Photochemistry of proteins and nucleic acids:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Pergamon Press
1964
|
| Series: | International series of monographs on pure and applied biology Modern trends in physiological sciences
22 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 449 S. graph. Darst. |
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Record in the Search Index
| _version_ | 1804121678169505792 |
|---|---|
| adam_text | A
PHOTOCHEMISTRY OF
PROTEINS AND
NUCLEIC ACIDS
B Y
A D MCLAREN
Professor, College of Agriculture,
University of California, Berkeley
A N D
D SHUGAR
Professor, Institute of Biochemistry and
Biophysics, and State Institute of Hygiene,
Academy of Sciences, Warsaw
PERGAMONPRESS
OXFORD • LONDON • EDINBURGH • NEWYORK
PARIS • FRANKFURT
t
Contents
PREFACE xi
ISOMEPRINCIPLESOFPHOTOCHEMISTRY1
A Introduction 1
1 The laws of photochemistry 1
2 Absorption spectroscopy 4
3 Transfer mechanisms of excitation energy 11
B Factors of influence in photochemical reactions in solution 15
1 The absorption of light and the quantum yield 15
2 General nature of photochemical reactions in solution 18
(a) Some reactions of small molecules 18
(b) Detection and identification of free radicals 24
(c) Oxygen and photosensitization 26
IIABSORPTIONANDLUMINESCENCESPECTRAOFNU-
CLEOPROTEINSANDTHEIRCOMPONENTS
A Proteins 29
1 Principal absorbing groups in proteins 29
2 Free and bound phenolic hydroxyl groups in proteins 37
3 Peptide absorption in the range 2400-3200 A 39
4 Absorption by fibrous proteins 43
5 Apparent absorption of light attributable to scattering 45
6 Extraneous absorption in proteins 46
7 Peptide absorption below 2400 A 48
8 Excited states of proteins 51
^ B Nucleic acids 58
1 Purines and pyrimidines 59
2 Nucleosides and nucleotides 64
3 Nucleic acids, polynucleotides and oligonucleotides 66
C Nucleoproteins 79
D Viruses 83
V
VLi1 Lj l I o
£
IIIACTIONOFULTRAVIOLETLIGHTONAMINO-ACIDS,
PEPTIDESANDRELATEDSUBSTANCES
A Direct Action 88
1 Photochemistry of I he end groups 89
2 Photochemistry of the peptide bond 90
3 Photochemistry of side groups and of amino-acids 97
B Photosensitized Destruction of Amino-acids in the Presence
of Dyes 107
IVACTIONOFULTRAVIOLETLIGHTONPROTEINS:
GENERAL
1 Site of action of ultraviolet light on proteins 110
2 Changes in the absorption spectra of proteins with
irradiation 113
3 Photolysis and aggregation of irradiated proteins 118
(a) Photolysis of t he peptide bond 118
(b) Effect of ultraviolet light on disulfide linkages 121
(c) Aggregation phenomena 122
4- Irradiation of protein monolayers 129
|VPHOTOCHEMICALANDPHOTOSENSITIZEDINACTIVA-
TIONOFENZYMES
1 Kinetics of enzyme inactivation in solution 133
2 Mechanism of inactivation of enzymes by ultraviolet
light 137
3 Kinetics of inactivation of dry enzymes 151
4 Photosensitized inactivation of enzymes 156
VIPHOTOCHEMISTRYOFPURINEANDPYRIMIDINEDERI
VATIVES
1 Carbohydrates 163
2 Purine derivatives 165
^ 3 Purine nucleotides 170
4 Nucleotide co-enzymes 171
5 Pyrimidine derivatives 174
6 Reversible photoproducts of uracil derivatives 176
7 Photochemically induced additions to double bonds 182
8 Dimer photoproducts 184
9 Kinetics and mechanism of photochemical transforma
tion of some uracil analogues 191
-iCONTENTSVli
t
10 Reversible photoproducts of cytosine derivatives 196
(a) Nature of photoproducts of cytosine glycosides 198
(b) Cytosine and 1-methyl cytosine 200
(c) Quantum yields for cytosine derivatives 203
(d) Kinetics of reverse reaction 204
11 Primary photoproducts of substituted pyrimidine de
rivatives 209
12 Photodegradation products of pyrimidine derivatives 216
VIINUCLEICACIDSANDOLIGO-ANDPOLYNUCLEOTIDES
A General
B Photochemical Degradation of Nucleic Acids
1 Deoxyribonucleic acids
2 Nucleic acid films
3 Ribonucleic acids
C Nucleoproteins
D Biological Inactivation
1 Infectious RNA
2 Transforming deoxyi iboneucleic acids (T-DNA)
3 RNA core
E Kinetics of Biological Inactivation of Nucleic Acids
F Reversibility of Nucleic Acid Photolysis
1 Physico-chemical evidence for reversibility
(a) Natural nucleic acid preparations
(b) Pyrimidine dimer formation in DNA
(c) Natural and synthetic oligo- and polynucleotides 251
(i) Purine oligonucleotides 253
(ii) Oligonucleotides of uridylic acid 253
(iii) Oligonucleotides of thymidylic acid 260
(iv) Oligonucleotides of cytidylic acid 263
(v) Hetero-oligonucleotides 264
(vi) Twin-stranded polynucleotides 267
2 Reversal of biological inactivation 270
G Summary of Primary Effects of Ultraviolet Light on Nucleic
Acids 273
H Indirect Irradiation Effocts 275
VIIIINACTIVATIONOFVIRUSES
A Introduction 279
B Inactivation Studies with a Plant Virus 280
viaiCONTENTS
£
C Photochemically Produced Vaccines 291
D Bacteriophages 295
1 DNA content and UV lethality 295
2 Action spectra 297
3 Quantum yields 298
4 Kinetics of inactivation of infectivity 299
5 Phage-host interactions 301
(a) Kinetics of survival 303
(b) Photoreactivation 304
(c) Multiplicity reactivation 306
(d) Cross reactivation 309
(e) Gene-controlled reactivation 310
E Photosenisitized Inactivation 313
IXSOMESELECTEDPROBLEMSINPHOTOBIOLOGY
A Radiation Receptors in Biological Systems: Action Spectra 320
1 Wavelength dependence of quantum yields 324
(a) Nucleic acids 324
(b) Proteins 327
2 Examples of action spectra studies 328
3 Partial cell irradiation 333
B Reversal of Initial Photobiological Effects: Photoreactiva
tion 334
1 Ultimate effects of ultraviolet irradiation 335
2 Characteristics of photoreactivation 336
3 Radiation receptors in photoreactivation 339
4 Physical models as analogies of photoreactivation 340
5 Alternative methods for reversal of ultraviolet effects 342
6 Potential reversible photochemical transformations in
nucleic acids 343
C Radiation Induced Syntheses: Origin of Life 346
APPENDIX Some Techniques in Photochemistry 358
A Light Sources 358
1 Mercury arcs 358
(a) Medium pressure mercury arcs 358
(b) High pressure mercury arcs 358
2 Carbon arcs 359
3 Xenon arcs 359
4 Low-pressure mercury resonance lamps 360
5 1849 A resonance lamp 362
CONTENTSix
%
6 Simple laboratory sources of 2537 A radiation for
inactivation studies and preparative photochemistry 362
7 Monochromators 365
8 Flash discharge sources 365
B Flash-photolysis Flash-spectroscopy 367
C Spectral Filters 369
1 Solid filters 369
2 Chemical filter combinations 371
(a) Short wavelength cut-off filters 371
(b) Bandpass filters 373
D Measurement of Light Intensity 376
1 Physical methods 376
2 Chemical actinometry 378
(a) Uranyl oxalate actinometer 378
(b) Malachite green leucocyanide actinometer 380
(c) Ferrioxalate actinometer 381
(d) Other actinometer systems 383
E Microbeam, or Partial Cell, Irradiation 384
BIBLIOGRAPHY387
INDEX 435
|
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| indexdate | 2024-07-09T17:01:48Z |
| institution | BVB |
| language | English |
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| series | International series of monographs on pure and applied biology Modern trends in physiological sciences |
| series2 | International series of monographs on pure and applied biology : Modern trends in physiological sciences Pergamon student ed. |
| spelling | MacLaren, Arthur D. Verfasser aut Photochemistry of proteins and nucleic acids by A. D. McLaren and D. Shugar Oxford [u.a.] Pergamon Press 1964 XII, 449 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier International series of monographs on pure and applied biology : Modern trends in physiological sciences 22 Pergamon student ed. Fotochemie (DE-588)4045873-8 gnd rswk-swf Proteine (DE-588)4076388-2 gnd rswk-swf Nucleinsäuren (DE-588)4172117-2 gnd rswk-swf Proteine (DE-588)4076388-2 s Fotochemie (DE-588)4045873-8 s DE-604 Nucleinsäuren (DE-588)4172117-2 s Shugar, David Verfasser aut International series of monographs on pure and applied biology Modern trends in physiological sciences 22 (DE-604)BV001888634 22 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004800797&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | MacLaren, Arthur D. Shugar, David Photochemistry of proteins and nucleic acids International series of monographs on pure and applied biology Modern trends in physiological sciences Fotochemie (DE-588)4045873-8 gnd Proteine (DE-588)4076388-2 gnd Nucleinsäuren (DE-588)4172117-2 gnd |
| subject_GND | (DE-588)4045873-8 (DE-588)4076388-2 (DE-588)4172117-2 |
| title | Photochemistry of proteins and nucleic acids |
| title_auth | Photochemistry of proteins and nucleic acids |
| title_exact_search | Photochemistry of proteins and nucleic acids |
| title_full | Photochemistry of proteins and nucleic acids by A. D. McLaren and D. Shugar |
| title_fullStr | Photochemistry of proteins and nucleic acids by A. D. McLaren and D. Shugar |
| title_full_unstemmed | Photochemistry of proteins and nucleic acids by A. D. McLaren and D. Shugar |
| title_short | Photochemistry of proteins and nucleic acids |
| title_sort | photochemistry of proteins and nucleic acids |
| topic | Fotochemie (DE-588)4045873-8 gnd Proteine (DE-588)4076388-2 gnd Nucleinsäuren (DE-588)4172117-2 gnd |
| topic_facet | Fotochemie Proteine Nucleinsäuren |
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