Molecular biology and differentiation of megakaryocytes: proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989
Gespeichert in:
Format: | Tagungsbericht Buch |
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Sprache: | English |
Veröffentlicht: |
New York u.a.
Wiley-Liss
1990
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Schriftenreihe: | Progress in clinical and biological research
356 |
Schlagworte: | |
Online-Zugang: | Inhaltsverzeichnis |
Beschreibung: | XIX, 372 S. Ill. |
ISBN: | 0471568228 |
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adam_text | MOLECULAR BIOLOGY
AND DIFFERENTIATION
OF MEGAKARYOCYTES
Proceedings of the Third International Conference on Megakaryocytes:
Megakaryocytes: Cellular and Molecular Biology, Held at Conseil
Regional de Bourgogne, Dijon, France, July 23-27, 1989
Editors
Janine Breton-Gorius
INSERM U 91
Hopital Henri Mondor
Creteil, France
Jack Levin
University of California School of Medicine
and Veterans Administration Medical Center
San Francisco, California
Alan T Nurden
Section Pathologie Cellulaire
de l Hemostase
Hopital Cardiologique
Pessac, France
Neil Williams
Department of Physiology
University of Melbourne
Melbourne, Australia
WILEY-LISS
A JOHN WILEY amp; SONS, INC , PUBLICATION
NEW YORK • CHICHESTER • BRISBANE • TORONTO • SINGAPORE
Contents
Contributors xi
Preface
Janine Breton-Gorius, Jack Levin, Alan T Nurden, and Neil Williams xvii
Acknowledgments xix
MATURATION OF MEGAKARYOCYTES
PARTI
An Overview of Megakaryocytopoiesis
Jack Levin 1
Megakaryocytopoiesis in Man and Laboratory Animals Conclusions
Derived From Comparative Studies and Recently Discovered Animal
Models With Megakaryocyte Anomalies
Carl W Jackson, Nancy K Hutson, Shirley A Steward,
and Ted P McDonald 11
Delivery of Platelets From Megakaryocytes
James G White 25
Circulating Megakaryocytes and Platelet Production in the Lungs
Richard F Levine, Pam Shoff, Zhong C Han, and Amiram Eldor 41
Summary of Discussions: Maturation of Megakaryocytes, Part I
John M Radley and Olav Behnke 53
PARTn
Platelet GPIIb as a Marker for Megakaryocytopoiesis
Gdrard Marguerie, Alain Troesch, Philippe Frachet, Michel Prenant,
Eric Denarier, Rolande Berthier, Alain Duperray, Marie Helene Prandini,
and Georges Uzan 55
Molecular Biology of the Megakaryocyte-Specific Gene Platelet Factor 4
Mortimer Poncz 65
Molecular Biology of Human Platelet Membrane Glycoprotein IB
Kenneth J Clemetson, Roland H Wenger, Andreas N Wicki,
Jeannine M Clemetson, Nelly Kieffer, and Jeanne Drouin 77
vii
viii / Contents
Summary of Discussions: Maturation of Megakaryocytes, Part II
Robert I Handin 89
PART in
Proteoglycans in Megakaryocyte Development
Barbara P Schick 93
Use of In Situ Hybridization to Study Human Megakaryocyte Gene
Expression
Alan M Gewirtz 105
The Origin of Platelet a-Granule Proteins
Prem J Handagama, Marc A Shuman, and Dorothy F Bainton 119
Uncoordinated Expression of Alpha-Granule Proteins in Human
Megakaryocytes
Elisabeth M Cramer, Paul Harrison, Geoffrey F Savidge,
Barry Wilbourn, Najet Debili, William Vainchenker,
and Janine Breton-Gorius 131
Summary of Discussions: Maturation of Megakaryocytes, Part III
James G White and Janine Breton-Gorius 143
REGULATION OF MEGAKARYOCYTOPOIESIS
PARTI
The Regulatory Control of Hemopoietic Populations
Donald Metcalf 147
Growth Factor Stimulation of Murine Megakaryocyte Colony Formation
Peter J Quesenberry, Helen E McGrath, Ian K McNiece,
Daniel S Temeles, and Brian E Robinson 155
Studies on Paracrine Regulation of Murine Megakaryocytopoiesis
N Williams, N Banu, H Jackson, K Ettlinger, T De Giorgio,
J Fawcett, and R Withy 167
Regulation of In Vitro Human Megakaryocyte Maturation
Lynne Williams, Connie H Heffner, and Michael W Long 181
Regulation of Human Megakaryocytopoiesis by Interacting Cytokines
Ronald Hoffman, John Straneva, Norman Hudson, Timothy Guscar,
Robert Briddell, and Edward Bruno 199
Summary of Discussions: Regulation of Megakaryocytopoiesis, Part I
Jack Levin and William Vainchenker 217
PART II
Role of Thrombopoietin in Controlling Blood Platelet Production
T P McDonald and C W Jackson 219
Control and Implications of Polyploidization in Human Megakaryocytes
Eric M Mazur 231
Contents / ix
Platelets Contain Several Inhibitors of Megakaryocyte Growth and
Ploidization
David J Kuter, Dianne Gminski, and Robert D Rosenberg 245
Growth and Differentiation of Two Human Megakaryoblastic Cell Lines:
CMK and UT-7
Yasusada Miura, Norio Komatsu, and Toshio Suda 259
Summary of Discussions: Regulation of Megakaryocytopoiesis, Part n
Neil Williams and Bruce L Evatt 271
PATHOLOGY OF MEGAKARYOCYTOPOIESIS
PARTI
Retroviral Antigen Expression on Megakaryocytes and Platelets: Possible
Implications in the Pathogenesis of Thrombocytopenia
Georges E Grau and Paul-Henri Lambert 275
Analysis of c-sis/PDGF-B mRNA Expression in Megakaryocytic Cells of
Patients With Myeloproliferative Disorders
Lothar Kanz, Andreas Luig, Reinhard Mielke, Marc Azemar,
Axel A Fauser, and Hans E Schaefer 287
Summary of Discussions: Pathology of Megakaryocytopoiesis, Part I
Gerard Marguerie 299
PARTn
Flow Cytometric Analysis of Megakaryocytes (Mks) From Patients With
Platelet Disorders
Richard J Conklin, Aaron Tomer, Paul Friese, Wes Bales,
and Samuel A Burstein 303
Megakaryocytes and Thrombopoiesis in Vascular Disease
John F Martin 319
Inherited Disorders of Platelets and Megakaryocytes
Alan T Nurden, Marta Pico, Eric Heilmann, Vincent Jallu,
and Paquita Hourdille 333
Summary of Discussions: Pathology of Megakaryocytopoiesis, Part II
Laurence Corash and R F Levine 347
Summary of Workshop I: Methods for the Isolation of Megakaryocytes
John F Martin and Samuel A Burstein 351
Summary of Workshop II: Flow Cytometric Determination of
Megakaryocyte Ploidy
J M Paulus 357
Index 361
|
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format | Conference Proceeding Book |
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spelling | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 ed.: Janine Breton-Gorius ... New York u.a. Wiley-Liss 1990 XIX, 372 S. Ill. txt rdacontent n rdamedia nc rdacarrier Progress in clinical and biological research 356 Blood platelets Congresses Megakaryocytes Differentiation Congresses Megakaryocytes cytology Congresses Megakaryocytes pathology Congresses Megakaryocytes physiology Congresses Pathology, Cellular Congresses Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Pathologie (DE-588)4044893-9 gnd rswk-swf Megakaryozyt (DE-588)4169265-2 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1989 Dijon gnd-content Megakaryozyt (DE-588)4169265-2 s Entwicklungsbiologie (DE-588)4152440-8 s DE-604 Molekularbiologie (DE-588)4039983-7 s Pathologie (DE-588)4044893-9 s Breton-Gorius, Janine Sonstige oth International Conference on Megakaryocytes 3 1989 Dijon Sonstige (DE-588)5035745-1 oth Progress in clinical and biological research 356 (DE-604)BV000001177 356 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002611825&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 Progress in clinical and biological research Blood platelets Congresses Megakaryocytes Differentiation Congresses Megakaryocytes cytology Congresses Megakaryocytes pathology Congresses Megakaryocytes physiology Congresses Pathology, Cellular Congresses Entwicklungsbiologie (DE-588)4152440-8 gnd Pathologie (DE-588)4044893-9 gnd Megakaryozyt (DE-588)4169265-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
subject_GND | (DE-588)4152440-8 (DE-588)4044893-9 (DE-588)4169265-2 (DE-588)4039983-7 (DE-588)1071861417 |
title | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 |
title_auth | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 |
title_exact_search | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 |
title_full | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 ed.: Janine Breton-Gorius ... |
title_fullStr | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 ed.: Janine Breton-Gorius ... |
title_full_unstemmed | Molecular biology and differentiation of megakaryocytes proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 ed.: Janine Breton-Gorius ... |
title_short | Molecular biology and differentiation of megakaryocytes |
title_sort | molecular biology and differentiation of megakaryocytes proceedings of the third international conference on megakaryocytes megakaryocytes cellular and molecular biology held at conseil regional de bourgogne dijon france july 23 27 1989 |
title_sub | proceedings of the Third International Conference on Megakaryocytes: Megakaryocytes: Cellular and Molecular Biology, held at Conseil Régional de Bourgogne, Dijon, France, July 23 - 27, 1989 |
topic | Blood platelets Congresses Megakaryocytes Differentiation Congresses Megakaryocytes cytology Congresses Megakaryocytes pathology Congresses Megakaryocytes physiology Congresses Pathology, Cellular Congresses Entwicklungsbiologie (DE-588)4152440-8 gnd Pathologie (DE-588)4044893-9 gnd Megakaryozyt (DE-588)4169265-2 gnd Molekularbiologie (DE-588)4039983-7 gnd |
topic_facet | Blood platelets Congresses Megakaryocytes Differentiation Congresses Megakaryocytes cytology Congresses Megakaryocytes pathology Congresses Megakaryocytes physiology Congresses Pathology, Cellular Congresses Entwicklungsbiologie Pathologie Megakaryozyt Molekularbiologie Konferenzschrift 1989 Dijon |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002611825&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
volume_link | (DE-604)BV000001177 |
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