Animals and alternatives in toxicology: present status and future prospects
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York
VCH
1991
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IX, 390 S. graph. Darst. |
| ISBN: | 1560815116 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV007924892 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 930624s1991 d||| |||| 00||| eng d | ||
| 020 | |a 1560815116 |9 1-56081-511-6 | ||
| 035 | |a (OCoLC)22956178 | ||
| 035 | |a (DE-599)BVBBV007924892 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 050 | 0 | |a RA1199.4.A54 | |
| 082 | 0 | |a 615.9/0072 |2 20 | |
| 084 | |a WC 6300 |0 (DE-625)148126: |2 rvk | ||
| 245 | 1 | 0 | |a Animals and alternatives in toxicology |b present status and future prospects |c ed. by Michael Balls ... |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a New York |b VCH |c 1991 | |
| 300 | |a IX, 390 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Toxicité - Congrès | |
| 650 | 4 | |a Toxicologie - Modèles animaux - Congrès | |
| 650 | 4 | |a Alternative toxicity testing | |
| 650 | 4 | |a Animal Testing Alternatives |v Congresses | |
| 650 | 4 | |a Animals, Laboratory |v Congresses | |
| 650 | 4 | |a Research Design |v Congresses | |
| 650 | 4 | |a Toxicology |x Animal models |v Congresses | |
| 650 | 4 | |a Toxicology |x methods |v Congresses | |
| 650 | 0 | 7 | |a Tiere |0 (DE-588)4060087-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Toxikologie |0 (DE-588)4060538-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 1990 |z London |2 gnd-content | |
| 689 | 0 | 0 | |a Toxikologie |0 (DE-588)4060538-3 |D s |
| 689 | 0 | 1 | |a Tiere |0 (DE-588)4060087-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Balls, Michael |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005237272&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-005237272 | ||
Datensatz im Suchindex
| _version_ | 1804122331814035456 |
|---|---|
| adam_text | Animals and Alternatives
in Toxicology
Present Status and Future Prospects
Edited by
Michael Balls
Professor of Medical Cell Biology
University of Nottingham, UK
James Bridges
Professor of Toxicology
University of Surrey, Guildford, UK
Jacqueline Southee
Scientific Executive
FRAME, Nottingham, UK
FACHBEREICH BIOLOGIE (10)
der Technischea Hochschule Darmstadt
- Bibl iothek -
D-6100 Darmstadt ,
SdinfflspahnstraBe
M
MACMILLAN
PRESS
Scientific amp; Medical
Contents
Preface xi
1 The future for acute oral toxicity testing 1
D G Clark, R Fielder, C Joseph, J Gardner and M Smith
Introduction 1
Uses of acute toxicity data 2
Regulatory requirements 4
Alternative methods 5
Evaluation of alternative methods 8
The acceptance of alternatives 11
Recommendations 12
Acute toxicity testing, by D Straughan 13
Acute toxicity testing, by E Walum 15
Discussion 18
2 The current status of non-animal alternative methods in skin and
eye irritancy testing 23
D W Swanston, J G Black, P A Duffy and M A Pemberton
Introduction 23
Dermal irritancy 24
Photoirritancy (Phototoxicity) • 28
Ocular irritancy 29
Discussion 33
Conclusions 37
Recommendations 38
Irritancy testing, by J Teal 39
Irritancy testing, by A Walker 43
Discussion 46
vi Contents
3 Chronic toxicity testing: present perspectives and the way toward
shorter screening, decreased use of resources and better risk
assessment 53
P H Bach, A Cockburn, D J Esdaile, P Grasso and
C E Lumley
Introduction 53
Perspective: chronic testing as it is currently conducted 54
Rationalisation and harmonisation of chronic testing 59
The duration of chronic studies 63
Rationalising long-term and carcinogenicity study guidelines 66
Future areas for reduction of animals 70
Assessing chronic toxicity in vitro 72
Conclusions 74
Summary and recommendations 75
Long-term toxicity testing, by R Hey wood 77
Chronic toxicity testing, by M Chamberlain 80
Discussion 83
4 Genotoxicity testing 91
R C Garner
Introduction 91
Cancer screening using experimental animals 92
• Metabolic activation and electrophilic attack 93
Mutation tests 94
Other in vivo tests employed to detect genotoxicity 104
Future prospects 106
Conclusions 108
Recommendations 108
Genotoxicity testing, by R Carter 109
Genotoxicity testing, by S Venitt I l l
Discussion 115
5 Alternative methods and their application in neurotoxicity testing 121
C K Atterwill, M G Simpson, R J Evans, S L ^Allen and
D Ray
Introduction 121
In vitro techniques in relation to general neurotoxicology 122
In vitro systems: model systems, practical applications and
validation 128
Recommendations 134
Neurotoxicity testing, by S Iversen 135
Neurotoxicity testing, by R A Smith 142
Discussion 144
Appendix: Regulatory guidelines for neurotoxicity testing 150
Contents vii
6 Immunotoxicology and allergy: options for ex vivo and in vitro
experimentation 153
P Botham and I Kimber
Introduction 153
Immunotoxicology 153
_ Allergy 158
Conclusions 163
Immunotoxicology and in vitro pathways for cell-mediated
allergy, by W E Parish 164
Immunotoxicology, by K Miller 169
Discussion 172
7 The future of alternative approaches in reproductive toxicity
testing 177
P Duffy, S Freeman and D Newall
Introduction 177
Regulations and requirements for testing 177
Prescreens 181
Research 186
Alternative approaches in reproduction and development: time
for a fresh outlook, by N A Brown 189
Reproductive toxicology, by J Zijlstra 191
Discussion 195
8 Toxicity data derived from man 201
G Vplans, P Blain, P Bennett, C Berry, J Sims and
S Warrington
Introduction 201
Human volunteer studies 202
Surveillance schemes 206
Occupational and environmental toxicology—future
developments 209
Summary and recommendations 211
Human and clinical toxicology, by A Houston 213
Human and clinical toxicology, by D Ver e^^ 215
Discussion 217
9 Ecotoxicology 223
C H Walker, P W Greig-Smith, N O Crossland and R Brown
Introduction 223
Testing the environmental safety of pesticides 225
Testing of industrial chemicals 232
Summary 235
Recommendations 236
Ecotoxicology, by G Persoone 237
viii Contents
Ecotoxicology, by D Osborn and M C French 242
Discussion 246
10 Computer modelling and information technology 253
D Bawden, M S TuteandJ C Dearden
-Introduction 253
Techniques for establishing models 256
Databases and information technology 271
Conclusions and recommendations 275
Computers and mathematical modelling, by D Lewis 276
Computers and mathematical modelling, by D Livingstone 278
Discussion 280
11 The development, validation and acceptance of in vitro toxicity
tests 291
M Balls, C A Reinhardt, H Spielmann and E Walum
Introduction 291
The evolution of alternative methods 292
Development 293
Validation 294
Acceptance 296
Summary 299
Recommendations 300
Validation, by J Parry 301
Validation, by M Roberfroid 304
Discussion 307
12 Future developments in in vitro methodology 313
M Balls, M Garle and R Clothier
Introduction 313
Culture media and culture methods 315
Cell immortalisation and gene manipulation 317
Metabolism 319
Reactive metabolites and toxicity 322
Strategies for the integrated use of in vitro methods and other
alternatives 325
Summary 328
Recommendations 329
Current and future developments in in vitro toxicology, by
P S Goldfarb 330
Discussion 332
13 Concluding remarks 341
A McLean
Contents ix
Appendix Report of the FRAME Toxicity Committee 1990 345
The participants ; 376
Index 381
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV007924892 |
| callnumber-first | R - Medicine |
| callnumber-label | RA1199 |
| callnumber-raw | RA1199.4.A54 |
| callnumber-search | RA1199.4.A54 |
| callnumber-sort | RA 41199.4 A54 |
| callnumber-subject | RA - Public Medicine |
| classification_rvk | WC 6300 |
| ctrlnum | (OCoLC)22956178 (DE-599)BVBBV007924892 |
| dewey-full | 615.9/0072 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.9/0072 |
| dewey-search | 615.9/0072 |
| dewey-sort | 3615.9 272 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 1. publ. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01826nam a2200481 c 4500</leader><controlfield tag="001">BV007924892</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">930624s1991 d||| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1560815116</subfield><subfield code="9">1-56081-511-6</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)22956178</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV007924892</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RA1199.4.A54</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.9/0072</subfield><subfield code="2">20</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 6300</subfield><subfield code="0">(DE-625)148126:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Animals and alternatives in toxicology</subfield><subfield code="b">present status and future prospects</subfield><subfield code="c">ed. by Michael Balls ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. publ.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">New York</subfield><subfield code="b">VCH</subfield><subfield code="c">1991</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">IX, 390 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicité - Congrès</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicologie - Modèles animaux - Congrès</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Alternative toxicity testing</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Animal Testing Alternatives</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Animals, Laboratory</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Research Design</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield><subfield code="x">Animal models</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Toxicology</subfield><subfield code="x">methods</subfield><subfield code="v">Congresses</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Tiere</subfield><subfield code="0">(DE-588)4060087-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)1071861417</subfield><subfield code="a">Konferenzschrift</subfield><subfield code="y">1990</subfield><subfield code="z">London</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Tiere</subfield><subfield code="0">(DE-588)4060087-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Balls, Michael</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005237272&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-005237272</subfield></datafield></record></collection> |
| genre | (DE-588)1071861417 Konferenzschrift 1990 London gnd-content |
| genre_facet | Konferenzschrift 1990 London |
| id | DE-604.BV007924892 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:12:11Z |
| institution | BVB |
| isbn | 1560815116 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-005237272 |
| oclc_num | 22956178 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | IX, 390 S. graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | VCH |
| record_format | marc |
| spelling | Animals and alternatives in toxicology present status and future prospects ed. by Michael Balls ... 1. publ. New York VCH 1991 IX, 390 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Toxicité - Congrès Toxicologie - Modèles animaux - Congrès Alternative toxicity testing Animal Testing Alternatives Congresses Animals, Laboratory Congresses Research Design Congresses Toxicology Animal models Congresses Toxicology methods Congresses Tiere (DE-588)4060087-7 gnd rswk-swf Toxikologie (DE-588)4060538-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1990 London gnd-content Toxikologie (DE-588)4060538-3 s Tiere (DE-588)4060087-7 s DE-604 Balls, Michael Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005237272&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Animals and alternatives in toxicology present status and future prospects Toxicité - Congrès Toxicologie - Modèles animaux - Congrès Alternative toxicity testing Animal Testing Alternatives Congresses Animals, Laboratory Congresses Research Design Congresses Toxicology Animal models Congresses Toxicology methods Congresses Tiere (DE-588)4060087-7 gnd Toxikologie (DE-588)4060538-3 gnd |
| subject_GND | (DE-588)4060087-7 (DE-588)4060538-3 (DE-588)1071861417 |
| title | Animals and alternatives in toxicology present status and future prospects |
| title_auth | Animals and alternatives in toxicology present status and future prospects |
| title_exact_search | Animals and alternatives in toxicology present status and future prospects |
| title_full | Animals and alternatives in toxicology present status and future prospects ed. by Michael Balls ... |
| title_fullStr | Animals and alternatives in toxicology present status and future prospects ed. by Michael Balls ... |
| title_full_unstemmed | Animals and alternatives in toxicology present status and future prospects ed. by Michael Balls ... |
| title_short | Animals and alternatives in toxicology |
| title_sort | animals and alternatives in toxicology present status and future prospects |
| title_sub | present status and future prospects |
| topic | Toxicité - Congrès Toxicologie - Modèles animaux - Congrès Alternative toxicity testing Animal Testing Alternatives Congresses Animals, Laboratory Congresses Research Design Congresses Toxicology Animal models Congresses Toxicology methods Congresses Tiere (DE-588)4060087-7 gnd Toxikologie (DE-588)4060538-3 gnd |
| topic_facet | Toxicité - Congrès Toxicologie - Modèles animaux - Congrès Alternative toxicity testing Animal Testing Alternatives Congresses Animals, Laboratory Congresses Research Design Congresses Toxicology Animal models Congresses Toxicology methods Congresses Tiere Toxikologie Konferenzschrift 1990 London |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005237272&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ballsmichael animalsandalternativesintoxicologypresentstatusandfutureprospects |