Vitamin D Receptor in
Osteocalcin Gene Activation 245
A The Vitamin D Receptor Is Essential to 1,25-
DihydroxyvitaminD3Activationof Osteocalcin 245
B Characteristics of Binding of the Vitamin D
Receptor to Vitamin D-Responsive
Element DNA in Vitro 247
VI Properties of Nuclear Accessory Factor and Other
Steroid Receptor Accessory Factors 249
A Distribution of Nuclear Accessory Factor 249
B Properties of Nuclear Accessory Factor 249
C Retinoid X Receptors Display Nuclear
Accessory Factor Activity 250
Contents xi •
VII Summary 251
References 252
8 MOLECULAR MECHANISMS OF ESTROGEN AND
THYROID HORMONE ACTION
Christopher K Glass and Myles A Brown
I Overview of Estrogen and Thyroid Hormone Action 258
II Characterization of Estrogen- and Thyroid Hormone-
Responsive Genes 260
III Identification and Characterization of Hormone
Response Elements 261
IV Estrogen and Thyroid Hormone Receptor Genes 267
V DNA-Binding Properties of the Estrogen Receptor 271
VI DNA-Binding Properties of the Thyroid
Hormone Receptor 273
VII Mechanisms Responsible for Transcriptional Activa-
tion by Estrogen and Thyroid Hormone Receptors 275
VIII Implications for the Study of the Mechanisms of
Action of Estrogen and Thyroid Hormones on
Bone Development and Homeostasis 277
References 278
9 RECENT ADVANCES IN THE BIOLOGY OF RETINOIDS
Gregor Eichele, Christina Thaller, and Susan M Smith
I Introduction 288
II Retinoid Receptors 291
III New Retinoids 296
IV Retinoids in Development 299
A Retinoids and the Anteroposterior Pattern in
Vertebrate Limbs 300
B Retinoids and the Formation of the Primary
Body Axis of Vertebrates 303
V Conclusion 313
References 313
10 PARATHYROID HORMONE BIOSYNTHESIS AND
ACTION: Molecular Analysis of the Parathyroid
Hormone Gene and Parathyroid Hormone/Parathyroid
Hormone-Related Peptide Receptor
Marie Demay, Harald Jiippner, Abdul-Badi Abou-Samra,
Gino Segre, and Henry Kronenberg
I Introduction 322
II Parathyroid Hormone Gene Structure 322
xii Contents
III Regulation of Parathyroid Hormone
Gene Expression 323
A Role of Calcium 322
B Role of 1,25-Dihydroxyvitamin D3 325
C Role of Other Factors 327
D Summary 327
IV Parathyroid Hormone/Parathyroid Hormone-
Related Peptide Receptor 328
A Isolation and Structure of Receptor cDNAs:
Encoding the Parathyroid Hormone/
Parathyroid Hormone-Related
Peptide Receptor 328
B Function of Cloned Parathyroid Hormone/
Parathyroid Hormone-Related Receptors 331
C Summary 336
References 336
11 MOLECULAR MECHANISMS OF CALCITONIN GENE
- TRANSCRIPTION AND POST-TRANSCRIPTIONAL
RNA PROCESSING
Sara Peleg, Gilbert J Cote, and Robert F Gagel
I Introduction 344
II The Cellular Distribution of Calcitonin and
Calcitonin Gene-Related Peptide 344
III Transcriptional Regulation of the Calcitonin Gene 346
A Identification of cis Elements 346
B Transcriptional Activation of the Calcitonin
Gene by cAMP and Phorbol Esters 354
C Regulation of Calcitonin Gene Transcription
by Cell Cycle Events 355
D Down-Regulation of Transcription of the
Calcitonin Gene by Vitamin D3 356
E A Model for Transcription Regulation of the
Calcitonin / Calcitonin Gene-Related
Peptide Gene 359
IV Post-transcriptional Processing of the Calcitonin
Gene Primary Transcript 360
A Models for Studying RNA Processing of the
Calcitonin Gene 361
B Regulatory Elements of Calcitonin/
Calcitonin Gene-Related Peptide
pre-mRNA Splicing 362
Contents xiii •
C Proposed Mechanism for Calcitonin/
Calcitonin Gene-Related Peptide
RNA Processing 367
References 370
12 CYTOKINES IN BONE: Local Translators in
Cell-to-Cell Communications
Toshiyuki Yoneda
I Introduction 376
II Osteotropic Cytokines and Growth Factors in Bone 376
III Cellular Components in Bone Microenvironment 377
A Cellular Source of Osteotropic Cytokines
and Growth Factors 377
B Target Cells for Osteotropic Cytokines and
Growth Factors 379
IV Mediation of Cell-to-Cell Communication by
Osteotropic Cytokines 379
V Actions of Cytokines and Growth Factors on Bone 382
A Interleukin 1 382
B Interleukin 4 387
C Interleukin 6
j 387
D Colony-Stimulating Factors 391
E Tumor Necrosis Factor and Lymphotoxin 394
F Leukemia Inhibitory Factor (Differentiation-
Inducing Factor) 397
G Interferon-7 398
H Osteoclastpoietic Factor 399
VI Conclusion 400
References 401
13 SIGNAL TRANSDUCTION IN OSTEOBLASTS
AND OSTEOCLASTS
Keith A Hruska, Felice Rolnick, Randall L Duncan,
Meetha Medhora, and Kensuke Yamakawa
I Introduction 414
II Substances with Effects in Bone Cells 415
A Hormones 415
B Cytokines 417
C Growth Factors 417
D Paracrine/Autocrine Factors 418
E Cell Adhesion Molecules 418
xiv Contents
III Mechanisms of Signal Generation
A Receptors
B Signal-Generating Complexes
C Effector Elements
D Signals
IV Specific Examples of Signal Transduction in
Osteoblasts: Parathyroid Hormone/Parathyroid
Hormone-Related Peptides
A The Parathyroid Hormone/Parathyroid
Hormone-Related Peptide Receptor
B Parathyroid Hormone/Parathyroid
Hormone-Related Peptide Signal-
Generating Complexes
C Effectors
D Signals
E Biological Effects
V Specific Examples of Signal Transduction
in Osteoclasts
A Role of Specific Paracrine Substances
B Hydrogen Ion
C Calcium
D Osteopontin/avp3 Integrin Signaling
E Calcitonin
References
14 CELLULAR AND MOLECULAR BIOLOGY
OF THE OSTEOCLAST
Roland Baron, Jan-Hindrik Ravesloot, Lynn Neff,
Munmun Chakraborty, Diptendu Chatterjee,
Abderrahim Lomri, and William Home
I Introduction 446
A Morphological Features of the Osteoclast 447
B Structure-Function Relationship 450
II Motility, Attachment, and Establishment of the
Bone Resorbing Compartment 451
A Cytoskeletal Organization 451
B Attachment Apparatus 452
C Summary 458
III Proteins Destined for Export: Biosynthetic and
Secretory Functions of the Osteoclast 459
A Acid Phosphatase and Other Lysosomal
Enzymes Found in the Secretory Pathway 459
Contents xv •
B Nature and Specificity of the
Secreted Enzymes 462
C Synthesis and Secretion of Other Proteins
by the Osteoclast 464
D Generation of Oxygen-Derived Free Radicals 465
E Summary 465
IV Cytosolic and Membrane Proteins: Membrane
Composition and Ion Transport 466
A The Apical Membrane and the Process
of Acidification 467
B Role of the Basolateral Membrane and Ion
Channels in Acidification, Intracellular
pH, and Membrane Potential Regulation 471
C Role of Calcium in Osteoclast Regulation 475
V Regulation of the Mature Osteoclast 478
VI Origin and Differentiation of the Osteoclast 480
VII A New Challenge: The Protooncogene c-src Is
Required for Normal Osteoclast Function 481
VIII Summary and Conclusion 484
References 484
15 c-fos ONCOGENE EXPRESSION IN CARTILAGE
AND BONE TISSUES OF TRANSGENIC AND
CHIMERIC MICE
Agamemnon E Grigoriadis, Zhao-Qi Wang,
and Erwin F Wagner
I Introduction 498
A Bone, Cartilage, and Oncogenes 498
B Oncogene Function Studied in Transgenic
and Chimeric Mice 500
II The fos Oncogene 503
A Structure and Regulation of Expression - 504
B Biological Role of c-fos 506
C Fos-Related Genes 507
III Overexpression of c-fos Leads to Skeletal Defects
in Transgenic and Chimeric Mice 509
A Rationale 509
B Different Skeletal Tissues Are Affected 510
C Osteogenic and Chondrogenic Tumors
Are the Results of c-fos Overexpression 515
D Targets for Ectopic c-fos Expression Are
Osteogenic and Chondrogenic Cells 517
E Summary 521
xvi Contents
IV Specificity of c-fos Action 523
A Timing of c-/os Expression 523
B Does the 3 FBJ-Long Terminal Repeat Affect
the Target Cell Specificity of c-fos? 526
C Model for c-fos Action in Osteogenic and
Chondrogenic Cells 527
V Conclusions and Perspectives 528
References 531
16 MOLECULAR BIOLOGY OF CARTILAGE MATRIX
Sergio Line, Craig Rhodes, and Yoshihiko Yamada
I Introduction 540
II Collagen Type II 541
A cDNA and Exon-Intron Structure 541
B Genetic Defects 543
C Transcriptional Regulation 543
III Aggrecan 545
A Protein Structure 546
B Gene Structure 549
IV Link Protein 550
A Protein Structure 550
B Transcriptional Regulation 550
V Summary 551
References 552
Index 557
|
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| bvnumber | BV008422383 |
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| callnumber-subject | QP - Physiology |
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| ctrlnum | (OCoLC)27726765 (DE-599)BVBBV008422383 |
| dewey-full | 599/.087 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 599 - Mammalia |
| dewey-raw | 599/.087 |
| dewey-search | 599/.087 |
| dewey-sort | 3599 287 |
| dewey-tens | 590 - Animals |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV008422383 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:19:29Z |
| institution | BVB |
| isbn | 0125202253 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-005549185 |
| oclc_num | 27726765 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-188 |
| physical | XXI, 567 S. Ill., graph. Darst. |
| publishDate | 1993 |
| publishDateSearch | 1993 |
| publishDateSort | 1993 |
| publisher | Acad. Press |
| record_format | marc |
| spelling | Cellular and molecular biology of bone ed. by Masaki Noda San Diego u.a. Acad. Press 1993 XXI, 567 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologie moléculaire Histologia geral larpcal Os - Anatomie ram Os - Histologie ram Os - Métabolisme ram Os et tissu osseux Ossos (sistema locomotor) larpcal Ostéoblastes - Cytologie ram Ostéoclastes - Cytologie ram Bone Development Bone and Bones anatomy & histology Bone and Bones metabolism Bone cells Bones Molecular aspects Osteoblasts cytology Osteoclasts cytology Knochen (DE-588)4128031-3 gnd rswk-swf Osteozyt (DE-588)4275595-5 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Osteozyt (DE-588)4275595-5 s DE-188 Knochen (DE-588)4128031-3 s Molekularbiologie (DE-588)4039983-7 s Noda, Masaki Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005549185&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cellular and molecular biology of bone Biologie moléculaire Histologia geral larpcal Os - Anatomie ram Os - Histologie ram Os - Métabolisme ram Os et tissu osseux Ossos (sistema locomotor) larpcal Ostéoblastes - Cytologie ram Ostéoclastes - Cytologie ram Bone Development Bone and Bones anatomy & histology Bone and Bones metabolism Bone cells Bones Molecular aspects Osteoblasts cytology Osteoclasts cytology Knochen (DE-588)4128031-3 gnd Osteozyt (DE-588)4275595-5 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4128031-3 (DE-588)4275595-5 (DE-588)4039983-7 |
| title | Cellular and molecular biology of bone |
| title_auth | Cellular and molecular biology of bone |
| title_exact_search | Cellular and molecular biology of bone |
| title_full | Cellular and molecular biology of bone ed. by Masaki Noda |
| title_fullStr | Cellular and molecular biology of bone ed. by Masaki Noda |
| title_full_unstemmed | Cellular and molecular biology of bone ed. by Masaki Noda |
| title_short | Cellular and molecular biology of bone |
| title_sort | cellular and molecular biology of bone |
| topic | Biologie moléculaire Histologia geral larpcal Os - Anatomie ram Os - Histologie ram Os - Métabolisme ram Os et tissu osseux Ossos (sistema locomotor) larpcal Ostéoblastes - Cytologie ram Ostéoclastes - Cytologie ram Bone Development Bone and Bones anatomy & histology Bone and Bones metabolism Bone cells Bones Molecular aspects Osteoblasts cytology Osteoclasts cytology Knochen (DE-588)4128031-3 gnd Osteozyt (DE-588)4275595-5 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Biologie moléculaire Histologia geral Os - Anatomie Os - Histologie Os - Métabolisme Os et tissu osseux Ossos (sistema locomotor) Ostéoblastes - Cytologie Ostéoclastes - Cytologie Bone Development Bone and Bones anatomy & histology Bone and Bones metabolism Bone cells Bones Molecular aspects Osteoblasts cytology Osteoclasts cytology Knochen Osteozyt Molekularbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005549185&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nodamasaki cellularandmolecularbiologyofbone |