The pharmacology of noradrenaline in the central nervous system:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford u.a.
Oxford Univ. Press
1990
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXII, 522 S. Ill. |
| ISBN: | 0192617842 |
Staff View
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Record in the Search Index
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| adam_text |
THE PHARMACOLOGY OF NORADRENALINE IN THE CENTRAL NERVOUS SYSTEM EDITED
BY DAVID J. HEAL BOOTS PHARMACEUTICALS RESEARCH DEPARTMENT, NOTTINGHAM
AND CHARLES A. MARSDEN DEPARTMENT OF PHYSIOLOGY AND PHARMACOLOGY,
MEDICAL SCHOOL QUEEN'S MEDICAL CENTRE, NOTTINGHAM OXFORD NEW YORK TOKYO
OXFORD UNIVERSITY PRESS 1990 CONTENTS LIST OF CONTRIBUTORS XV LIST OF
ABBREVIATIONS XVII CHEMICAL STRUCTURES OF COMPOUNDS WITH PHARMACEUTICAL
XXI COMPANY CODE NUMBERS THE ANATOMY AND FUNCTION OF NORADRENALINE IN
THE 1 MAMMALIAN BRAIN VICKY R. HOLETS 1.1 INTRODUCTION 1 1.2 DEVELOPMENT
OF NORADRENERGIC SYSTEMS 2 1.3 PERIKARYA 3 1.4 NORADRENERGIC AXON
BUNDLES 9 1.5 TERMINAL FIELDS 11 1.6 COEXISTENCE OF NEUROTRANSMITTERS 18
1.7 SUMMARY AND FUTURE DIRECTIONS 27 ADRENOCEPTOR AUTORADIOGRAPHY 41 C.
RICHARD JONES, DANIEL HOYER, AND JOSE M. PALACIOS 2.1 INTRODUCTION 41
2.2 METHODOLOGICAL ASPECTS 41 2.3 PROPERTIES OF ADRENERGIC LIGANDS 43
'2.4 ANATOMICAL LOCALIZATION OF ADRENOCEPTORS 48 2.5
RECEPTOR-NEUROTRANSMITTER MISMATCH 62 2.6 LOCALIZATION OF
ADRENOCEPTOR-MEDIATED RESPONSES 64 2.7 SUMMARY AND CONCLUDING REMARKS 65
MOLECULAR PHARMACOLOGY OF ADRENERGIC RECEPTORS 76 AND THEIR CELLULAR
LOCALIZATION IN BRAIN CELLS IN CULTURE JOEL BOCKAERT, VINCENT HOMBURGER,
AND FRITZ SLADECZEK 3.1 INTRODUCTION 76 3.2 STRUCTURE, CLONING, AND
MUTAGENESIS OF ADRENERGIC RECEPTORS 77 3.3 METABOLISM OF ADRENERGIC
RECEPTORS 82 3.4 MOLECULAR MECHANISMS OF DESENSITIZATION 88 CONTENTS 3.5
LOCALIZATION OF ADRENERGIC RECEPTORS ON NEURONES AND GLIAL 97 CELLS IN
CULTURES 3.6 CONCLUDING REMARKS 105 BIOCHEMICAL AND FUNCTIONAL
CORRELATES OF ADRENOCEPTOR 118 FUNCTION IN THE CENTRAL NERVOUS SYSTEM
DAVID A. KENDALL AND JEAN P. ROBINSON 4.1 INTRODUCTION 118 4.2
P-ADRENOCEPTORS 119 4.3 A-ADRENOCEPTORS 121 4.4 POTENTIATION OF
(J-ADRENOCEPTOR-STIMULATED CYCLIC AMP 125 FORMATION BY CT-ADRENOCEPTOR
STIMULATION 4.5 CYCLIC GMP 132 4.6 ADRENOCEPTOR ACTIVATION OF
PHOSPHOLIPASE A 2 133 4.7 MODIFICATION OF ADRENOCEPTOR FUNCTION BY DRUG
TREATMENTS 134 THE REGULATION OF NEUROTRANSMITTER RELEASE BY 141 A 2
-ADRENOCEPTORS IN THE CENTRAL NERVOUS SYSTEM SONIA ARBILLA AND SALOMON
Z. LANGER 5.1 INTRODUCTION 141 5.2 THE ROLE OF ENDOGENOUS NORADRENALINE
IN THE REGULATION OF 143 NEUROTRANSMITTER RELEASE: ACTIVATION OF A 2
-ADRENERGIC HETERORECEPTORS ON 5-HYDROXYTRYPTAMINERGIC NERVE TERMINALS
5.3 CHANGES IN A 2 -ADRENOCEPTOR SENSITIVITY: DIFFERENCES BETWEEN 145 A
2 -ADRENERGIC AUTORECEPTORS AND A 2 -ADRENERGIC HETERORECEPTORS ON
5-HYDROXYTRYPTAMINERGIC NERVE TERMINALS 5.4 THE INVOLVEMENT OF CYCLIC
NUCLEOTIDES IN THE MODULATION OF 146 NEUROTRANSMITTER RELEASE VIA
PRESYNAPTIC RECEPTORS: POSSIBLE DIFFERENCES BETWEEN A 2 -ADRENERGIC
AUTORECEPTORS AND A 2 -ADRENERGIC HETERORECEPTORS 5.5 THE PHARMACOLOGY
OF A 2 -ADRENOCEPTORS: DIFFERENCES 148 BETWEEN A 2 -ADRENERGIC
AUTORECEPTORS AND A 2 -ADRENERGIC HETERORECEPTORS ON PRESYNAPTIC
5-HYDROXYTRYPTAMINERGIC NERVE TERMINALS 5.6 SUMMARY AND CONCLUSIONS 149
A CRITICAL ASSESSMENT OF METHODS FOR MONITORING 155 NORADRENALINE
RELEASE IN VIVO C. A. MARSDEN 6.1 INTRODUCTION 155 CONTENTS XI 6.2 WHAT
CAN WE HOPE TO MONITOR 155 6.3 USE OF CONSCIOUS OR ANAESTHETIZED ANIMALS
157 6.4 MICRODIALYSIS OF EXTRACELLULAR NORADRENALINE 160 6.5 VOLTAMMETRY
172 6.6 CONCLUSIONS 180 RESTRICTED AFFERENT CONTROL OF LOCUS COERULEUS
NEURONES 187 REVEALED BY ANATOMICAL, PHYSIOLOGICAL, AND PHARMACOLOGICAL
STUDIES GARY ASTON-JONES, MICHAELT. SHIPLEY, MATTHEW ENNIS, JOHNT.
WILLIAMS, AND VINCENT PIERIBONE 7.1 INTRODUCTION 187 7.2 DISCHARGE
PROPERTIES OF LOCUS COERULEUS NEURONES IN 188 BEHAVING ANIMALS 7.3
AFFERENTS TO THE LOCUS COERULEUS: TRACT-TRACING STUDIES 190 7.4
AFFERENTS TO THE LOCUS COERULEUS: PHYSIOLOGICAL AND 204 PHARMACOLOGICAL
STUDIES IN VIVO 7.5* SYNAPTIC POTENTIALS IN THE LOCUS COERULEUS IN VITRO
216 7.6 NEUROCHEMICAL IDENTITY OF LOCUS COERULEUS AFFERENTS 220 7.7
FUNCTIONAL IMPLICATIONS 229 LOCUS COERULEUS NEURONAL ACTIVITY IN
BEHAVING ANIMALS 248 BARRYL. JACOBS 8.1 INTRODUCTION 248 8.2
NEUROCHEMICAL IDENTIFICATION 249 8.3 EXPERIMENTAL STUDIES 250 8.4
SUMMARY AND CONCLUSIONS 259 THE EFFECTS OF DRUGS ON BEHAVIOURAL MODELS
OF CENTRAL 266 NORADRENERGIC FUNCTION DAVID J. HEAL 9.1 INTRODUCTION 266
9.2 BEHAVIOURAL MODELS USED FOR INVESTIGATING A,-ADRENOCEPTOR 267
FUNCTION IN THE CENTRAL NERVOUS SYSTEM 9.3 BEHAVIOURAL MODELS FOR
INVESTIGATING A 2 -ADRENOCEPTORS IN 276 THE CENTRAL NERVOUS SYSTEM 9.4
BEHAVIOURAL MODELS FOR INVESTIGATING P-ADRENOCEPTOR ' 297 FUNCTION IN
THE CENTRAL NERVOUS SYSTEM 9.5 CONCLUSIONS 301 XII CONTENTS 10 THE
EFFECTS OF ANTIDEPRESSANT DRUGS ON NORADRENERGIC / 316 X RECEPTOR
MECHANISMS IN THE CENTRAL NERVOUS SYSTEM \^ Y A. RICHARD GREEN 10.1
INTRODUCTION 316 10.2 THE EFFECTS OF ANTIDEPRESSANT DRUGS ON
NORADRENALINE 317 METABOLISM 10.3 EFFECTS OF ANTIDEPRESSANT DRUGS AND
ECS ON 318 P-ADRENOCEPTORS 10.4 EFFECTS OF ANTIDEPRESSANT DRUGS AND ECS
ON 328 A 2 -ADRENOCEPTORS : 10.5 A R ADRENOCEPTOR FUNCTION AFTER
ANTIDEPRESSANT TREATMENTS: 334 BIOCHEMICAL AND BEHAVIOURAL STUDIES 10.6
THE [ 3 H]-DESIPRAMINE BINDING SITE IN BRAIN 336 10.7 GENERAL DISCUSSION
336 11 FUNCTIONS OF THE LOCUS COERULEUS NORADRENERGIC SYSTEM: A
NEUROBIOLOGICAL AND BEHAVIOURAL SYNTHESIS BARRY J. EVERITT, TREVOR W.
ROBBINS, AND NATHAN R. W. SELDEN 11.1 NEUROANATOMICAL AND
NEUROPHYSIOLOGICAL CONSIDERATIONS 349 11.2 BEHAVIOURAL STUDIES 356 11.3
EFFECTS OF DORSAL NORADRENERGIC BUNDLE LESIONS 357 11.4 NEUROANATOMICAL
SPECIFICITY OF COERULEO-CORTICAL 360 NORADRENERGIC LESIONS AND THE
EFFECTS OF HYPOTHALAMIC NORADRENERGIC DENERVATION 11.5 THE EFFECTS OF
LESIONS OF THE DORSAL NORADRENERGIC BUNDLE ON 365 CONTEXTUAL LEARNING
11.6 THEORETICAL IMPLICATIONS 367 12 CENTRAL ADRENOCEPTORS IN RESPONSE
AND ADAPTATION TO / 379 STRESS S. CLARE STANFORD 12.1 INTRODUCTION 379
12.2 EXPERIMENTAL PROTOCOL 380 12.3 REPEATED (CHRONIC) STRESS 381 12.4
SINGLE (ACUTE) STRESS 387 12.5 ADRENOCEPTORS AND BEHAVIOURAL ADAPTATION
TO STRESS 392 12.6 LEARNED HELPLESSNESS AND BEHAVIOURAL DESPAIR 395 12.7
GAB A AND ADRENOCEPTOR CHANGES IN RESPONSE TO STRESS 401 12.8
BEHAVIOURAL IMPLICATIONS OF DELAYED CHANGES IN 406 ADRENOCEPTORS 12.9
CONCLUSIONS 410 CONTENTS XIII 13 CENTRAL NORADRENERGIC NEURONES AND
CARDIOVASCULAR 423 CONTROL: FOCUS ON POSSIBLE NEUROPEPTIDE-NORADRENALINE
INTERACTIONS SHEILA M. GARDINER AND TERENCE BENNETT 13.1 INTRODUCTION
423 13.2 NORADRENALINE 423 13.3 ANGIOTENSIN 426 13.4 VASOPRESSIN 428
13.5 CORTICOTROPHIN-RELEASING FACTOR (CRF) 431 13.6 ADRENOCORTICOTROPHIC
HORMONE (ACTH) 431 13.7 THYROTROPHIN-RELEASING HORMONE (TRH) 432 13.8
ATRIAL NATRIURETIC FACTOR (ANF) 433 13.9 GALANIN 434 13.10 CALCITONIN
GENE-RELATED PEPTIDE (CGRP) 436 13.11 NEUROPEPTIDE Y 437 13.12
SOMATOSTATIN 440 13.13 CHOLECYSTOKININ 441 13.14 SUBSTANCE P 442 13.15
BRADYKININ 442 13.16 NEUROTENSIN 444 13.17 SUMMARY AND CONCLUSIONS 444
14 FUNCTIONAL INTERACTIONS BETWEEN NEUROPEPTIDES AND 454 NORADRENALINE
IN THE BRAIN AND SPINAL CORD GEOFFREY W. BENNETT 14.1 INTRODUCTION 454
14.2 NORADRENALINE-PEPTIDE COEXISTENCE IN BRAIN 455 14.3
NORADRENALINE-NEUROPEPTIDE INTERACTIONS IN THE 458 HYPOTHALAMUS 14.4
EFFECTS OF NORADRENALINE ON NEUROENDOCRINE MECHANISMS 460 14.5
NORADRENALINE-PEPTIDE INTERACTIONS IN BRAIN 464 14.6 MEASUREMENT OF
NORADRENALINE RELEASE IN THE BRAIN 468 14.7 FUNCTIONAL INTERACTIONS
BETWEEN TRH AND NORADRENALINE IN 470 BRAIN 14.8
NEUROPEPTIDE-NORADRENALINE INTERACTIONS IN THE SPINAL CORD 476 14.9
FUNCTIONAL INTERACTIONS BETWEEN TRH AND NORADRENALINE IN 478 THE SPINAL
CORD 14.10 CONCLUSIONS AND COMMENTS 483 15 SUMMARY 495 DAVID J. HEAL AND
CHARLES A. MARSDEN 15.1 MAPPING OF NEURONAL PATHWAYS AND THE
SIGNIFICANCE OF 495 NORADRENALINE-PEPTIDE COEXISTENCE XIV CONTENTS 15.2
RECEPTORS 496 15.3 BEHAVIOURAL PHARMACOLOGY 496 15.4 DRUG DEVELOPMENT
498 15.5 CONCLUDING REMARKS 499 INDEX 501 |
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| isbn | 0192617842 |
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| spelling | The pharmacology of noradrenaline in the central nervous system ed. by David J. Heal ... Oxford u.a. Oxford Univ. Press 1990 XXII, 522 S. Ill. txt rdacontent n rdamedia nc rdacarrier Brain drug effects Neuropharmacology Noradrenaline Norepinephrine pharmacology Norepinephrine physiology Neurophysiologie (DE-588)4041897-2 gnd rswk-swf Neuropharmakologie (DE-588)4041896-0 gnd rswk-swf Noradrenalin (DE-588)4171995-5 gnd rswk-swf Zentralnervensystem (DE-588)4067637-7 gnd rswk-swf Zentralnervensystem (DE-588)4067637-7 s Noradrenalin (DE-588)4171995-5 s Neurophysiologie (DE-588)4041897-2 s DE-604 Neuropharmakologie (DE-588)4041896-0 s Heal, David J. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002676654&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The pharmacology of noradrenaline in the central nervous system Brain drug effects Neuropharmacology Noradrenaline Norepinephrine pharmacology Norepinephrine physiology Neurophysiologie (DE-588)4041897-2 gnd Neuropharmakologie (DE-588)4041896-0 gnd Noradrenalin (DE-588)4171995-5 gnd Zentralnervensystem (DE-588)4067637-7 gnd |
| subject_GND | (DE-588)4041897-2 (DE-588)4041896-0 (DE-588)4171995-5 (DE-588)4067637-7 |
| title | The pharmacology of noradrenaline in the central nervous system |
| title_auth | The pharmacology of noradrenaline in the central nervous system |
| title_exact_search | The pharmacology of noradrenaline in the central nervous system |
| title_full | The pharmacology of noradrenaline in the central nervous system ed. by David J. Heal ... |
| title_fullStr | The pharmacology of noradrenaline in the central nervous system ed. by David J. Heal ... |
| title_full_unstemmed | The pharmacology of noradrenaline in the central nervous system ed. by David J. Heal ... |
| title_short | The pharmacology of noradrenaline in the central nervous system |
| title_sort | the pharmacology of noradrenaline in the central nervous system |
| topic | Brain drug effects Neuropharmacology Noradrenaline Norepinephrine pharmacology Norepinephrine physiology Neurophysiologie (DE-588)4041897-2 gnd Neuropharmakologie (DE-588)4041896-0 gnd Noradrenalin (DE-588)4171995-5 gnd Zentralnervensystem (DE-588)4067637-7 gnd |
| topic_facet | Brain drug effects Neuropharmacology Noradrenaline Norepinephrine pharmacology Norepinephrine physiology Neurophysiologie Neuropharmakologie Noradrenalin Zentralnervensystem |
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