Second generation of calcium antagonists:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin u.a.
Springer
1991
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. [197] - 226 |
| Physical Description: | XIII, 226 S. Ill., zahlr. graph. Darst. |
| ISBN: | 3540542159 0387542159 |
Staff View
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| 245 | 1 | 0 | |a Second generation of calcium antagonists |c Winifred G. Nayler |
| 264 | 1 | |a Berlin u.a. |b Springer |c 1991 | |
| 300 | |a XIII, 226 S. |b Ill., zahlr. graph. Darst. | ||
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| 650 | 4 | |a Accidents vasculaires cérébraux - Chimiothérapie | |
| 650 | 4 | |a Calcium - Antagonistes | |
| 650 | 7 | |a Calciumantagonisten |2 gtt | |
| 650 | 4 | |a Cur - Maladies - Chimiothérapie | |
| 650 | 4 | |a Brain Ischemia |x drug therapy | |
| 650 | 4 | |a Calcium Channel Blockers |x pharmacology | |
| 650 | 4 | |a Calcium Channel Blockers |x therapeutic use | |
| 650 | 4 | |a Calcium |x Antagonists | |
| 650 | 4 | |a Calcium |x Antagonists |x Therapeutic use | |
| 650 | 4 | |a Cerebrovascular disease |x Chemotherapy | |
| 650 | 4 | |a Heart Diseases |x drug therapy | |
| 650 | 4 | |a Heart |x Diseases |x Chemotherapy | |
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Record in the Search Index
| _version_ | 1804118654311202816 |
|---|---|
| adam_text | WINIFRED G. NAYLER SECOND GENERATION OF CALCIUM ANTAGONISTS WITH 81
FIGURES AND 63 TABLES SPRINGER-VERLAG BERLIN HEIDELBERG NEW YORK LONDON
PARIS TOKYO HONG KONG BARCELONA BUDAPEST CONTENTS FOREWORD VII CHAPTER 1
THE SECOND GENERATION OF CALCIUM ANTAGONISTS: WHAT ARE THEY? - RATIONALE
FOR THE DEVELOPMENT OF THE SECOND GENERATION CALCIUM ANTAGONISTS:
LIMITATIONS OF THE FIRST GENERATION . 2 - ARE THE SECOND GENERATION
CALCIUM ANTAGONISTS NEEDED? . 4 - SUMMARY 7 CHAPTER 2 THE CHEMISTRY OF
THE SECOND GENERATION CALCIUM ANTAGONISTS - DERIVATIVES OF THE PROTOTYPE
CALCIUM ANTAGONISTS WHICH INTERACT WITH THE ALPHA I SUBUNIT BINDING
SITES OF THE L-TYPE CA 2+ CHANNELS 12 - OTHER NEW CALCIUM ANTAGONISTS 19
- NOVEL CALCIUM ANTAGONISTS WITH ADDITIONAL ANTAGONIST ACTIVITY , 22 -
SUMMARY 23 CHAPTER 3 THE MOLECULAR BIOLOGY OF THE VOLTAGE-DEPENDENT,
CALCIUM ANTAGONIST-SENSITIVE CALCIUM CHANNELS - CA 2+ -CONDUCTING
CHANNELS 26 - THE VOLTAGE-SENSITIVE CA 2+ CHANNELS 26 - THE MOLECULAR
BIOLOGY OF THE L-TYPE CA 2+ CHANNEL 27 - THE VOLTAGE-DEPENDENT CALCIUM
ANTAGONIST-SENSITIVE CA 2+ CHANNEL COMPLEX OF SKELETAL MUSCLE T-TUBULES:
SUBUNIT STRUCTURE AND FUNCTION 28 - THE TISSUE SPECIFICITY OF THE ALPHA!
SUBUNIT 34 - SUMMARY 36 X CONTENTS CHAPTER 4 CALCIUM ANTAGONISTS AND THE
CALCIUM RELEASE CHANNELS OF THE SARCOPLASMIC RETICULUM - THE GENERAL
PROPERTIES OF THE SARCOPLASMIC RETICULUM ... 40 - THE GENERAL MORPHOLOGY
OF THE SARCOPLASMIC RETICULUM (SR): EVIDENCE OF SPECIALIZATION 41 - THE
BIOCHEMISTRY OF THE SARCOPLASMIC RETICULUM 43 - THE ULTRASTRUCTURE AND
CHEMISTRY OF THE SR FEET (THE SR RYANODINE RECEPTOR - CA 2+ RELEASE
CHANNEL) ... 44 - CHEMISTRY 46 - THE INTRALUMINAL CONTENTS OF THE
JUNCTIONAL SR 48 - CHARACTERISTICS OF THE SR RYANODINE RECEPTOR - CA 2+
RELEASE CHANNEL COMPLEX 48 - SR CA 2+ RELEASE CHANNELS IN VARIOUS
PATHOLOGIES 50 - THE TRIGGER FOR SR CA 2+ RELEASE: DIFFERENCES BETWEEN
SKELETAL AND CARDIAC MUSCLE 52 - CALCIUM ANTAGONISTS AND SR CA 2+
RELEASE 53 - SUMMARY / 54 CHAPTER 5 UP AND DOWN REGULATION OF THE
CALCIUM ANTAGONIST BINDING SITES - AGE-DEPENDENT CHANGES IN CALCIUM
ANTAGONIST BINDING SITE DENSITY 55 - CARDIOMYOPATHIES 56 - ISCHAEMIA AS
A CAUSE OF DOWN REGULATION 58 - EFFECT OF ISCHAEMIA ON OTHER CARDIAC
RECEPTORS 60 - EFFECT OF DRUGS AND CHEMICALS ON CALCIUM ANTAGONIST
BINDING SITE DENSITY 62 - THE EFFECT OF OTHER PHYSIOLOGICAL
INTERVENTIONS 65 - SUMMARY 65 CHAPTER 6 OXYRADICAL-INDUCED LIPID
PEROXIDATION: DO CALCIUM ANTAGONISTS PROVIDE ANY PROTECTION? - CHEMISTRY
AND PRODUCTION OF THE OXYRADICALS 68 - SITES OF OXYRADICAL PRODUCTION 70
- PROTECTIVE MECHANISMS . * 71 - MODE OF ACTION 71 - EVIDENCE OF
OXYRADICAL PRODUCTION IN THE HEART 73 - OXYRADICAL-INDUCED INJURY 74 -
OXYRADICAL-INDUCED LOSS OF CA 2+ HOMEOSTASIS 77 - EVIDENCE OF EXCESS
OXYRADICAL PRODUCTION DURING MYOCARDIAL ISCHAEMIA AND POST ISCHAEMIC
REPERFUSION ... 78 - ROLE OF CALCIUM ANTAGONISTS AS PROTECTIVE AGENTS 79
CONTENTS XI - PROTECTION AGAINST OXYRADICAL-INDUCED INJURY: ARE THE
CALCIUM ANTAGONISTS EFFECTIVE? 80 - MODE OF ACTION 83 - SUMMARY 83
CHAPTER 7 ENDOTHELIN-1 AND THE CALCIUM ANTAGONISTS - THE PRODUCTION OF
ENDOTHELIN-1 86 - AGENTS AND CONDITIONS WHICH STIMULATE ENDOTHELIN-1
PRODUCTION 88 - THE ENDOTHELIN RECEPTOR 88 - THE ENDOTHELIN-1 RECEPTOR
89 - ENDOTHELIN-1 AND THE CALCIUM ANTAGONISTS 90 - THE INVOLVEMENT OF
ENDOTHELIN-1 IN THE MAINTENANCE OF VASCULAR TONE 93 - ENDOTHELIN-1 AND
THE CORONARY CIRCULATION: THE ROLE OF THE CALCIUM ANTAGONISTS 94 -
ENDOTHELIN AND HYPERTENSION 95 - ENDOTHELIN-1 AND ATHEROSCLEROSIS 95 -
SUMMARY 95 CHAPTER 8 CALCIUM ANTAGONISTS AND THE STUNNED HEART -
STUNNING, HIBERNATION OR INFARCTION? 97 - THE CLINICAL RELEVANCE OF
MYOCARDIAL STUNNING 98 - ANIMAL MODELS OF MYOCARDIAL STUNNING 99 - THE
ELECTRICAL, MECHANICAL, MORPHOLOGICAL AND BIOCHEMICAL PROPERTIES OF THE
PRE-STUNNED AND STUNNED MYOCARDIUM .. 100 - POSSIBLE MECHANISMS OF
MYOCARDIAL STUNNING 108 - IS ENERGY UTILIZATION IMPAIRED? 108 - IS THE
ALTERED ULTRASTRUCTURE RESPONSIBLE? 108 - IS PERFUSION ADEQUATE DURING
REPERFUSION? 109 - IS THERE AN ABNORMAL CA 2+ INFLUX? 110 - DO THE
MYOFIBRILS BECOME RELATIVELY INSENSITIVE TO CA 2+ ? . 110 -
OXYRADICAL-MEDIATED DYSFUNCTION: IS THIS RELEVANT? 110 - THE
SARCOPLASMIC RETICULUM: IS IT INVOLVED? 112 - MYOCARDIAL STUNNING: A
MULTIFACTORIAL EVENT 112 - CALCIUM ANTAGONISTS AND THE STUNNED
MYOCARDIUM ...... 114 - SUMMARY 116 CHAPTER 9 CALCIUM ANTAGONISTS AND
THE HIBERNATING MYOCARDIUM - THE HIBERNATING MYOCARDIUM 118 - IS
MYOCARDIAL HIBERNATION AN ADAPTIVE PROCESS? 119 - THE IDENTIFICATION OF
THE HIBERNATING MYOCARDIUM 119 - THE HIBERNATING MYOCARDIUM: IT S
CLINICAL OCCURRENCE ... 120 XII CONTENTS - THE POSSIBLE CAUSES OF THE
DEPRESSED CONTRACTILE STATE ... 121 - EFFECTIVE REMEDIAL MEASURES 126 -
SUMMARY 128 CHAPTER 10 SECOND GENERATION CALCIUM ANTAGONISTS AND THE
ISCHAEMIC MYOCARDIUM - MYOCARDIAL INFARCTION 131 - THE SIGNIFICANCE OF
THE EARLY RISE IN CYTOSOLIC CA 2+ 132 - THE POSSIBLE CONTRIBUTION OF
ENDOTHELIN-1 TO ISCHAEMIA-REPERFUSION INJURY 133 - CLINICAL EVIDENCE OF
A PROTECTIVE ROLE FOR THE SECOND GENERATION ANTAGONISTS 135 - SUMMARY
135 CHAPTER 11 THE MOLECULAR MECHANISMS INVOLVED IN THE ANTI-ATHEROGENIC
EFFECT OF THE CALCIUM ANTAGONISTS - LESION FORMATION: SEQUENCE OF EVENTS
139 - FACTORS CONCERNED WITH THE INITIATION OF PLAQUE FORMATION 140 -
THE MECHANISM INVOLVED IN THE MACROPHAGE ACCUMULATION OF LOW DENSITY
LIPOPROTEINS (LDL) 142 - THE PROGRESSION OF THE FATTY STREAK TO THE
ADULT PLAQUE .. 143 - CALCIUM-DEPENDENT PROCESSES WHICH CONTRIBUTE TO
THE FORMATION OF ATHEROSCLEROTIC LESIONS 144 - HUMAN STUDIES SHOWING AN
ANTIATHEROSCLEROTIC EFFECT OF CALCIUM ANTAGONIST THERAPY 145 -
LABORATORY STUDIES RELATING TO THE ANTIATHEROSCLEROTIC EFFECT OF FIRST
AND SECOND GENERATION CALCIUM ANTAGONISTS 146 - THE MOLECULAR MECHANISMS
INVOLVED IN THE ANTIATHEROGENIC EFFECT OF THE CALCIUM ANTAGONISTS 146 -
EFFECT OF CALCIUM ANTAGONISTS ON RESTENOSIS AFTER PTCA . 149 - EFFECT OF
CALCIUM ANTAGONISTS ON CORONARY GRAFT PATENCY . 149 - ENDOTHELIAL
DYSFUNCTION EARLY IN THE ATHEROGENIC PROCESS . 150 - SUMMARY 151 CHAPTER
12 SECOND GENERATION CALCIUM ANTAGONISTS: THEIR USE IN CONGESTIVE HEART
FAILURE - THE PATHOPHYSIOLOGY OF CONGESTIVE HEART FAILURE 154 - THE
THERAPEUTIC MANAGEMENT OF THE FAILING HEART 157 - THE SECOND GENERATION
CALCIUM ANTAGONISTS 158 - SUMMARY 161 CONTENTS XIII CHAPTER 13 SECOND
GENERATION CALCIUM ANTAGONISTS AS BLOOD PRESSURE LOWERING AGENTS: THE
PREVENTION OF CARDIAC HYPERTROPHY - CALCIUM AND VASCULAR SMOOTH MUSCLE
CONTRACTION 163 - THE PATHOPHYSIOLOGY OF HYPERTENSION 165 - CALCIUM
ANTAGONISTS AS BLOOD PRESSURE LOWERING AGENTS . 167 - MODE OF ACTION 170
- SUMMARY 172 CHAPTER 14 SECOND GENERATION CALCIUM ANTAGONISTS AND THE
MANAGEMENT OF CEREBRAL ISCHAEMIA - THE ISCHAEMIC BRAIN 173 - CAUSES OF
CEREBRAL ISCHAEMIA 174 - ISCHAEMIC STROKE AND SUBARACHNOID HAEMORRHAGE
175 - AETIOLOGY OF ACUTE CEREBRAL ISCHAEMIA (STROKE) AND SUBARACHNOID
HAEMORRHAGE 176 - CONSEQUENCES OF CEREBRAL ISCHAEMIA 177 - PROTECTION OF
THE ISCHAEMICALLY-INJURED BRAIN 179 - EFFICACY OF SECOND GENERATION
CALCIUM ANTAGONISTS IN THE MANAGEMENT OF ACUTE CEREBRAL ISCHAEMIA 179 -
CLINICAL DATA 182 - MODE OF ACTION 182 - SUBARACHNOID HAEMORRHAGE 183 -
EFFECT OF SECOND GENERATION CALCIUM ANTAGONISTS ON RECOVERY AFTER
SUBARACHNOID HAEMORRHAGE 184 - SUMMARY 184 CHAPTER 15 SECOND GENERATION
CALCIUM ANTAGONISTS AND THE CORONARY CIRCULATION - CORONARY SPASM 187 -
ANGINA PECTORIS 188 - SILENT ISCHAEMIA 191 - SUMMARY 191 CHAPTER 16 THE
SECOND GENERATION CALCIUM ANTAGONISTS - IMPROVED TISSUE SELECTIVITY 192
- RELEVANCE OF IMPROVED TISSUE SELECTIVITY 193 - DURATION OF ACTION 194
- FUTURE DIRECTIONS 195 REFERENCES 197
|
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| id | DE-604.BV004514316 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:13:44Z |
| institution | BVB |
| isbn | 3540542159 0387542159 |
| language | English |
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| oclc_num | 24174322 |
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| owner_facet | DE-19 DE-BY-UBM DE-188 |
| physical | XIII, 226 S. Ill., zahlr. graph. Darst. |
| publishDate | 1991 |
| publishDateSearch | 1991 |
| publishDateSort | 1991 |
| publisher | Springer |
| record_format | marc |
| spelling | Nayler, Winifred G. Verfasser aut Second generation of calcium antagonists Winifred G. Nayler Berlin u.a. Springer 1991 XIII, 226 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. [197] - 226 Accidents vasculaires cérébraux - Chimiothérapie Calcium - Antagonistes Calciumantagonisten gtt Cur - Maladies - Chimiothérapie Brain Ischemia drug therapy Calcium Channel Blockers pharmacology Calcium Channel Blockers therapeutic use Calcium Antagonists Calcium Antagonists Therapeutic use Cerebrovascular disease Chemotherapy Heart Diseases drug therapy Heart Diseases Chemotherapy Calciumantagonist (DE-588)4069807-5 gnd rswk-swf Pharmakotherapie (DE-588)4076066-2 gnd rswk-swf Molekularpharmakologie (DE-588)4170397-2 gnd rswk-swf Calciumantagonist (DE-588)4069807-5 s Pharmakotherapie (DE-588)4076066-2 s 1\p DE-604 Molekularpharmakologie (DE-588)4170397-2 s 2\p DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002781308&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Nayler, Winifred G. Second generation of calcium antagonists Accidents vasculaires cérébraux - Chimiothérapie Calcium - Antagonistes Calciumantagonisten gtt Cur - Maladies - Chimiothérapie Brain Ischemia drug therapy Calcium Channel Blockers pharmacology Calcium Channel Blockers therapeutic use Calcium Antagonists Calcium Antagonists Therapeutic use Cerebrovascular disease Chemotherapy Heart Diseases drug therapy Heart Diseases Chemotherapy Calciumantagonist (DE-588)4069807-5 gnd Pharmakotherapie (DE-588)4076066-2 gnd Molekularpharmakologie (DE-588)4170397-2 gnd |
| subject_GND | (DE-588)4069807-5 (DE-588)4076066-2 (DE-588)4170397-2 |
| title | Second generation of calcium antagonists |
| title_auth | Second generation of calcium antagonists |
| title_exact_search | Second generation of calcium antagonists |
| title_full | Second generation of calcium antagonists Winifred G. Nayler |
| title_fullStr | Second generation of calcium antagonists Winifred G. Nayler |
| title_full_unstemmed | Second generation of calcium antagonists Winifred G. Nayler |
| title_short | Second generation of calcium antagonists |
| title_sort | second generation of calcium antagonists |
| topic | Accidents vasculaires cérébraux - Chimiothérapie Calcium - Antagonistes Calciumantagonisten gtt Cur - Maladies - Chimiothérapie Brain Ischemia drug therapy Calcium Channel Blockers pharmacology Calcium Channel Blockers therapeutic use Calcium Antagonists Calcium Antagonists Therapeutic use Cerebrovascular disease Chemotherapy Heart Diseases drug therapy Heart Diseases Chemotherapy Calciumantagonist (DE-588)4069807-5 gnd Pharmakotherapie (DE-588)4076066-2 gnd Molekularpharmakologie (DE-588)4170397-2 gnd |
| topic_facet | Accidents vasculaires cérébraux - Chimiothérapie Calcium - Antagonistes Calciumantagonisten Cur - Maladies - Chimiothérapie Brain Ischemia drug therapy Calcium Channel Blockers pharmacology Calcium Channel Blockers therapeutic use Calcium Antagonists Calcium Antagonists Therapeutic use Cerebrovascular disease Chemotherapy Heart Diseases drug therapy Heart Diseases Chemotherapy Calciumantagonist Pharmakotherapie Molekularpharmakologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002781308&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT naylerwinifredg secondgenerationofcalciumantagonists |