Gene rearrangement:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Oxford u.a.
IRL Press
1990
|
| Series: | Frontiers in molecular biology
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 154 S. Ill. |
| ISBN: | 019963050X 0199630518 1852211415 1852211423 |
Staff View
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| 245 | 1 | 0 | |a Gene rearrangement |c ed. by B. D. Hames ... |
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| 650 | 4 | |a DNA |x genetics | |
| 650 | 4 | |a Gene Amplification | |
| 650 | 4 | |a Gene Rearrangement | |
| 650 | 4 | |a Gene amplification | |
| 650 | 4 | |a Gene expression | |
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Record in the Search Index
| _version_ | 1804118367960825856 |
|---|---|
| adam_text | GENE
REARRANGEMENT
Edited by
B D Hames
Department of Biochemistry, University of Leeds, Leeds LS2 9JT, UK
and
D M Glover
Cancer Research Campaign, Eukaryotic Molecular Genetics
Research Group, Department of Biochemistry, Imperial College
of Science and Technology, London SW7 2AZ, UK
OIRL PRESS
at
OXFORD UNIVERSITY PRESS
Oxford New York Tokyo
Contents
Abbreviations
l Genomic rearrangements in prokaryotes 1
Douglas E Berg
Introduction 1
Homologous Recombination and Genome Organization 1
Intermolecular recombination 3
Recombination between direct repeats 4
Unequal intermolecular crossing-over 4
Recombination between inverted repeats: permitted and
forbidden chromosomal inversions 4
Homologous recombination and phase variation: Neisseria
gonorrhoeae pilin genes 6
Site-specific Recombination 7
Integration and excision of phage X 8
Resolution of transposition co-integrates 14
Site-specific recombination and colEl plasmid stability 15
Cre-loxP recombination: PI lysogenization and plasmid
maintenance 16
DNA inversion and phase variation 17
DNA excision and nitrogen fixation in cyanobacteria 20
DNA rearrangement that changes transcription specificity 20
Transposition 21
Overview 21
Transposition mechanisms 24
Insertion specificity 26
Consequences of intramolecular transposition 27
Regulation of transposition 28
Illegitimate Recombination 32
Rearrangements associated with DNA breakage 32
Deletions associated with initiation and termination of
replication 34
Illegitimate recombination associated with direct and inverted
repeats 35
Duplications and deletions in phage X 40
ix
Acknowledgements 43
References 43
2 Antigenic variation in African trypanosomes: genetic
recombination and transcriptional control of VSG
genes 51
Lex H T Van der Ploeg
Introduction 51
African Trypanosomes and Immune-evasion 51
The cell surface coat and antigenic variation 52
Structure of the cell surface coat 53
The flagellar pocket 55
Ploidy, Life-cycle, and Chromosome Structure 55
Karyotype analysis 56
Karyotype variability 58
Chromosome and nuclear structure 58
DNA Recombinational Mechanisms in Differential VSG Gene
Expression 60
Structure of expression sites 61
General description of antigenic switches 62
Antigenic switches as a result of VSG gene displacement at
an active expression site 63
Antigenic switches resulting from differential transcriptional
control of expression sites 67
Control of expression site switching 73
Identification of Transcriptional Initiation Sites 74
Discontinuous transcription and tams-splicing 74
Polygenic transcription of VSG gene expression sites by
a-amanitin-insensitive RNA polymerases 77
Trypanosomes in the Insect Vector and Expression Site
Transcriptional Control 80
Procyclic trypanosomes and DNA recombinational events 81
Metacyclic trypanosomes 82
Evolution of the VSG Gene Repertoire 83
Unequal sister chromatid exchange and retroposition 83
Segmental gene conversion 85
Concluding Remarks 85
Acknowledgements 85
References 85
3 DNA amplification in eukaryotes 99
George R Stark, Michelle Debatisse, Geoffrey M Wahl, and
David M Glover
Introduction 99
Developmental^ Regulated rDNA Amplification 100
XI
rDNA amplification in ciliates 100
rDNA amplification in amphibian oocytes 101
Gene Amplification During the Development of Dipteran Flies 101
Cell division and polytenization during dipteran development 101
The distribution of replication origins in Drosophila
chromosomes 103
Differential replication of DNA in polytene chromosomes 105
Amplification of single copy genes 107
Amplification of Genes Mediating Resistance to Toxic Agents in
Whole Organisms 115
Amplification in Mammalian Cells in Culture 116
Amplification in drug-resistant cell lines 116
Multidrug resistance 116
Parameters of amplification 117
Amplification as an abnormal event 118
Mammalian Gene Amplification In Vivo 118
Amplification of oncogenes 118
Correlation of amplification with metastasis 120
General methods to detect or clone amplified genes 120
Stimulation of Amplification 121
Stimulation by exogenous agents 121
Amplificator cell lines 122
Amplification and other chromosomal abnormalities 123
Forms and Structures of Amplified DNA 123
Cytological manifestations: interrelationships of ECRs and
DMs 123
Characterization of DMs 126
Characterization of ECRs 126
Novel joints in amplified DNA 127
Evolution of Amplified DNA 128
Preferential reamplification 128
Stability of amplified DNA 129
Mechanisms of Amplification in Mammalian Cells 129
Replication-driven mechanisms 130
Segregation-driven mechanisms 133
Prospects for the Future 136
References 138
Index 151
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| physical | XIII, 154 S. Ill. |
| publishDate | 1990 |
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| spelling | Gene rearrangement ed. by B. D. Hames ... Oxford u.a. IRL Press 1990 XIII, 154 S. Ill. txt rdacontent n rdamedia nc rdacarrier Frontiers in molecular biology DNA genetics Gene Amplification Gene Rearrangement Gene amplification Gene expression Genetic recombination Recombination, Genetic Rekombination (DE-588)4049338-6 gnd rswk-swf DNS (DE-588)4070512-2 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content DNS (DE-588)4070512-2 s Rekombination (DE-588)4049338-6 s DE-604 Genetik (DE-588)4071711-2 s Hames, B. D. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002591877&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gene rearrangement DNA genetics Gene Amplification Gene Rearrangement Gene amplification Gene expression Genetic recombination Recombination, Genetic Rekombination (DE-588)4049338-6 gnd DNS (DE-588)4070512-2 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4049338-6 (DE-588)4070512-2 (DE-588)4071711-2 (DE-588)4143413-4 |
| title | Gene rearrangement |
| title_auth | Gene rearrangement |
| title_exact_search | Gene rearrangement |
| title_full | Gene rearrangement ed. by B. D. Hames ... |
| title_fullStr | Gene rearrangement ed. by B. D. Hames ... |
| title_full_unstemmed | Gene rearrangement ed. by B. D. Hames ... |
| title_short | Gene rearrangement |
| title_sort | gene rearrangement |
| topic | DNA genetics Gene Amplification Gene Rearrangement Gene amplification Gene expression Genetic recombination Recombination, Genetic Rekombination (DE-588)4049338-6 gnd DNS (DE-588)4070512-2 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | DNA genetics Gene Amplification Gene Rearrangement Gene amplification Gene expression Genetic recombination Recombination, Genetic Rekombination DNS Genetik Aufsatzsammlung |
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