Combined effects of drugs and toxic agents: modern evaluation in theory and practice
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Wien [u.a.]
Springer
1993
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. [151] - 161 |
| Physical Description: | XI, 167 S. zahlr. graph. Darst. |
| ISBN: | 3211824340 0387824340 |
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Record in the Search Index
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| adam_text | GERALD POCH COMBINED EFFECTS OF DRUGS AND TOXIC AGENTS MODERN EVALUATION
IN THEORY AND PRACTICE SPRINGER-VERLAG WIEN NEW YORK CONTENTS 1
PRINCIPLE CONSIDERATIONS OF DRUG ACTIONS AND INTERACTIONS 1 1.1
INTRODUCTION 1 1.2 DOSE-RESPONSE CURVES 4 1.2.1 THE PARAMETERS OF
DOSE-RESPONSE CURVES 4 1.2.2 MODELS AND CURVE-FITTING 7 1.2.3 COMPARISON
OF CURVES 7 1.3 TIME COURSE OF EFFECTS 8 1.4 PHENOMENA AND MECHANISMS:
INTERACTIONS BETWEEN DRUGS * ANTAGONISM AND SYNERGISM 8 1.4.1 SIMPLE
INTERACTIONS 9 1.4.2 COMPLEX INTERACTIONS 10 PHENOMENA 11 * MECHANISMS
OF INTERACTION 13 2 CONCEPTS AND MODELS OF INTERACTIONS - ADDITIVITY AND
INDEPENDENCE 15 2.1 CONCEPT AND PHENOMENON OF ADDITIVITY 15 2.1.1
HISTORICAL PERSPECTIVE 16 2.1.2 THE ISOBOLOGRAM 16 2.1.3 DOSE-RESPONSE
CURVES 18 2.1.4 MECHANISM UNDERLYING ADDITIVITY 19 2.1.5 ADDITIVE
DOSE-RESPONSE CURVES 24 2.1.6 COMPARISON OF EFFECT-ADDITIVE WITH
DOSE-ADDITIVE COMBINATIONS 27 2.2 SITE-DIRECTED ANALYSIS 28 2.3 CONCEPT
OF INDEPENDENCE 29 2.3.1 CALCULATION OF INDEPENDENT EFFECTS 30 2.3.2
INDEPENDENT DOSE-RESPONSE CURVES 31 2.4 RELATIONSHIP BETWEEN ADDITIVITY
AND INDEPENDENCE 34 2.4.1 DOSE-ADDITIVE AND INDEPENDENT COMBINATIONS 34
2.4.2 EFFECT-ADDITIVE AND INDEPENDENT COMBINATIONS 36 2.5 SUMMARY AND
CONCLUSIONS 36 2.6 TIPS AND HINTS 37 3 SYNERGISM/POTENTIATION AND
ANTAGONISM - PHENOMENA AND MECHANISMS 39 3.1 THE CURRENT DILEMMA 39
3.1.1 THE EFFECT APPROACH 40 3.1.2 THE DOSE APPROACH (EVALUATION OF
ISOBOLOGRAMS) 41 3.2 TOWARDS A UNIFORM CHARACTERIZATION OF
SYNERGISM/POTENTIATION AND ANTAGONISM 44 3.3 POTENTIATION (SYNERGISM) 44
3.3.1 NET EFFECTS 44 3.3.2 TOTAL EFFECTS 46 3.4 ANTAGONISM 49 3.4.1 THE
EFFECT APPROACH 49 3.4.2 THE DOSE APPROACH (EVALUATION OF
ISOBOLOGRAMS) 50 3.5 COMPARISON OF COMPLEX WITH SIMPLE INTERACTIONS 50
3.6 QUANTITATIVE EXPRESSION OF COMBINED EFFECTS 51 X CONTENTS 3.6.1 THE
COMBINATION INDEX (CI) 51 3.6.2 COMPARISON OF CI AND COMBINED-EFFECT
GRAPH 52 3.7 SUGGESTIONS FOR QUANTITATION OF COMBINED EFFECTS 52 3.8
TIPS AND HINTS 53 4 EVALUATION BY DOSE-RESPONSE CURVES 54 4.1 NEW
METHODOLOGICAL APPROACH: FIXED-DOSE STUDIES 56 4.1.1 CONSTRUCTION OF
EXPERIMENTAL AND THEORETICAL DOSE-RESPONSE CURVES 57 4.1.2 STATISTICAL
COMPARISON OF OBSERVED AND EXPECTED RESPONSE 58 CHI-SQUARE
GOODNESS-OF-FIT TEST 58 * F-TEST 59 4.1.3 EXPRESSION OF RESULTS AND
EXAMPLES 59 . 4.2 FIXED DOSE-RATIO COMBINATIONS 62 4.2.1 DOSE-ADDITIVE
INTERACTIONS 62 4.2.2 INDEPENDENT ACTIONS 65 4.2.3 MULTIPLE COMBINATIONS
65 4.3 TIPS AND HINTS 66 5 EVALUATION BY TIME-COURSE STUDIES 67 5.1 TIME
COURSE OF INDEPENDENT ACTIONS 67 5.2 DOSE-ADDITIVE TIME COURSE 68 5.3
STATISTICAL COMPARISON OF OBSERVED AND EXPECTED TIME COURSE 69 5.4
TIME-COURSE STUDIES WIDI LOG RESPONSE SCALE 72 5.5 COMPARISON OF
TIME-COURSE STUDIES AND DOSE-RESPONSE STUDIES 73 5.6 CONCLUSIONS 74 6
SINGLE-DOSE AND OTHER STUDIES 76 6.1 SINGLE-DOSE STUDIES 76 6.1.1
COMPARISON WITH EFFECT-ADDITIVE 76 6.1.2 COMPARISON WITH INDEPENDENCE 78
6.1.3 COMPARISON WITH ADDITIVITY 81 6.1.4 TIPS AND HINTS 82 6.2 OTHER
STUDIES 82 7 COMBINED-EFFECT GRAPH AND OTHER GRAPHS 83 7.1 THE
CONSTRUCTION OF THE COMBINED-EFFECT GRAPH 83 7.1.1 PERCENT OF MAXIMUM
RESPONSE 83 7.1.2 PERCENT OF CONTROL RESPONSE 84 7.2 COMPARISON OF
OBSERVED WITH INDEPENDENT EFFECTS 85 7.3 YONETANI*THEORELL PLOT FOR
ENZYME INHIBITORS 86 7.4 TIPS AND HINTS 88 8 APPLICATIONS OF THE NEW
APPROACH AND OBSERVATIONS 89 8.1 BIOCHEMISTRY AND
PHYSIOLOGY/PATHOPHYSIOLOGY 89 8.1.1 DUAL INHIBITION OF ENZYME ACTIVITY
89 8.1.2 PHYSIOLOGY 91 8.1.3 PATHOPHYSIOLOGY 92 8.2 EXPERIMENTAL
PHARMACOLOGY 93 8.2.1 DOSE-RESPONSE STUDIES: SITE OF ACTION 93 8.2.2
EXTENT OF ENHANCEMENT 95 8.2.3 UNSPECIFICALLY ACTING AGENTS IN
COMBINATION 97 8.3 CLINICAL PHARMACOLOGY * DRUG COMBINATIONS 97 8.3.1
DOSE-RESPONSE STUDIES 97 8.3.2 DRUG MIXTURES: DOSE-RESPONSE STUDIES 99
8.3.3 DRUG MIXTURES: TIME-COURSE STUDIES 100 8.3.4 SINGLE-DOSE STUDIES
100 CONTENTS XI 8.4 CHEMOTHERAPY OF INFECTIONS AND TUMORS 102 8.4.1
THERAPY OF INFECTIONS 103 8.4.2 TUMORTHERAPY 105 8.5 EXPERIMENTAL AND
ENVIRONMENTAL TOXICOLOGY 106 8.5.1 EXAMPLES OF TOXIC INTERACTIONS 108
8.6 EPIDEMIOLOGY - RISKS 112 8.7 HERBICIDES 113 8.8 CONCLUSIONS AND
DISCUSSION 113 8.8.1 METHODS 113 8.8.2 COMPARISON WITH MODEL
INTERACTIONS 115 9 A NEW AND CRITICAL VIEW OF ISOBOLOGRAMS 117 9.1
INAPPROPRIATE CONCLUSIONS 117 9.2 PITFALLS 119 10 COMPARISON OF THE NEW
WITH THE CONVENTIONAL APPROACH 122 10.1 EXPERIMENTAL DOSE-RESPONSE
CURVES AND ISOBOLOGRAMS 122 10.1.1 CONCURRING INTERPRETATION 123 10.1.2
DIFFERENT AND CONTROVERSIAL INTERPRETATION 124 ENVELOPE OF ADDITIVITY IN
ISOBOLOGRAMS 124 * NONCONSIDERATION AND INCORRECT CALCULATION OF
INDEPENDENCE 125 10.2 EVALUATION OF COMBINED EFFECTS IN THE FUTURE 129
EPILOG 130 APPENDIX A - GLOSSARY OF TERMS AND ABBREVIATIONS 132 APPENDIX
B - GUIDE TO PRACTICAL WORK: EXERCISE EXAMPLES 138 REFERENCES 151
SUBJECT INDEX 162
|
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-sort | 3615 47045 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| isbn | 3211824340 0387824340 |
| language | English |
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| spelling | Pöch, Gerald 1932- Verfasser (DE-588)172310393 aut Combined effects of drugs and toxic agents modern evaluation in theory and practice Gerald Pöch Wien [u.a.] Springer 1993 XI, 167 S. zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. [151] - 161 Geneesmiddeleninteracties gtt Interactions médicamenteuses Vergif gtt Drug Interactions Drug interactions Gift (DE-588)4021007-8 gnd rswk-swf Kombinationstherapie (DE-588)4194534-7 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Gift (DE-588)4021007-8 s Arzneimittel (DE-588)4003115-9 s Kombinationstherapie (DE-588)4194534-7 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005391607&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pöch, Gerald 1932- Combined effects of drugs and toxic agents modern evaluation in theory and practice Geneesmiddeleninteracties gtt Interactions médicamenteuses Vergif gtt Drug Interactions Drug interactions Gift (DE-588)4021007-8 gnd Kombinationstherapie (DE-588)4194534-7 gnd Arzneimittel (DE-588)4003115-9 gnd |
| subject_GND | (DE-588)4021007-8 (DE-588)4194534-7 (DE-588)4003115-9 |
| title | Combined effects of drugs and toxic agents modern evaluation in theory and practice |
| title_auth | Combined effects of drugs and toxic agents modern evaluation in theory and practice |
| title_exact_search | Combined effects of drugs and toxic agents modern evaluation in theory and practice |
| title_full | Combined effects of drugs and toxic agents modern evaluation in theory and practice Gerald Pöch |
| title_fullStr | Combined effects of drugs and toxic agents modern evaluation in theory and practice Gerald Pöch |
| title_full_unstemmed | Combined effects of drugs and toxic agents modern evaluation in theory and practice Gerald Pöch |
| title_short | Combined effects of drugs and toxic agents |
| title_sort | combined effects of drugs and toxic agents modern evaluation in theory and practice |
| title_sub | modern evaluation in theory and practice |
| topic | Geneesmiddeleninteracties gtt Interactions médicamenteuses Vergif gtt Drug Interactions Drug interactions Gift (DE-588)4021007-8 gnd Kombinationstherapie (DE-588)4194534-7 gnd Arzneimittel (DE-588)4003115-9 gnd |
| topic_facet | Geneesmiddeleninteracties Interactions médicamenteuses Vergif Drug Interactions Drug interactions Gift Kombinationstherapie Arzneimittel |
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