CRC Handbook of sample size guidelines for clinical trials:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Boca Raton ; Ann Arbor ; Boston
CRC Press
1990
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 854 Seiten Diagramme |
| ISBN: | 0849335426 |
Staff View
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| 650 | 7 | |a random sampling |2 cabt | |
| 650 | 7 | |a sample size |2 cabt | |
| 650 | 7 | |a samples |2 cabt | |
| 650 | 7 | |a randomized controlled trials |2 cabt | |
| 650 | 7 | |a representative sampling |2 cabt | |
| 650 | 7 | |a methodology |2 cabt | |
| 650 | 4 | |a Statistik | |
| 650 | 4 | |a Clinical Trials |x methods | |
| 650 | 4 | |a Clinical trials |x Statistical methods | |
| 650 | 4 | |a Drugs |x Testing |x Statistical methods | |
| 650 | 4 | |a Research Design | |
| 650 | 4 | |a Sampling (Statistics) | |
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Record in the Search Index
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| adam_text | CRC HANDBOOK OF SAMPLE SIZE GUIDELINES FOR CLINICAL TRIALS AUTHOR
JONATHAN J. SHUSTER, PH.D. PROFESSOR OF STATISTICS, UNIVERSITY OF HORIDA
GAINESVILLE, FLORIDA AND CO-PRINCIPAL INVESTIGATOR PEDIATRIC ONCOLOGY
GROUP STATISTICAL OFFICE ST. LOUIS, MISSOURI CRC PRESS BOCA RATON ANN
ARBOR BOSTON TABLE OF CONTENTS CHAPTER 1 HOW TO USE THE SAMPLE SIZE
TABLES 1 1.1. IDENTIFICATION OF PARAMETERS 2 REFERENCES 5 CHAPTER 2
DESIGN AND ANALYSIS OF RANDOMIZED CLINICAL TRIALS 9 2.1. FORMULATION OF
THE THERAPEUTIC QUESTION 9 2.1.1 ONE SIDED VS. TWO-SIDED QUESTION 9 2.2.
DESIGN OF THE CLINICAL TRIAL 11 2.2.1. STATISTICAL CONSIDERATIONS 12
2.3. CONDUCT OF THE TRIAL 20 2.4. ANALYSIS AND REPORTING OF THE TRIAL 21
2.4.1. CRUCIAL ELEMENTS 21 2.4.2. BINOMIAL COMPARISON 22 2.4.2.1. LARGE
SAMPLE METHODOLOGY 22 2.4.2.2. CONFIDENCE INTERVALS 23 2.4.2.3.
NUMERICAL EXAMPLE (TEST) 24 2.4.2.4. NUMERICAL EXAMPLE (ONE-SIDED
CONFIDENCE INTERVAL) 25 2.4.2.5. NUMERICAL EXAMPLE (TWO-SIDED CONFIDENCE
INTERVAL) 25 2.4.2.6. SMALL SAMPLE METHODOLOGY 25 2.4.3 KAPLAN-MEIER
COMPARISON (LARGE SAMPLE) 28 2.4.3.1. ASSUMPTIONS UNDERLYING
KAPLAN-MEIER CURVE 28 2.4.3.2. CALCULATION OF THE KAPLAN-MEIER CURVE 29
2.4.3.3. NUMERICAL EXAMPLE 30 2.4.3.4. STANDARD ERROR 31 2.4.3.5. THE
KAPLAN-MEIER COMPARISON OF TWO TREATMENTS 32 2.4.3.6. CONFIDENCE
INTERVALS FOR DIFFERENCE IN FIXED-TERM SURVIVAL 33 2.4.4. LOGRANK TEST
34 2.4.4.1. IMPORTANT OBSERVATIONS WITH RESPECT TO THE LOGRANK TEST 36
2.4.4.2. NUMERICAL EXAMPLE 36 2.4.4.3. FOOTNOTES TO NUMERICAL EXAMPLE
AND THE LOGRANK TEST 38 2.4.4.4. PROPORTIONAL HAZARDS AND THE LOGRANK
TEST 39 REFERENCES 40 CHAPTER 3 DERIVATION OF THE STATISTICAL RESULTS 51
3.1. DERIVATION OF THE LARGE SAMPLE DISTRIBUTION OF THE LOGRANK
STATISTIC 53 3.2. DERIVATION OF THE LARGE SAMPLE DISTRIBUTION OF THE
KAPLAN-MEIER STATISTIC 63 3.2.1. DIFFERENCE BETWEEN KAPLAN-MEIER CURVES
85 3-3. EXPONENTIAL SURVIVAL 86 3.4. APPLICATION OF THE LOGRANK TEST
WHEN SURVIVAL IS EXPONENTIAL 93 3.5. EXPONENTIAL SURVIVAL WITH A POISSON
ACCRUAL PROCESS 98 3.6. EXTENSION TO THE TWO-SAMPLE PROBLEM 110 3.7.
EXPONENTIAL SURVIVAL WITH UP-FRONT ACCRUAL 114 3.8. PROPORTIONAL
HAZARD MODELS AND THE EXPONENTIAL DISTRIBUTION 117 3.9. CONSIDERATION IN
PLANNING A TRIAL UNDER PROPORTIONAL HAZARDS: PUTTING IT ALL TOGETHER 120
3.10. LOSSES TO FOLLOW-UP AND SAMPLE SIZE ADJUSTMENT 128 3.11.
INTERPRETATION OF THE TABLES 130 3.12. MULTI-TREATMENT TRIALS 130
3.12.1. TYPE A 131 3.12.2. TYPE B : 132 3.12.3. TYPE C 133 3.12.4. TYPE
D 136 3.13. STRATIFIED LOGRANK TEST 137 3.13.1. ADVICE ON STRATIFICATION
139 3.14. INTUITIVE JUSTIFICATION WHY THE LOGRANK TEST AND KAPLAN-MEIER
ESTIMATION FOR ACTUAL ACCRUAL PROCESS BEHAVE IN THE LIMIT IN THE SAME
WAY AS THE FIXED BINOMIAL ASSUMPTION 140 3.15. ALTERNATE STANDARD ERROR
FOR THE KAPLAN-MEIER ESTIMATOR 141 3.16. CONNECTION BETWEEN KAPLAN-MEIER
WITH BINOMIAL 144 REFERENCES 145 FIGURES 1. CODES FOR TABLES 6 2.
WORKSHEET FOR SAMPLE SIZE DETERMINATION 7 3. MODIFICATIONS OF FIGURE 2 8
4. SIMPLE RANDOMIZATION FOR 1200 PATIENTS 43 5. RANDOM LENGTH PERMUTED
BLOCKS OF FOUR OR SIX PATIENTS 44 6. ONE-SIDED P-VALUES FOR NORMAL
CURVES 45 7. TWO-SIDED P-VALUES FOR NORMAL CURVES; IGNORE SIGN OF Z + VS
- 46 8. VALUES FOR W IN ONE-SIDED CONFIDENCE INTERVALS FOR APPROXIMATELY
NORMALLY DISTRIBUTED ESTIMATES 47 9. VALUES FOR W IN TWO-SIDED
CONFIDENCE INTERVALS FOR APPROXIMATELY NORMALLY DISTRIBUTED ESTIMATES 47
10. SURVIVAL IN RANDOMIZED PEDIATRIC CANCER TRIAL ENTRIES ARE IN DAYS
WITH + TO INDICATED SURVIVORS 48 11. SURVIVAL COMPARISON 49 NOTATION
CHART 52 APPENDIX I A REVIEW OF MATHEMATICAL STATISTICS 147 EXPECTED
VALUE OF A FUNCTION OF A RANDOM VECTOR (DEFINITION) 155 SPECIAL
DISTRIBUTIONS 162 TRANSFORMATIONS (CONTINUOUS VARIABLES) (CONSEQUENCE)
169 STATISTICAL INFERENCE 189 SAMPLE SIZE DETERMINATION 197 THE POISSON
PROCESS 201 REFERENCES 210 APPENDIX II TABLES 211 TABLE 1: ALPHA = 0.005
AND POWER = 0.80 213 TABLE 2: ALPHA = 0.005 AND POWER = 0.90 293 TABLE
3: ALPHA = 0.01 AND POWER = 0.80 373 TABLE 4: ALPHA = 0.01 AND POWER =
0.90 453 TABLE 5: ALPHA = 0.025 AND POWER = 0.80 533 TABLE 6: ALPHA =
0.025 AND POWER = 0.90 613 TABLE 7: ALPHA = 0.05 AND POWER = 0.80 693
TABLE 8: ALPHA = 0.05 AND POWER = 0.90 773 INDEX 853
|
| any_adam_object | 1 |
| author | Shuster, Jonathan J. 1943- |
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| callnumber-subject | RM - Therapeutics and Pharmacology |
| ctrlnum | (OCoLC)187400816 (DE-599)BVBBV004197263 |
| dewey-full | 610/.72 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610/.72 |
| dewey-search | 610/.72 |
| dewey-sort | 3610 272 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV004197263 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T16:09:42Z |
| institution | BVB |
| isbn | 0849335426 |
| language | English |
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| physical | 854 Seiten Diagramme |
| publishDate | 1990 |
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| publishDateSort | 1990 |
| publisher | CRC Press |
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| spelling | Shuster, Jonathan J. 1943- Verfasser (DE-588)1146079648 aut CRC Handbook of sample size guidelines for clinical trials author: Jonathan J. Shuster Handbook of sample size guidelines for clinical trials Boca Raton ; Ann Arbor ; Boston CRC Press 1990 854 Seiten Diagramme txt rdacontent n rdamedia nc rdacarrier random sampling cabt sample size cabt samples cabt randomized controlled trials cabt representative sampling cabt methodology cabt Statistik Clinical Trials methods Clinical trials Statistical methods Drugs Testing Statistical methods Research Design Sampling (Statistics) Statistics Klinische Prüfung (DE-588)4031192-2 gnd rswk-swf Forschungsplanung (DE-588)4155051-1 gnd rswk-swf Klinische Prüfung (DE-588)4031192-2 s Forschungsplanung (DE-588)4155051-1 s DE-604 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002614635&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Shuster, Jonathan J. 1943- CRC Handbook of sample size guidelines for clinical trials random sampling cabt sample size cabt samples cabt randomized controlled trials cabt representative sampling cabt methodology cabt Statistik Clinical Trials methods Clinical trials Statistical methods Drugs Testing Statistical methods Research Design Sampling (Statistics) Statistics Klinische Prüfung (DE-588)4031192-2 gnd Forschungsplanung (DE-588)4155051-1 gnd |
| subject_GND | (DE-588)4031192-2 (DE-588)4155051-1 |
| title | CRC Handbook of sample size guidelines for clinical trials |
| title_alt | Handbook of sample size guidelines for clinical trials |
| title_auth | CRC Handbook of sample size guidelines for clinical trials |
| title_exact_search | CRC Handbook of sample size guidelines for clinical trials |
| title_full | CRC Handbook of sample size guidelines for clinical trials author: Jonathan J. Shuster |
| title_fullStr | CRC Handbook of sample size guidelines for clinical trials author: Jonathan J. Shuster |
| title_full_unstemmed | CRC Handbook of sample size guidelines for clinical trials author: Jonathan J. Shuster |
| title_short | CRC Handbook of sample size guidelines for clinical trials |
| title_sort | crc handbook of sample size guidelines for clinical trials |
| topic | random sampling cabt sample size cabt samples cabt randomized controlled trials cabt representative sampling cabt methodology cabt Statistik Clinical Trials methods Clinical trials Statistical methods Drugs Testing Statistical methods Research Design Sampling (Statistics) Statistics Klinische Prüfung (DE-588)4031192-2 gnd Forschungsplanung (DE-588)4155051-1 gnd |
| topic_facet | random sampling sample size samples randomized controlled trials representative sampling methodology Statistik Clinical Trials methods Clinical trials Statistical methods Drugs Testing Statistical methods Research Design Sampling (Statistics) Statistics Klinische Prüfung Forschungsplanung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002614635&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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