Toxicology from discovery and experimentation to the human perspective: proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992
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| Sprache: | English |
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Amsterdam u.a.
Elsevier Science
1992
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| Schriftenreihe: | Toxicology letters
64/65 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zs.-Bandes |
| Beschreibung: | XIII, 800 S. graph. Darst. |
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| adam_text | TOXICOLOGY
FROM DISCOVERY AND
EXPERIMENTATION TO
THE HUMAN PERSPECTIVE
Proceedings of the Vlth International Congress of
Toxicology, Rome, Italy, 28 June - 3 July 1992
Edited by
PJJ Chambers and CM Chambers
Department of Pharmacology amp; Therapeutics, University of Dublin,
Trinity College, Dublin 2, Ireland
HM Bolt
Institut fur Arbeitsphysiologie, Universitat Dortmund,
Ardeystrasse 67, DW-4000 Dortmund 1, Germany
P Preziosi
Department of Pharmacology, Catholic University Medical School,
Largo F Vito 1,1-00198 Rome, Italy
Assisted by
Giovanni Ciabat toni, Fintain 6 Gharbhain, Marian Kent,
Cesare Mancuso, Paolo Montuschi, Pier Luigi Navarra,
Giacomo Pozzoli, and Claud io Sorrentino
This volume is reprinted from the journal
Toxicology Letters Volumes 64/65,1992
ELSEVIER
Amsterdam-London-New York-Tokyo 1992
CONTENTS
Preface
Cholesterol and mevalonic acid modulation in cell metabolism and multiplication
M R Soma, A Corsini and R Paoletti (Italy) 1
Assessment of accumulated body burden of metals
S Skerfving and U Nilsson (Sweden) 17
Molecular biology approaches to biological monitoring of genotoxic substances
E Nieboer, F E Rossetto and J D Turnbull (Canada) 25
Monitoring of early nephrotoxic effects of industrial chemicals
R Lauwerys, A Bernard, A Cardenas (Belgium) 33
Individual susceptibility to toxicity
P Grandjean (Denmark) 43
Evaluation of-adverse effects in the standard-setting process
D Henschler (Germany) 53
The Toxic Oil Syndrome (TOS, 1981): from the disease towards a toxicological
understanding of its chemical aetiology and mechanism
W N Aldridge (UK) 59
Qualitative and quantitative experimental models to aid in risk assessment for
immunotoxicology
M I Luster, D G Pait, C Portier, G J Rosenthal, D R Germolec, C E Comment,
A E Munson, K White and P Pollock (USA) 71
The mechanisms and evaluation of chemically induced allergy ,
I Kimber and R J Dearman (UK) 79
Athymic experimental animals in pharmaco-immunological research
P Juult, H B Christensen, H P Hougen, 0 Svendsen, P Thygesen and
J Rygaard (Denmark) 85
Cellular and humoral mechanisms of immunotoxicological tissue manifestations
induced by immunotoxic drugs
K Udaka (Japan) 93
The popliteal lymph node assay: a tool for studying the mechanisms of drug-induced
autoimmune disorders
J Descotes (France) 101
Molecular basis for differences in susceptibility to toxicants: introduction
A R Boobis (UK) 109
Genetically determined differences in drug metabolism as a risk factor in drug toxicity
M Eichelbaum, H K Kroemer, and G Mikus (Germany) 115
Acetyltransferases and susceptibility to chemicals
D W Hein, T D Rustan, M A Doll, K D Bucher, R J Ferguson, Y Feng,
E J Furman and K Gray (USA) 123
The molecular mechanism of peroxisome proliferator action: a model for species
differences and mechanistic risk assessment
S Green, J D Tugwood and I Issemann (UK) 131
Inherited defects in DNA repair and susceptibility to DNA-damaging agents
J Hansson (Sweden) 141
Are newer scientific concepts in regulatory toxicology used timely and appropriately?
C Hodel (France) and R Bass (Germany) 149
New approaches to the assessment of eye and skin irritation
G Calvin (Belgium) 157
Classification of chemicals as sensitisers based on new test methods
P A Botham (UK) 165
Classification of chemicals for carcinogenic and mutagenic properties
PGN Kramers and H Roelfzema (The Netherlands) 173
The European Community classification of chemicals for reproductive toxicity
F M Sullivan (UK) 183
Public health problems of organic solvents
M Ikeda (Japan) 191
Methodology in neurotoxicology — activities within the World Health Organization
and International Programme on Chemical Safety
G C Becking (USA) 203
Principles of identifying and characterizing neurotoxicity
R C MacPhail (USA) 209
International validation of a neurobehavioral screening battery: the IPCS/WHO
collaborative study
V C Moser and R C MacPhail (USA) 217
Integration of behavioral and neurophysiological approaches in neurotoxicology
E Frantik and M Horvath (Czechoslovakia) 225
Developmental aspects of neurobehavioural toxicity
G Bignami, G Laviola, E Alleva, R Cagiano, C Lacomba and V Cuomo (Italy) 231
Extrapolation from animals to humans: scientific and regulatory aspects
G Winneke and H Lilienthal (Germany) 239
The evolution of toxic effluents in fires and the assessment of toxic hazard
D A Purser (UK) 247
The development of a new small-scale smoke toxicity test method and its comparison
with real-scale fire tests
B C Levin (USA) 257
Modeling of toxicological effects of fire effluents: prediction of toxicity and evaluation
of animal model
J Pauluhn (Germany) 265
Pre-hospital strategy for therapeutic intervention of fire victims
F J Baud, F Richter, H Julien and C Bismuth (France) 273
Hospital treatment of victims exposed to combustion products
P Kulling (Sweden) -- 283
Progress and challenges in the preclinical assessment of cytokines
T J Hayes and J A Cavagnaro (USA) 291
Preclinical evaluation of recombinant human interleukin-4
J B Cornacoff, K A Gossett, T A Barbolt and J H Dean (USA) 299
Pathology induced by Interleukin-6
B Ryffel, M Kammiiller (Switzerland), R Robison and L Myers (USA) 311
Utilization of homologous proteins to evaluate the safety of recombinant human
proteins — case study: recombinant human interferon-gamma (rhIFN-7)
J D Green and T G Terrell (USA) 321
Experience with the preclinical assessment of basic fibroblast growth factor (bFGF)
G Mazue, F Bertolero, L Garofano, M Brughera and P Carminati (Italy) 329
Current guidelines for the preclinical safety assessment of therapeutic proteins
R Bass, U Kleeberg, H Schroder and E Scheibner (Germany) 339
Difficulties in conceiving and applying guidelines for the safety evaluation of
biotechnologically-produced drugs: some examples
J -R Claude (France) 349
Ca2*-dependent mechanisms of cytotoxicity and programmed cell death
S Orrenius, M J McCabe Jr and P Nicotera (Sweden) 357
Structural and functional aspects of the thyroid follicular epithelium
L E Ericson and M Nilsson (Sweden) 365
Cell proliferation and thyroid neoplasia
E D Williams (UK) 375
Pathophysiology of chemical injury of the thyroid gland
C C Capen (USA) 381
Chemical carcinogenesis in the thyroid gland
Y Hiasa, Y Kitahori, N Konishi and M Ohshima (Japan) 389
Thyroid gland neoplasia: non-genotoxic mechanisms
R M McClain (USA) 397
Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design
P Krogsgaard-Larsen and J J Hansen (Denmark) 409
Role of GAB A in the genesis of chemoconvulsant seizures
K Gale (USA) 417
Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes
T Narahashi, J M Frey, K S Ginsburg and M L Roy (USA) 429
Second messengers in cholinergic-induced convulsions and neuronal injury
K M Savolainen and M -R Hirvonen (Finland) 437
Glutamate transmission is involved in the mechanisms of neuronal degeneration
produced by intrahippocampal tetanus toxin in rats
G Bagetta and G Nistico (Italy) 447
Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in
relation to HBV infection and hepatocellular carcinoma in The Gambia and Thailand
C P Wild (France), S M Shrestha (Nepal), W A Anwar (Egypt) and R Montesano
(France) 455
The use of biomarkers in epidemiology: the example of bladder cancer
P Vineis (Italy) 463
Advantages and limitations of laboratory methods for measurement of
carcinogen-DNA adducts for epidemiological studies
R K Kaderlik, D -X Lin, N P Lang and F F Kadlubar (USA) 469
Expression of pulmonary cytochrome P4501 Al and carcinogen DNA adduct formation
in high risk subjects for tobacco-related lung cancer
H Bartsch, M Castegnaro, M Rojas, A -M Camus, K Alexandrov and M Lang
(France) 477
Use of biomarkers in epidemiology: quantitative aspects
L Ehrenberg and M Tornqvist (Sweden) 485
Use of white rot fungi in the degradation of environmental chemicals
M M Shah, D P Barr, N Chung and S D Aust (USA) 493
Hazard assessment of chemical contaminants in soil
CLM Poels and W Veerkamp (The Netherlands) 503
Hazard assessment in freshwater ecosystems
N O Crossland (USA) 511
Advances in prediction of exposure for organic chemicals
D Calamari (Italy) 519
Biochemical responses as indicators of toxic effects of chemicals in ecosystems
C H Walker (UK) 527
Environmental hazard classification of chemicals
A Lundgren (Sweden) J 535
Role of reactive oxygen species in cell toxicity
H Sies and H de Groot (Germany) 547
xii
Mechanisms of cytotoxicity caused by antitumour drugs
J A Hickman, H M Beere, A C Wood, CM Waters, and R Parmar (UK) 553
Thiol modification and cell signalling in chemical toxicity
P Nicotera, J M Dypbukt, A D Rossi (Sweden), L Manzo (Italy) and S Orrenius
(Sweden) 563
Programmed cell death and its protective role with particular reference to apoptosis
R Schulte-Hermann, W Bur sen, B Kraupp-Grasl, F Oberhammer and A Wagner
(Austria) 569
Paracetamol toxicity and its prevention by cytoprotection with iloprost
D S Davies, D J Fawthrop, P Nasseri-Sina, J W Wilson, S J Hardwickand
A R Boobis (UK) 575
Protection from oxidative damage in mouse liver cells
A W Harman, G M Adamson and S G Shaw (Australia) 581
The clinical toxicology of Chlordecone as an example of toxicological risk assessment
for man
P S Guzelian (USA) 589
Interaction and distinction of genotoxic and non-genotoxic events in carcinogenesis
H Yamasaki, M Mesnil and H Nakazawa (France) 597
Prediction of non-genotoxic carcinogenesis
J Ashby (UK) 605
Pathological markers for non-genotoxic agent-associated carcinogenesis
N Ito, R Hasegawa, K Imaida, T Masui, S Takahashi and T Shirai (Japan) 613
Non-genotoxic factors in the carcinogenetic process: problems of detection and hazard
evaluation
S Parodi, D Malacarne and M Taningher (Italy) 621
Risk assessment of non-genotoxic carcinogens
S H Moolgavkar and E G Luebeck (USA) 631
Chemicals classified by IARC: an investigation of some of their toxicological
characteristics
D B McGregor (France) • 637
Molecular and cellular basis for adequate metabolic design of genotoxicity studies
F Oesch, B Oesch-Bartlomowicz, H J Arens, T Friedberg, D Utesch, H R Glatt
and K L Platt (Germany) 643
Problems and opportunities in toxicity testing arising from species differences in
xenobiotic metabolism -
J Caldwell (UK) 651
Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug
toxicity
R Kato and Y Yamazoe (Japan) 661
Dose-dependent metabolism and dose setting in chronic studies
J S Bus and R H Reitz (USA) 669
Metabolic studies as a basis for the interpretation of metal toxicity
L Manzo (Italy), L G Costa (USA), M Tonini, C Minoia and E Sabbioni (Italy) 677
Characterization of the effects of aluminum on luciferase biosensors for the detection
ofecotoxicity
J Guzzo, A Guzzo and M S DuBow (Canada) 687
Cell injury and death caused by bacterial protein toxins
G Donelli and C Fiorentini (Italy) 695
Induction of apoptosis in cultured hepatocytes and in the regressing liver by
transforming growth factor-(Jl occurs without activation of an endonuclease
F Oberhammer, G Fritsch, M Pavelka, G Froschl, R Tiefenbacher (Austria),
T Purchio (USA) and R Schulte-Hermann (Austria) 701
xiii
Toxicity in animals and safety in humans: the predictive value of animal studies
G Rosati, A Morisetti and P Tirone (Italy) 705
Epidemiology of adverse reactions to intravascular iodinated contrast media
G Ansell (UK) 717
The profile evolution of acute severe poisoning in Spain
S Nogue, L Marruecos, J Nolla, J Monteis, A Ferrer and E Civeira (Spain) 725
Rapidly developing cocaine-induced peripheral portal liver damage
S J Charles and C J Powell (UK) 729
Mechanism of pain induced by radiocontrast media
A P Corrado, G Ballejo, E Antunes and G de Nucci (Brazil) 739
A dual effect of some 5-HT3 receptor antagonists on cisplatin-induced emesis in the
pigeon
P Navarra, M Martire, R del Carmine, G Pozzoli and P Preziosi (Italy) 745
Production of lipid hydroperoxides and depletion of reduced glutathione in liver
mitochondria after acute ethanol administration to rats
T Trenti, E Sternieri, D Ceccarelli, D Gallesi and A Masini (Italy) 751
Plasma glutathione level in paracetamol daily abuser patients Changes in plasma
cysteine and thiol groups after reduced glutathione administration
T Trenti, M Bertolotti, C N Castellana, A Ferrari, L A Pini and E Sternieri
(Italy) 757
Properties of bolesatine, a translational inhibitor from Boletus satanas Lenz
Amino-terminal sequence determination and inhibition of rat mitochondrial
protein synthesis
0 Kretz, J Reinbolt, E -E Creppy and G Dirheimer (France) 763
Molecular basis for differences in susceptibility to coal workers pneumoconiosis
PJA Borm, R Schins, YMW Janssen and L Lenaerts (The Netherlands) 767
Behavioral toxicity of guanidinosuccinic acid in adult and young mice
R D Hooge, Y -Q Pei, B Marescau and P P De Deyn (Belgium) 773
Three-generation reproductive studies of a synthetic pyrethroid — cyhalothrin
P B Deshmukh (India) 779
Safety/risk assessment of pesticides: principles, procedures and examples
F C Lu and M L Dourson (USA) 783
Author Index Vol 64/65 (1992) 789
Subject Index Vol 64/65 (1992) 795
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| spelling | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 eds.: P. L. Chambers ... Amsterdam u.a. Elsevier Science 1992 XIII, 800 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Toxicology letters 64/65 Einzelaufnahme eines Zs.-Bandes Toxicologie gtt Toxicology Congresses Toxikologie (DE-588)4060538-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1992 Rom gnd-content Toxikologie (DE-588)4060538-3 s DE-604 Chambers, P. L. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005499205&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 Toxicologie gtt Toxicology Congresses Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4060538-3 (DE-588)1071861417 |
| title | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 |
| title_auth | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 |
| title_exact_search | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 |
| title_full | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 eds.: P. L. Chambers ... |
| title_fullStr | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 eds.: P. L. Chambers ... |
| title_full_unstemmed | Toxicology from discovery and experimentation to the human perspective proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 eds.: P. L. Chambers ... |
| title_short | Toxicology from discovery and experimentation to the human perspective |
| title_sort | toxicology from discovery and experimentation to the human perspective proceedings of the vith international congress of toxicology rome italy 28 june 3 july 1992 |
| title_sub | proceedings of the VIth International Congress of Toxicology, Rome, Italy, 28 June - 3 July, 1992 |
| topic | Toxicologie gtt Toxicology Congresses Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Toxicologie Toxicology Congresses Toxikologie Konferenzschrift 1992 Rom |
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