Gastrointestinal regulatory peptides:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
1993
|
| Schriftenreihe: | Handbook of experimental pharmacology
106 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XX, 446 S. Ill., graph. Darst. |
| ISBN: | 3540559701 0387559701 |
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| 245 | 1 | 0 | |a Gastrointestinal regulatory peptides |c contributors A. Alemayehu ... Ed. David R. Brown |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 1993 | |
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| 650 | 7 | |a Neuropeptides |2 cabt | |
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Datensatz im Suchindex
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| adam_text | LS A -?H- HI -Z -2 GASTROINTESTINAL REGULATORY PEPTIDES CONTRIBUTORS
A. ALEMAYEHU, B. AMIRANOFF, D.L. BARBER, S.R. BLOOM J. CALAM, R.E.
CARRAWAY, FENG CHEN, C.S. CHEW, C.C. CHOU, J.M. CONLON, A. COUVINEAU, E.
EKBLAD, T.S. GAGINELLA, J.J. GALLIGAN, J.R. GRIDER, R. HAKANSON P.
KITABGI, M. LABURTHE, Y.P. LOH, M.S. O DORISIO S.M. O GRADY, R.K.
PEARSON, R.J. PLAYFORD E. ROZENGURT, F. SUNDLER, I. ZACHARY EDITOR DAVID
R. BROWN SPRINGER-VERLAG BERLIN HEIDELBERG NEW YORK LONDON PARIS TOKYO
HONG KONG BARCELONA BUDAPEST CONTENTS CHAPTER 1 LOCALIZATION AND
COLOCALIZATION OF GASTROINTESTINAL PEPTIDES F. SUNDLER, E. EKBLAD, AND
R. HAKANSON. WITH 10 FIGURES 1 A. INTRODUCTION 1 B. COEXISTENCE OF
MESSENGERS 2 C. ENDOCRINE AND PARACRINE CELLS 3 I. STOMACH 4 II. SMALL
INTESTINE 6 III. LARGE INTESTINE 8 IV. COEXISTENCE OF PEPTIDES IN GUT
ENDOCRINE CELLS 8 D. ENTERIC NEURONS 11 I. DISTRIBUTION OF
PEPTIDE-CONTAINING NERVE FIBERS IN THE DIGESTIVE TRACT 12 II.
PROJECTIONS OF ENTERIC NEURONS IN THE RAT 16 1. MYENTERIC NEURONS 16 2.
SUBMUCOUS NEURONS 17 III. COEXISTENCE OF PEPTIDES IN ENTERIC NEURONS 18
REFERENCES 20 CHAPTER 2 REGULATION OF GASTROINTESTINAL PEPTIDE HORMONE
GENE EXPRESSION R.K. PEARSON. WITH 5 FIGURES 29 A. INTRODUCTION 29 B.
GENE STRUCTURE 30 C. RNA POLYMERASE II 31 D. TRANSCRIPTIONAL REGULATION
OVERVIEW 33 I. DNA ELEMENTS 33 II. TRANSCRIPTION FACTORS 35 1. GENERAL
TRANSCRIPTION FACTORS 35 2. REGULATED TRANSCRIPTION FACTORS 35 3.
MODULATION OF TRANSCRIPTION FACTOR ACTIVITY 38 X CONTENTS III.
TRANSCRIPTIONAL REPRESSION 41 IV. GENES LACKING TATA ELEMENTS 44 E.
ANALYSIS OF GENE EXPRESSION 45 I. RNA QUANTITATION 45 II. PROMOTER
STUDIES 45 F. REGULATION OF SPECIFIC HORMONE GENE EXPRESSION 48 I.
PREFACE 48 II. GASTRIN/CHOLECYSTOKININ FAMILY 48 1. GASTRIN: BACKGROUND
49 2. LUMINAL REGULATION OF GASTRIN GENE EXPRESSION 49 3. ISLET CELL
GASTRIN EXPRESSION 50 4. GASTRIN PROMOTER ANALYSIS 51 A) STUDIES IN
PITUITARY CELL LINES 52 B) STUDIES IN ISLET CELLS 53 5. CHOLECYSTOKININ:
BACKGROUND 53 6. CHOLECYSTOKININ GENE REGULATION: RNA QUANTITATION .. 54
7. CHOLECYSTOKININ: PROMOTER ANALYSIS 55 III. SOMATOSTATIN 56 1.
SOMATOSTATIN GENE REGULATION 56 2. MODEL OF CAMP REGULATION 57 3. TISSUE
SPECIFIC EXPRESSION 58 IV. GLUCAGON 59 V. SECRETIN 60 VI. MOTILIN 60 G.
CONCLUSION 61 REFERENCES 61 CHAPTER 3 POST-TRANSLATIONAL PROCESSING OF
REGULATORY PEPTIDES R.E. CARRAWAY AND Y.P. LOH. WITH 4 FIGURES 69 A.
INTRODUCTION 69 B. GENERAL DESIGN OF PROCESSING SYSTEMS 69 I. ACTIVE
PEPTIDE STORED IN SECRETORY VESICLES 70 II. ACTIVE PEPTIDE RELEASED
CONSTITUTIVELY 72 III. PRECURSOR ACTIVATED IN OR NEAR CELL OF ORIGIN 73
1. PRECURSOR STORED INTRACELLULARLY 73 2. PRECURSOR ANCHORED TO CELL
SURFACE 74 IV. PRECURSOR ACTIVATED IN THE INTERSTITIAL SPACE OR BLOOD 75
V. PRECURSOR ACTIVATED AT TARGET OR BY OTHER CELLS 77 1. PRECURSOR
STORED OUTSIDE TARGET 78 2. PRECURSOR STORED INSIDE TARGET 78 VI. MIXED
SYSTEMS 79 C. INTRACELLULAR TRAFFICKING AND PROCESSING PATHWAYS 80
CONTENTS XI D. PROCESSING SITES AND GENERAL MECHANISMS 81 I. TWO-STEP
PROCESSING 81 II. DIBASIC, MONOBASIC AND NONBASIC SITES 81 III.
CONFORMATION AND CONSENSUS FEATURES 81 IV. SEQUENTIALLY ORDERED
REACTIONS 82 V. TISSUE-SPECIFIC PROCESSING 82 E. ENZYMES INVOLVED IN THE
PROCESSING OF PROHORMONES 83 I. DIBASIC RESIDUE-SPECIFIC ENDOPROTEASES
83 II. MONOBASIC RESIDUE-SPECIFIC ENDOPROTEASES 86 III. TETRABASIC
RESIDUE-SPECIFIC ENDOPROTEASES 86 IV. EXOPEPTIDASES 88 V. ENZYMES
INVOLVED IN N- AND C-TERMINAL MODIFICATION 88 1. ACETYLTRANSFERASE 88 2.
GLUTAMINYL CYCLASE 89 3. PEPTIDYLGLYCINE A-AMIDATING MONOOXYGENASE 89
VI. ENZYMES INVOLVED IN SULFATION AND PHOSPHORYLATION 90 1. TYROSINE
SULFATION ENZYME 90 2. SERINE PHOSPHORYLATING ENZYMES 90 F. PROCESSING
OF SPECIFIC PROHORMONES 91 I. YEAST PHEROMONES 91 II.
PROOPIOMELANOCORTIN 92 III. GASTROINTESTINAL HORMONES 93 1. GLUCAGON AND
RELATED PEPTIDES 93 2. CHOLECYSTOKININ 94 3. GASTRIN 94 4. SOMATOSTATIN
95 5. NEUROTENSIN AND NEUROMEDIN-N 95 6. PANCREATIC POLYPEPTIDE 96 G.
CONCLUSION 96 REFERENCES 96 CHAPTER 4 REGULATION OF PEPTIDE SECRETION
FROM GASTROENTERIC ENDOCRINE CELLS D.L. BARBER. WITH 7 FIGURES 105 A.
INTRODUCTION 105 B. GASTROENTERIC ENDOCRINE CELLS 105 I. LOCALIZATION
105 II. METHODS FOR STUDYING PEPTIDE RELEASE 106 C. NEUROTRANSMITTER AND
PEPTIDE REGULATION OF RELEASE 108 I. ACETYLCHOLINE -... 108 II.
NOREPINEPHRINE ILL III. SOMATOSTATIN 112 IV. GASTRIN-RELEASING PEPTIDE
AND BOMBESIN 115 XII CONTENTS V. GASTRIN AND CHOLECYSTOKININ 118 D.
NUTRIENT REGULATION OF PEPTIDE RELEASE 120 I. PROTEINS AND AMINO ACIDS
120 II. FATTY ACIDS 121 E. REGULATION OF RELEASE BY LUMINAL PH 122 F.
SUMMARY 123 REFERENCES 124 CHAPTER 5 PEPTIDE RECEPTORS AND SIGNAL
TRANSDUCTION IN THE DIGESTIVE TRACT M. LABURTHE, P. KITABGI, A.
COUVINEAU, AND B. AMIRANOFF. WITH 4 FIGURES 133 A. INTRODUCTION 133 B.
GENERAL CONSIDERATIONS AND METHODOLOGY 133 I. RECEPTOR CONCEPT AND
GENERAL PROPERTIES 133 II. METHODS FOR STUDY OF RECEPTORS 134 1. TISSUE
PREPARATIONS 134 2. RADIOLABELED LIGAND 134 3. SEPARATION OF BOUND AND
UNBOUND LIGAND 135 III. MOLECULAR CHARACTERIZATION AND PURIFICATION 135
IV. RECEPTOR CLONING STRATEGIES 137 C. SIGNAL TRANSDUCTION BY RECEPTORS
140 I. ADENYLYL CYCLASE: CYCLIC AMP PATHWAY 141 II. PHOSPHATIDYL
INOSITOL SIGNALING 142 D. PEPTIDE RECEPTORS IN THE DIGESTIVE TRACT 142
I. VASOACTIVE INTESTINAL PEPTIDE 148 II. GALANIN 153 III. NEUROTENSIN
157 E. CONCLUSION AND PERSPECTIVES 161 REFERENCES 162 CHAPTER 6
PROTEOLYTIC INACTIVATION OF NEUROHORMONAL PEPTIDES IN THE
GASTROINTESTINAL TRACT GASTROINTESTINAL TRACT J.M. CONLON 177 A.
INTRODUCTION 177 B. PROTEOLYTIC ENZYMES IMPLICATED IN THE INACTIVATION
OF NEUROHORMONAL PEPTIDES IN THE GASTROINTESTINAL TRACT 178 I.
ENDOPEPTIDASES 178 1. ENDOPEPTIDASE 24.11 178 CONTENTS XIII 2.
ENDOPEPTIDASE 24.15 180 3. ENDOPEPTIDASE 24.16 181 II. EXOPEPTIDASES 181
1. PEPTIDYL DIPEPTIDASE A 181 2. AMINOPEPTIDASES 183 3. DIPEPTIDYL
AMINOPEPTIDASE IV 184 4. CARBOXYPEPTIDASES 184 C. PATHWAYS OF
PROTEOLYTIC INACTIVATION OF SOME GASTROINTESTINAL HORMONES 184 I.
NEUROTENSIN 184 II. GASTRIN 186 III. CHOLECYSTOKININ 187 IV.
SOMATOSTATIN 188 D. PATHWAYS OF PROTEOLYTIC INACTIVATION OF SOME
GASTROINTESTINAL NEUROPEPTIDES 189 I. TACHYKININS 189 II. ENKEPHALINS
190 III. VASOACTIVE INTESTINAL POLYPEPTIDE 192 E. CONCLUSION 192
REFERENCES 193 CHAPTER 7 PEPTIDERGIC REGULATION OF GASTRIC ACID
SECRETION C.S. CHEW. WITH 3 FIGURES 199 A. INTRODUCTION 199 B. ACID
SECRETORY CONTROL MECHANISMS IN VIVO 200 I. EXTRINSIC INNERVATION AND
CENTRAL CONTROL 200 II. INTRINSIC INNERVATION 205 III. CEPHALIC AND
GASTRIC PHASES OF SECRETION 205 1. GASTRIN RELEASE MECHANISMS 206 2.
EFFECTS OF OTHER PEPTIDES 207 IV. INTESTINAL FACTORS 209 V. INHIBITORY
PHASES OF ACID SECRETION 209 1. CEPHALIC INFLUENCES 209 2. ANTRAL AND
FUNDIC MECHANISMS 210 3. INTESTINAL INHIBITORY MECHANISMS 213 A)
SECRETIN 214 B) CHOLECYSTOKININ 215 C) GASTRIC INHIBITORY POLYPEPTIDE
215 D) SOMATOSTATIN 216 E) NEUROTENSIN 216 F) GLUCAGON-LIKE PEPTIDES 216
G) PEPTIDE YY 217 XIV CONTENTS 4. NEUROPEPTIDE INHIBITORS 217 A)
SUBSTANCE P 218 B) GALANIN 218 C. PEPTIDE EFFECTS ON ISOLATED CELLS 218
I. PARIETAL CELLS . 220 1. PEPTIDE ACTIVATION MECHANISMS 220 A) GASTRIN
221 B) EFFECTS OF OTHER PEPTIDES 223 2. PEPTIDE INHIBITORY MECHANISMS
224 A) SOMATOSTATIN 224 B) EPIDERMAL GROWTH FACTOR 226 C) OTHER
INHIBITORY PEPTIDES 227 II. ANTRAL G CELLS 228 III. FUNDIC AND ANTRAL D
CELLS 230 IV. HISTAMINE-CONTAINING CELLS 232 REFERENCES 233 CHAPTER 8
PEPTIDES AND ENTERIC NEURAL ACTIVITY J.J. GALLIGAN. WITH 4 FIGURES 253
A. INTRODUCTION 253 B. ELECTROPHYSIOLOGY OF ENTERIC NERVES 253 C.
ACTIONS OF PEPTIDES ON ENTERIC NERVES 254 I. TACHYKININ PEPTIDES 254 1.
TACHYKININ PEPTIDES IN ENTERIC NERVES 254 2. TACHYKININS DEPOLARIZE
ENTERIC NEURONS 254 3. TACHYKININS DECREASE RESTING POTASSIUM
CONDUCTANCE (G K ) 254 4. TACHYKININ-INDUCED DEPOLARIZATIONS ASSOCIATED
WITH A CONDUCTANCE INCREASE 257 5. TACHYKININ RECEPTORS ON ENTERIC
NEURONS 258 6. TACHYKININ RECEPTORS COUPLED TO POLYPHOSPHOINOSITIDE
HYDROLYSIS 259 7. SYNAPTIC ACTIVATION OF TACHYKININ RECEPTORS 260 II.
VASOACTIVE INTESTINAL PEPTIDE 261 1. VASOACTIVE INTESTINAL PEPTIDE
RECEPTORS COUPLED TO G K DECREASE 261 2. VASOACTIVE INTESTINAL PEPTIDE
RECEPTORS MAY BE COUPLED TO ADENYLATE CYCLASE IN ENTERIC NERVES 261 3.
SYNAPTIC POTENTIALS MEDIATED BY VASOACTIVE INTESTINAL PEPTIDE 262 III.
CALCITONIN GENE-RELATED PEPTIDE 262 1. CALCITONIN GENE-RELATED PEPTIDE
RECEPTORS COUPLED TO G K DECREASE 262 CONTENTS XV 2. TRANSDUCTION
MECHANISM 262 IV. CHOLECYSTOKININ 263 1. CHOLECYSTOKININ RECEPTORS
COUPLED TO A G K DECREASE .. 263 2. TRANSDUCTION MECHANISM 263 3.
RECEPTORS ON ENTERIC NEURONS 263 4. CHOLECYSTOKININ FACILITATES
NEUROTRANSMISSION IN PANCREATIC AND GALLBLADDER GANGLIA 263 V.
GASTRIN-RELEASING PEPTIDE/BOMBESIN 264 VI. MOTILIN 264 VII. OPIOID
PEPTIDES 264 1. OPIOID PEPTIDES HYPERPOLARIZE ENTERIC NEURONS AND
INCREASE G K 264 2. OPIOID PEPTIDES ACTIVATE AN INWARDLY RECTIFYING G K
*.. 265 3. TRANSDUCTION MECHANISM FOR OPIOID-ACTIVATED G K 265 4. OPIOID
RECEPTORS ON ENTERIC NEURONS 265 5. OPIOID RECEPTORS COUPLED TO
INHIBITION OF CALCIUM CHANNELS 266 6. FUNCTIONAL IMPLICATIONS OF OPIOID
PEPTIDE ACTION ON ENTERIC NERVES 266 VIII. SOMATOSTATIN 267 1.
SOMATOSTATIN HYPERPOLARIZES ENTERIC NEURONS BY INCREASING AN INWARDLY
RECTIFYING G K 267 2. AG-PROTEIN COUPLES THE SOMATOSTATIN RECEPTOR TO
THE POTASSIUM CHANNEL 268 3. NONADRENERGIC INHIBITORY POSTSYNAPTIC
POTENTIAL MIMICKED BY SOMATOSTATIN 268 4. SOMATOSTATIN INHIBITS CALCIUM
CURRENTS 269 5. FUNCTIONAL CONSEQUENCES OF SOMATOSTATIN ACTION ON
ENTERIC NEURONS 269 IX. GALANIN 269 X. NEUROPEPTIDE Y 270 D. CONCLUSIONS
270 REFERENCES 271 CHAPTER 9 PEPTIDERGIC REGULATION OF SMOOTH MUSCLE
CONTRACTILITY J.R. GRIDER. WITH 3 FIGURES 277 A. INTRODUCTION 277 B.
REGULATION OF SMOOTH MUSCLE BY PEPTIDE HORMONES 277 I. CHOLECYSTOKININ
277 II. MOTILIN 279 III. PEPTIDE YY AND NEUROPEPTIDE Y 279 IV.
NEUROTENSIN 280 C. REGULATION OF SMOOTH MUSCLE BY NEURAL PEPTIDES 281
XVI CONTENTS I. VASOACTIVE INTESTINAL PEPTIDE, PEPTIDE HISTIDINE
ISOLEUCIRIE, AND PEPTIDE HISTIDINE METHIONINE 281 II. TACHYKININS
(NEUROKININS) 285 III. OPIOID PEPTIDES 286 IV. SOMATOSTATIN 287 V.
GASTRIN-RELEASING PEPTIDE AND NEUROMEDIN B 288 VI. GALANIN 289 VII.
CALCITONIN GENE-RELATED PEPTIDE 289 REFERENCES 289 CHAPTER 10
PEPTIDERGIC REGULATION OF INTESTINAL ELECTROLYTE TRANSPORT S.M. O GRADY.
WITH 3 FIGURES 297 A. INTRODUCTION 297 B. TRANSPORT MODELS FOR
ABSORPTION AND SECRETION 297 I. SODIUM, CHLORIDE AND BICARBONATE
ABSORPTION 298 II. CHLORIDE AND BICARBONATE SECRETION 302 III. POTASSIUM
TRANSPORT 303 IV. PARACELLULAR PATHWAY AND SOLUTE TRANSPORT 304 C.
REGULATION OF INTESTINAL TRANSPORT BY PEPTIDE NEUROHORMONES ... 305 I.
PEPTIDES THAT STIMULATE INTESTINAL SECRETION OR INHIBIT ABSORPTION 305
1. VASOACTIVE INTESTINAL PEPTIDE AND RELATED PEPTIDES .... 305 2.
GASTRIN-RELEASING PEPTIDE AND RELATED PEPTIDES 307 3. SUBSTANCE P AND
NEUROKININS 307 4. NEUROTENSIN 308 5. NATRIURETIC PEPTIDES 309 II.
PEPTIDES THAT STIMULATE INTESTINAL ABSORPTION OR INHIBIT SECRETION 311
1. ANGIOTENSIN 311 2. VASOPRESSIN 311 3. NEUROPEPTIDE Y 312 4.
SOMATOSTATIN 312 5. OPIOID PEPTIDES 313 III. OTHER PEPTIDES THAT
REGULATE INTESTINAL ELECTROLYTE TRANSPORT 314 D. CONCLUDING REMARKS 315
REFERENCES 316 CONTENTS XVII CHAPTER 11 PEPTIDERGIC REGULATION OF
GASTROINTESTINAL BLOOD FLOW C.C. CHOU AND A. ALEMAYEHU 325 A.
INTRODUCTION 325 B. GASTROINTESTINAL PEPTIDES 326 I. CHOLECYSTOKININ 326
II. SECRETIN 328 III. GASTRIN 328 IV. GASTRIC INHIBITORY POLYPEPTIDE 329
V. NEUROTENSIN 330 VI. GLUCAGON 330 VII. VASOACTIVE INTESTINAL
POLYPEPTIDE 331 VIII. SUBSTANCE P 332 IX. SOMATOSTATIN 333 X. CALCITONIN
GENE-RELATED PEPTIDE 334 XI. PEPTIDE YY 334 XII. NEUROMEDIN U 335 C.
CAPSAICIN-SENSITIVE AFFERENT NERVES 336 REFERENCES 339 CHAPTER 12
PEPTIDERGIC REGULATION OF CELL PROLIFERATION THROUGH MULTIPLE SIGNALING
PATHWAYS I. ZACHARY AND E. ROZENGURT. WITH 1 FIGURE 343 A. INTRODUCTION
343 B. GROWTH-PROMOTING ACTIVITIES OF NEUROPEPTIDES IN CULTURED CELLS
344 I. MITOGENIC ACTION OF BOMBESIN IN SWISS 3T3 CELLS: A PARADIGM FOR
PEPTIDERGIC REGULATION OF CELL PROLIFERATION 346 II. PURIFICATION AND
MOLECULAR CLONING 347 C. EARLY SIGNALING EVENTS 348 I. INOSITOL
PHOSPHOLIPID TURNOVER AND CA 2+ MOBILIZATION .... 348 II. PROTEIN KINASE
C AND INITIATION OF DNA SYNTHESIS 349 1. ACTIVATION OF PROTEIN KINASE C
IN INTACT FIBROBLASTS .... 349 2. CROSS-TALK BETWEEN PROTEIN KINASE C,
CYCLIC AMP, AND EPIDERMAL GROWTH FACTOR RECEPTOR AFFINITY 350 III.
MONOVALENT ION FLUXES 352 IV. NEUROPEPTIDE STIMULATION OF TYROSINE
KINASE ACTIVITY .... 352 V. ARACHIDONIC ACID RELEASE AND PROSTAGLANDIN
SYNTHESIS: DIFFERENTIAL EFFECTS OF BOMBESIN AND VASOPRESSIN 353 VI.
BOMBESIN INDUCTION OF THE PROTO-ONCOGENES C-FOS AND C-MYC 354 XVIII
CONTENTS VII. REGULATION OF CELLULAR RESPONSIVENESS TO BOMBESIN-
STIMULATED MITOGENESIS 354 D. EVIDENCE FOR GROWTH-PROMOTING EFFECTS OF
NEUROPEPTIDES IN VIVO 355 I. TROPHIC EFFECTS OF GASTROINTESTINAL
PEPTIDES IN THE GUT .... 356 II. DEVELOPMENT, TISSUE REPAIR AND
TUMORIGENESIS 357 E. CONCLUSIONS 358 REFERENCES 360 CHAPTER 13
PEPTIDERGIC REGULATION OF MUCOSAL IMMUNE FUNCTION FENG CHEN AND M.S.
O DORISIO 363 A. INTRODUCTION 363 B. OVERVIEW OF IMMUNE FUNCTION IN
GUT-ASSOCIATED LYMPHOID TISSUE 363 C. PEPTIDE EFFECTS ON IMMUNE FUNCTION
367 I. VASOACTIVE INTESTINAL PEPTIDE 367 II. SOMATOSTATIN 371 III.
SUBSTANCE P 372 IV. OPIOID PEPTIDES 374 V. NEUROPEPTIDE Y 376 VI.
CALCITONIN GENE-RELATED PEPTIDE 377 VII. CHOLECYSTOKININ 377 D.
CONCLUSION 378 REFERENCES 379 CHAPTER 14 PATHOPHYSIOLOGICAL ASPECTS OF
GUT PEPTIDE HORMONES R.J. PLAYFORD, J. CALAM, AND S.R. BLOOM. WITH 4
FIGURES 387 A. INTRODUCTION 387 B. ESOPHAGUS 387 I. ANATOMY 387 II.
ACHALASIA 387 III. REFLUX ESOPHAGITIS 388 C. STOMACH 388 I. ANATOMY 388
1. NERVES OF THE EPITHELIUM 389 2. INTERACTIONS 389 II. GASTRIC ULCER
DISEASE 390 III. GASTRIC CANCER 390 IV. PERNICIOUS ANEMIA 391 CONTENTS
XIX V. DRUGS AND HYPERGASTRINEMIA 391 D. DUODENUM 392 I. DUODENAL ULCERS
: 392 E. PANCREAS 395 I. ANATOMY 395 II. GASTRINOMA AND THE
ZOLLINGER-ELLISON SYNDROME 396 1. TREATMENT 397 III. VIPOMAS AND THE
VERNER-MORRISON OR WDHA SYNDROME .. 397 IV. GLUCAGONOMAS 398 V.
SOMATOSTATINOMAS 399 VI. MULTIPLE HORMONE ELEVATIONS 399 VII. CHRONIC
PANCREATITIS 399 VIII. PANCREATIC CANCER 400 F. GALLSTONES 401 G. SMALL
BOWEL 403 I. ANATOMY 403 II. EFFECTS OF GASTRIC SURGERY 404 III.
GASTROINTESTINAL HORMONES DURING DIARRHEA 405 IV. INFLAMMATORY BOWEL
DISEASE 406 H. COLON 407 I. ANATOMY 407 II. COLON AND MALABSORPTION 407
III. POLYP AND CANCERS 407 IV. ABNORMALITIES OF GUT PEPTIDERGIC
INNERVATION IN THE COLON 408 V. IRRITABLE BOWEL SYNDROME (IBS) 408 J.
GASTROINTESTINAL HORMONES AND CARDIOVASCULAR FUNCTION 409 K. CONCLUSIONS
409 REFERENCES 410 CHAPTER 15 GASTROINTESTINAL PEPTIDES AS THERAPEUTIC
AGENTS AND TARGETS: PAST, PRESENT AND FUTURE T.S. GAGINELLA. WITH 2
FIGURES 417 A. INTRODUCTION 417 B. DIAGNOSTIC USE OF GASTROINTESTINAL
PEPTIDES 417 C. PEPTIDES AS AGONISTS IN THERAPEUTICS 419 I. SOMATOSTATIN
419 II. GLUCAGON 422 III. MOTILIN ,. 423 D. ANTAGONISTS OF PEPTIDES IN
THERAPY 424 I. GASTRIN ANTAGONISTS 424 II. CHOLECYSTOKININ RECEPTOR
BLOCKERS 427 III. VASOACTIVE INTESTINAL PEPTIDE ANTAGONISTS 428 XX
CONTENTS IV. SUBSTANCE P ANTAGONISTS 430 V. OPIOID PEPTIDES 431 E. THE
FUTURE 432 REFERENCES 432 SUBJECT INDEX 43 9
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| any_adam_object | 1 |
| author_GND | (DE-588)171991842 |
| building | Verbundindex |
| bvnumber | BV006171393 |
| callnumber-first | Q - Science |
| callnumber-label | QP905 |
| callnumber-raw | QP905 |
| callnumber-search | QP905 |
| callnumber-sort | QP 3905 |
| callnumber-subject | QP - Physiology |
| classification_rvk | XI 1701 |
| classification_tum | MED 308f MED 430f CHE 834f CHE 820f |
| ctrlnum | (OCoLC)26636517 (DE-599)BVBBV006171393 |
| dewey-full | 612.32 615.1 615/.1 612.3/2 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology 615 - Pharmacology and therapeutics |
| dewey-raw | 612.32 615.1 615/.1 612.3/2 |
| dewey-search | 612.32 615.1 615/.1 612.3/2 |
| dewey-sort | 3612.32 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie Medizin |
| format | Book |
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| id | DE-604.BV006171393 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:41:30Z |
| institution | BVB |
| isbn | 3540559701 0387559701 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-003904653 |
| oclc_num | 26636517 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| owner_facet | DE-19 DE-BY-UBM DE-12 DE-355 DE-BY-UBR DE-20 DE-11 DE-188 DE-578 |
| physical | XX, 446 S. Ill., graph. Darst. |
| publishDate | 1993 |
| publishDateSearch | 1993 |
| publishDateSort | 1993 |
| publisher | Springer |
| record_format | marc |
| series | Handbook of experimental pharmacology |
| series2 | Handbook of experimental pharmacology |
| spelling | Gastrointestinal regulatory peptides contributors A. Alemayehu ... Ed. David R. Brown Berlin [u.a.] Springer 1993 XX, 446 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of experimental pharmacology 106 Literaturangaben Gastrointestinal Hormones cabt Neuropeptides cabt Physiology cabt Pharmacology cabt Hormonen gtt Maagdarmstelsel gtt Peptiden gtt Regelmechanismen gtt Digestive System Physiological Phenomena Gastrointestinal Hormones physiology Gastrointestinal hormones Neuropeptides pharmacology Neuropeptides physiology Peptide (DE-588)4045125-2 gnd rswk-swf Gastrointestinales Hormon (DE-588)4019409-7 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Neuropeptide (DE-588)4041895-9 gnd rswk-swf Gastrointestinaltrakt (DE-588)4074445-0 gnd rswk-swf Gastrointestinales Hormon (DE-588)4019409-7 s DE-604 Gastrointestinaltrakt (DE-588)4074445-0 s Peptide (DE-588)4045125-2 s Regulation (DE-588)4049075-0 s Neuropeptide (DE-588)4041895-9 s Brown, David Robert 1954- Sonstige (DE-588)171991842 oth Alemayehu, Adinew Sonstige oth Handbook of experimental pharmacology 106 (DE-604)BV002390716 106 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003904653&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gastrointestinal regulatory peptides Handbook of experimental pharmacology Gastrointestinal Hormones cabt Neuropeptides cabt Physiology cabt Pharmacology cabt Hormonen gtt Maagdarmstelsel gtt Peptiden gtt Regelmechanismen gtt Digestive System Physiological Phenomena Gastrointestinal Hormones physiology Gastrointestinal hormones Neuropeptides pharmacology Neuropeptides physiology Peptide (DE-588)4045125-2 gnd Gastrointestinales Hormon (DE-588)4019409-7 gnd Regulation (DE-588)4049075-0 gnd Neuropeptide (DE-588)4041895-9 gnd Gastrointestinaltrakt (DE-588)4074445-0 gnd |
| subject_GND | (DE-588)4045125-2 (DE-588)4019409-7 (DE-588)4049075-0 (DE-588)4041895-9 (DE-588)4074445-0 |
| title | Gastrointestinal regulatory peptides |
| title_auth | Gastrointestinal regulatory peptides |
| title_exact_search | Gastrointestinal regulatory peptides |
| title_full | Gastrointestinal regulatory peptides contributors A. Alemayehu ... Ed. David R. Brown |
| title_fullStr | Gastrointestinal regulatory peptides contributors A. Alemayehu ... Ed. David R. Brown |
| title_full_unstemmed | Gastrointestinal regulatory peptides contributors A. Alemayehu ... Ed. David R. Brown |
| title_short | Gastrointestinal regulatory peptides |
| title_sort | gastrointestinal regulatory peptides |
| topic | Gastrointestinal Hormones cabt Neuropeptides cabt Physiology cabt Pharmacology cabt Hormonen gtt Maagdarmstelsel gtt Peptiden gtt Regelmechanismen gtt Digestive System Physiological Phenomena Gastrointestinal Hormones physiology Gastrointestinal hormones Neuropeptides pharmacology Neuropeptides physiology Peptide (DE-588)4045125-2 gnd Gastrointestinales Hormon (DE-588)4019409-7 gnd Regulation (DE-588)4049075-0 gnd Neuropeptide (DE-588)4041895-9 gnd Gastrointestinaltrakt (DE-588)4074445-0 gnd |
| topic_facet | Gastrointestinal Hormones Neuropeptides Physiology Pharmacology Hormonen Maagdarmstelsel Peptiden Regelmechanismen Digestive System Physiological Phenomena Gastrointestinal Hormones physiology Gastrointestinal hormones Neuropeptides pharmacology Neuropeptides physiology Peptide Gastrointestinales Hormon Regulation Neuropeptide Gastrointestinaltrakt |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003904653&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002390716 |
| work_keys_str_mv | AT browndavidrobert gastrointestinalregulatorypeptides AT alemayehuadinew gastrointestinalregulatorypeptides |