Autoimmunity and toxicology: immune disregulation induced by drugs and chemicals
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam u.a.
Elsevier
1989
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIX, 473 S. graph. Darst. |
| ISBN: | 0444810234 |
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| 245 | 1 | 0 | |a Autoimmunity and toxicology |b immune disregulation induced by drugs and chemicals |c eds.: M. E. Kammüller ... |
| 264 | 1 | |a Amsterdam u.a. |b Elsevier |c 1989 | |
| 300 | |a XXIX, 473 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 2 | |a Autoimmunes, maladies - Induit chimiquement | |
| 650 | 2 | |a Immunité - Action des produits chimiques | |
| 650 | 4 | |a Immunotoxicologie | |
| 650 | 4 | |a Maladies auto-immunes - Pathogenèse | |
| 650 | 4 | |a Système immunitaire, Effets des médicaments sur le | |
| 650 | 4 | |a Système immunitaire, Effets des produits chimiques sur le | |
| 650 | 2 | |a Toxicologie | |
| 650 | 4 | |a Autoimmune Diseases |x chemically induced | |
| 650 | 4 | |a Autoimmune diseases |x Pathogenesis | |
| 650 | 4 | |a Disease Models, Animal | |
| 650 | 4 | |a Immune system |x Effect of chemicals on | |
| 650 | 4 | |a Immune system |x Effect of drugs on | |
| 650 | 4 | |a Immunity |x drug effects | |
| 650 | 4 | |a Immunotoxicology | |
| 650 | 4 | |a Toxicology | |
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Datensatz im Suchindex
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| adam_text | AUTOIMMUNITY AND TOXICOLOGY IMMUNE DISREGULATION INDUCED BY DRUGS AND
CHEMICALS EDITORS M.E. KAMMULLER, N. BLOKSMA AND W. SEINEN DEPARTMENT OF
BASIC VETERINARY SCIENCES SECTION OF IMMUNOTOXICOLOGY FACULTY OF
VETERINARY SCIENCES UNIVERSITY OF UTRECHT YALELAAN 2, NL-3508 TD UTRECHT
THE NETHERLANDS 1989 ELSEVIER AMSTERDAM * NEW YORK * OXFORD CONTENTS
LIST OF CONTRIBUTORS XVN FOREWORD J.G. VOS AND J.H. DEAN * XXI PREFACE
M.E. KAMMULLER, N. BLOKSMA AND W. SEINEN XXM LIST OF ABBREVIATIONS XXV
SECTION I - INTRODUCTION 1 CHAPTER 1 AUTOIMMUNITY AND TOXICOLOGY. IMMUNE
DISREGULATION INDUCED BY DRUGS AND CHEMICALS M.E. KAMMULLER, N. BLOKSMA
AND W. SEINEN 3 I. SCOPE 3 II. AUTOIMMUNITY AND AUTOIMMUNE DISEASES 4 1.
ANTIBODY- AND CELL-MEDIATED AUTOREACTIVITY 4 2. AUTOIMMUNE AND ALLERGIC
DISEASES 5 3. EPIDEMIOLOGY 6 4. ETIOLOGIC AND PATHOGENIC FACTORS 7 III.
DRUG- AND CHEMICAL-INDUCED AUTOIMMUNE DISEASES IN HUMANS 10 1.
DRUG-INDUCED AND IDIOPATHIC SLE 10 2. CLASSES OF DRUGS AND CHEMICALS 11
3. ASPECTS OF METABOLISM AND DISPOSITION IN RELATION TO DRUG-INDUCED
AUTOIMMUNE DISEASES 15 IV. MECHANISMS AND ANIMAL MODELS OF IDIOPATHIC
AND CHEMICAL-INDUCED AUTOIMMUNE REACTIONS 16 1. MECHANISMS OF SLE 16 2.
ANIMAL MODELS OF SPONTANEOUS SLE 17 (A) NZB AND (NZB X NZW)F, MICE 18
(B) BXSB MICE 18 (C) MRL/MP-LPR/IPR AND C3H/HE-GW/GW MICE 18 (D)
CONTRIBUTION OF ACCELERATOR GENES TO DEVELOPMENT OF AD 19 (E) GVH
REACTIONS 19 3. ANIMAL MODELS OF DRUG-INDUCED AUTOIMMUNE REACTIONS 20
(A) MOUSE MODELS 20 (B) RAT MODELS 22 (C) CAT MODELS 23 (D) DOG MODELS
23 (E) MONKEY MODELS 24 (F) TOXICOLOGICAL CONSIDERATIONS 24 CONCLUSIONS
24 REFERENCES 25 SECTION II - BASIC CONCEPTS 35 CHAPTER 2 BASIC
MECHANISMS OF ADAPTIVE IMMUNE SYSTEM FUNCTION N. BLOKSMA AND H.-J.
SCHUURMAN 37 I. INTRODUCTION 37 II. COMPONENTS OF THE IMMUNE SYSTEM 38
1. CELLS AND TISSUES 38 (A) GRANULOCYTES 38 (B) MONOCYTES AND
MACROPHAGES 39 39 40 42 43 44 45 46 48 48 51 52 III. ANTIGENS 53 53 53
54 54 54 54 55 55 55 IV. THE IMMUNE RESPONSE 56 1. HELPER T CELL
ACTIVATION 56 2. ANTIBODY RESPONSES 58 3. CYTOTOXIC T LYMPHOCYTE
RESPONSES 60 4. DELAYED TYPE HYPERSENSITIVITY 62 (C) (D) (E) (0 (G)
LYMPHOCYTES B LYMPHOCYTES T LYMPHOCYTES LYMPHOID ORGANS LYMPHOCYTE
RECIRCULATION 2. MOLECULES (A) (B) (C) (D) (E) ANTIGENS MAJOR
HISTOCOMPATIBILITY COMPLEX (MHC) MOLECULES LEUKOCYTE FUNCTION-ASSOCIATED
ANTIGENS INTERLEUKINS ANTIBODIES COMPLEMENT 1. DEFINITIONS 2. REQUISITES
FOR IMMUNOGENICITY (A) (B) (C) (D) (E) (0 (G) FOREIGNNESS MOLECULAR SIZE
CHEMICAL COMPLEXITY PRESENCE AND ACCESSIBILITY OF EPITOPES
PHYSICO-CHEMICAL PROPERTIES DOSE AND MODE OF ADMINISTRATION HOST FACTORS
V. REGULATION OF THE IMMUNE RESPONSE 1. FEEDBACK REGULATION 2. TOLERANCE
BIBLIOGRAPHY 63 63 63 64 CHAPTER 3 THEORIES OF SELF TOLERANCE AND
AUTOIMMUNITY A.C. ALLISON 67 I. INTRODUCTION 67 II. QUALITATIVE AND
QUANTITATIVE REQUIREMENTS FOR ACTIVATION OF T LYMPHOCYTES 70 III. T CELL
CLONAL ELIMINATION IN THE THYMUS 73 IV. ANTIGEN-PRESENTING CELLS (APC)
74 1. THE LANGERHANS CELL LINEAGE 74 2. FOLLICULAR DENDRITIC CELLS (FDC)
75 3. B LYMPHOCYTES 75 4. MHCII EXPRESSION ON OTHER CELL TYPES . 76 V.
REGULATION OF MHC EXPRESSION 77 VI. INCREASED MHCII EXPRESSION IN
AUTOIMMUNE MICE 78 VII. CONTROL OF EXPRESSION OF GENES FOR MHC
GLYCOPROTEINS AND CYTOKINES 79 VIII. GRAFT-VERSUS-HOST (GVH) REACTIONS
80 IX. FACTORS INCREASING B CELL PROLIFERATION AND/OR DIFFERENTIATION 82
X. USE OF TRANSGENIC MICE FOR INVESTIGATING AUTOIMMUNITY 85 XI. LACK OF
TOLERANCE TO SELF ANTIGENS IN B LYMPHOCYTES 85 XII. SELECTIVE TOLERANCE
IN T LYMPHOCYTES 88 XIII. T LYMPHOCYTE MEDIATED SUPPRESSION OF
AUTOIMMUNITY 89 XIV. IDIOTYPIC REGULATION OF AUTOIMMUNITY 92 XV.
SECLUSION OF AUTOANTIGENS FROM THE IMMUNE SYSTEM 93 XVI. PARTIAL
DEGRADATION OF AUTOANTIGENS 94 XVII. CROSS-REACTIVITY OF EXOGENOUS AND
SELF ANTIGENS 94 XVIII. VIRUS INFECTIONS 95 XIX. BACTERIAL INFECTIONS
AND PRODUCTS 96 XX. AUTOIMMUNITY FOLLOWING ADMINISTRATION OF DRUGS . 97
XXI. HOLES IN THE REPERTOIRE OF RECEPTORS FOR ANTIGEN 100 XXII. LY-1 + B
CELLS IN MICE AND LEU-1 + B CELLS IN HUMANS 100 XXIII. AUTOANTIBODIES IN
NORMAL PERSONS 101 XXIV. SOMATIC MUTATION AND FORBIDDEN CLONES 101 XXV.
OLD AND NEW HYPOTHESES FOR THE DEVELOPMENT OF AUTOIMMUNITY 102
REFERENCES 104 SECTION HI - AUTOIMMUNE(-LIKE) REACTIONS IN HUMANS
INDUCED BY DRUGS AND CHEMICALS 1 17 CHAPTER 4 AUTOIMMUNE REACTIONS
INDUCED BY PROCAINAMIDE AND HYDRALAZINE R.L. RUBIN 119 I. INTRODUCTION
119 1. DEFINITION OF AUTOIMMUNE-LIKE REACTIONS INDUCED BY PROCAINAMIDE
AND HYDRALAZINE 119 2. HISTORICAL PERSPECTIVE 120 II. FEATURES OF
PROCAINAMIDE-INDUCED AUTOIMMUNITY 120 1. TIME COURSE AND DOSE DEPENDENCY
120 2. CLINICAL AND LABORATORY FEATURES 121 3. IMMUNOLOGICAL
ABNORMALITIES 123 (A) HUMORAL AUTOIMMUNE ABNORMALITIES 123 (B) CELLULAR
IMMUNE ABNORMALITIES 129 4. GENETIC FACTORS 130 III. FEATURES OF
HYDRALAZINE-INDUCED AUTOIMMUNITY 132 1. TIME COURSE AND DOSE DEPENDENCY
132 2. CLINICAL AND LABORATORY FEATURES 133 3. IMMUNOLOGICAL
ABNORMALITIES 134 (A) HUMORAL AUTOIMMUNE ABNORMALITIES 134 (B) CELLULAR
IMMUNE ABNORMALITIES 136 4. GENETIC FACTORS 136 IV. INTERACTIONS OF
HYDRALAZINE AND PROCAINAMIDE WITH MACROMOLECULES 137 1. BINDING TO DNA
AND NUCLEOPROTEIN 137 2. IMMUNOGENICITY STUDIES 138 3. BINDING TO
COMPLEMENT 138 4. SUMMARY 138 V. OXIDATIVE METABOLISM OF PROCAINAMIDE
AND HYDRALAZINE 139 VI. ANIMAL MODELS OF PROCAINAMIDE- OR
HYDRALAZINE-INDUCED AUTOIMMUNITY 140 VII. POSSIBLE MECHANISMS UNDERLYING
DRUG-INDUCED AUTOIMMUNITY 141 1. IMMUNE RESPONSE TO DRUG OR TO
DRUG-ALTERED ANTIGEN 141 2. DRUGS ACT AS POLYCLONAL ACTIVATORS EITHER BY
DIRECT STIMULATION OF B OR T CELLS OR THROUGH AN ADJUVANT EFFECT 142 3.
DRUGS AFFECT ANTIGEN CATABOLISM OR PROCESSING 143 4. PERTURBATION OF
LYMPHOCYTE RECOGNITION MECHANISMS 143 VIII. SUMMARY AND FUTURE
DIRECTIONS 143 REFERENCES 144 CHAPTER 5 AUTOIMMUNE REACTIONS IN HUMANS
INDUCED BY DIPHENYLHYDANTOIN AND NITROFURANTOIN D. ALARCON-SEGOVIA AND
M. ALARCON-RIQUELME 151 I. DIPHENYLHYDANTOIN 151 1. ADVERSE REACTIONS:
EPIDEMIOLOGY AND PREDISPOSING FACTORS 152 2. POSSIBLE MECHANISMS 158 II.
NITROFURANTOIN 1. ADVERSE REACTIONS: EPIDEMIOLOGY AND PREDISPOSING
FACTORS 2. DISEASE PATTERNS AND THEIR PATHOLOGY REFERENCES 159 160 160
162 CHAPTER 6 AUTOIMMUNE REACTIONS TO D-PENICILLAMINE P. EMERY AND G.S.
PANAYI 167 I. INTRODUCTION II. ABSORPTION AND PHARMACOKINETICS III.
PHARMACOLOGY AND MODE OF ACTION IV. DISEASE PATTERNS AND EPIDEMIOLOGY 1.
HAEMATOLOGICAL ABNORMALITIES 2. RENAL SIDE EFFECTS 3. LUNG ABNORMALITIES
4. OTHER AUTOIMMUNE PHENOMENA 5. AUTOANTIBODY PRODUCTION 6. SYSTEMIC
LUPUS ERYTHEMATOSUS (SLE) 7. POLYMYOSITIS/DERMATOMYOSITIS 8. MYASTHENIA
GRAVIS 9. DERMATOLOGICAL ABNORMALITIES 10. MAMMARY GIGANTISM V. FACTORS
DETERMINING TOXICITY 1. METABOLIC FACTORS IN D-PENICILLAMINE TOXICITY 2.
HLA AND D-PENICILLAMINE TOXICITY 3. IMMUNOLOGICAL FACTORS IN
D-PENICILLAMINE TOXICITY VI. SUMMARY AND CONCLUSIONS REFERENCES 167 167
168 169 169 170 171 172 172 172 173 173 174 174 174 174 176 176 177 177
CHAPTER 7 ZIMELDINE: FEBRILE REACTIONS AND PERIPHERAL NEUROPATHY A.
KRISTOFFERSON AND B.S. NILSSON 183 I. INTRODUCTION II. PROPERTIES OF
ZIMELDINE 1. EXPERIMENTAL DATA 2. PHARMACOKINETICS AND HUMAN
PHARMACOLOGY 3. CLINICAL STUDIES III. EPIDEMIOLOGY AND CLINICAL
CHARACTERISTICS OF FEBRILE REACTIONS 1. FINDINGS IN CLINICAL TRIALS (A)
INCIDENCE FIGURES (B) GEOGRAPHICAL DISTRIBUTION (C) SYMPTOMATOLOGY AND
DEVIATIONS IN LABORATORY VARIABLES (D) TREATMENT AND OUTCOME OF FEBRILE
REACTIONS 2. OTHER REPORTS OF FEBRILE REACTIONS IV. EPIDEMIOLOGY AND
CLINICAL CHARACTERISTICS OF CASES OF NEUROPATHY 1. BACKGROUND DATA ON
THE GUILLAIN-BARRE SYNDROME 183 184 184 186 186 187 187 188 189 189 190
191 191 191 2. THE GUILLAIN-BARRE CASES IN ZIMELDINE-TREATED PATIENTS
192 3. INCIDENCE - RISK INCREASE 193 4. OTHER CASES OF PERIPHERAL
NEUROPATHY 194 V. INVESTIGATIONS INTO THE PATHOGENETIE MECHANISMS OF
ADVERSE REACTIONS 194 1. TOXICITY OF ZIMELDINE OR METABOLITES TO THE
IMMUNE SYSTEM 195 2. IMMUNOMODULATORY EFFECTS OF SEROTONIN 196 3.
IMMUNOLOGIC RESPONSE TO ZIMELDINE AND ZIMELDINE-DERIVED STRUCTURES 198
(A) EXPERIMENTAL STUDIES OF THE IMMUNOGENIC POTENTIAL OF ZIMELDINE 199
(B) IMMUNOGENIC POTENTIAL OF ZIMELDINE IN MAN 202 (C) LTT RESPONSES IN
PATIENTS WITH FEBRILE REACTIONS AND/OR NEUROPATHY 204 4. CHARACTERISTICS
OF PATIENTS WITH FEBRILE REACTIONS - A CASE-CONTROL STUDY 206 (A)
RESULTS OF INTERVIEWS * MEDICAL BACKGROUND CHARACTERISTICS 207 (B) HLA
ANTIGEN DETERMINATIONS 207 (C) PHARMACOLOGIC INVESTIGATIONS IN ADVERSE
REACTION PATIENTS 208 VI. SUMMARIZING DISCUSSION 208 REFERENCES 210
CHAPTER 8 HALOTHANE HEPATITIS * AN EXAMPLE OF POSSIBLY IMMUNE-MEDIATED
HEPATOTOXICITY J. NEUBERGER 215 I. INTRODUCTION 215 II. CLINICAL
FEATURES OF HALOTHANE HEPATITIS 216 1. TYPE I HALOTHANE HEPATITIS 217 2.
TYPE II HALOTHANE HEPATITIS 218 3. OTHER FEATURES OF HALOTHANE HEPATITIS
218 III. HALOTHANE HEPATITIS - AN IMMUNE-MEDIATED REACTION 222 1.
SENSITIZATION TO HALOTHANE-ALTERED LIVER CELL COMPONENTS 222 2.
IDENTIFICATION OF ANTIGEN 225 3. HALOTHANE ANTIGEN IN MAN 228 IV.
MECHANISM OF HALOTHANE HEPATITIS 229 V. ANIMAL MODELS 231 VI. CONCLUSION
233 REFERENCES 234 SECTION IV - PROPERTIES OF IMMUNOMODULATING DRUGS AND
CHEMICALS 111 CHAPTER 9 METABOLISM OF PROCAINAMIDE, HYDRALAZINE, AND
ISONIAZID IN RELATION TO AUTOIMMUNE(-LIKE) REACTIONS D. W. HEIN AND W.
W. WEBER 239 I. INTRODUCTION 239 II. METABOLISM OF PROCAINAMIDE 242 III.
IV. V. METABOLISM METABOLISM SUMMARY REFERENCES OF OF HYDRALAZINE
ISONIAZID 249 254 259 260 CHAPTER 10 DRUG INTERACTIONS WITH COMPLEMENT
COMPONENTS IN RELATION TO THE INDUCTION OF AUTO-IMMUNE(-LIKE) REACTIONS
E. SIM 267 I. INTRODUCTION 267 II. HYPERSENSITIVITY REACTIONS 276 1.
RADIOGRAPHIC CONTRAST MEDIA 276 2. OTHER DRUGS 277 III. DRUG-INDUCED SLE
278 1. HYDRALAZINE AND ISONIAZID 278 2. PROCAINAMIDE AND PRACTOLOL 282
3. D-PENICILLAMINE 284 4. INDIVIDUAL VARIATION 285 REFERENCES 288
CHAPTER 11 IMMUNOMODULATING PROPERTIES OF AMPHIPHILIC AGENTS L.A. TH.
HILGERS, G.J.W.J. ZIGTERMAN AND H. SNIPPE 293 I. INTRODUCTION 293 II.
PHYSICOCHEMICAL PROPERTIES OF SURFACTANTS 294 III. IMMUNOSTIMULATION BY
CATIONIC LIPOPHILIC AMINES 295 IV. IMMUNOSTIMULATION BY NON-IONIC BLOCK
POLYMERS (NBPS) 297 V. IMMUNOSTIMULATION BY SULPHOLIPOPOLYSACCHARIDES
(SLPS) 299 VI. GENERAL CONCLUSIONS AND DISCUSSION 301 REFERENCES 303
SECTION V - EXPERIMENTAL APPROACHES TO ASSESS THE POTENTIAL OF CHEMICALS
TO INDUCE AUTOIMMUNE(-LIKE) DISEASES 307 CHAPTER 12
PROPYLTHIOURACIL-INDUCED IMMUNE-MEDIATED DISEASE SYNDROME IN THE CAT: A
NOVEL ANIMAL MODEL FOR A DRUG-INDUCED LUPUS-LIKE DISEASE D.P. AUCOIN 309
I. INTRODUCTION 309 II. INDUCTION OF PTU-INDUCED IMDS 310 1.
STRUCTURE-ACTIVITY RELATIONSHIP 310 2. DURATION OF DRUG EXPOSURE AND
DOSE-DEPENDENCY FOR INDUCTION 312 III. PHARMACOLOGY OF PTU 313 1.
DISPOSITION OF PTU IN THE CAT 313 2. METABOLISM 315 IV. PTU-INDUCED ANA
SPECIFICITY 317 V. CONCLUSION 319 REFERENCES 320 CHAPTER 13 AUTOIMMUNE
REACTIONS INDUCED BY DIETARY ANTIGENS WITH AN EMPHASIS ON AMINO ACIDS
E.J. BARDANA, JR., A. MONTANARO AND M.R. MALINOW 323 I. II. III. IV. V.
VI. VII. INTRODUCTION HISTORICAL REVIEW IMMUNOPATHOGENESIS 1. IMMEDIATE
HYPERSENSITIVITY 2. CIRCULATING IMMUNE COMPLEXES 3. IGA DEFICIENCY 4.
GASTROINTESTINAL ABNORMALITIES ANIMAL MODELS CANAVANINE-INDUCED SLE IN
PRIMATES RECENT STUDIES ON THE IMMUNOMODULATORY ROLE OF L-CANAVANINE AS
WELL AS OTHER DIETARY FACTORS 1. L-CANAVANINE 2. HYDRAZINE 3. RED MEAT
AND DAIRY PRODUCTS 4. POLYUNSATURATED FATTY ACIDS AND EICOSAPENTENOIC
ACID SUMMARY REFERENCES 323 324 325 325 326 327 327 328 329 337 337 338
338 339 339 340 CHAPTER 14 AUTOIMMUNE REACTIONS INDUCED BY METALS P.
DRUET, L. PELLETIER, J. ROSSERT, E. DRUET, F. HIRSCH AND C. SAPIN 347 I.
INTRODUCTION 347 II. MERCURY-INDUCED AUTOIMMUNITY 348 1. MERCURY-INDUCED
AUTOIMMUNITY IN BROWN-NORWAY RATS 348 (A) DESCRIPTION OF THE DISEASE 348
(B) GENETIC CONTROL OF SUSCEPTIBILITY 350 (C) MECHANISMS OF INDUCTION OF
AUTOIMMUNITY 351 (D) AUTOREGULATION OF MERCURY-INDUCED AUTOIMMUNITY 352
2. EFFECTS OF HGCL 2 IN LEWIS RATS 353 3. AUTOIMMUNE GLOMERULONEPHRITIS
IN OTHER STRAINS OF RATS 354 4. MERCURY-INDUCED NEPHRITIS IN OTHER
SPECIES 356 III. OTHER METALS 357 IV. CONCLUSION 357 REFERENCES 358
CHAPTER 15 TESTING THE SENSITIZATION OF T CELLS TO CHEMICALS. FROM
MURINE GRAFT-VERSUS-HOST (GVH) REACTIONS TO CHEMICAL-INDUCED GVH-LIKE
IMMUNOLOGICAL DISEASES E. GLEICHMANN, H.-W. VOHR, C. STRINGER, J. NUYENS
AND H. GLEICHMANN 363 I. INTRODUCTION 363 II. THE PARENT -» F, HYBRID
GVH REACTIONS: A MODEL FOR DISEASES CAUSED BY CHEMICAL MODIFICATION OF
CELL-SURFACE MOLECULES 364 1. EXPERIMENTAL DESIGN 364 2. SPECTRUM OF GVH
REACTION-INDUCED IMMUNOLOGICAL DISORDERS 364 3. SUBSETS OF ALLOREACTIVE
T LYMPHOCYTES INDUCE EITHER STIMULATORY OR SUP- PRESSIVE GVH DISEASE
SYNDROMES 366 4. MECHANISM OF AUTOANTIBODY FORMATION DURING GVH REACTION
367 III. CAN GVH REACTION-LIKE IMMUNOLOGICAL DISORDERS BE INDUCED BY
MODIFIED SELF? 368 1. CONCEPTS OF PATHOGENESIS 368 2. DRUGS INDUCING GVH
REACTION-LIKE LESIONS AS AN ADVERSE IMMUNOLOGICAL. SIDE EFFECT 369 IV.
MURINE T CELL REACTIONS TO A VARIETY OF DIFFERENT CHEMICALS 369 1.
MURINE T CELL REACTIONS TO DIPHENYLHYDANTOIN (DPH) DETECTED BY THE PLNA
369 2. MURINE T CELL REACTIONS TO D-PENICILLAMINE (D-PEN) DETECTED BY IN
VITRO STUDIES AND BY THE PLNA 372 (A) IN VITRO RESTIMULATION OF SPECIFIC
T CELLS PRIMED TO D-PEN IN VIVO 372 (B) SPECIFIC T CELL RESPONSES TO
D-PEN DETECTED BY THE PLNA 373 3. MURINE T CELL REACTIONS TO
STREPTOZOTOCIN DETECTED BY THE PLNA 375 4. PLNA RESPONSES TO OTHER DRUGS
376 5. THE MURINE PLN REACTION TO QUARTZ (SIO 2 ) 376 6. EVALUATION OF
THE PLN ASSAY AS A TEST PREDICTING THE IMMUNOSTIMULATORY AND/OR
SENSITIZING POTENTIAL OF XENOBIOTICS 377 V. AUTOIMMUNIZING AND
IGE-ENHANCING EFFECTS OF HGCL 2 IN MICE 381 VI. CONCLUSIONS 385
REFERENCES 385 CHAPTER 16 THE PATHOLOGY OF DIPHENYLHYDANTOIN-INDUCED
LYMPHOPROLIFERATIVE REACTIONS IN ANIMALS G.R.F. KRUEGER 391 I.
INTRODUCTION 391 II. CLINICAL SIDE EFFECTS IN MAN 392 1.
IMMUNOSUPPRESSIVE EFFECTS OF DIPHENYLHYDANTOIN 392 2. ALLERGIC AND
AUTOIMMUNE REACTIONS FOLLOWING DPH TREATMENT 393 3. ATYPICAL
LYMPHOPROLIFERATION AND MALIGNANT LYMPHOMAS FOLLOWING DPH TREATMENT 394
III. EXPERIMENTAL LYMPHOMA INDUCTION BY DIPHENYLHYDANTOIN 395 1.
EXPERIMENTAL DESIGN 395 2. GROSS PATHOLOGIC CHANGES 397 3. LIGHT
MICROSCOPY 397 4. ULTRASTRUCTURAL STUDIES 404 5. IMMUNOCYTOLOGICAL
LYMPHOMA TYPING 408 6. IMMUNOLOGICAL STUDIES 408 IV. SUMMARY OF RESULTS
AND DISCUSSION 408 REFERENCES 410 CHAPTER 17 IMMUNE-ENDOCRINE
INTERACTIONS AND AUTOIMMUNE DISEASES S. ANSAR AHMED AND N. TALAL 415 I.
GENERAL INTRODUCTION 415 II. SEX HORMONES AND AUTOIMMUNE DISEASES 416
III. SEX HORMONE-INFLUENCED CELLULAR EVENTS: TARGETS AND MECHANISMS OF
ACTION 418 IV. SEX STEROID RECEPTORS 422 V. SUMMARY 423 REFERENCES 424
CHAPTER 18 TOXICITY OF PURINE METABOLITES FOR HUMAN LYMPHOID CELLS:
MECHANISMS AND DISEASE ASSOCIATIONS B.J.M. ZEGERS, J.G.M. SCHARENBERG
AND G.T. RIJKERS 429 I. INTRODUCTION 429 II. PURINE METABOLISM IN MAN
430 III. TOXICITY OF PURINE METABOLITES FOR HUMAN LYMPHOID CELLS IN
PURINE ENZYME DEFI- CIENT CONDITIONS 432 IV. TOXICITY OF DEOXYADENOSINE
IN MODEL STUDIES 433 V. TOXICITY OF ADENOSINE 435 VI. TOXICITY OF DGUO
AND GUO 435 VII. DISEASE ASSOCIATIONS 436 VIII. FINAL COMMENTS AND
CONCLUSIONS 438 REFERENCES 439 CHAPTER 19 TOXICOLOGICAL CONSIDERATIONS
ON IMMUNE DISREGULATION INDUCED BY DRUGS AND CHEMICALS M.E. KAMMULLER,
N. BLOKSMA AND W. SEINEN 443 I. SCOPE 443 II. PROTOCOL TOXICOLOGY 444 1.
LIKELY REASONS FOR THE UNPREDICTABILITY OF IMMUNE DISREGULATION IN TOX-
ICOLOGY 444 2. POSSIBLE IMPROVEMENTS 445 III. EXPERIMENTAL STRATEGIES
446 1. ANIMAL-RELATED APPROACHES 446 (A) SHORT-TERM ASSAYS 446 (B)
LONG-TERM EXPERIMENTS 447 2. CHEMICAL-RELATED APPROACHES 449 (A)
CHEMICAL REACTIVITY OF PARENT COMPOUNDS 450 (B) METABOLISM 451 (C)
IMMUNOTOXICOLOGICALLY RELEVANT TARGETS 452 IV. CONCLUSIONS 453
REFERENCES 453 SUBJECT INDEX 459
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV007672918 |
| callnumber-first | R - Medicine |
| callnumber-label | RC600 |
| callnumber-raw | RC600 |
| callnumber-search | RC600 |
| callnumber-sort | RC 3600 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | VS 5700 |
| ctrlnum | (OCoLC)18780224 (DE-599)BVBBV007672918 |
| dewey-full | 616.97/071 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.97/071 |
| dewey-search | 616.97/071 |
| dewey-sort | 3616.97 271 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| id | DE-604.BV007672918 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T17:07:22Z |
| institution | BVB |
| isbn | 0444810234 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-005032628 |
| oclc_num | 18780224 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-188 |
| physical | XXIX, 473 S. graph. Darst. |
| publishDate | 1989 |
| publishDateSearch | 1989 |
| publishDateSort | 1989 |
| publisher | Elsevier |
| record_format | marc |
| spelling | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals eds.: M. E. Kammüller ... Amsterdam u.a. Elsevier 1989 XXIX, 473 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Autoimmunes, maladies - Induit chimiquement Immunité - Action des produits chimiques Immunotoxicologie Maladies auto-immunes - Pathogenèse Système immunitaire, Effets des médicaments sur le Système immunitaire, Effets des produits chimiques sur le Toxicologie Autoimmune Diseases chemically induced Autoimmune diseases Pathogenesis Disease Models, Animal Immune system Effect of chemicals on Immune system Effect of drugs on Immunity drug effects Immunotoxicology Toxicology Immunsystem (DE-588)4026643-6 gnd rswk-swf Umweltkrankheit (DE-588)4131100-0 gnd rswk-swf Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf Autoimmunität (DE-588)4319435-7 gnd rswk-swf Chemikalie (DE-588)4009833-3 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Immunsystem (DE-588)4026643-6 s Chemikalie (DE-588)4009833-3 s DE-604 Arzneimittel (DE-588)4003115-9 s Autoimmunität (DE-588)4319435-7 s Autoaggressionskrankheit (DE-588)4003935-3 s Umweltkrankheit (DE-588)4131100-0 s b DE-604 Kammüller, Michael E. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005032628&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals Autoimmunes, maladies - Induit chimiquement Immunité - Action des produits chimiques Immunotoxicologie Maladies auto-immunes - Pathogenèse Système immunitaire, Effets des médicaments sur le Système immunitaire, Effets des produits chimiques sur le Toxicologie Autoimmune Diseases chemically induced Autoimmune diseases Pathogenesis Disease Models, Animal Immune system Effect of chemicals on Immune system Effect of drugs on Immunity drug effects Immunotoxicology Toxicology Immunsystem (DE-588)4026643-6 gnd Umweltkrankheit (DE-588)4131100-0 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd Autoimmunität (DE-588)4319435-7 gnd Chemikalie (DE-588)4009833-3 gnd Arzneimittel (DE-588)4003115-9 gnd |
| subject_GND | (DE-588)4026643-6 (DE-588)4131100-0 (DE-588)4003935-3 (DE-588)4319435-7 (DE-588)4009833-3 (DE-588)4003115-9 |
| title | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals |
| title_auth | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals |
| title_exact_search | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals |
| title_full | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals eds.: M. E. Kammüller ... |
| title_fullStr | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals eds.: M. E. Kammüller ... |
| title_full_unstemmed | Autoimmunity and toxicology immune disregulation induced by drugs and chemicals eds.: M. E. Kammüller ... |
| title_short | Autoimmunity and toxicology |
| title_sort | autoimmunity and toxicology immune disregulation induced by drugs and chemicals |
| title_sub | immune disregulation induced by drugs and chemicals |
| topic | Autoimmunes, maladies - Induit chimiquement Immunité - Action des produits chimiques Immunotoxicologie Maladies auto-immunes - Pathogenèse Système immunitaire, Effets des médicaments sur le Système immunitaire, Effets des produits chimiques sur le Toxicologie Autoimmune Diseases chemically induced Autoimmune diseases Pathogenesis Disease Models, Animal Immune system Effect of chemicals on Immune system Effect of drugs on Immunity drug effects Immunotoxicology Toxicology Immunsystem (DE-588)4026643-6 gnd Umweltkrankheit (DE-588)4131100-0 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd Autoimmunität (DE-588)4319435-7 gnd Chemikalie (DE-588)4009833-3 gnd Arzneimittel (DE-588)4003115-9 gnd |
| topic_facet | Autoimmunes, maladies - Induit chimiquement Immunité - Action des produits chimiques Immunotoxicologie Maladies auto-immunes - Pathogenèse Système immunitaire, Effets des médicaments sur le Système immunitaire, Effets des produits chimiques sur le Toxicologie Autoimmune Diseases chemically induced Autoimmune diseases Pathogenesis Disease Models, Animal Immune system Effect of chemicals on Immune system Effect of drugs on Immunity drug effects Immunotoxicology Toxicology Immunsystem Umweltkrankheit Autoaggressionskrankheit Autoimmunität Chemikalie Arzneimittel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=005032628&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kammullermichaele autoimmunityandtoxicologyimmunedisregulationinducedbydrugsandchemicals |