Central regulation of energy metabolism with special reference to circadian rhythm:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton u.a.
CRC Press
1992
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 194 S. graph. Darst. |
| ISBN: | 0849366577 |
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Record in the Search Index
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| adam_text | Central Regulation of
Energy Metabolism
with
Special Reference to
Circadian Rhythm
Katsuya_Nagai and Hachiro Nakagawa
Division of Protein Metabolism
Institute for Protein Research
Osaka University
Osaka, Japan
CRC Press
Boca Raton Ann Arbor London Tokyo
TABLE OF CONTENTS
Chapter 1
HOMEOSTATIC CONTROL OF ENERGY METABOLISM 1
I Historical Background of Homeostasis 1
II Homeostatic Control of Energy Metabolism 1
A Why Should Homeostasis of the Level
of Blood Glucose Be Maintained? 1
B Glycogen Storage in the Liver as a Source
of Energy to the Brain 2
C Food Intake 2
D Gluconeogenesis 2
III Role of the Hypothalamus in Central Regulation
of Energy Metabolism 6
A Hypothalamic Control of Food Intake 6
B Hypothalamus and Glucose Metabolism 7
C Hypothalamic Control of Fat Metabolism 8
D Hypothalamic Control of Heat Production
in Brown Adipose Tissue 9
E Functional Relationship Between the
Hypothalamus and the Autonomic Nervous
System in Regard to Energy Metabolism 10
1 Pancreatic Hormones 10
2 Adrenaline 12
References 12
Chapter 2
INVOLVEMENT OF THE AUTONOMIC NERVOUS SYSTEM
IN THE REGULATION OF ENERGY METABOLISM 15
I Time-Dependent Hyperglycemic Response
to Energy Deficiency in the Brain 15
A Hyperglycemic Responses
to Intracranial Injections of 2DG 15
B Time Dependency of Hyperglycemic Responses
to 2DG, MA, and GL Injections 15
C Glucagon as a Causative Factor
for the Hyperglycemic Response to 2DG 17
II Involvement of the Adrenal Medulla
in the Hyperglycemic Response 18
A Suppression of Insulin Secretion
by Intracranial Injections of 2DG, MA, and GL 18
III Effects of Adrenergic Blockers
on the Hyperglycemic Response 23
References 34
Chapter 3
ORCADIAN RHYTHMS AND THEIR SIGNIFICANCES
IN SURVIVAL OF ANIMALS 35
I Time Dependency and Circadian Rhythms 35
A The Effects of Changing Environmental Factors
on the Lives of Animals 35
B Food Intake 35
II Circadian Rhythms of Animal Behaviors 36
A Water Intake 36
B Sleep and Wakefulness 37
C Locomotive Activity 38
III Daily Changes in Metabolism 38
A Energy Consumption and Respiratory Quotient 38
B Enzyme Activities 40
C Autonomic and Endocrinological Regulations
of Energy Metabolism 42
D The Autonomic Nervous System and Daily
Changes in PEPCK Activity in a Normal
Environment 45
E Generation of Daily Change in Gluconeogenesis
in Close Relation with Food Intake 46
IV Circadian Rhythms of Endocrine Functions 52
A Corticosteroids 52
B Insulin and Glucagon 54
V Body Temperature 58
References 60
Chapter 4
SUPRACHIASMATIC NUCLEUS AS A SITE OF THE
CIRCADIAN CLOCK 65
I Light Information Pathway to the Circadian Clock 65
A Involvement of the Suprachiasmatic Nucleus in
Generations of Various Circadian Rhythms 65
B Anatomy of the Suprachiasmatic Nucleus 67
II Suprachiasmatic Nucleus as a Master Circadian Clock 69
A Electrolytical and Immunological Lesions
oftheSCN 69
B SCN as a Self-Sustaining Circadian Oscillator 72
C Number of Oscillators Driving Circadian
Rhythms 76
1 Persistence of Some Circadian Rhythms
after SCN Lesions 76
2 Internal Desynchronization 77
3 Splitting of Circadian Rhythms 78
4 Daily Changes Caused
by Restricted Feeding 78
III Synchronization Mechanisms of Circadian Rhythms 83
A Synchronization by Light-Dark Information 83
B Artificial Synchronization 86
IV Relationships Between the Time Signal from the SCN
and Overt Circadian Rhythms 87
V Circadian Clock and Temporal Memory 88
VI The Possibility of the Presence of Other
Circadian Clocks 93
References 97
Chapter 5
THE ROLE OF THE SCN IN REGULATION OF ENERGY
METABOLISM , 103
I Roles of the SCN in Central Action
of 2-Deoxy-D-Glucose 103
A Elimination of Hyperglycemic Response
to 2-Deoxy-D-Glucose by SCN Lesions 103
B SCN and Insulin Secretion 103
C SCN and Glucagon Secretion 104
D SCN and Lipolytic and Feeding Responses
to 2DG 106
II Roles of the SCN in Central Actions of Insulin 109
A Effect of Insulin Infusion on Feeding Behavior 109
B Effect of Intracranial Administration of Insulin
on Blood Glucose Concentration 112
C Effects of SCN Lesions on Responses
to Intracranial Administration of Insulin 117
III Time-Dependent Control of Glucose Tolerance 119
A Daily Variations of Blood Concentrations
of Glucose, FFA, Insulin, and Glucagon 119
1 Physiological Meaning of the Daily
Changes in Brain Energy Sources and
Their Regulatory Hormones 119
2 Effects of SCN Lesions 121
B Glucose Tolerance 121
C Endogenous Mechanism of Daily Change
of Blood Insulin Level 123
IV Similarities Between Blinding and SCN Lesions
in Energy Metabolism 125
A Hyperglycemia Elicited by Electrical Stimulation
of the SCN 125
B Effects of Surgical Blinding on Time-Dependent
Hyperglycemic Response to 2DG 126
C Effect of Blinding on Hyperglycemia
Due to Electrical Stimulation of the SCN 131
D Effects of SCN Lesions and Blinding
on Hyperglycemia Due to Stimulation
of Other Brain Areas 131
1 Hyperglycemia Due to Electrical
Stimulation of the Lateral Part
of thePBD 131
2 Effects of SCN Lesions and Blinding 134
References 140
Chapter 6
PATHOLOGY OF THE SCN 145
I Abnormal Energy Metabolism
in Hereditary Microphthalmic Blind Rats 145
A Absence of Hyperglycemic Response to 2DG 145
B Putative Neurons in the SCN Responsible
for Central Regulation of Energy Metabolism 145
C Synchronization of Pup s Rhythm
with Real vs Foster Mother 146
II Morphological Changes of the SCN in Surgical and
Congenital Blind Rats 151
A Involvement of SCN Neurons Receiving Retinal
Input in Central Regulation of Energy
Metabolism 151
B Positional Plasticity of VIP Neurons 152
C Growth Factors Sustaining SCN Functions 153
III Obesity as a Result of Abnormal Function of the SCN 154
References 159
Chapter 7
OTHER FUNCTIONS OF THE SCN 161
I Macronutrient Selection 161
II The SCN as a Relay Point of Light Information
for Alteration of the Autonomic Nervous System 168
III Miscellaneous Possible Functions of the SCN 169
References 172
Chapter 8
SUMMARY OF FUNCTIONS OF THE SUPRACHIASMATIC
NUCLEUS IN REGULATION OF ENERGY METABOLISM 173
I Metabolic Functions of the SCN 173
A Possible Neural Pathways 173
B Carbohydrate Metabolism 174
C Lipid Metabolism 175
D Protein and Amino Acid Metabolism 178
II Respiratory Quotient and Oxygen Consumption 178
III Neural Activity of the SCN and Circadian Changes
in Metabolism 180
IV Mechanism of Involvement of the SCN
in Metabolic Regulation 181
A Circadian Regulation 181
B Noncircadian Regulation 183
C Aging and the SCN 183
References 184
CONCLUSION 187
INDEX 189
|
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| author | Nagai, Katsuya Nakagawa, Hachiro |
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| discipline | Biologie |
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| spelling | Nagai, Katsuya Verfasser aut Central regulation of energy metabolism with special reference to circadian rhythm Katsuya Nagai and Hachiro Nakagawa Boca Raton u.a. CRC Press 1992 194 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cerveau - Métabolisme Glucose - Métabolisme Métabolisme énergétique Brain Metabolism Brain metabolism Circadian Rhythm Energy Metabolism Energy metabolism Glucose Metabolism Glucose metabolism Nervale Regulation (DE-588)4041634-3 gnd rswk-swf Tagesrhythmus (DE-588)4078131-8 gnd rswk-swf Energiestoffwechsel (DE-588)4125217-2 gnd rswk-swf Neuroendokrine Regulation (DE-588)4277113-4 gnd rswk-swf Energiestoffwechsel (DE-588)4125217-2 s Neuroendokrine Regulation (DE-588)4277113-4 s DE-604 Nervale Regulation (DE-588)4041634-3 s Tagesrhythmus (DE-588)4078131-8 s Nakagawa, Hachiro Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=003893911&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nagai, Katsuya Nakagawa, Hachiro Central regulation of energy metabolism with special reference to circadian rhythm Cerveau - Métabolisme Glucose - Métabolisme Métabolisme énergétique Brain Metabolism Brain metabolism Circadian Rhythm Energy Metabolism Energy metabolism Glucose Metabolism Glucose metabolism Nervale Regulation (DE-588)4041634-3 gnd Tagesrhythmus (DE-588)4078131-8 gnd Energiestoffwechsel (DE-588)4125217-2 gnd Neuroendokrine Regulation (DE-588)4277113-4 gnd |
| subject_GND | (DE-588)4041634-3 (DE-588)4078131-8 (DE-588)4125217-2 (DE-588)4277113-4 |
| title | Central regulation of energy metabolism with special reference to circadian rhythm |
| title_auth | Central regulation of energy metabolism with special reference to circadian rhythm |
| title_exact_search | Central regulation of energy metabolism with special reference to circadian rhythm |
| title_full | Central regulation of energy metabolism with special reference to circadian rhythm Katsuya Nagai and Hachiro Nakagawa |
| title_fullStr | Central regulation of energy metabolism with special reference to circadian rhythm Katsuya Nagai and Hachiro Nakagawa |
| title_full_unstemmed | Central regulation of energy metabolism with special reference to circadian rhythm Katsuya Nagai and Hachiro Nakagawa |
| title_short | Central regulation of energy metabolism with special reference to circadian rhythm |
| title_sort | central regulation of energy metabolism with special reference to circadian rhythm |
| topic | Cerveau - Métabolisme Glucose - Métabolisme Métabolisme énergétique Brain Metabolism Brain metabolism Circadian Rhythm Energy Metabolism Energy metabolism Glucose Metabolism Glucose metabolism Nervale Regulation (DE-588)4041634-3 gnd Tagesrhythmus (DE-588)4078131-8 gnd Energiestoffwechsel (DE-588)4125217-2 gnd Neuroendokrine Regulation (DE-588)4277113-4 gnd |
| topic_facet | Cerveau - Métabolisme Glucose - Métabolisme Métabolisme énergétique Brain Metabolism Brain metabolism Circadian Rhythm Energy Metabolism Energy metabolism Glucose Metabolism Glucose metabolism Nervale Regulation Tagesrhythmus Energiestoffwechsel Neuroendokrine Regulation |
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