Bioaccumulation in aquatic systems: contributions to the assessment ; proceedings of an international workshop, Berlin 1990
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Weinheim u. a.
VCH
1991
|
| Edition: | 1. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XV, 239 S.: graph. Darst. |
| ISBN: | 3527283951 156081201X |
Staff View
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| 245 | 1 | 0 | |a Bioaccumulation in aquatic systems |b contributions to the assessment ; proceedings of an international workshop, Berlin 1990 |c ed. by R. Nagel ... |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Weinheim u. a. |b VCH |c 1991 | |
| 300 | |a XV, 239 S.: graph. Darst. | ||
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Record in the Search Index
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| adam_text | Contents
List of Contributors ................................. XIII
1. Welcome Address and Introduction ................... 1
B. Beck
2. Purpose of the Workshop ......................... 7
5. BohlingandR. Loskill
2.1 Introduction.................................. 7
2.2 Data Basis for the Assessment of Bioaccumulation.............. 9
2.3 The Lacking Concept for Assessment - a Gross Deficiency.......... 10
2.4 Challenges of the Workshop.......................... 11
2.5 References................................... 12
3. BCF and P: Limitations of the Determination Methods and
Interpretation of Data in the Case of Organic Colorants........ 13
P. Moser and R. Anliker
3.1 Abstracts ................................... 13
3.2 Introduction.................................. 13
3.3 Bioaccumulation Testing ........................... 17
3.4 Partition Coefficients ............................. 19
3.5 Conclusions.................................. 23
3.6 References................................... 24
4. Mathematical Description of Uptake, Accumulation and
Elimination of Xenobiotics in a Fish/Water System........... 29
W. Butte
4.1 Calculation of Bioconcentration Factors.................... 29
4.2 Models to Describe the Uptake and Clearance of Chemicals by Fish..... 30
VIII Contents
4.2.1 The Two-Compartment Model ........................ 30
4.2.2 The Three-Compartment Model........................ 31
4.2.3 Solutions of the Differential Equations .................... 32
4.3 Mathematical Modelling............................ 33
4.3.1 Graphical Methods .............................. 33
4.3.2 Linear Regression (Least Squares) ...................... 35
4.3.3 Non-Linear Regression............................ 36
4.4 Examples and Discussion........................... 38
4.4.1 Rate Constants and Half Life......................... 38
4.4.2 Comparison of Results: The Two-Compartment Compared to the
Three-Compartment Model.......................... 39
4.5 References................................... 41
4.6 Glossary.................................... 42
5. QSARs of Bioconcentration: Validity Assessment of
log Pow/log BCF Correlations ....................... 43
M. Nendza
5.1 Introduction.................................. 43
5.2 Structural Characteristics of Accumulating Compounds............ 44
5.3 Descriptor of Partitioning Processes...................... 44
5.4 Established log Pow/log BCF Correlations................... 45
5.5 QSARs Variability due to Variance in Underlying Experimental Data .... 46
5.5.1 QSARs Variability due to Non-Equilibrium Partitioning during Experiments . 47
5.5.2 QSARs Variability due to Variant Bioavailability............... 48
5.6 Reliability of QSAR Estimated BCF Values ................. 48
5.6.1 Parameter Range Limitations......................... 53
5.6.2 Deviations due to Extreme Lipophilicity ................... 57
5.6.3 Deviations due to Large Molecular Diameter................. 60
5.6.4 Deviations due to Substructure Contributions................. 60
5.6.5 Deviations due to Degradation ........................ 60
5.6.6 Outliers Revealing Apparant Excess Bioconcentration............ 61
5.7 Conclusions.................................. 61
5.8 References................................... 62
6. Bioconcentration and Biomagnification: is a Distinction Necessary? . 67
A. Opperhuizen
6.1 Abstract.................................... 67
6.2 Introduction.................................. 68
6.3 Bioconcentration: Uptake from Water .................... 69
Contents IX
6.4 Biomagnification: Uptake from Food and Sediment.............. 74
6.5 Worst Case Assessment of Bioaccumulation ................. 77
6.6 Conclusions.................................. 79
6.7 References................................... 80
7. Bioconcentration of Xenobiotics from the Chemical Industry s
Point of View ................................ 81
N. Caspers and G. Schiiurmann
7.1 Introduction.................................. 81
7.2 Informative Value of BCFs with Respect to a Hazard Assessment of
Xenobiotics.................................. 81
7.3 Consequences of high BCFs-Example: PCBs................. 82
7.4 Legal Requirements.............................. 84
7.5 Test Guidelines................................ 84
7.5.1 OECD..................................... 85
7.5.2 EC....................................... 87
7.5.3 EPA...................................... 87
7.6 Test Expenditure ............................... 88
7.7 General Comments on BCF Prediction Models................ 89
7.8 Assessment of BCF Predictability Using Several Classes of Chemical
Compounds.................................. 90
7.9 Conclusions.................................. 96
7.10 References................................... 96
8. Testing Bioconcentration of Organic Chemicals with the
Common Mussel (Mytilus edulis)..................... 99
W. Ernst, S. Weigelt, H. RosenthalandP. D. Hansen
8.1 Introduction.................................. 99
8.2 Elaboration of the Test ............................ 100
8.2.1 General Outline................................ 100
8.2.2 Mussels .................................... 102
8.2.2.1 Supply, Transport and Maintenance...................... 102
8.2.2.2 Quality of Mussels............................... 102
8.2.3 The Test Procedure and Variation of Experimental Parameters -
Principle of the Test.............................. 103
8.2.4 Testing Effects of Various Parameters on the Bioconcentration Factor
ofy-HCH, Dieldrin and pp -DDD....................... 103
8.2.5 Origin and Maintenance............................ 103
8.2.6 Variation of Exposure Concentration..................... 113
X Contents
8.2.7 Variation of BiomassAVater-Relationship................... 114
8.2.8 Saisonality of the Lipid Content of Mussels.................. 116
8.2.9 BCF of y-HCH, Dieldrin and pp -DDD in a Flow-Through Test....... 116
8.2.10 Comparison of Results Obtained in the Static Mussel Test with those from
other Tests................................... 116
8.2.11 Examination of Stress in Mussels Caused by Transport and Maintenance ... 118
8.2.12 Metabolism .................................. 118
8.3 Summary ................................... 120
8.4 Guideline Draft: Bioaccumulation Testing with the Common Mussel,
Mytilus edulis................................. 125
8.4.1 Introductory Information........................... 125
8.4.2 Method .................................... 125
8.4.2.1 Introduction.................................. 125
8.4.2.2 Definitions and Units............................. 126
8.4.2.3 Principle of the Test Method ......................... 126
8.4.2.4 Quality Criteria................................ 126
8.4.2.5 Description of the Test Procedure....................... 127
8.4.2.6 Transportation................................. 127
8.4.2.7 Selection of Test Animals........................... 127
8.4.2.8 Life Storage for later Use........................... 128
8.4.2.9 Analysis.................................... 128
8.4.3 Performance of the Test............................ 128
8.4.3.1 Exposure ................................... 128
8.4.3.2 Preparation and Analysis of the Mussels.................... 129
8.4.3.3 Data and Reporting.............................. 130
8.5 References................................... 130
9. Extrapolating Test Results on Bioaccumulation between
Organism Groups.............................. 133
D. W. Connell
9.1 Abstract.................................... 133
9.2 Introduction.................................. 133
9.3 Influence of Type of Compound on Bioaccumulation............. 135
9.4 Variation in Bioaccumulation with Biological Group............. 136
9.5 Bioconcentration by Aquatic Organisms ................... 138
9.6 Bioaccumulation by Aquatic Infauna..................... 143
9.7 The Soil to Earthworm System ........................ 146
9.8 Bioaccumulation by Terrestrial Biota..................... 146
9.9 Conclusions.................................. 147
9.10 References................................... 147
Contents XI
10. Extrapolating the Laboratory Results to Environmental Conditions . 151
D. T. H. M. Sijm
10.1 Abstract.................................... 151
10.2 Introduction.................................. 151
10.3 Comparing Laboratory and Field Conditions................. 152
10.3.1 Fish ...................................... 153
10.3.2 Food...................................... 155
10.3.3 Water..................................... 155
10.3.4 Temperature.................................. 156
10.3.5 Time...................................... 156
10.3.6 Single/multiple Compounds.......................... 157
10.4 Discussion................................... 157
10.5 Conclusions.................................. 158
10.6 References................................... 159
11. Bioaccumulation: Does it Reflect Toxicity?............... 161
/. M. McKim and P. K. Schmieder
11.1 Abstract.................................... 161
11.2 Introduction.................................. 161
11.3 QSAR Approach in Aquatic Toxicology ................... 163
11.3.1 Bioconcentration QSAR............................ 163
11.3.2 Toxicity QSAR ................................ 164
11.3.3 Fish Acute Toxicity Syndromes and QSAR Development........... 164
11.4 Relationship Between Toxicity and Bioconcentration............. 171
11.5 Estimated Toxic Internal Tissue Residues................... 172
11.6 Comparison of Measured Internal Toxic Residues to
Toxicity/Bioconcentration-Based Residue Estimates............. 175
11.7 Internal Toxic Residues and Mode of Action................. 178
11.8 Conclusions.................................. 183
11.9 References................................... 184
12. The Assessment of Bioaccumulation................... 189
P. Kristensen and H. Tyle
12.1 Introduction.................................. 189
12.2 Methods for the Assessment of the Bioaccumulation Potential of Chemicals . 191
12.2.1 Estimation of the BCF by use of log Pow.................... 192
12.2.2 Determination of the BCF........................... 193
XII Contents
12.2.3 Determination of the Potential for Bioaccumulation/Biomagnification .... 201
12.3 Use of Data on Bioaccumulation in Formalized Environmental Hazard
Assessment Procedures............................ 201
12.3.1 EEC-Criteria for Classification and Labelling of Chemicals: Dangerous
for the Environment ............................. 203
12.3.2 EEC Working Procedure for Initial Hazard Assessment of New Chemicals . . 205
12.3.3 Danish Criteria for Approval of the Active Ingredient in Pesticides...... 208
12.3 A Other Examples of Formalized Environmental Hazard Assessment Schemes . 217
12.4 Conclusions.................................. 221
12.5 References................................... 222
13. Final Considerations ............................. 229
R. Nagel
13.1 Introduction.................................. 229
13.2 Validation................................... 229
13.3 Extrapolation................................. 230
13.4 Evaluation................................... 231
13.5 References................................... 232
Index.......................................... 235
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| genre_facet | Konferenzschrift 1990 Berlin Konferenzschrift 1990 Berlin West |
| id | DE-604.BV004672078 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T16:15:54Z |
| institution | BVB |
| isbn | 3527283951 156081201X |
| language | English |
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| physical | XV, 239 S.: graph. Darst. |
| publishDate | 1991 |
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| publisher | VCH |
| record_format | marc |
| spelling | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 ed. by R. Nagel ... 1. ed. Weinheim u. a. VCH 1991 XV, 239 S.: graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Bioaccumulation - Congrès ram Composés organiques - Congrès Composés organiques - Congrès ram Eau - Pollution - Congrès Eau - Pollution - Congrès ram Poluicao da agua larpcal Organic compounds Bioaccumulation Congresses Water Pollution Congresses Bioakkumulation (DE-588)4275028-3 gnd rswk-swf Wasserverschmutzung (DE-588)4189299-9 gnd rswk-swf Organischer Stoff (DE-588)4203832-7 gnd rswk-swf Umweltchemikalie (DE-588)4117281-4 gnd rswk-swf Gewässer (DE-588)4020820-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1990 Berlin gnd-content (DE-588)1071861417 Konferenzschrift 1990 Berlin West gnd-content Gewässer (DE-588)4020820-5 s Bioakkumulation (DE-588)4275028-3 s DE-604 Umweltchemikalie (DE-588)4117281-4 s Organischer Stoff (DE-588)4203832-7 s Wasserverschmutzung (DE-588)4189299-9 s Nagel, Roland Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002870710&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 Bioaccumulation - Congrès ram Composés organiques - Congrès Composés organiques - Congrès ram Eau - Pollution - Congrès Eau - Pollution - Congrès ram Poluicao da agua larpcal Organic compounds Bioaccumulation Congresses Water Pollution Congresses Bioakkumulation (DE-588)4275028-3 gnd Wasserverschmutzung (DE-588)4189299-9 gnd Organischer Stoff (DE-588)4203832-7 gnd Umweltchemikalie (DE-588)4117281-4 gnd Gewässer (DE-588)4020820-5 gnd |
| subject_GND | (DE-588)4275028-3 (DE-588)4189299-9 (DE-588)4203832-7 (DE-588)4117281-4 (DE-588)4020820-5 (DE-588)1071861417 |
| title | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 |
| title_auth | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 |
| title_exact_search | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 |
| title_full | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 ed. by R. Nagel ... |
| title_fullStr | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 ed. by R. Nagel ... |
| title_full_unstemmed | Bioaccumulation in aquatic systems contributions to the assessment ; proceedings of an international workshop, Berlin 1990 ed. by R. Nagel ... |
| title_short | Bioaccumulation in aquatic systems |
| title_sort | bioaccumulation in aquatic systems contributions to the assessment proceedings of an international workshop berlin 1990 |
| title_sub | contributions to the assessment ; proceedings of an international workshop, Berlin 1990 |
| topic | Bioaccumulation - Congrès ram Composés organiques - Congrès Composés organiques - Congrès ram Eau - Pollution - Congrès Eau - Pollution - Congrès ram Poluicao da agua larpcal Organic compounds Bioaccumulation Congresses Water Pollution Congresses Bioakkumulation (DE-588)4275028-3 gnd Wasserverschmutzung (DE-588)4189299-9 gnd Organischer Stoff (DE-588)4203832-7 gnd Umweltchemikalie (DE-588)4117281-4 gnd Gewässer (DE-588)4020820-5 gnd |
| topic_facet | Bioaccumulation - Congrès Composés organiques - Congrès Eau - Pollution - Congrès Poluicao da agua Organic compounds Bioaccumulation Congresses Water Pollution Congresses Bioakkumulation Wasserverschmutzung Organischer Stoff Umweltchemikalie Gewässer Konferenzschrift 1990 Berlin Konferenzschrift 1990 Berlin West |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002870710&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nagelroland bioaccumulationinaquaticsystemscontributionstotheassessmentproceedingsofaninternationalworkshopberlin1990 |