Essential immunology:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Blackwell
1991
|
| Edition: | 7. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 356 S. Ill., graph. Darst. |
| ISBN: | 0632028777 |
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| 245 | 1 | 0 | |a Essential immunology |c Ivan M. Roitt |
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
PREFACE, IX ACKNOWLEDGEMENTS, XI USER GUIDE, XII 1 THE BASIS OF
IMMUNOLOGY I-INNATE IMMUNITY BARRIERS AGAINST INFECTION, 2 PHAGOCYTIC
CELLS KILL MICRO-ORGANISMS, 2 COMPLEMENT FACILITATES PHAGOCYTOSIS, 6 THE
COMPLEMENT-MEDIATED ACUTE INFLAMMATORY REACTION, 11 HUMORAL MECHANISMS
PROVIDE A SECOND DEFENSIVE STRATEGY, 13 EXTRACELLULAR KILLING, 14 2 THE
BASIS OF IMMUNOLOGY II-SPECIFIC ACQUIRED IMMUNITY THE NEED FOR SPECIFIC
IMMUNE MECHANISMS, 17 ANTIBODY-THE SPECIFIC ADAPTOR, 17 CELLULAR BASIS
OF ANTIBODY PRODUCTION, 20 ACQUIRED MEMORY, 24 THE SPECIFICITY OF
ACQUIRED IMMUNITY, 26 VACCINATION, 26 CELL-MEDIATED IMMUNITY PROTECTS
AGAINST INTRACELLULAR ORGANISMS, 28 IMMUNOPATHOLOGY, 29 SUMMARY, 29
FURTHER READING, 32 3 MOLECULES WHICH RECOGNIZE
ANTIGEN
THE IMMUNOGLOBULINS, 35 THE BASIC STRUCTURE IS A FOUR-PEPTIDE UNIT, 35
AMINO ACID SEQUENCES REVEAL VARIATIONS IN IMMUNOGLOBULIN STRUCTURE, 36
IMMUNOGLOBULINS ARE FOLDED INTO GLOBULAR DOMAINS WHICH
SUBSERVE DIFFERENT FUNCTIONS, 40 IMMUNOGLOBULIN CLASSES AND SUBCLASSES,
45 THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC), 51 CLASS I AND CLASS II
MOLECULES ARE MEMBRANE-BOUND
HETERODIMERS, 51 COMPLEMENT GENES CONTRIBUTE TO THE REMAINING CLASS III
REGION OF THE MHC, 51 GENE MAP OF THE MAJOR HISTOCOMPATIBILITY COMPLEX,
51 THE GENES OF THE MHC DISPLAY REMARKABLE POLYMORPHISM, 51
INHERITANCE OF THE MHC, 56 THE TISSUE DISTRIBUTION OF MHC MOLECULES, 56
MHC FUNCTIONS, 56 THE T-CELL RECEPTOR, 56 THE GENERATION OF DIVERSITY
FOR ANTIGEN RECOGNITION, 58 MULTIPLE GENE SEGMENTS CODE FOR ANTIBODY, 58
A SIMILAR PATTERN OF GENES CODES FOR THE T-CELL RECEPTOR, 59 THE
MECHANISMS WHICH GENERATE TREMENDOUS DIVERSITY FROM
LIMITED GENE POOLS, 59 SUMMARY, 62 FURTHER READING, 64
4 * THE RECOGNITION OF ANTIGEN
I-PRIMARY INTERACTION
WHAT IS AN ANTIGEN?, 65 OF EPITOPES AND ANTIGEN DETERMINANTS, 65
IMAGE 2
ANTIGENS AND ANTIBODIES INTERACT BY SPATIAL COMPLEMENTARITY
NOT BY COVALENT BONDING, 66 THE FORCES BINDING ANTIGEN TO ANTIBODY
BECOME LARGE AS INTERMOLECULAR DISTANCES BECOME SMALL, 68 THE AFFINITY
OR STRENGTH OF BINDING OF ANTIGEN AND
ANTIBODY, 71
THE AVIDITY OF ANTISERUM FOR ANTIGEN - THE BONUS EFFECT OF MULTIVALENCY,
72 THE SPECIFICITY OF ANTIGEN RECOGNITION BY ANTIBODY IS NOT ABSOLUTE,
74
WHAT THE T-CELL SEES, 74 FEATURES ASSOCIATED WITH ANTIGENICITY, 81
SUMMARY, 82
FURTHER READING, 83
5 THE RECOGNITION OF ANTIGEN
II-DETECTION AND APPLICATION
PRECIPITATION, 85 AGGLUTINATION BY ANTIBODY, 91 PURIFICATION OF ANTIGENS
A ND ANTIBODIES BY AFFINITY CHROMATOGRAPHY, 92 IMMUNOASSAY OF ANTIGEN A
ND ANTIBODY WITH LABELLED VI REAGENTS, 93
IMMUNOBLOTTING (WESTERN BTOTS), 96 IMMUNOHISTOCHEMISTRY - LOCALIZATION
OF ANTIGENS IN CELLS A ND TISSUES, 96 CELL SEPARATION TECHNIQUES, 101
NEUTRALIZATION OF BIOLOGICAL ACTIVITY, 102 SUMMARY, 103 FURTHER READING,
103
6 THE ACQUIRED IMMUNE
RESPONSE I - CONSEQUENCES OF ANTIGEN RECOGNITION
WHERE DOES IT ALL HAPPEN? - THE ANATOMY OF THE IMMUNE RESPONSE, 105
LYMPHOCYTES TRAFFIC BETWEEN LYMPHOID TISSUES, 106 LYMPH NODE, 107
SPLEEN, 110 MUCOSAL-ASSOCIATED LYMPHOID TISSUE, 110
BONE MARROW CAN BE A MAJOR SITE OF ANTIBODY SYNTHESIS, 112 THE HANDLING
OF ANTIGEN, 113 THE ACTIVATION OF T-CELLS, 115 THE SURFACE MARKERS OF
CELLS IN THE IMMUNE SYSTEM, 115 IMMUNOCOMPETENT T- AND B-CELLS DIFFER IN
MANY
RESPECTS, 116
THE ACTIVATION OF T-CELLS REQUIRES TWO SIGNALS, 117 ACCESSORY MOLECULES
PLAY A ROLE IN T-CELL ACTIVATION, 118 T-CELL SIGNALLING IS REGULATED BY
PROTEIN TYROSINE PHOSPHORYLATION, 120 THE ACTIVATION OF B-CELLS, 120
B-CELLS RESPOND TO THREE DIFFERENT TYPES OF ANTIGEN, 120 THE NATURE OF
B-CELL ACTIVATION, 122
CLONAL EXPANSION IS ACHIEVED BY T-CELL SOLUBLE FACTORS, 123
FURTHER T-CELL FACTORS BRING ABOUT MATURATION OF EFFECTOR CELLS, 124
WHAT IS GOING ON IN THE GERMINAL CENTRE?, 125 SUMMARY, 127 FURTHER
READING, 127
7 THE ACQUIRED IMMUNE
RESPONSE II - PRODUCTION OF EFFECTORS
THE SYNTHESIS OF HUMORAL ANTIBODY, 129 DETECTION AND ENUMERATION OF
ANTIBODY-FORMING CELLS, 129 PROTEIN SYNTHESIS, 129 CLASS SWITCHING
OCCURS IN INDIVIDUAL B-CELLS, 130 IS THE SPECIFICITY OF ANTIBODY
SECRETED BY THE PROGENY THE
SAME AS THAT OF THE SURFACE IMMUNOGLOBULIN OF THE CLONAL PARENT?, 134
ANTIBODY AFFINITY, 135 THE MONOCLONAL ANTIBODY REVOLUTION, 136
CELL-MEDIATED IMMUNITY HAS TWO ARMS, 140 LYMPHOKINES ARE PART OF A
COMPLEX CYTOKINE NETWORK, 141 CYTOKINES CONTROL HAEMOPOIESIS, 144
CYTOKINE FUNCTION IN THE ADAPTIVE IMMUNE RESPONSE, 144 CYTOKINES MEDIATE
CHRONIC INFLAMMATORY RESPONSES, 146 KILLER T-CELLS, 147 MEMORY CELLS,
148
SUMMARY, 150 FURTHER READING, 151
8 * THE ACQUIRED IMMUNE
RESPONSE III-CONTROL
ANTIGEN IS A MAJOR FACTOR IN CONTROL, 153 ANTIBODY EXERTS FEEDBACK
CONTROL, 153 T-CELL REGULATION, 154 IDIOTYPE NETWORKS, 159 THE INFLUENCE
OF GENETIC FACTORS, 164
ARE THERE REGULATORY IMMUNO-NEUROENDOCRINE NETWORKS?, 168 EFFECTS OF
DIET, EXERCISE, TRAUMA AND AGE ON IMMUNITY, 169 SUMMARY, 171 FURTHER
READING, 171
9 * THE ACQUIRED IMMUNE
RESPONSE IV - DEVELOPMENT
T-CELL DEVELOPMENT, 173 THE MULTIPOTENTIAL HAEMOPOIETIC STEM CELL GIVES
RISE TO THE FORMED ELEMENTS OF THE BLOOD, 173 THE THYMUS PROVIDES THE
ENVIRONMENT FOR T-CELL
DIFFERENTIATION, 173
CONTENTS
IMAGE 3
FT-
BONE MARROW STEM CELLS BECOME IMMUNOCOMPETENT T-CELLS IN THE THYMUS, 175
DIFFERENTIATION IS ACCOMPANIED BY CHANGES IN SURFACE MARKERS, 176
CELLS ARE POSITIVELY SELECTED FOR SELF-MHC RESTRICTION IN THE THYMUS,
178 THE INDUCTION OF IMMUNOLOGICAL TOLERANCE IS NECESSARY TO AVOID
SELF-REACTIVITY, 179
INDUCTION OF SELF-TOLERANCE IN THE THYMUS, 181 B-CELL DEVELOPMENT, 183
B-CELLS DIFFERENTIATE IN THE FETAL LIVER AND THEN IN BONE MARROW, 183
PHENOTYPIC CHANGES IN DIFFERENTIATING B-CELLS, 183 THE SEQUENCE OF
IMMUNOGLOBULIN GENE REARRANGEMENTS, 184 THE INDUCTION OF TOLERANCE IN
B-LYMPHOCYTES, 185 THE OVERALL RESPONSE IN THE NEONATE, 187
UNREGULATED DEVELOPMENT GIVES RISE TO LYMPHOPROLIFERATIVE DISORDERS, 188
DEREGULATION OF THE C-MYC PROTO-ONCOGENE IS A CHARACTERISTIC FEATURE OF
MANY B-CELL TUMOURS, 188 CHROMOSOME TRANSLOCATIONS ARE COMMON IN
LYMPHOPROLIFERATIVE DISORDERS, 189 DIFFERENT LYMPHOID MALIGNANCIES SHOW
MATURATION ARREST AT CHARACTERISTIC STAGES IN DIFFERENTIATION, 190
IMMUNOHISTOLOGICAL DIAGNOSIS OF LYMPHOID NEOPLASIAS, 191 PLASMA CELL
DYSCRASIAS, 194 IMMUNODEFICIENCY SECONDARY TO LYMPHOPROLIFERATIVE
DISORDERS, 195 THE EVOLUTION OF THE IMMUNE RESPONSE, 196 RECOGNITION OF
SELF IS FUNDAMENTAL FOR MULTICELLULAR ORGANISMS, 196 INVERTEBRATES HAVE
HUMORAL DEFENCE MECHANISMS, 196 B- AND T-CELL RESPONSES ARE WELL DEFINED
IN THE
VERTEBRATES, 196 THE EVOLUTION OF DISTINCT B- AND T-CELL LINEAGES WAS
ACCOMPANIED BY THE DEVELOPMENT OF SEPARATE SITES FOR DIFFERENTIATION,
198 CELLULAR RECOGNITION MOLECULES EXPLOIT GENE
SUPERFAMILIES, 198 SUMMARY, 200 FURTHER READING, 201
10 IMMUNITY TO INFECTION
I-ADVERSARIAL STRATEGIES
EXTRACELLULAR BACTERIA SUSCEPTIBLE TO KILLING BY PHAGOCYTOSIS AND
COMPLEMENT, 203 BACTERIAL STRATEGIES TO AVOID DEATH, 203 THE HOST
COUNTER-ATTACK, 204
SOME SPECIFIC EXAMPLES, 207 BACTERIA WHICH GROW IN AN INTRACELLULAR
HABITAT, 208 BACTERIAL GAMBITS, 208
DEFENCE IS BY CELL-MEDIATED IMMUNITY (CMI), 209 ACTIVATED MACROPHAGES
KILL INTRACELLULAR PARASITES, 210 IMMUNITY TO VIRAL INFECTION, 212
ANTIGENIC DRIFT AND SHIFT, 213
PLAYING GAMES WITH THE COMPLEMENT SYSTEM, 213 PROTECTION BY SERUM
ANTIBODY, 214 LOCAL FACTORS, 214 CELL-MEDIATED IMMUNITY GETS TO THE
INTRACELLULAR VIRUS, 214
IMMUNITY TO PARASITIC INFECTIONS, 216 THE HOST RESPONSES, 216 EVASIVE
STRATEGIES BY THE PARASITE, 219 IMMUNOPATHOLOGY, 221
SUMMARY, 221 FURTHER READING, 223
11 IMMUNITY TO INFECTION
II-PROPHYLAXIS AND IMMUNODEFICIENCY
PASSIVELY ACQUIRED IMMUNITY, 225 MATERNALLY ACQUIRED ANTIBODY, 225
POOLED HUMAN *-GLOBULIN, 225 CULTURED ANTIBODIES MADE TO ORDER, 226
VACCINATION, 226 HERD IMMUNITY, 226
STRATEGIC CONSIDERATIONS, 226 KILLED ORGANISMS AS VACCINES, 227 LIVE
ATTENUATED ORGANISMS HAVE MANY ADVANTAGES AS VACCINES, 228
VACCINES CONTAINING INDIVIDUAL PROTECTIVE ANTIGENS, 231 ADJUVANTS, 237
NEW APPROACHES TO THE PRESENTATION OF ANTIGEN, 238 PRIMARY
IMMUNODEFICIENCY STATES IN THE HUMAN, 239 DEFICIENCIES OF INNATE IMMUNE
MECHANISMS, 239 B-CELL DEFICIENCY, 240 T-CELL DEFICIENCY, 242 COMBINED
IMMUNODEFICIENCY, 243 RECOGNITION OF IMMUNODEFICIENCIES, 244
SECONDARY IMMUNODEFICIENCY, 244 ACQUIRED IMMUNODEFICIENCY SYNDROME
(AIDS), 245 SUMMARY, 251 FURTHER READING, 252
12 * HYPERSENSITIVITY
AN INAPPROPRIATE IMMUNE RESPONSE CAN LEAD TO TISSUE DAMAGE, 253 TYPE I -
ANAPHYLACTIC HYPERSENSITIVITY, 253 THE PHENOMENON OF ANAPHYLAXIS, 253
CROSS-LINKING OF IGE RECEPTORS TRIGGERS MAST CELLS, 253 ATOPIC ALLERGY,
255 TYPE II - ANTIBODY-DEPENDENT CYTOTOXIC HYPERSENSITIVITY, 260 TYPE II
REACTIONS BETWEEN MEMBERS OF THE SAME SPECIES
(ISOIMMUNE), 261 AUTOIMMUNE TYPE II HYPERSENSITIVITY REACTIONS, 263 TYPE
II DRUG REACTIONS, 263 TYPE III - IMMUNE-COMPLEX-MEDIATED
HYPERSENSITIVITY, 264 INFLAMMATORY LESIONS DUE TO LOCALLY FORMED
COMPLEXES, 265 DISEASE RESULTING FROM CIRCULATING COMPLEXES, 266
DETECTION OF IMMUNE COMPLEX FORMATION, 269 TREATMENT, 269 TYPE
IV-CELL-MEDIATED (DELAYED-TYPE) HYPERSENSITIVITY, 270 THE CELLULAR BASIS
OF TYPE IV HYPERSENSITIVITY, 270 TISSUE DAMAGE PRODUCED BY TYPE IV
REACTIONS, 270 TYPE V-STIMULATORY HYPERSENSITIVITY, 272
VII
CONTENTS
IMAGE 4
VIII
INNATE HYPERSENSITIVITY REACTIONS, 272 SUMMARY, 273 FURTHER READING,
275
13 * TRANSPLANTATION
GRAFT REJECTION, 277 EVIDENCE THAT REJECTION IS IMMUNOLOGICAL, 277
GENETIC CONTROL OF TRANSPLANTATION ANTIGENS, 278 SOME OTHER CONSEQUENCES
OF H-2 INCOMPATIBILITY, 279 MECHANISMS OF GRAFT REJECTION, 280 THE
PREVENTION OF GRAFT REJECTION, 282
MATCHING TISSUE TYPES ON GRAFT DONOR AND RECIPIENT, 282 AGENTS PRODUCING
GENERAL IMMUNOSUPPRESSION, 286 STRATEGIES FOR ANTIGEN-SPECIFIC
DEPRESSION OF ALLOGRAFT REACTIVITY, 288
CLINICAL EXPERIENCE IN GRAFTING, 291 PRIVILEGED SITES, 291 KIDNEY
GRAFTS, 291 HEART TRANSPLANTS, 292 LIVER TRANSPLANTS, 292 BONE MARROW
GRAFTING, 292 OTHER ORGANS, 293 ASSOCIATION OF HLA TYPE WITH DISEASE,
293 LINKAGE DISEQUILIBRIUM AND DISEASE SUSCEPTIBILITY, 293
ASSOCIATION WITH IMMUNOLOGICAL DISEASES, 294 THE IMMUNOLOGICAL
RELATIONSHIP OF MOTHER AND FETUS, 296 IS THE CANCER CELL LIKE AN
ALLOGRAFT?, 296 CHANGES ON THE SURFACE OF TUMOUR CELLS, 297
IMMUNE RESPONSE TO TUMOURS, 298 APPROACHES TO CANCER IMMUNOTHERAPY, 299
IMMUNODIAGNOSIS, 302 SUMMARY, 303
FURTHER READING, 303
OVERLAP OF AUTOIMMUNE DISORDERS, 309 GENETIC FACTORS IN AUTOIMMUNE
DISEASE, 310 SEX INFLUENCES IN AUTOIMMUNITY, 312 DOES THE ENVIRONMENT
CONTRIBUTE?, 312 AETIOLOGY OF AUTOIMMUNE RESPONSES, 245 AUTOREACRIVITY
IS NATURAL, 313 IS AUTOIMMUNITY DRIVEN BY ANTIGEN?, 314 THE T-HELPER
CELL IS PIVOTAL FOR CONTROL, 315 T-HELPER BYPASS MECHANISMS LEADING TO
AUTOIMMUNITY, 316 AUTOIMMUNITY ARISING THROUGH BYPASS OF REGULATORY
MECHANISMS, 320 CYTOKINE IMBALANCE MAY INDUCE AUTOIMMUNITY, 323
AUTOIMMUNE DISORDERS ARE MULTIFACTORIAL, 324 SUMMARY, 324
15 AUTOIMMUNE DISEASES
II-PATHOGENESIS/DIAGNOSIS AND TREATMENT
PATHOGENIC MECHANISMS IN AUTOIMMUNE DISEASE, 325 EFFECTS OF HUMORAL
ANTIBODY, 325 EFFECTS OF COMPLEXES, 330 CELLULAR HYPERSENSITIVITY, 335
EXPERIMENTAL MODELS OF AUTOIMMUNE DISEASE, 336 DIAGNOSTIC VALUE OF
AUTOANTIBODY TESTS, 340 TREATMENT OF AUTOIMMUNE DISORDERS, 340 METABOLIC
CONTROL, 340 ANTI-INFLAMMATORY DRUGS, 340 IMMUNOSUPPRESSIVE DRUGS, 341
IMMUNOLOGICAL CONTROL STRATEGIES, 342
SUMMARY, 345 FURTHER READING, 346
INDEX, 347
14 AUTOIMMUNE DISEASES
I-SCOPE AND AETIOLOGY
THE SPECTRUM OF AUTOIMMUNE DISEASES, 305 AUTOANTIBODIES IN HUMAN
DISEASE, 309
CONTENTS
|
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| author | Roitt, Ivan M. |
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| discipline | Chemie Medizin |
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| publisher | Blackwell |
| record_format | marc |
| spelling | Roitt, Ivan M. Verfasser aut Essential immunology Ivan M. Roitt 7. ed. Oxford [u.a.] Blackwell 1991 XII, 356 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Immunité Immunologie gtt Immunity Immunology Immunologie (DE-588)4026637-0 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Immunologie (DE-588)4026637-0 s DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005068820&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Roitt, Ivan M. Essential immunology Immunité Immunologie gtt Immunity Immunology Immunologie (DE-588)4026637-0 gnd |
| subject_GND | (DE-588)4026637-0 (DE-588)4151278-9 |
| title | Essential immunology |
| title_auth | Essential immunology |
| title_exact_search | Essential immunology |
| title_full | Essential immunology Ivan M. Roitt |
| title_fullStr | Essential immunology Ivan M. Roitt |
| title_full_unstemmed | Essential immunology Ivan M. Roitt |
| title_short | Essential immunology |
| title_sort | essential immunology |
| topic | Immunité Immunologie gtt Immunity Immunology Immunologie (DE-588)4026637-0 gnd |
| topic_facet | Immunité Immunologie Immunity Immunology Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005068820&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT roittivanm essentialimmunology |