Cytochrome P-450:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Tokyo
Kodansha u.a.
1993
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XII, 292 S. Ill., graph. Darst. |
| ISBN: | 3527300163 1560817100 4062054604 |
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MARC
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| 245 | 1 | 0 | |a Cytochrome P-450 |c ed. by Tsuneo Omura ... |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Tokyo |b Kodansha u.a. |c 1993 | |
| 300 | |a XII, 292 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Cytochroom P450 |2 gtt | |
| 650 | 4 | |a Cytochrome P-450 | |
| 650 | 4 | |a Cytochrome P-450 Enzyme System | |
| 650 | 0 | 7 | |a Stoffwechsel |0 (DE-588)4057699-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Cytochrom P-450 |0 (DE-588)4148705-9 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Cytochrom P-450 |0 (DE-588)4148705-9 |D s |
| 689 | 0 | 1 | |a Stoffwechsel |0 (DE-588)4057699-1 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Ōmura, Tsuneo |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004392953&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Record in the Search Index
| _version_ | 1804121102968946688 |
|---|---|
| adam_text | ^ytochrome P-450
Second Edition
Edited by
Tsuneo Omura
Yuzuru Ishimura
Yoshiaki Fujii-Kuriyama
KODANSHA VCH
Weinheim • New York
Tokyo Basel • Cambridge
Contents
List of Contributors v
Preface xi
1 Introduction: History of Cytochrome P-450 (T Omura) 1
1 1 Discovery of Cytochrome P-450 in Liver Microsomes 1
1 2 Discovery of the Physiological Function of Cytochrome P-450 4
1 3 Wide Distribution of Cytochrome P-450 among Various Forms of Life 6
1 4 Constitution of Cytochrome P-450-containing Oxygenase Systems 8
1 5 Mechanism of Cytochrome P-450-catalyzed Reactions 10
1 6 Elucidation of the Molecular Properties of Cytochrome P-450 12
2 Molecular Properties and Reaction Mechanisms 17
2 1 Structures of Cytochrome P-450 (R Makino and H Shimada) 17
1 Introduction 17
2 Crystal structure of cytochrome P-450ram 17
3 Conserved amino acid residues and their functional roles 21
4 Site-directed mutagenetic study of cytochrome P-450 23
5 Structure of membrane-bound cytochrome P-450 27
2 2 Characteristics at the Heme Locus of Cytochrome P-450 in Comparison with
Other Oxygen-binding Heme Proteins (T Kitagawa) 31
221 Introduction 31
222 Ligands of the heme iron and physicochemical properties of heme proteins 31
223 Effects of thiolate ligation 34
2 3 Cytochrome P-450-Linked Electron Transport System in Monooxygenase Reac-
tion (S Takemori, T Yamazaki and S Ikushiro) 44
231 Introduction 44
232 Mitochondrial cytochrome P-450 linked electron transport system 46
233 Microsomal cytochrome P-450 linked electron transport system 51
234 Successive monooxygenase reactions catalyzed by cytochrome P-450 58
2 4 Substrate Binding and the Reduction of Cytochrome P-450 (S Kominami) 64
241 Catalytic cycle of cytochrome P-450 dependent monooxygenase reaction 64
242 Hydrophobic interaction in substrate binding site 67
243 Optical absorption spectra of cytochrome P-450 67
244 Spin state of oxidized cytochrome P-450 70
245 Spin equilibrium of oxidized cytochrome P-450 72
246 Relationship between the spin state and reduction rate of cytochrome P-450 74
247 Effects of membranes on substrate binding 75
viii Contents
2 5 Oxygen Activation and Transfer (Y Ishimura) 80
251 Introduction 80
252 Formation of oxycytochrome P-450 and its structure 81
253 Second electron transfer and decomposition of the oxyform 83
254 Splitting of the O-O bond and substrate monooxygenation 85
255 Other important aspects 89
3 P-450 Oxygenase Systems of Animal Tissues 93
3 1 Sterol Biosynthesis (Y Yoshida) 93
311 Biosynthetic pathway of sterol and role of P-450 93
312 Lanosterol 14a-demethylation catalyzed by P-450(14DM) 94
3 2 Steroid Hormone Biosynthesis (M Katagiri and K Suhara) 101
321 P-450 monooxygenase systems specific for steroid hormone biosynthesis 101
322 Cholesterol side chain cleavage (P-450scC) 102
323 21-Hydroxylation of steroids (P-450C2i) 105
324 17a-Hydroxylation and the second side chain cleavage of steroids (P-450|7o)
325 Biosynthesis of glucocorticoids and mineralocorticoids (P-450m) 108
326 Biosynthesis of estrogens (P-450arOm) 112
3 3 Bile Acid Synthesis (K Okuda) 116
331 Introduction 116
332 Cholesterol 7a-hydroxylase 116
333 Steroid 12a-hydroxylase 121
334 5/?-Cholestane-3a,7a,12a-triol 27-hydroxylases 122
335 Concluding remarks 125
3 4 Fatty Acid Omega-Oxidation and Eicosanoid Metabolism (M Kusunose) 127
341 Fatty acid and prostaglandin cu-hydroxylases 127
342 Epoxygenase 138
3 5 Metabolism of Xenobiotics (T Kamataki) 141
351 Introduction 141
352 Pharmacological and toxicological significance of drug metabolism 142
353 Cytochrome P-450-mediated metabolism of foreign compounds 143
354 Requirements for metabolism of drugs to reconstitute a cytochrome P-450-contain-
ing monooxygenase system 143
355 Metabolism of xenobiotics by cytochrome P-450 144
356 Metabolism of xenobiotics by cytochrome P-450 expressed in yeast and other
cells 144
357 Substrates and metabolic reactions seen with cytochrome P-450 either purified
from liver microsomes or expressed in cells: animal studies 145
358 Substrates and metabolic reactions seen with cytochrome P-450 either purified
from liver microsomes or expressed in cells: human studies 150
Contents ix
3 6 Activation of Chemical Carcinogens (Y Yamazoe and R Kato) • 159
361 P-450 family involved in the metabolic activation of carcinogenic chemicals
362 P-450-mediated metabolism of typical chemical carcinogens 162
4 P-450 Monooxygenase System of Microorganisms 171
4 1 P-450 Monooxygenase System of Yeast and Filamentous Fungi (Y Yoshida)
411 The state of investigation of P-450 of yeast and filamentous fungi 171
412 P-450 of yeast 172
413 P-450 of filamentous fungi 180
414 Regulation of P-450 formation by eukaryotic microorganisms 183
4 2 Bacterial P-450 Enzymes (T Horiuchi, H Koga and Y Sagara) 186
421 Bacterial P-450 enzymes 186
422 Camphor 5-exo-hydroxylase: P-450cam 187
423 Structure and function of P^O^ 188
424 Structure-function relationship of P-450Cam 191
425 Other bacterial P-450 systems 199
5 P-450 Genes and Their Expression 207
5 1 Structure of P-450 Genes (O Gotoh) 207
1 P-450 Gene families and subfamilies 207
2 Mammalian P-450 gene clusters 207
3 Basic organization of mammalian P-450 genes 209
4 Bimodal distribution of G+C contents 211
5 CpG islands and DNA methylation 213
6 Diverse exon-intron organizations 215
7 Alternative splicing 217
8 Bacterial and fungal genes 219
5 2 Drug-inducible P-450s (Y Fujii-Kuriyama) 224
521 P-450c and P-450d genes (P-450 1 family) 224
522 P-450b and P-450 genes (P-450 2B1 and P-450 2B2 genes) 227
523 P-450PCN (P-450 3A) 228
5 3 Sexually Dimorphic Expression of P-450 Genes (M Negishi, K Aida and
H Yoshioka) 230
531 Sex-specific P-450s are steroid hydroxylases 230
532 Sex-specific expression also occurs in extrahepatic tissues 231
533 Growth hormone regulates all sex-specific P-450 expression 232
534 Transcriptional regulation of sex-specific P-450 genes 234
535 C/5-acting transcription elements 236
536 Genetic regulation of sex-specific P-450 and transgenic mouse 238
537 Evolutionary processes of sex-specific P-450 238
x Contents
5 4 Steroidogenic P-450s (M Okamoto and Y Nonaka) 242
541 Introduction 242
542 P-450scc 245
543 P-450|7tt 246
544 P-450C2i 246
545 P-450,,/) 248
546 P-450arora 250
547 Concluding comments 250
6 Evolution and Differentiation of P-450 Genes (O Gotoh) 255
6 1 Introduction 255
6 2 Unique Origin of P-450 Genes 255
6 3 Not All P-450s are Cytochrome P-450s 256
6 4 Conserved Regions in P-450 Proteins 259
6 5 Rates of Amino-acid Substitutions 260
6 6 Phylogenetic Relationship of P-450 Proteins 261
6 7 Evolution of P-450 Functions 264
6 8 Adaptive Evolution of CYP2 Family Genes 265
6 9 Evolution of P-450 Genes at the Nucleotide Sequence Level 268
6 10 Concluding Remarks 269
Appendix: Classification and List of Cytochrome P-450 (Y Imai) 273
Index 287
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| indexdate | 2024-07-09T16:52:39Z |
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| language | English |
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| physical | XII, 292 S. Ill., graph. Darst. |
| publishDate | 1993 |
| publishDateSearch | 1993 |
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| publisher | Kodansha u.a. |
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| spelling | Cytochrome P-450 ed. by Tsuneo Omura ... 2. ed. Tokyo Kodansha u.a. 1993 XII, 292 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Cytochroom P450 gtt Cytochrome P-450 Cytochrome P-450 Enzyme System Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Cytochrom P-450 (DE-588)4148705-9 gnd rswk-swf Cytochrom P-450 (DE-588)4148705-9 s Stoffwechsel (DE-588)4057699-1 s DE-604 Ōmura, Tsuneo Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004392953&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cytochrome P-450 Cytochroom P450 gtt Cytochrome P-450 Cytochrome P-450 Enzyme System Stoffwechsel (DE-588)4057699-1 gnd Cytochrom P-450 (DE-588)4148705-9 gnd |
| subject_GND | (DE-588)4057699-1 (DE-588)4148705-9 |
| title | Cytochrome P-450 |
| title_auth | Cytochrome P-450 |
| title_exact_search | Cytochrome P-450 |
| title_full | Cytochrome P-450 ed. by Tsuneo Omura ... |
| title_fullStr | Cytochrome P-450 ed. by Tsuneo Omura ... |
| title_full_unstemmed | Cytochrome P-450 ed. by Tsuneo Omura ... |
| title_short | Cytochrome P-450 |
| title_sort | cytochrome p 450 |
| topic | Cytochroom P450 gtt Cytochrome P-450 Cytochrome P-450 Enzyme System Stoffwechsel (DE-588)4057699-1 gnd Cytochrom P-450 (DE-588)4148705-9 gnd |
| topic_facet | Cytochroom P450 Cytochrome P-450 Cytochrome P-450 Enzyme System Stoffwechsel Cytochrom P-450 |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=004392953&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT omuratsuneo cytochromep450 |