Immunopharmacology of the gastrointestinal system:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London u.a.
Acad. Press
1993
|
| Schriftenreihe: | The handbook of immunopharmacology
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 198 S. Ill., graph. Darst. |
| ISBN: | 0127328602 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804122556888776704 |
|---|---|
| adam_text | -88? G IMMUNOPHARMACOLOGY OF THE GASTROINTESTINAL SYSTEM EDITED BY JOHN
L. WALLACE GASTROINTESTINAL RESEARCH GROUP UNIVERSITY OF CALGARY
CALGARY, ALBERTA, CANADA ACADEMIC PRESS HARCOURT BRACE JOVANOVICH,
PUBLISHERS LONDON SAN DIEGO NEW YORK BOSTON SYDNEY TOKYO TORONTO
CONTENTS CONTRIBUTORS IX SERIES PREFACE XI PREFACE XIII 1.
NEUROMODUKTION OF GASTROINTESTINAL IMMUNE AND INFLAMMATORY RESPONSES 1
A. DEAN BEFUS 1. INTRODUCTION 1 3. 1.1 NEUROGENIC INFLAMMATION 2 4. 1.2
NEUROIMMUNOLOGY OF THE GASTROINTESTINAL TRACT 3 5. 2. THE INTESTINAL
IMMUNE SYSTEM 3 2.1 GUT-ASSOCIATED LYMPHOID TISSUE GALT 3 2.2
SPECIALIZED CELLS OF THE MUCOSAL IMMUNE SYSTEM 4 2.2.1 IGA DEVELOPMENT 5
2.2.2 INTRAEPITHELIAL LEUCOCYTES 5 6. 2.2.3 GASTROINTESTINAL MAST CELL
POPULATIONS 5 7. INNERVATION OF THE GASTROINTESTINAL TRACT 6
INFLAMMATION AND GASTROINTESTINAL NEUROPLASTICITY NEUROREGULATION OF
CELLS OF THE MUCOSAL IMMUNE SYSTEM 8 5.1 LYMPHOCYTES AND THE IGA CELL
CYCLE 8 5.2 INTRAEPITHELIAL LEUCOCYTES 10 5.3 MAST CELL POPULATIONS 10
5.4 OTHER CELLS 11 INTEGRATION OF INTESTINAL NEUROIMMUNOLOGY 11
REFERENCES 12 ; 2. IMMUNOMODULATION OF THE GASTROINTESTINAL EPITHELIUM
15 MARY H. PERDUE AND DEREK M. MCKAY 1. INTRODUCTION 15 2. EPITHELIAL
FORM AND FUNCTION 16 3. ANTIGEN IN SENSITIZED HOSTS 17 3.1 PARASITE/RAT
MODEL 17 3.1.1 NIPPOSTRONGYLM BNTSILIENSIS 17 3.1.2 TRICHINELLA SPIRALIS
19 3.2 EGG ALBUMIN/RODENT MODEL 19 3.2.1 PROLONGED ANTIGEN EXPOSURE 20
3.3 /3-LACTOGLOBULIN/GUINEA PIG MODEL 21 4. IMMUNOCOMPETENT CELLS 21 4.1
MAST CELLS 21 4.1.1 HISTAMINE 22 4.1.2 SEROTONIN 22 4.1.3 ADENOSINE 23
4.1.4 EICOSANOTDS 23 4.1.4.1 LEUKOTRIENES 23 4.1.4.2 PROSTAGLANDINS 24
4.1.5 PLATELET-ACTIVATING FACTOR 24 5. 6. 7. 8. 9. 10. 11. 12. 25 4.2
4.1.6 CYTOKINES PHAGOCYTES 25 4.2.1 REACTIVE OXYGEN METABOLITES 25 4.2.2
BACTERIAL PEPTIDES 26 4.3 LYMPHOCYTES 26 4.3.1 ANTIBODY PRODUCTION 27
4.3.2 CYTOKINES 27 4.4 INTRAEPITHELIAL LEUCOCYTES 29 FIBROBLASTS 29
GOBLET CELLS 30 NEURONAL AMPLIFICATION AND INHIBITION OF GI EPITHELIUM
30 NEGATIVE FEEDBACK OFF MECHANISMS 31 PHARMACOLOGICAL MODIFICATION OF
EPITHELIAL FUNCTION CONCLUSIONS 32 ACKNOWLEDGEMENTS 33 REFERENCES 34 32
VI CONTENTS 3. THE IMMUNE MODULATION OF INTESTINAL MOTOR FUNCTION 41
STEPHEN M. COLLINS 1. OVERVIEW 41 2. EVIDENCE OF ALTERED MOTOR FUNCTION
IN VIVO IN THE INFLAMED GUT 41 2.1 STUDIES IN MAN 41 2.2 STUDIES IN
ANIMALS 42 2.2.1 STUDIES IN ANIMAL MODELS OF INTESTINAL INFLAMMATION 42
2.2.2 STUDIES IN ANIMAL MODELS OF COLITIS 42 2.2.3 STUDIES IN ANIMAL
MODELS OF INTESTINAL SENSITIZATION 43 3. STRUCTURAL ABNORMALITIES IN THE
MOTOR SYSTEM IN INFLAMED GUT 43 3.1 STUDIES IN MAN 43 3.1.1 CHANGES IN
ENTERIC NERVES 43 3.1.2 CHANGES IN SMOOTH MUSCLE 44 3.1.3 STRUCTURAL
RELATIONSHIPS BETWEEN IMMUNE CELLS, ENTERIC NERVES AND SMOOTH MUSCLE 44
44 3.2 STUDIES IN ANIMALS 44 4. ALTERED CONTRACTILITY OF MUSCLE IN THE
INFLAMED GUT 4.1 STUDIES IN MAN 44 4.2 STUDIES IN ANIMALS 45 4.2.1
STUDIES IN VITRO ON SMOOTH MUSCLE FROM THE INFLAMED INTESTINE 45 4.2.2
STUDIES IN VITRO ON SMOOTH MUSCLE IN ANIMAL MODELS OF COLITIS 46 4.2.3
SMOOTH MUSCLE FUNCTION IN IMMUNODEFICIENT MICE 46 5. CHANGES IN ENTERIC
NERVE FUNCTION IN THE INFLAMED GUT 46 5.1 STUDIES IN MAN 46 5.2 STUDIES
IN ANIMALS 46 6. CONCLUSIONS 47 7. ACKNOWLEDGEMENTS 47 8. REFERENCES 47
4. MODULATION OFNEUTROPHIL FUNCTION AS A MODE OF THERAPY FOR
GASTROINTESTINAL INFLAMMATION 51 IQBAL S. SANDHU AND MATTHEW B. GRISHAM
INTRODUCTION 51 NEUTROPHIL-DERIVED REACTIVE OXYGEN METABOLISM 52 2.1
SUPEROXIDE RADICAL 53 2.2 HYDROGEN PEROXIDE 53 2.3 HYDROXYL RADICAL 53
2.4 PEROXYL RADICALS 54 2.5 HYPOHALOUS ACIDS AND N-HALOGENATED AMINES 55
2.6 BIOLOGICAL ACTIVITY OF REACTIVE OXYGEN METABOLITES 56 ANTIOXIDANTS
AND FREE RADICAL SCAVENGERS 57 3.1 SUPEROXIDE DISMUTASE 57 3.2 CATALASE
58 3.3 GLUTATHIONE PEROXIDASE 58 3.4 NONENZYMATIC ANTIOXIDANTS 58 3.5
ANTIOXIDANTS IN THE GASTROINTESTINAL TRACT 58 4. ROLE OF NEUTROPHILS AND
OXIDANTS IN GASTROINTESTINAL INFLAMMATION: MECHANISTIC AND PHARMACOLOGIC
APPROACHES 59 5. NEUTROPHIL-DERIVED PROTEASES 62 5.1 STRUCTURE OF THE
INTESTINAL MUCOSA 62 5.2 PROTEASES 62 5.3 ANTIPROTEASES 62 ; . ROLE OF
NEUTROPHIL-DERIVED PROTEASES IN GASTROINTESTINAL INFLAMMATION:
MECHANISTIC AND PHARMACOLOGIC APPROACHES 63 CATIONIC PROTEINS 63 SUMMARY
64 REFERENCES 64 6. 7. 9. 5. THE VASCULAR ENDOTHELIUM IN
GASTROINTESTINAL INFLAMMATION 69 PETER R. KVIETYS AND D. NEIL GRANGER
INTRODUCTION 69 STRUCTURE OF VASCULAR ENDOTHELIUM 70
NEUTROPHIL-ENDOTHELIAL CELL INTERACTIONS 70 3.1 02 INTEGRINS 71 3.2
INTERCELLULAR ADHESION MOLECULES 72 3.3 SELECTINS 72 3.4 SHEAR STRESS 74
3.5 LEUCOCYTE ROLLING 74 3.6 TRANSENDOTHELIAL MIGRATION 75 MICROVASCULAR
EXCHANGE OF FLUID AND PROTEIN 76 4.1 NET CAPILLARY FLUID FILTRATION RATE
77 4.2 CAPILLARY FILTRATION COEFFICIENT 77 4.3 CAPILLARY PRESSURE 77 4.4
INTERSTITIAL FLUID PRESSURE 77 4.5 OSMOTIC REFLECTION COEFFICIENT 78 4.6
TRANSCAPILLARY ONCOTIC PRESSURE GRADIENT 78 4.7 INTERACTION OF CAPILLARY
AND INTERSTITIAL FORCES: ENHANCED CAPILLARY FILTRATION AND EDEMA SAFETY
FACTORS 78 ISCHEMIA/REPERFUSION-INDUCED INFLAMMATION 80 5.1 NATURE OF
INFLAMMATORY RESPONSE 80 5.2 MEDIATORS OF REPERFUSION-INDUCED
INFLAMMATORY CELL INFILTRATE 80 5.3 MOLECULAR DETERMINANTS OF
INFLAMMATORY CELL INFILTRATE 82 CONTENTS VII 5.4 NATURE OF
REPERFUSION-INDUCED MICROVASCULAR DYSFUNCTION 83 5.5 MEDIATORS OF
REPERFUSION-INDUCED MICROVASCULAR DYSFUNCTION 83 ETHANOL-INDUCED
INFLAMMATION 85 6.1 NATURE OF INFLAMMATORY RESPONSE 85 6.2 LEUCOCYTE
ENDOTHELIAL CELL INTERACTIONS 86 6.3 PROINFLAMMATORY EFFECTS ON ETHANOL
87 6.4 NATURE OF ETHANOL-INDUCED MICROVASCULAR DYSFUNCTION 88 9. 10.
INFLAMMATION INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS 89 7.1
NATURE OF INFLAMMATORY RESPONSE 89 7.2 NATURE OF NSAID-INDUCED
MICROVASCULAR DYSFUNCTION 90 SUMMARY 90 ACKNOWLEDGEMENTS 90 REFERENCES
90 6. MODULATION OF MAST CELL FUNCTION IN THE GASTROINTESTINAL TRACT 95
ELYSE Y. BISSONNETTE AND A. DEAN BEFUS INTRODUCTION 95 HETEROGENEITY OF
MAST CELLS 96 2.1 MAST CELL HETEROGENEITY IN RODENTS 2.2 MAST CELL
HETEROGENEITY IN HUMANS MAST CELL MEDIATORS 96 MAST CELL ACTIVATION 97
MODULATION OF MAST CELL FUNCTIONS 98 5.1 EFFECTS OF DRUGS 98 96 96 5.1.1
5.1.2 5.1.3 5.1.4 DISODIUM CROMOGLYCATE AND NEDOCROMIL SODIUM 98
CORTICOSTEROIDS 99 SULFASALAZINE 99 IMMUNOSUPPRESSANTS 100 5.2 CYTOKINES
100 6. CONCLUSIONS 7. REFERENCES 100 101 7. IMMUNOPATHOPHYSIOLOGY OF THE
GASTROINTESTINAL TRACT: BOLE OF PLATELET ACTIVATING FACTOR 105 PAUL
KUBES 1. INTRODUCTION 105 2. HISTORICAL OVERVIEW 105 3. PLATELET
ACTIVATING FACTOR AND BLOOD FLOW 106 4. PLATELET ACTIVATING
FACTOR-INDUCED VASOCONSTRICTION: ROLE OF SECONDARY MEDIATORS 107 5.
PLATELET ACTIVATING FACTOR AND POLYMORPHONUCLEAR LEUCOCYTES 109 6.
MICROVASCULAR DYSFUNCTION 110 6.1 NEUTROPHIL-DEPENDENT ALTERATIONS IN
MICROVASCULAR INTEGRITY 111 6.2 NEUTROPHIL-INDEPENDENT EFFECT OF
PLATELET ACTIVATING FACTOR ON THE MICROVASCULATURE 112 7. MUCOSAL
DYSFUNCTION 113 8. PLATELET ACTIVATING FACTOR AND GASTROINTESTINAL
DISEASE 114 8.1 ISCHEMIA-REPERFUSION 114 8.2 ENDOTOXEMIA 116 8.3
INFLAMMATORY BOWEL DISEASE 117 9. SOURCES OF PLATELET ACTIVATING FACTOR
117. 10. SUMMARY 119 11. ACKNOWLEDGEMENTS 119 12. REFERENCES 119 8.
CYTOKINES 123 FABIO COMINELLI 1. OVERVIEW 123 1.1 INTERLEUKIN-1 AND
INTERLEUKIN-1 RECEPTOR ANTAGONIST 124 1.2 INTERLEUKIN-2 125 1.3
INTERLEUKIN-3 AND COLONY STIMULATING FACTORS 126 1.4 INTERLEUKIN-4 126
1.5 INTERLEUKIN-5 126 1.6 INTERLEUKIN-6 126 1.7 TUMOUR NECROSIS FACTOR
127 1.8 INTERLEUKIN-7 127 1.9 INTERLEUKIN-8 AND RELATED CHEMOTACTIC
PEPTIDES 127 1.10INTERLEUKIN-9 AND INTERLEUKIN-10 128 1.11 INTERFERONS
128 1.12 TRANSFORMING GROWTH FACTOR-/3 128 CYTOKINES IN GASTROINTESTINAL
DISEASES 129 2.1 CYTOKINES IN ANIMAL MODELS OF INTESTINAL INFLAMMATION
129 2.2 CYTOKINES IN HUMAN INFLAMMATORY BOWEL DISEASE 129 2.3 CYTOKINES
IN ANIMAL MODELS OF GASTRODUODENAL DAMAGE 131 2.4 CYTOKINES IN
HELICOBACTER PYLORI GASTRITIS 132 SUMMARY 132 REFERENCES 132 VIII
CONTENTS 9. IMMUNOPHARMACOLOGJ OF EICOSAMIDS IN THE GASTROINTESTINAL
TRACT 137 JOHN L. WALLACE OVERVIEW 137 1.1 PROSTAGLANDINS 138 1.2
THROMBOXANE 139 1.3 LEUKOTRIENES 139 EICOSANOIDS IN THE GASTROINTESTINAL
TRACT: ACTIONS, SOURCES AND RECEPTORS 139 2.1 PROSTAGLANDINS 139 2.2
THROMBOXANE 140 2.3 LEUKOTRIENES 141 ROLE OF EICOSANOIDS IN
GASTROINTESTINAL DISEASE 141 3.1 CYTOPROTECTION 141 3.2 NONSTEROIDAL
ANTI-INFLAMMATORY DRUG GASTROPATHY 142 3.2.1 OVERVIEW OF CLINICAL ENTITY
142 3.2.2 PATHOGENESIS 143 3.2.3 CLINICAL UTILITY OF PROSTAGLANDINS 144
3.3 INFLAMMATORY BOWEL DISEASE 144 3.3.1 OVERVIEW OF CLINICAL ENTITY 144
3.3.2 PATHOGENESIS 144 3.3.3 EICOSANOIDS IN INFLAMMATORY BOWEL DISEASE:
ANIMAL STUDIES 146 3.3.4 EICOSANOIDS IN INFLAMMATORY BOWEL DISEASE:
CLINICAL STUDIES 147 3.4 SHOCK AND ISCHEMIA*REPERFUSION INJUN 148 4.
CONCLUSIONS 149 5. REFERENCES 149 1. 2. 10. NITRIC OXIDE AND THE
GASTROINTESTINAL TRACT 155 BRENDAN J.R. WHITTLE 1. INTRODUCTION 155 2.
NITRIC OXIDE SYNTHASE 156 2.1 ASSAY OF NITRIC OXIDE IN GASTRIC TISSUE
156 3. ROLE OF NITRIC OXIDE IN GASTROINTESTINAL MOTILITY 158 4. NITRIC
OXIDE AND THE GASTRIC MICROCIRCULATION 158 4.1 BASAL BLOOD FLOW 158 4.2
FUNCTIONAL HYPERAEMIA 159 5. ROLE OF NITRIC OXIDE IN MODULATING GASTRIC
INTEGRITY 159 6. NITRIC OXIDE AND THE INTESTINAL VASCULATURE 160 6.1
INTESTINAL BLOOD FLOW 160 6.2 PORTAL HYPERTENSION 160 7. NITRIC OXIDE
AND INTESTINAL VASCULAR INTEGRITY 160 8. CELLULAR INTERACTIONS IN
VASCULAR DAMAGE 161 9. ROLE OF NITRIC OXIDE IN IMMUNOLOGICALLY ACTIVATED
PROCESSES 162 10. FURTHER IMPLICATIONS OF THE NITRIC OXIDE 162 11.
REFERENCES 163 11. GLUCOCORTICOIDS AND GASTROINTESTINAL INFLAMMATION 169
LUCA PARENTE AND KENNETH G. MUGRIDGE 3.3 INTRODUCTION 169 GLUCOCORTICOID
USE AND ASSOCIATION WITH GASTROINTESTINAL DISEASE: CLINICAL AND
EXPERIMENTAL EVIDENCE 170 MECHANISMS OF THE ANTI-INFLAMMATORY ACTION OF
GLUCOCORTICOIDS 170 3.1 EFFECTS ON ENZYMES INVOLVED IN THE METABOLISM OF
ARACHIDONIC ACID 170 3.1.1 PHOSPHOLIPASE A 2 170 3.1.2 CYCLOOXYGENASE
AND LIPOXYGENASE 171 3.2 RELATIONSHIP BETWEEN THE EFFECT OF
GLUCOCORTICOIDS ON EICOSANOIDS AND THEIR ACTION ON GASTROINTESTINAL
INFLAMMATION 171 EFFECT OF GLUCOCORTICOIDS ON LEUCOCYTE MIGRATION AND
FUNCTION 173 3.4 RELATIONSHIP BETWEEN THE EFFECT OF GLUCOCORTICOIDS ON
NEUTROPHILS AND THEIR ACTION ON GASTROINTESTINAL INFLAMMATION 174 3.5 DO
GLUCOCORTICOIDS EXERT THEIR BENEFICIAL EFFECTS IN IBD THROUGH INHIBITION
OF CYTOKINE PRODUCTION? 175 CONCLUSIONS 177 REFERENCES 177 GLOSSARY 185
KEY TO ILLUSTRATIONS 189 INDEX 195
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| illustrated | Illustrated |
| indexdate | 2024-07-09T17:15:46Z |
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| language | English |
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| record_format | marc |
| series2 | The handbook of immunopharmacology |
| spelling | Immunopharmacology of the gastrointestinal system ed. by John L. Wallace London u.a. Acad. Press 1993 X, 198 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier The handbook of immunopharmacology Geneesmiddelen gtt Immunologie gtt Immunopharmacologie Maagdarmstelsel gtt Tractus gastro-intestinal - Maladies - Immunologie Ziekten gtt Adjuvants, Immunologic therapeutic use Gastrointestinal Diseases drug therapy Gastrointestinal system Gastrointestinal system Diseases Immunological aspects Immunity drug effects Gastrointestinaltrakt (DE-588)4074445-0 gnd rswk-swf Immunpharmakologie (DE-588)4026639-4 gnd rswk-swf Gastrointestinaltrakt (DE-588)4074445-0 s Immunpharmakologie (DE-588)4026639-4 s DE-604 Wallace, John L. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005393145&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Immunopharmacology of the gastrointestinal system Geneesmiddelen gtt Immunologie gtt Immunopharmacologie Maagdarmstelsel gtt Tractus gastro-intestinal - Maladies - Immunologie Ziekten gtt Adjuvants, Immunologic therapeutic use Gastrointestinal Diseases drug therapy Gastrointestinal system Gastrointestinal system Diseases Immunological aspects Immunity drug effects Gastrointestinaltrakt (DE-588)4074445-0 gnd Immunpharmakologie (DE-588)4026639-4 gnd |
| subject_GND | (DE-588)4074445-0 (DE-588)4026639-4 |
| title | Immunopharmacology of the gastrointestinal system |
| title_auth | Immunopharmacology of the gastrointestinal system |
| title_exact_search | Immunopharmacology of the gastrointestinal system |
| title_full | Immunopharmacology of the gastrointestinal system ed. by John L. Wallace |
| title_fullStr | Immunopharmacology of the gastrointestinal system ed. by John L. Wallace |
| title_full_unstemmed | Immunopharmacology of the gastrointestinal system ed. by John L. Wallace |
| title_short | Immunopharmacology of the gastrointestinal system |
| title_sort | immunopharmacology of the gastrointestinal system |
| topic | Geneesmiddelen gtt Immunologie gtt Immunopharmacologie Maagdarmstelsel gtt Tractus gastro-intestinal - Maladies - Immunologie Ziekten gtt Adjuvants, Immunologic therapeutic use Gastrointestinal Diseases drug therapy Gastrointestinal system Gastrointestinal system Diseases Immunological aspects Immunity drug effects Gastrointestinaltrakt (DE-588)4074445-0 gnd Immunpharmakologie (DE-588)4026639-4 gnd |
| topic_facet | Geneesmiddelen Immunologie Immunopharmacologie Maagdarmstelsel Tractus gastro-intestinal - Maladies - Immunologie Ziekten Adjuvants, Immunologic therapeutic use Gastrointestinal Diseases drug therapy Gastrointestinal system Gastrointestinal system Diseases Immunological aspects Immunity drug effects Gastrointestinaltrakt Immunpharmakologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005393145&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wallacejohnl immunopharmacologyofthegastrointestinalsystem |