Molecular and cellular biology of multidrug resistance in tumor cells:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Plenum Press
1991
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVIII, 406 S. Ill., graph. Darst. |
| ISBN: | 0306435470 |
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| 245 | 1 | 0 | |a Molecular and cellular biology of multidrug resistance in tumor cells |c ed. by Igor B. Roninson |
| 264 | 1 | |a New York u.a. |b Plenum Press |c 1991 | |
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| 650 | 4 | |a Antineoplastic Agents |x pharmacology | |
| 650 | 4 | |a Cell Line |x physiology | |
| 650 | 4 | |a Drug Resistance | |
| 650 | 4 | |a Drug resistance in cancer cells | |
| 650 | 4 | |a Membrane Glycoproteins |x physiology | |
| 650 | 4 | |a Multidrug resistance | |
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| adam_text | MOLECULAR AND CELLULAR BIOLOGY OF MULTIDRUG RESISTANCE IN TUMOR CELLS
EDITED BY IGOR B. RONINSON . THE UNIVERSITY OF ILLINOIS AT CHICAGO
CHICAGO, ILLINOIS PLENUM PRESS * NEW YORK AND LONDON CONTENTS PART I.
ISOLATION AND PROPERTIES OF MULTIDRUG-RESISTANT CELL LINES CHAPTER 1
CHARACTERISTICS OF MULTIDRUG RESISTANCE IN HUMAN TUMOR CELLS WILLIAM T.
BECK AND MARY K. DANKS 1. INTRODUCTION 3 2. HUMAN MDR CELL LINES AND
THEIR ORIGINS 4 3. RESISTANCE AND CROSS-RESISTANCE OF HUMAN MDR CELLS 19
4. CELLULAR PHARMACOLOGY AND MODULATION OF DRUG CYTOTOXICITY IN HUMAN
MDR CELLS 32 5. MOLECULAR BIOLOGY AND BIOCHEMISTRY OF HUMAN MDR CELL
LINES 33 6. ATYPICAL MDR IN HUMAN TUMOR CELL LINES 42 7. IN VIVO
SELECTION OF HUMAN MDR CELL LINES 42 8. MDR EXPRESSION IN PATIENT TUMORS
AND NORMAL TISSUES 43 9. SUMMARY AND CONCLUSIONS 43 10. ABBREVIATIONS 44
REFERENCES 46 CHAPTER 2 DEVELOPMENT OF MULTIDRUG RESISTANCE IN RODENT
CELL LINES YOSHIKAZU SUGIMOTO AND TAKASHI TSURUO 1. INTRODUCTION 57 2.
IN VIVO SELECTION OF MDR CELL LINES 58 3. IN VITRO SELECTION OF MDR CELL
LINES 58 4. ORIGIN OF MDR CELL LINES 60 5. USE OF RODENT MDR CELLS IN
THE DEVELOPMENT OF ANTICANCER DRUGS 64 REFERENCES : 65 IX X CONTENTS
PART II. MOLECULAR GENETICS OF MULTIDRUG RESISTANCE CHAPTER 3 CLONING
AND CHARACTERIZATION OF MOUSE MDR GENES PHILIPPE GROS, MARTINE RAYMOND,
AND DAVID HOUSMAN 1 . INTRODUCTION 73 2. RESULTS 74 2.1. CLONING AND
CHARACTERIZATION OF A GENOMIC DOMAIN COMMONLY AMPLIFIED IN TWO MDR
HAMSTER CELL LINES 74 2.2. CLONING OF CDNAS CORRESPONDING TO
TRANSCRIPTIONALLY ACTIVE MOUSE MDR GENES 76 2.3. CHROMOSOME-MEDIATED
GENE TRANSFER OF MDR 79 2.4. TRANSFECTION EXPERIMENTS WITH A CLONED MDR
CDNA 81 2.5. CHARACTERIZATION OF THE BIOLOGICALLY ACTIVE MDR CDNA CLONE
.. . 83 3. DISCUSSION 86 REFERENCES 88 CHAPTER 4 ISOLATION AND
CHARACTERIZATION OF THE HUMAN MDR (P-GLYCOPROTEIN) GENES IGOR B.
RONINSON, IRA PASTAN, AND MICHAEL M. GOTTESMAN 1. ISOLATION AND
CHARACTERIZATION OF MDR KB CELL LINES 91 2. AMPLIFICATION AND EXPRESSION
OF MDR (P-GLYCOPROTEIN) SEQUENCES IN MDR KB CELL LINES 93 3. SEQUENCE
ANALYSIS OF MDRL CDNA 95 4. STRUCTURE AND AMPLIFICATION OF THE HUMAN MDR
(P-GLYCOPROTEIN) GENE FAMILY 97 5. MDRL MUTATIONS IN MDR KB CELLS WITH A
PREFERENTIAL RESISTANCE TO COLCHICINE 99 6. MDR OF DNA-MEDIATED
TRANSFECTANTS IS LINKED TO THE TRANSFER OF THE MDRL GENE 100 7.
EXPRESSION OF WILD-TYPE AND MUTANT MDRL CDNA IN BIOLOGICALLY ACTIVE
CLONES 101 REFERENCES 104 CHAPTER 5 AMPLIFICATION OF SEVERAL DIFFERENT
GENES IN MULTIDRUG-RESISTANT CHINESE HAMSTER CELL LINES P. BORST AND A.
M. VAN DER BLIEK 1. INTRODUCTION 107 2. SIX GENE CLASSES ARE
OVEREXPRESSED IN THE MDR CHO LINE CH 1 ^ 108 3. THE SIX GENES THAT ARE
OVEREXPRESSED AND AMPLIFIED IN MDR CHO CELLS ARE LINKED IN ONE LARGE
AMPLICON 108 CONTENTS XI 4. THE P-GLYCOPROTEIN (CLASS 2) GENES ARE THE
COMMON DENOMINATOR OF DIFFERENT MDR AMPLICONS IN HAMSTER CELLS 109 5.
THE GENES COAMPLIFIED IN MDR HAMSTER CELLS ARE SYNTENIC IN MICE AND
HUMANS 109 6. GENESIS OF THE MDR AMPLICON IN THE CH 1 ^ CELLS 112 7. THE
MULTIPLICITY OF P-GLYCOPROTEIN GENES AND THE DIVERSITY OF MDR PHENOTYPES
113 8. SUMMARY AND OUTLOOK 114 REFERENCES 115 CHAPTER 6 MOLECULAR AND
CYTOGENETIC ANALYSIS OF MULTIDRUG RESISTANCE-ASSOCIATED GENE
AMPLIFICATION IN CHINESE HAMSTER, MOUSE SARCOMA, AND HUMAN NEUROBLASTOMA
CELLS PETER W. MELERA AND JUNE L. BIEDLER 1 . INTRODUCTION 117 1.1.
BACKGROUND 117 1.2. SELECTION PROCEDURES AND CROSS-RESISTANCE PATTERNS
119 2. CYTOGENETIC EVIDENCE OF AMPLIFIED GENES 121 2.1. VINCRISTINE-,
ACTINOMYCIN D-, AND DAUNORUBICIN-RESISTANT CHL CELLS .. 122 2.2.
VINCRISTINE- AND ACTINOMYCIN D-RESISTANT MOUSE TUMOR CELLS 125 2.3.
VINCRISTINE-RESISTANT HUMAN NEUROBLASTOMA CELLS 126 3. MOLECULAR STUDIES
126 3.1. ISOLATION OF CDNA PROBES TO P-GLYCOPROTEIN GENES 126 3.2.
AMPLIFICATION AND EXPRESSION OF P-GLYCOPROTEIN GENES 129 4. MOLECULAR
CYTOGENETIC STUDIES 131 4.1. MAPPING OF THE NATIVE (P-GLYCOPROTEIN) GENE
132 4.2. CHROMOSOMAL ORGANIZATION OF THE AMPLIFIED GENES ..... 132 5.
INSTABILITY OF THE DRUG-RESISTANT PHENOTYPE 135 5.1.
ANTIFOLATE-RESISTANT CELLS 135 5.2. MDR CELLS 136 6. SUMMARY AND
OVERVIEW 140 REFERENCES 141 CHAPTER 7 KARYOTYPE AND AMPLICON EVOLUTION
DURING STEPWISE DEVELOPMENT OF MULTIDRUG RESISTANCE IN DJUNGARIAN
HAMSTER CELL LINES A. V. GUDKOV, O. B. CHEMOVA, AND B. P. KOPNIN 1.
INTRODUCTION 147 2. CHARACTERISTICS OF MDR DJUNGARIAN HAMSTER CELL LINES
148 2.1. SELECTION OF MDR CELL LINES: LEVELS OF RESISTANCE AND DECREASE
IN UPTAKE OF UNRELATED DRAGS 148 2.2. GENE AMPLIFICATION IN MDR
DJUNGARIAN HAMSTER CELL LINES 149 XLL CONTENTS 3. KARYOTYPIC EVOLUTION
DURING GENE AMPLIFICATION 151 3.1. REGULAR PATTERN OF KARYOTYPIC
ALTERATIONS DURING DEVELOPMENT OF MDR 153 3.2. THE PATTERN OF KARYOTYPIC
ALTERATIONS SPECIFIC FOR THE DEVELOPMENT OF MDR MAY BE CHANGED BY AN
ADDITIONAL DHFR GENE AMPLIFICATION 156 3.3. HSRS IN MDR DJUNGARIAN
HAMSTER CELLS ARE FORMED AT THE SITE OF THE RESIDENT MDR GENE 157 4.
AMPLICON EVOLUTION IN MDR CELLS 159 4.1. AMPLICON COMPOSITION VARIES
AMONG MDR CELL LINES 159 4.2. SPORADICALLY AMPLIFIED SEQUENCES MAY BE
LOST IN THE COURSE OF SELECTION 160 4.3. AMPLICON STRUCTURE AND LENGTH
162 5. GENE AMPLIFICATION IN MULTIDRUG-RESISTANT MOUSE TUMORS SELECTED
IN VIVO 163 REFERENCES .:- 165 *J CHAPTER 8 CHROMOSOME LOCALIZATION OF
P-GLYCOPROTEIN GENES IN DRUG-SENSITIVE AND -RESISTANT HUMAN CELLS J. M.
TRENT AND D. F. CALLEN 1. INTRODUCTION 169 2. GENERAL COMMENTS ON MDR
170 3. CHROMOSOMAL LOCALIZATION IN DRUG-SENSITIVE CELLS 170 3.1. HYBRID
PANEL ANALYSIS 171 3.2. IN SITU HYBRIDIZATION 172 3.3. CHROMOSOME 7
DELETION-MAPPING ANALYSIS 173 4. CHROMOSOMAL LOCALIZATION IN
DRUG-RESISTANT CELLS 175 4.1. NUMERIC CHANGES 176 4.2. STRUCTURAL
CHANGES 178 4.3. CYTOLOGIC EVIDENCE OF GENE AMPLIFICATION 184 5. SUMMARY
184 REFERENCES 186 CHAPTER 9 STRUCTURE AND EVOLUTION OF P-GLYCOPROTEINS
/. B. RONINSON 1. INTRODUCTION 189 2. GENERAL ORGANIZATION OF
P-GLYCOPROTEINS 190 3. HOMOLOGY WITH OTHER PROTEINS 193 CONTENTS XLLL 4.
INTRON-EXON STRUCTURE AND ORIGIN OF MDR GENES 197 5. MDR GENES IN
MALARIAL PLASMODIUM 200 6. FUNCTION OF A YEAST MDR GENE 204 7. EVOLUTION
OF MAMMALIAN P-GLYCOPROTEINS 204 8. P-GLYCOPROTEIN AS A PROTOTYPE OF A
NOVEL CLASS OF MEMBRANE TRANSPORTERS 205 REFERENCES 209 PART III.
BIOCHEMICAL ANALYSIS OF MULTIDRUG RESISTANCE CHAPTER 10 DRUG
ACCUMULATION AND BINDING IN P-GLYCOPROTEIN-ASSOCIATED MULTIDRUG
RESISTANCE WILLIAM T. BECK 1. INTRODUCTION 215 2. CELLULAR PHARMACOLOGY
OF PGP-MDR 216 3. MECHANISM OF DRAG ACCUMULATION IN PGP-MDR 217 4. DRAG
BINDING IN PGP-MDR 217 5. ENERGETICS OF DRAG ACCUMULATION AND RETENTION:
ATP- AND DRAG-BINDING SITES ON P-GLYCOPROTEIN 218 6. EFFLUX PUMPS AND
DECREASED DRAG BINDING IN PGP-MDR 219 7. MODULATORS OF PGP-MDR 220 8.
OTHER ACTIONS OF P-GLYCOPROTEIN 222 9. SUMMARY AND OTHER CONSIDERATIONS
223 REFERENCES :*... 224 CHAPTER 11 BINDING OF DRUGS AND ATP BY
P-GLYCOPROTEIN AND TRANSPORT OF DRUGS BY VESICLES FROM HUMAN
MULTIDRUG-RESISTANT CELLS MARILYN M. CORNWELL, IRA PASTAN, AND MICHAEL
M. GOTTESMAN 1. INTRODUCTION 229 2. BINDING OF DRAGS TO MEMBRANE
VESICLES IN MDR CELL LINES 230 3. IDENTIFICATION OF P-GLYCOPROTEIN AS
THE DRAG-BINDING PROTEIN IN MEMBRANE VESICLES FROM MDR CELL LINES 232 4.
DRAGS THAT REVERSE THE MDR PHENOTYPE INHIBIT PHOTOAFFINITY LABELING OF
P-GLYCOPROTEIN 235 5. BINDING OF ATP ANALOGS TO P-GLYCOPROTEIN 236 6.
TRANSPORT OF [ 3 H]VINBLASTINE BY VESICLES FROM MDR CELLS 238 XIV
CONTENTS 7. FUTURE DIRECTIONS: MOLECULAR GENETIC ANALYSIS OF ATP AND
DRAG-BINDING SITES AND IDENTIFICATION OF OTHER DRAG-BINDING COMPONENTS
239 REFERENCES 240 CHAPTER 12 PROTEIN CHANGES IN MULTIDRUG-RESISTANT
CELLS M. B. MEYERS AND J. L. BIEDLER 1. INTRODUCTION 243 2. SORCIN, A
CYTOSOLIC PROTEIN 244 2.1. IDENTIFICATION OF SORCIN BY TWO-DIMENSIONAL
GEL ELECTROPHORESIS 244 2.2. PURIFICATION OF SORCIN AND ANTIBODY
PREPARATION 245 2.3. MOLECULAR MECHANISMS OF OVERPRODUCTION 245 2.4.
FUNCTIONAL ASPECTS OF SORCIN 248 2.5. PREVALENCE OF SORCIN
OVERPRODUCTION 250 2.6. OTHER LOW-MOLECULAR-WEIGHT PROTEINS 251 3.
EPIDERMAL GROWTH FACTOR RECEPTOR 251 3.1. RECEPTOR INCREASE IN MDR
HAMSTER AND MOUSE CELLS 252 3.2. RECEPTOR INCREASE IN HUMAN
NEUROBLASTOMA CELLS 252 3.3. ROLE OF RECEPTOR INCREASE IN MDR CELLS 254
4. OTHER PROTEIN CHANGES 256 4.1. SOLUBLE PROTEINS 256 4.2. MEMBRANE
PROTEINS 257 5. SUMMARY 257 REFERENCES 257 CHAPTER 13 MEMBRANE LIPIDS OF
MULTIDRUG-RESISTANT CELLS: CHEMICAL COMPOSITION . AND PHYSICAL STATE N.
ALON, R. BUSCHE, B. TUMMLER, AND J. R. RIORDAN 1. INTRODUCTION 263 2.
COMPOSITIONAL ANALYSIS OF MDR CELL MEMBRANE LIPIDS 263 3. MEMBRANE
FLUIDITY AND DRAG UPTAKE 267 4. FREEZE-FRACTURE ELECTRON MICROSCOPY OF
MDR CELL MEMBRANES 268 5. ELECTRON SPIN RESONANCE STUDIES OF LIPID
STRUCTURAL ORDER 268 6. FLUORESCENCE SPECTROSCOPY OF MDR CELLS AND
MEMBRANES 270 7. CONCLUDING REMARKS 272 REFERENCES 275 CONTENTS XV PART
IV. P-GLYCOPROTEIN EXPRESSION IN NORMAL AND TUMOR TISSUES F Y CHAPTER 14
EXPRESSION OF THE MDRL GENE IN NORMAL HUMAN TISSUES MICHAEL M.
GOTTESMAN, MARK C. WILLINGHAM, FRANZ THIEBAUT, AND IRA PASTAN 1.
RATIONALE FOR LOCALIZATION OF MDR 1 GENE 279 2. MDRL MRNA EXPRESSION IN
NORMAL HUMAN TISSUES 280 2.1. MDRL RNA EXPRESSION IS HIGHEST IN ADRENAL,
KIDNEY, LIVER, COLON, AND JEJUNUM 280 2.2. MDRL RNA EXPRESSION IN NORMAL
TISSUES INITIATES FROM ONE MAJOR PROMOTER 281 2.3. INDUCTION OF THE MDR
GENE IN LIVER 283 3. LOCALIZATION OF P-GLYCOPROTEIN, THE PRODUCT OF THE
MDRL GENE . . 284 4. SPECULATION ON THE NORMAL FUNCTION OF THE MDRL GENE
285 REFERENCES 288 J CHAPTER 15 EXPRESSION OF THE MULTIDRUG RESISTANT
GENE IN HUMAN CANCER MICHAEL M. GOTTESMAN, LORI J. GOLDSTEIN, ANTONIO
FOJO, HANAN GALSKI, AND IRA PASTAN 1. THE PROBLEM OF MULTIDRUG
RESISTANCE IN HUMAN CANCER 291 2. MANY INTRINSICALLY DRAG-RESISTANT
HUMAN CANCERS EXPRESS THE MDRL GENE 292 2.1. KIDNEY CANCER 292 2.2.
COLON CANCER . . 294 2.3. OTHER CANCERS :. . 294 3. SOME HUMAN
CANCERS THAT ACQUIRE DRAG RESISTANCE EXPRESS INCREASED AMOUNTS OF MDRL
RNA 296 4. IS EXPRESSION OF MDRL RNA RESPONSIBLE FOR MDR OF HUMAN CANCER
CELLS? 298 5. POSSIBLE STRATEGIES FOR USING INFORMATION ABOUT MDRL RNA
EXPRESSION TO TREAT HUMAN CANCER 299 REFERENCES 300 J CHAPTER 16
IMMUNOHISTOCHEMICAL ANALYSIS OF P-GLYCOPROTEIN EXPRESSION IN NORMAL AND
TUMOR TISSUES IN HUMANS CARLOS CORDON-CARDO 1. INTRODUCTION 303 2.
MATERIALS AND METHODS 304 XVI CONTENTS 2.1. SOURCE OF CELL LINES 304
2.2. SOURCE OF TISSUES 304 2.3. REAGENTS 304 2.4. IMMUNOHISTOCHEMISTRY
305 3. RESULTS 306 3.1. EXPRESSION OF P-GLYCOPROTEIN IN NORMAL HUMAN
TISSUES 306 3.2. EXPRESSION OF P-GLYCOPROTEIN IN ENDOTHELIAL CELLS 307
3.3. EXPRESSION OF P-GLYCOPROTEIN IN HUMAN TUMORS 307 4. DISCUSSION 311
4.1. COMPARATIVE ANALYSIS OF FORMALIN-FIXED, PARAFFIN-EMBEDDED, AND
FROZEN TISSUE SECTIONS 314 4.2. EXPRESSION OF P-GLYCOPROTEIN IN
EPITHELIAL CELLS WITH EXCRETORY/SECRETORY FUNCTIONS 314 4.3. EXPRESSION
OF P-GLYCOPROTEIN IN BLOOD-TISSUE BARRIER SITES 315 4.4. EXPRESSION OF
P-GLYCOPROTEIN IN HUMAN TUMORS :** 316 REFERENCES 316 [J CHAPTER 17
QUANTITATIVE ESTIMATION OF MDRL MRNA LEVELS BY POLYMERASE CHAIN REACTION
KEVIN E. NOONAN AND IGOR B. RONINSON 1. INTRODUCTION 319 2. GENERAL
DESCRIPTION OF THE ASSAY 319 3. THEORETICAL BASIS OF QUANTITATIVE MRNA
DETERMINATION BY PCR 322 4. ANALYSIS OF MDRL EXPRESSION IN CELL LINES
AND CLINICAL SAMPLES 324 5. PROTOCOLS FOR QUANTITATIVE CDNA PCR 327 6.
PRECAUTIONS 331 REFERENCES : 332 PART V. APPROACHES TO REVERSAL OF
MULTIDRUG RESISTANCE CHAPTER 18 COLLATERAL SENSITIVITY OF
MULTIDRUG-RESISTANT CELLS D. CANO-GAUCI AND J. R. RIORDAN 1.
INTRODUCTION 337 2. ACTIVE COMPOUNDS 338 2.1. NONIONIC DETERGENTS 338
2.2. STEROIDS 339 2.3. LOCAL ANESTHETICS 339 2.4. CALCIUM CHANNEL
BLOCKERS 340 CONTENTS XV11 * 2.5. TAXOL 340 2.6. BLEOMYCIN 340 3.
RELATIONSHIP BETWEEN COLLATERAL SENSITIVITY AND REVERSAL OF MDR 340 4.
HYPERSENSITIVITY TO CALCIUM ANTAGONISTS 341 5. ROLE OF P-GLYCOPROTEIN
342 6. ROLE OF SECONDARY MEMBRANE CHANGES 345 7. SCOPE FOR EXPLOITATION
. 346 REFERENCES . 346 CHAPTER 19 REVERSAL OF MULTIDRUG RESISTANCE BY
CALCIUM CHANNEL BLOCKERS AND OTHER AGENTS TAKASHI TSURUO 1. INTRODUCTION
349 2. CALCIUM MODIFIERS AND CANCER CHEMOTHERAPY 349 3. REVERSAL OF DRAG
RESISTANCE 350 3.1. MULTIDRUG RESISTANCE 350 3.2. CALCIUM CHANNEL
BLOCKERS AND CALMODULIN INHIBITORS 351 3.3. OTHER AGENTS 356 3.4.
MECHANISMS OF ACTION 359 3.5. CLINICAL APPROACH, PRESENT AND FUTURE 363
4. FUTURE PERSPECTIVES 364 REFERENCES 365 CHAPTER 20 GROWTH INHIBITION
OF MULTIDRUG-RESISTANT CELLS BY MONOCLONAL ANTIBODIES AGAINST
P-GLYCOPROTEIN HIROFUMI HAMADA AND TAKASHI TSURUO 1. INTRODUCTION 373 2.
GROWTH INHIBITION OF MDR CELLS BY MONOCLONAL ANTIBODIES AGAINST P-
GLYCOPROTEIN 374 2.1. GENERATION OF MONOCLONAL ANTIBODIES MRK16 AND
MRK17 SPECIFIC TO MDR TUMOR CELLS 374 2.2. BIOLOGICAL FUNCTION OF MRK16
AND MRK17 376 2.3. ANTIGEN SPECIFICITY OF MRK16 AND MRK17 377 2.4. THE
170- TO 180-KDA GLYCOPROTEIN SPECIFIC FOR MDR IS DIFFERENT FROM EGF
RECEPTOR 380 2.5. EXPRESSION OF THE 170- TO 180-KDA GLYCOPROTEIN IN
VARIOUS HUMAN CELL LINES 380 2.6. FUNCTIONAL ROLE OF P-GLYCOPROTEIN AS
REVEALED BY MONOCLONAL ANTIBODIES 383 XV111 CONTENTS 3. ANALYSIS OF
PHOSPHORYLATION OF P-GLYCOPROTEIN 384 3.1. CALCIUM-DEPENDENT
PHOSPHORYLATION OF P-GLYCOPROTEIN 384 3.2. PHORBOL DIESTER AND
DIACYLGLYCEROL ENHANCE PHOSPHORYLATION OF P-GLYCOPROTEIN 386 4. OUTLOOK
FOR IMMUNOTHERAPY OF MDR TUMORS 387 5. ABBREVIATIONS 388 REFERENCES .. ?
388 PART VI. SUMMARY CHAPTER 21 P-GLYCOPROTEIN-MEDIATED DRUG RESISTANCE:
PUZZLES AND PERSPECTIVES IGOR B. RONINSON 1. INTRODUCTION 395 2.
P-GLYCOPROTEIN EXPRESSION AND OTHER CHANGES IN MDR CELLS 395 3.
MECHANISM OF P-GLYCOPROTEIN-MEDIATED DRAG EFFLUX 396 4. P-GLYCOPROTEIN
FUNCTION IN NORMAL TISSUES 398 5. USE OF MDRL PROBES IN CLINICAL
DIAGNOSTICS OF MDR 399 6. P-GLYCOPROTEIN-MEDIATED DRAG RESISTANCE AND
NOVEL TREATMENT STRATEGIES .. 400 REFERENCES 401 INDEX 403
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV004669646 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:15:52Z |
| institution | BVB |
| isbn | 0306435470 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002868750 |
| oclc_num | 22665319 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XVIII, 406 S. Ill., graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | Plenum Press |
| record_format | marc |
| spelling | Molecular and cellular biology of multidrug resistance in tumor cells ed. by Igor B. Roninson New York u.a. Plenum Press 1991 XVIII, 406 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Antineoplastic Agents pharmacology Cell Line physiology Drug Resistance Drug resistance in cancer cells Membrane Glycoproteins physiology Multidrug resistance Neoplasms drug therapy P-glycoprotein Krebszelle (DE-588)4128704-6 gnd rswk-swf Arzneimittelresistenz (DE-588)4143180-7 gnd rswk-swf Tumorzelle (DE-588)4186433-5 gnd rswk-swf Cytostatikum (DE-588)4068347-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebszelle (DE-588)4128704-6 s Cytostatikum (DE-588)4068347-3 s Arzneimittelresistenz (DE-588)4143180-7 s DE-604 Tumorzelle (DE-588)4186433-5 s Roninson, Igor B. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002868750&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular and cellular biology of multidrug resistance in tumor cells Antineoplastic Agents pharmacology Cell Line physiology Drug Resistance Drug resistance in cancer cells Membrane Glycoproteins physiology Multidrug resistance Neoplasms drug therapy P-glycoprotein Krebszelle (DE-588)4128704-6 gnd Arzneimittelresistenz (DE-588)4143180-7 gnd Tumorzelle (DE-588)4186433-5 gnd Cytostatikum (DE-588)4068347-3 gnd |
| subject_GND | (DE-588)4128704-6 (DE-588)4143180-7 (DE-588)4186433-5 (DE-588)4068347-3 (DE-588)4143413-4 |
| title | Molecular and cellular biology of multidrug resistance in tumor cells |
| title_auth | Molecular and cellular biology of multidrug resistance in tumor cells |
| title_exact_search | Molecular and cellular biology of multidrug resistance in tumor cells |
| title_full | Molecular and cellular biology of multidrug resistance in tumor cells ed. by Igor B. Roninson |
| title_fullStr | Molecular and cellular biology of multidrug resistance in tumor cells ed. by Igor B. Roninson |
| title_full_unstemmed | Molecular and cellular biology of multidrug resistance in tumor cells ed. by Igor B. Roninson |
| title_short | Molecular and cellular biology of multidrug resistance in tumor cells |
| title_sort | molecular and cellular biology of multidrug resistance in tumor cells |
| topic | Antineoplastic Agents pharmacology Cell Line physiology Drug Resistance Drug resistance in cancer cells Membrane Glycoproteins physiology Multidrug resistance Neoplasms drug therapy P-glycoprotein Krebszelle (DE-588)4128704-6 gnd Arzneimittelresistenz (DE-588)4143180-7 gnd Tumorzelle (DE-588)4186433-5 gnd Cytostatikum (DE-588)4068347-3 gnd |
| topic_facet | Antineoplastic Agents pharmacology Cell Line physiology Drug Resistance Drug resistance in cancer cells Membrane Glycoproteins physiology Multidrug resistance Neoplasms drug therapy P-glycoprotein Krebszelle Arzneimittelresistenz Tumorzelle Cytostatikum Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002868750&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT roninsonigorb molecularandcellularbiologyofmultidrugresistanceintumorcells |