Molecular medical biochemistry:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge u.a.
Cambridge Univ. Press
1990
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 264 S. Ill. |
| ISBN: | 0521260833 0521278287 |
Staff View
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| 100 | 1 | |a Luzio, J. P. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Molecular medical biochemistry |c J. P. Luzio ; R. J. Thompson |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Cambridge u.a. |b Cambridge Univ. Press |c 1990 | |
| 300 | |a XIII, 264 S. |b Ill. | ||
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| 650 | 4 | |a Biochimie clinique | |
| 650 | 4 | |a Biologie moléculaire | |
| 650 | 4 | |a Pathologie moléculaire | |
| 650 | 4 | |a Biochemistry | |
| 650 | 4 | |a Clinical biochemistry | |
| 650 | 4 | |a Molecular Biology | |
| 650 | 4 | |a Molecular biology | |
| 650 | 4 | |a Pathology, Molecular | |
| 650 | 4 | |a Proteins | |
| 650 | 0 | 7 | |a Physiologische Chemie |0 (DE-588)4076124-1 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Thompson, Rodney J. |e Verfasser |4 aut | |
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Record in the Search Index
| _version_ | 1804118521394757632 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE IX
INTRODUCTION XI
1 PROTEINS IN MEDICINE 1
PROTEIN STRUCTURE, INCLUDING PROTEIN FOLDING AND DOMAINS 1
HOW TO PURIFY A PROTEIN 12
ANALYSING PROTEIN MIXTURES 17
SERUM PROTEINS 20
AJ-ANTITRYPSIN DEFICIENCY 23
THE ACUTE PHASE RESPONSE 26
2 ANTIBODIES IN MEDICINE 29
STRUCTURE AND PROPERTIES OF ANTIBODIES 29
ANTIBODIES AS SPECIFIC MEASURING REAGENTS 32
MONOCLONAL ANTIBODIES 38
3 TISSUE-SPECIFIC PROTEINS 53
IDENTIFICATION OF TISSUE-SPECIFIC PROTEINS 53
THE CYTOSKELETON 56
MICROTUBULES 56
MICROFILAMENTS 59
ACTIN-BINDING PROTEINS 59
INTERMEDIATE FILAMENTS 60
INTERMEDIATE FILAMENTS AND DISEASE 62
TISSUE-SPECIFIC ENZYMES IN MEDICINE 63
ISOENZYMES 65
ENZYMES AS DIAGNOSTIC REAGENTS 71
ENZYMES AS THERAPEUTIC AGENTS 73
IMAGE 2
VI CONTENTS
4 THE PLASMA MEMBRANE 79
THE PLASMA MEMBRANE AS THE LINK BETWEEN THE CELL AND ITS ENVIRONMENT 79
THE PLASMA MEMBRANE AS AN OSMOTIC BARRIER SURROUNDING CELLS 79
THE LIPID BILAYER AS THE BASIC STRUCTURE OF THE PLASMA MEMBRANE 80
THE LIPID COMPONENTS OF THE PLASMA MEMBRANE 82
LIPID ASYMMETRY IN THE PLASMA MEMBRANE 84
THE PROTEIN COMPONENTS OF THE PLASMA MEMBRANE 86 PROTEIN ASYMMETRY IN
THE PLASMA MEMBRANE 90
ELECTRON MICROSCOPY AND THE REALIZATION OF THE UNIVERSAL BILAYER
STRUCTURE OF BIOLOGICAL MEMBRANES 91 SUBCELLULAR FRACTIONATION AND THE
PREPARATIVE ISOLATION OF MEMBRANES 95
THE FLUID MOSAIC MODEL OF THE PLASMA MEMBRANE 99 LATERAL DIFFUSION OF
PHOSPHOLIPIDS 100
LATERAL DIFFUSION OF PROTEINS 100
MEMBRANE DOMAINS AND THE INTERACTION OF MEMBRANE COMPONENTS WITH
CYTOSKELETAL PROTEINS 102
MEMBRANE SYNTHESIS AND TURNOVER 105
ENDOCYTOSIS AND THE RECYCLING OF MEMBRANE COMPONENTS 110 CHOLESTEROL
UPTAKE: RECEPTOR-MEDIATED ENDOCYTOSIS OF LOW-DENSITY LIPOPROTEIN 114
TRANSCYTOSIS 118
TRANSPORT ACROSS THE PLASMA MEMBRANE 121
DISEASE AND THE PLASMA MEMBRANE 125
5 HORMONE ACTION 128
INTERCELLULAR COMMUNICATION 128
HORMONES AS CHEMICAL MESSENGERS 128
EXPERIMENTAL INVESTIGATION OF HORMONE ACTION AND HORMONE BINDING 132
CYCLIC AMP AS A HORMONE SECOND MESSENGER 135
THE COUPLING OF HORMONE-RECEPTOR BINDING TO ACTIVATION OF ADENYLATE
CYCLASE 137
SIGNAL AMPLIFICATION AND THE CONTROL OF METABOLIC PATHWAYS 142
THE CONTROL OF LIPOLYSIS 145
THE CONTROL OF GLYCOGEN BREAKDOWN AND SYNTHESIS 149 OTHER SECOND
MESSENGERS 154
IMAGE 3
CONTENTS V 11
THE MECHANISM OF INSULIN ACTION 157
LONG-TERM EFFECTS OF HORMONES (STEROID HORMONE ACTION) 161
HORMONE-HORMONE INTERACTIONS (THYROID DISEASE) 163
6 SECRETION 166
THE VARIETY OF SECRETORY PROCESSES 166
CONSTITUTIVE AND TRIGGERED PATHWAYS OF SECRETION 167 THE INTRACELLULAR
PATHWAYS OF SYNTHESIS AND SECRETION OF PROTEINS 169
THE SIGNAL HYPOTHESIS 170
THE INTRACELLULAR SORTING OF PROTEINS TO BE SECRETED 172 THE SYNTHESIS
AND INTRACELLULAR PACKAGING OF INSULIN IN PANCREATIC * CELLS 173
THE MECHANISM OF TRIGGERING INSULIN SECRETION 179 THE ORIGIN OF DIABETES
185
7 THE GENOME 188
GENES AND DISEASE 188
DNA, RNA AND THE GENETIC CODE 191
THE STRUCTURE OF THE HUMAN GENOME 196
TRANSFORMATION 201
CUTTING AND SPLICING DNA 203
TECHNIQUES OF DNA CLONING: HOW TO MAKE A LIBRARY 205 DNA SEQUENCING 211
SEQUENCE ORGANIZATION OF THE HUMAN GENOME 219 TRANSCRIPTION AND
TRANSCRIPTIONAL UNITS 222
COMPLEX TRANSCRIPTIONAL UNITS 225
CONTROL OF GENE EXPRESSION 227
SPLICING OF PRIMARY RNA TRANSCRIPTS 228
DUPLICATED PROTEIN-CODING GENES AND PSEUDOGENES 231 DEFECTS IN
EUKARYOTIC TRANSCRIPTION UNITS 232
GENE PROBES AND RESTRICTION FRAGMENT LENGTH POLYMORPHISMS (RFLPS) 235
RFLPS IN THE DIAGNOSIS OF HUMAN DISEASE 238
HYPERVARIABLE REGIONS IN THE HUMAN GENOME 241
GENETIC SCREENING AND GENE THERAPY 242
RETROVIRUSES AND ONCOGENES 250
FURTHER READING 257
INDEX 258
|
| any_adam_object | 1 |
| author | Luzio, J. P. Thompson, Rodney J. |
| author_facet | Luzio, J. P. Thompson, Rodney J. |
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| callnumber-first | R - Medicine |
| callnumber-label | RB112 |
| callnumber-raw | RB112.5 |
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| dewey-full | 612/.015 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612/.015 |
| dewey-search | 612/.015 |
| dewey-sort | 3612 215 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| edition | 1. publ. |
| format | Book |
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| indexdate | 2024-07-09T16:11:37Z |
| institution | BVB |
| isbn | 0521260833 0521278287 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002694515 |
| oclc_num | 18497269 |
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| owner | DE-12 DE-703 |
| owner_facet | DE-12 DE-703 |
| physical | XIII, 264 S. Ill. |
| publishDate | 1990 |
| publishDateSearch | 1990 |
| publishDateSort | 1990 |
| publisher | Cambridge Univ. Press |
| record_format | marc |
| spelling | Luzio, J. P. Verfasser aut Molecular medical biochemistry J. P. Luzio ; R. J. Thompson 1. publ. Cambridge u.a. Cambridge Univ. Press 1990 XIII, 264 S. Ill. txt rdacontent n rdamedia nc rdacarrier Biochimie clinique Biologie moléculaire Pathologie moléculaire Biochemistry Clinical biochemistry Molecular Biology Molecular biology Pathology, Molecular Proteins Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Molekularpathologie (DE-588)4170396-0 s DE-604 Physiologische Chemie (DE-588)4076124-1 s Thompson, Rodney J. Verfasser aut SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002694515&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Luzio, J. P. Thompson, Rodney J. Molecular medical biochemistry Biochimie clinique Biologie moléculaire Pathologie moléculaire Biochemistry Clinical biochemistry Molecular Biology Molecular biology Pathology, Molecular Proteins Physiologische Chemie (DE-588)4076124-1 gnd Molekularpathologie (DE-588)4170396-0 gnd |
| subject_GND | (DE-588)4076124-1 (DE-588)4170396-0 |
| title | Molecular medical biochemistry |
| title_auth | Molecular medical biochemistry |
| title_exact_search | Molecular medical biochemistry |
| title_full | Molecular medical biochemistry J. P. Luzio ; R. J. Thompson |
| title_fullStr | Molecular medical biochemistry J. P. Luzio ; R. J. Thompson |
| title_full_unstemmed | Molecular medical biochemistry J. P. Luzio ; R. J. Thompson |
| title_short | Molecular medical biochemistry |
| title_sort | molecular medical biochemistry |
| topic | Biochimie clinique Biologie moléculaire Pathologie moléculaire Biochemistry Clinical biochemistry Molecular Biology Molecular biology Pathology, Molecular Proteins Physiologische Chemie (DE-588)4076124-1 gnd Molekularpathologie (DE-588)4170396-0 gnd |
| topic_facet | Biochimie clinique Biologie moléculaire Pathologie moléculaire Biochemistry Clinical biochemistry Molecular Biology Molecular biology Pathology, Molecular Proteins Physiologische Chemie Molekularpathologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002694515&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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