Protein pharmacokinetics and metabolism:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Plenum Press
1992
|
| Schriftenreihe: | Pharmaceutical biotechnology
1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 275 S. graph. Darst. |
| ISBN: | 0306441519 |
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Datensatz im Suchindex
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|---|---|
| adam_text | CV PROTEIN PHARMACOKINETICS AND METABOLISM EDITED BY BOBBE L. FERRAIOLO
R. W. JOHNSON PHARMACEUTICAL RESEARCH INSTITUTE SPRING HOUSE,
PENNSYLVANIA MARJORIE A. MOHLER GENENTECH, INC. SOUTH SAN FRANCISCO,
CALIFORNIA AND CAROL A. GLOFF ALKERMES, INC. CAMBRIDGE, MASSACHUSETTS
PLENUM PRESS * NEW YORK AND LONDON CONTENTS CHAPTER 1 GOALS AND
ANALYTICAL METHODOLOGIES FOR PROTEIN DISPOSITION STUDIES BOBBE L.
FERRAIOLO AND MARJORIE A. MOHLER 1. INTRODUCTION 1 2. GOALS OF PROTEIN
DISPOSITION STUDIES 1 2.1. FATE OF INTACT DRUG 2 2.2.
PHARMACOKINETIC/PHARMACODYNAMIC CORRELATIONS 2 2.3. REGIMEN-DEPENDENT
EFFECTS 3 2.4. BINDING PROTEINS 3 2.5. CATABOLISM OF PROTEIN
THERAPEUTICS 5 2.6. DRUG-DRUG INTERACTIONS 7 2.7. INTERSPECIES SCALING 8
3. METHODS 8 3.1. IMMUNOASSAYS 9 3.2. BIOASSAYS 14 3.3. RADIOLABELS 14
3.4. OTHER ANALYTICAL METHODS 19 4. FUTURE DIRECTIONS 20 REFERENCES 21
CHAPTER 2 BINDING PROTEINS OF PROTEIN THERAPEUTICS MARJORIE A. MOHLER,
JENNIFER E. COOK, AND GERHARD BAUMANN II CONTENTS 1. HUMAN INSULINLIKE
GROWTH FACTOR-I 35 1.1. STRUCTURE 36 1.2. ACTIONS 36 1.3. REGULATION 37
1.4. INSULINLIKE GROWTH FACTOR BINDING PROTEINS 38 2. HUMAN GROWTH
HORMONE 44 2.1. HIGH-AFFINITY GROWTH HORMONE-BINDING PROTEIN 45 2.2.
LOW-AFFINITY GROWTH HORMONE-BINDING PROTEIN 51 3. HUMAN TISSUE
PLASMINOGEN ACTIVATOR 53 3.1. STRUCTURE AND FUNCTION 54 3.2. METABOLISM
AND PHARMACOKINETICS OF RT-PA 54 3.3. PROTEASE INHIBITORS 55 REFERENCES
59 CHAPTER 3 POTENTIAL EFFECTS OF ANTIBODY INDUCTION BY PROTEIN DRUGS
PETER K. WORKING 1. INTRODUCTION 73 2. ANTIBODIES TO RECOMBINANT
PROTEINS 74 2.1. WHAT ARE NEUTRALIZING ANTIBODIES? 74 2.2. DETECTION OF
ANTIBODIES 74 2.3. REAL-LIFE EFFECTS OF NEUTRALIZING ANTIBODIES 75 3.
FACTORS CONTRIBUTING TO IMMUNOGENICITY 76 3.1. PRIMARY STRUCTURE 77 3.2.
TERTIARY STRUCTURE 77 3.3. STRUCTURAL COMPLEXITY 78 4. EFFECTS OF STUDY
DESIGN 78 4.1. ROUTE OF ADMINISTRATION 79 4.2. DOSING CONSIDERATIONS 79
4.3. GENETIC CONSIDERATIONS 80 4.4. THE EFFECT OF DISEASE ON ANTIBODY
INDUCTION 81 4.5. MISCELLANEOUS EFFECTS 81 5. EFFECTS OF ANTIBODIES ON
STUDIES WITH PROTEIN DRUGS 82 5.1. DIRECT NULLIFICATION OF DRUG ACTION
83 5.2. INTERFERENCE WITH PHARMACOKINETICS 84 5.3. IMMUNE COMPLEX
REACTIONS 87 6. OVERVIEW 87 REFERENCES 88 CONTENTS XIII CHAPTER 4
PHARMACOKINETICS AND METABOLISM OF PROTEIN HORMONES JEROME A. MOORE AND
VICTOR J. WROBLEWSKI 1. INTRODUCTION 93 2. HUMAN INSULIN 94 2.1.
PHARMACOKINETICS 94 2.2. METABOLISM 95 3. RELAXIN 98 3.1. BACKGROUND 98
3.2. METABOLISM 98 3.3. PHARMACOKINETICS 98 3.4. TISSUE DISTRIBUTION 101
3.5. SUMMARY 101 4. HUMAN PROINSULIN 102 4.1. BACKGROUND 102 4.2.
METABOLISM 102 5. GROWTH HORMONE AND PROLACTIN 103 5.1. GROWTH HORMONE
BACKGROUND 103 5.2. GROWTH HORMONE PHARMACOKINETICS 105 5.3. SPECIES
SCALING OF GROWTH HORMONE PHARMACOKINETICS 106 5.4. METABOLISM OF GROWTH
HORMONE AND PROLACTIN 107 6. PARATHYROID HORMONE 110 6.1. BACKGROUND 110
6.2. PHARMACOKINETICS 110 6.3. METABOLISM ILL 7. ATRIAL NATRIURETIC
FACTOR 113 7.1. BACKGROUND 113 7.2. PHARMACOKINETICS 114 7.3. METABOLISM
114 8. OVERVIEW 115 REFERENCES 117 CHAPTER 5 PHARMACOKINETICS AND
METABOLISM OF THERAPEUTIC CYTOKINES CAROL A. GLOFF AND ROBERT J. WILLS
1. TUMOR NECROSIS FACTOR 127 1.1. CHEMISTRY 128 XIV CONTENTS 1.2.
ANALYTICAL TECHNIQUES 128 1.3. PHARMACOKINETICS 128 2. INTERFERONS 133
2.1. CHEMISTRY 133 2.2. ANALYTICAL CONSIDERATIONS 135 2.3.
PHARMACOKINETICS 135 REFERENCES 142 CHAPTER 6 PHARMACOKINETICS AND
METABOLISM OF CARDIOVASCULAR THERAPEUTIC PROTEINS PAUL A. COSSUM AND
ROBERT A. BAUGHMAN, JR. 1. PROTEINS OF THE BLOOD COAGULATION PATHWAY 151
2. FACTOR VIII 153 2.1. BACKGROUND 153 2.2. ENDOGENOUS DISTRIBUTION 153
2.3. PHARMACOKINETICS 154 2.4. METABOLISM 156 2.5. ANTIBODIES 157 3.
FACTOR IX 158 3.1. BACKGROUND 158 3.2. PHARMACOKINETICS 158 3.3.
METABOLISM 160 3.4. ANTIBODIES 160 4. FACTOR VH/VIIA 161 4.1. BACKGROUND
161 4.2. PHARMACOKINETICS 161 5. FACTOR XIII 162 5.1. BACKGROUND 162
5.2. PHARMACOKINETICS 163 6. TISSUE FACTOR (FACTOR III) 163 6.1.
BACKGROUND 163 6.2. PHARMACOKINETICS 164 6.3. METABOLISM/INACTIVATION
164 7. FIBRINOLYTIC THERAPEUTIC PROTEINS 165 8. TISSUE PLASMINOGEN
ACTIVATOR 166 8.1. BACKGROUND 166 8.2. ANALYTICAL ISSUES 167 CONTENTS XV
8.3. PHARMACOKINETICS 167 8.4. METABOLISM 172 9. STREPTOKINASE AND
ANISOYLATED STREPTOKINASE 173 9.1. BACKGROUND 173 9.2. PHARMACOKINETICS
174 10. UROKINASE AND SINGLE-CHAIN UROKINASE 175 10.1. BACKGROUND 175
10.2. PHARMACOKINETICS 176 11. CONCLUSIONS 177 REFERENCES 178 CHAPTER 7
PHARMACOKINETICS AND METABOLISM OF HEMATOPOIETIC PROTEINS JOHN B.
STOUDEMIRE 1. INTRODUCTION 189 2. ERYTHROPOIETIN 191 2.1. EPO
PRECLINICAL PHARMACOKINETICS 192 2.2. EPO CLINICAL PHARMACOKINETICS 197
3. GRANULOCYTE-COLONY STIMULATING FACTOR 201 4. GRANULOCYTE
MACROPHAGE-COLONY STIMULATING FACTOR 204 4.1. GM-CSF PRECLINICAL
PHARMACOKINETICS 204 4.2. GM-CSF CLINICAL PHARMACOKINETICS 206 5.
MACROPHAGE-COLONY STIMULATING FACTOR 208 6. CONCLUSIONS 212 REFERENCES
213 CHAPTER 8 PHARMACOKINETICS AND METABOLISM OF THERAPEUTIC AND
DIAGNOSTIC ANTIBODIES JOHN M. TRANG 1. INTRODUCTION 223 1-1. BACKGROUND
223 1.2. OVERVIEW OF IMMUNOGLOBULINS * 2. PHARMACOKINETICS AND
METABOLISM OF MURINE ANTIBODIES 227 2.1. MURINE NATIVE AND
RADIOIMMUNOCONJUGATE ANTIBODIES 227 AND FRAGMENTS XVI CONTENTS 2.2.
MURINE CHEMOIMMUNOCONJUGATE ANTIBODIES AND FRAGMENTS 236 2.3. MURINE
IMMUNOTOXIN ANTIBODIES AND FRAGMENTS 240 3. PHARMACOKINETICS AND
METABOLISM OF NONMURINE, HUMAN, AND CHIMERIC ANTIBODIES 247 3.1.
NONMURINE POLYCLONAL ANTIBODIES 247 3.2. HUMAN ANTIBODIES AND FRAGMENTS
251 3.3. CHIMERIC ANTIBODIES AND FRAGMENTS 255 4. CONCLUSIONS 260 4.1.
SUMMARY OF ANTIBODY PHARMACOKINETICS 260 4.2. FACTORS INFLUENCING
ANTIBODY PHARMACOKINETICS 261 4.3. LIMITATIONS OF MONOCLONAL ANTIBODY
APPLICATIONS IN DIAGNOSIS AND THERAPY 262 4.4. RECOMMENDATIONS FOR
FUTURE STUDY 263 REFERENCES 264 INDEX 271
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| indexdate | 2024-07-09T17:08:43Z |
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| isbn | 0306441519 |
| language | English |
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| series | Pharmaceutical biotechnology |
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| spelling | Protein pharmacokinetics and metabolism ed. by Bobbe L. Ferraiolo ... New York u.a. Plenum Press 1992 XVI, 275 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmaceutical biotechnology 1 Eiwitten gtt Farmacokinetica gtt Protéines - Métabolisme Protéines - Pharmacocinétique Stofwisseling gtt Protein drugs Pharmacokinetics Proteins Metabolism Proteins metabolism Proteins pharmacokinetics Proteine (DE-588)4076388-2 gnd rswk-swf Proteinstoffwechsel (DE-588)4014135-4 gnd rswk-swf Pharmakokinetik (DE-588)4115557-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteine (DE-588)4076388-2 s Pharmakokinetik (DE-588)4115557-9 s DE-604 Proteinstoffwechsel (DE-588)4014135-4 s Ferraiolo, Bobbe L. Sonstige oth Pharmaceutical biotechnology 1 (DE-604)BV007730074 1 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005089588&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Protein pharmacokinetics and metabolism Pharmaceutical biotechnology Eiwitten gtt Farmacokinetica gtt Protéines - Métabolisme Protéines - Pharmacocinétique Stofwisseling gtt Protein drugs Pharmacokinetics Proteins Metabolism Proteins metabolism Proteins pharmacokinetics Proteine (DE-588)4076388-2 gnd Proteinstoffwechsel (DE-588)4014135-4 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| subject_GND | (DE-588)4076388-2 (DE-588)4014135-4 (DE-588)4115557-9 (DE-588)4143413-4 |
| title | Protein pharmacokinetics and metabolism |
| title_auth | Protein pharmacokinetics and metabolism |
| title_exact_search | Protein pharmacokinetics and metabolism |
| title_full | Protein pharmacokinetics and metabolism ed. by Bobbe L. Ferraiolo ... |
| title_fullStr | Protein pharmacokinetics and metabolism ed. by Bobbe L. Ferraiolo ... |
| title_full_unstemmed | Protein pharmacokinetics and metabolism ed. by Bobbe L. Ferraiolo ... |
| title_short | Protein pharmacokinetics and metabolism |
| title_sort | protein pharmacokinetics and metabolism |
| topic | Eiwitten gtt Farmacokinetica gtt Protéines - Métabolisme Protéines - Pharmacocinétique Stofwisseling gtt Protein drugs Pharmacokinetics Proteins Metabolism Proteins metabolism Proteins pharmacokinetics Proteine (DE-588)4076388-2 gnd Proteinstoffwechsel (DE-588)4014135-4 gnd Pharmakokinetik (DE-588)4115557-9 gnd |
| topic_facet | Eiwitten Farmacokinetica Protéines - Métabolisme Protéines - Pharmacocinétique Stofwisseling Protein drugs Pharmacokinetics Proteins Metabolism Proteins metabolism Proteins pharmacokinetics Proteine Proteinstoffwechsel Pharmakokinetik Aufsatzsammlung |
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