Extracellular matrix genes:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
San Diego u.a.
Academic Press
1990
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| Series: | Biology of extracellular matrix
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 270 S. Ill. |
| ISBN: | 0126181551 |
Staff View
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| 245 | 1 | 0 | |a Extracellular matrix genes |c ed. by Linda J. Sandell |
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Record in the Search Index
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|---|---|
| adam_text | EXTRACELLULAR
MATRIX GENES
LINDA J SANDELL
University of Washington and Veterans Administration Medical Center
Departments of Orthopaedics and Biochemistry
School of Medicine
Seattle, Washington
CHARLES D BOYD
UMDNJ-Robert Wood Johnson Medical School
Department of Surgery
New Brunswick, New Jersey
ACADEMIC PRESS, INC
Harcourt Brace Jovanovich, Publishers
San Diego New York Boston
London Sydney Tokyo Toronto
Contents
CONTRIBUTORS xi
PREFACE xv
CONSERVED AND DIVERGENT SEQUENCE AND FUNCTIONAL
ELEMENTS WITHIN COLLAGEN GENES
LINDA J SANDELL and CHARLES D BOYD
I Introduction 1
II Collagens 2
HI Fibrillar Collagen Gene Structure 3
IV Exon Sizes in the C- and N-Terminal Domains of
Fibrillar Collagen Genes 18
V The Structure of the Nonfibrillar Collagen Genes 22
VI Introns 33
VII The Origins of the Structure of Present Day
Collagen Genes 34
VIII Regulatory Sequences—Promotors 40
IX Regulatory Sequences—CpG Islands 43
X Regulatory Sequences—Enhancer Elements 44
XI Alternative Exon Usage in Collagen Genes 47
XII Untranslated Exon Sequences in Collagen Genes 48
XIII Conclusions 49
References 50
TYPES III AND V PROCOLLAGENS: HOMOLOGY IN GENETIC
ORGANIZATION AND DIVERSITY IN STRUCTURE
JEANNE C MYERS and ARNOLD S DION
I Introduction 57
II Cloning and Sequencing of al(III) and a2(V)
cDNA Recombinants 58
vi CONTENTS
HI The Types III and V Genes Are Structurally Related
to Types I and II 63
IV The al(III) and a2(V) Procollagen Genes Are
Syntenic on Human Chromosome 2 64
V Restriction Fragment Length Polymorphisms
Associated with the al(III) Locus 66
VI Multiple mRNAs Are Transcribed from the al(III)
and a2(V) Procollagen Genes 66
VII Primary and Secondary Structural Comparisons of
the Triple Helix and C-Propeptide Domains of the
Types I, in, and V Procollagen Chains 68
VIII Concluding Remarks 73
References 74
THE MOLECULAR BIOLOGY OF COLLAGENS WITH SHORT
TRIPLE-HELICAL DOMAINS
Y NINOMIYA, P CASTAGNOLA, D GERECKE,
M K GORDON, O JACENKO, P LU VALLE,
M MCCARTHY, Y MURAGAKI, I NISHIMURA, S OH,
N ROSENBLUM, N SATO, S SUGRUE, R TAYLOR,
G VASIOS, N YAMAGUCHI, andB R OLSEN
I Introduction 80
II Type IX Collagen Genes 80
HI The Type XII Collagen Gene 94
IV The Function of Type IX and XII Collagens 99
V The Type X Collagen Gene • 101
VI Type VIII Collagen Genes 108
VII The Function of Type VIII and X Collagens 110
References I l l
STRUCTURE AND EVOLUTION OF COLLAGEN IV GENES
BR UCE BLUMBERG and MARKKU KURKINEN
I Introduction 115
II Properties of Collagen IV 118
III Two Collagen IV Chains Are Linked on Human
Chromosome 13 120
IV Extensive Similarity between the C-Terminal
Peptides of Collagens IV 121
CONTENTS vii
V Rate of Evolution in Collagen IV 124
VI Collagen IV Genes Are Different 126
VII How Similar Are al(IV) and a2(IV)? 129
VHI Summary 130
References 131
MOLECULAR BIOLOGY OF CARTILAGE PROTEOGLYCAN
(AGGRECAN) AND LINK PROTEIN
KURTDOEGE, CRAIG RHODES, MAKOTO SASAKI,
JOHNR HASSELL, and YOSHIYAMADA
I Introduction 137
II Link Protein cDNA and Gene Structure 139
HI Aggrecan cDNA and Gene Structure 142
IV Conclusion 152
References 152
STRUCTURE AND ROLE OF CLONED SMALL PROTEOGLYCANS
MARIO A BOURDON
I Introduction 157
II Syndecan 158
III Fibroblast Cell Surface Heparan
Sulfate Proteoglycan 160
IV Serglycin 161
V Invariant Chain Proteoglycan 163
VI Decorin 164
Biglycan (PGI) 165
Glycosaminoglycan Attachment Signal 166
References 170
GENES FOR THE HUMAN LAMININ B1 AND B2 CHAINS
REETTA VUOLTEENAHO, TUULA KALLUNKI,
LOUISE CHOW, JAANAIKONEN,
TIMO PIKKARAINEN, and KARL TRYGGVASON
I Introduction 175
II cDNA Clones Encoding Human Laminin Bl and
B2 Chains 178
viii CONTENTS
HI Structure of the Genes for Human Laminin Bl
and B2 Chains 179
References 191
THE FIBRONECTIN GENE
JEAN SCHWARZBA UER
I Protein Structure and Function 195
II The Structure of the Gene 198
III Concluding Remarks 213
References 215
STRUCTURE OF THE ELASTIN GENE AND ALTERNATIVE
SPLICING OF ELASTIN mRNA
ZEN AINDIK, HELENA YEH, NORMA ORNSTEIN-
GOLDSTEIN, and JOEL ROSENBLOOM
I Introduction 221
II cDNA Cloning and Sequence Analysis 222
III Structure of Elastin Genes 236
IV Species Comparison of Elastin Genes 237
V Intron Structure 239
VI Abundance of Repetitive Sequences of the Alu
Family 239
VII Copy Number of Elastin Gene 241
VIII Alternative Splicing of Elastin mRNA 242
IX Conclusions 245
References 247
MUTATIONS IN COLLAGEN GENES: BIOCHEMICAL AND
PHENOTYPIC CONSEQUENCES
PETER H BYERS
I Introduction 251
II Approaches to the Identification of Mutations in
Collagen Genes 252
III Multiexon Rearrangements in Type I Collagen
Genes Are Lethal but Are Tolerated in Type III
Collagen if the Protein Product Is Synthesized 252
CONTENTS IX
IV Point Mutations: Relation of the Phenotype
to the Location and Nature of the Substituting
Amino Acid 253
V Exon Deletion: Mechanisms and Phenotypic
Correlates 255
VI Altered Expression Usually Results in Mild
Phenotypes 256
VII Molecular-Phenotypic Correlation 257
Concluding Remarks 258
References 259
INDEX 265
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| physical | XVI, 270 S. Ill. |
| publishDate | 1990 |
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| series2 | Biology of extracellular matrix |
| spelling | Extracellular matrix genes ed. by Linda J. Sandell San Diego u.a. Academic Press 1990 XVI, 270 S. Ill. txt rdacontent n rdamedia nc rdacarrier Biology of extracellular matrix Extracellular Matrix Extracellular Matrix Proteins genetics Extracellular matrix Molecular Biology Molecular biology Molecular genetics Gen (DE-588)4128987-0 gnd rswk-swf Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Grundsubstanz (DE-588)4224942-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Grundsubstanz (DE-588)4224942-9 s Molekulargenetik (DE-588)4039987-4 s DE-604 Gen (DE-588)4128987-0 s Sandell, Linda J. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002688363&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Extracellular matrix genes Extracellular Matrix Extracellular Matrix Proteins genetics Extracellular matrix Molecular Biology Molecular biology Molecular genetics Gen (DE-588)4128987-0 gnd Molekulargenetik (DE-588)4039987-4 gnd Grundsubstanz (DE-588)4224942-9 gnd |
| subject_GND | (DE-588)4128987-0 (DE-588)4039987-4 (DE-588)4224942-9 (DE-588)4143413-4 |
| title | Extracellular matrix genes |
| title_auth | Extracellular matrix genes |
| title_exact_search | Extracellular matrix genes |
| title_full | Extracellular matrix genes ed. by Linda J. Sandell |
| title_fullStr | Extracellular matrix genes ed. by Linda J. Sandell |
| title_full_unstemmed | Extracellular matrix genes ed. by Linda J. Sandell |
| title_short | Extracellular matrix genes |
| title_sort | extracellular matrix genes |
| topic | Extracellular Matrix Extracellular Matrix Proteins genetics Extracellular matrix Molecular Biology Molecular biology Molecular genetics Gen (DE-588)4128987-0 gnd Molekulargenetik (DE-588)4039987-4 gnd Grundsubstanz (DE-588)4224942-9 gnd |
| topic_facet | Extracellular Matrix Extracellular Matrix Proteins genetics Extracellular matrix Molecular Biology Molecular biology Molecular genetics Gen Molekulargenetik Grundsubstanz Aufsatzsammlung |
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