Cellular and molecular biology of intermediate filaments:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York u.a.
Plenum Pr.
1990
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 479 S. Ill. |
| ISBN: | 0306433176 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Cellular and
Molecular Biology of
Intermediate Filaments
Edited by
Robert D Goldman
Northwestern University Medical School
Chicago, Illinois
and
Peter M Steinert
National Cancer Institute
National Institutes of Health
Bethesda, Maryland
Plenum Press • New York and London
Contents
I The Subcellular Organization of Intermediate Filaments
1 Intermediate Filaments: An Overview 3
Robert D Goldman, Robert V Zackroff, and Peter M Steinert
1 Historical Overview 3
2 A Comment on Nomenclature 5
3 The Complexity of IF 6
4 A Brief Overview of the Subcellular Organization of IF 7
References 15
2 Intermediate (10-nm) Filaments in Muscle 19
Marvin H Stromer
1 Introduction 19
2 Smooth Muscle 19
2 1 Location of 10-nm Filaments in Cells 19
2 2 Isolation and Preparation of Desmin and Vimentin 21
2 3 Molecular Properties of Desmin and Vimentin 22
2 4 FilamenTAssembly and Substructure 24
2 5 IF-Associated Proteins 27
2 6 Role or Function 28
3 Skeletal Muscle 28
3 1 Location of 10-nm Filaments in Cells 28
3 2 Isolation and Preparation of Desmin 29
3 3 Protein and Filament Properties 30
3 4 Role or Function 30
4 Cardiac Muscle 30
4 1 Location of 10-nm Filaments in Cells 30
4 2 Isolation and Preparation of Desmin 31
4 3 Role or Function 31
References 32
xi
xii Contents
3 Neurofilaments 37
PAM Eagles, H C Pant, and H Gainer
1 Introduction 37
2 Neurofilament Arrangement in the Neurons of Vertebrates 38
2 1 Isolation of Neurofilaments 41
2 2 Filament Solubility and Structure 42
2 3 Mammalian Neurofilament Polypeptides 43
2 4 Reassembly Properties 45
2 5 Amino Acid Composition and Sequence Studies 45
2 6 Arrangement of the Triplet Polypeptides within the Neurofilament 48
3 Invertebrate Neurofilaments 52
3 1 Myxicola 53
3 2 Squid 59
4 Interactions of Neurofilaments 63
5 Posttranslational Modifications of Neurofilaments 66
5 1 Calcium-Activated Proteolysis 66
5 2 Phosphorylation of Neurofilaments 70
6 Immunological Probes of Neurofilaments 72
7 Axonal Transport of Neurofilaments 80
8 Ontogeny and Phylogeny of Neurofilaments 81
References 82
4 The Proteins of Hair and Other Hard a-Keratins 95
J M Gillespie
1 The Nature of Hard a-Keratins 96
1 1 Solubility 96
1 2 Chemical Composition of Keratins 97
1 3 Fine Structure of Hard a-Keratins 99
2 Morphology and Development of the Hair Follicle 100
2 1 Morphogenesis of the Hair Follicle 100
2 2 Regulation of Hair Growthjlate 101
2 3 Development of Fiber Proteins 102
2 4 Assembly and Cross-Linking of Fiber Proteins 103
3 Constituent Proteins of Intermediate Filaments 104
3 1 Preparation and Properties of Low-Sulfur Proteins 104
3 2 Properties of Subunit Polypeptides 105
3 3 Amino Acid Sequences of Subunit Polypeptides 106
3 4 Assembly of Subunit Polypeptides 106
4 The Intermediate Filament-Associated Proteins 107
4 1 The High-Sulfur Proteins 107
4 2 The High-Tyrosine Proteins 113
5 The Regulation of Keratin Composition 117
5 1 Molecular Basis of Variability in Keratin Composition 117
5 2 Genetic Control of Keratin Composition 118
Contents xiii
5 3 Nutritional Control of Keratin Composition 122
5 4 Physiological Control of Keratin Composition 124
6 Concluding Remarks 124
References 125
5 The Nuclear Lamina: An Intermediate Filament Protein Structure of the
Cell Nucleus 129
George N Dessev
1 Introduction 129
2 Definition of NL and Lamin Classification 130
3 Isolation of NL 131
4 Composition of NL and Its Changes during Development 132
5 Biosynthesis of Lamins 133
6 Structure of Lamin Molecules and Their Assembly into Polymers 133
7 Association of NL with Nuclear and Cytoplasmic Structural Elements 134
7 1 NPC 134
7 2 Nuclear Membrane 135
7 3 Cytoskeletal Elements 136
7 4 Chromatin 136
8 Cell Cycle Dynamics of NL 137
9 The Same General Mechanism Is Likely to Be Involved in the Cell Cycle
Dynamics of NL and IF 140
10 Cell Cycle Regulation of NL Disassembly 141
References 141
6 Interaction of Intermediate Filaments with the Cell Surface 147
Kathleen J Green and Jonathan C R Jones
1 Introduction 147
2 IF-Desmosome anclHemidesmosome Interactions 148
3 Morphological Analysis of Desmosome-IF and Hemidesmosome-IF
Complexes 148
4 The Biochemical Composition of Desmosomes and Hemidesmosomes 151
5 Putative IF-Plaque Linkers 152
5 1 Desmocalmin 154
5 2 Band 6 or Desmoplakin IV 155
5 3 Desmoplakin I and II 155
6 IF-Cell Surface Association in Muscle Cells 157
7 Association of IF with Cortical Actin-Containing Structures 158
8 Interaction of IF with the Cell Membrane Complex 160
9 Conclusion 164
References 165
xiv Contents
II The Structure of Intermediate Filaments
7 Primary and Secondary Structure of IF Protein Chains and Modes of
Molecular Aggregation 175
David A D Parry
1 Introduction 175
2 Type I-IV IF Protein Chains 176
2 1 Primary Structure 176
2 2 Secondary Structure 177
3 Classification of IF Protein Chains 179
4 Structural Features of the Central a-Helix-Rich Domain
in IF Protein Chains 182
5 Structure of the Rod Domain of IF Protein Molecules 187
6 Structure of the Terminal Domains of IF Protein Molecules 191
7 Structure of the Four-Chain Aggregates 194
8 Nuclear Lamins: IF-Like Proteins 196
9 Conclusions 198
References 198
8 The Three-Dimensional Structure of IF 205
RDB Fraser, T P MacRae, and David A D Parry
1 Introduction 205
2 Molecular Structure 206
3 Molecular Aggregation 208
3 1 Enzymatically Derived Fragments 209
3 2 Ionic Interaction Score 209
3 3 Oligomers 213
3 4 Polymers 218
4 Filament Structure 219
41A Generic Model for IF 219
4 2 X-Ray Diffraction Studies 219
4 3 The Surface Lattice 221
4 4 Disposition of TerminaTDomains 223
4 5 Models Generated Using Interaction Scores 223
4 6 Radial Distribution of Coiled-Coil Rope Segments 223
5 Concluding Remarks 227
References 227
9 Intermediate Filament Structure: Diversity, Polymorphism, and Analogy to
Myosin 233
Alasdair C Steven
1 Introduction 233
2 How Many Different Kinds of IF Are There? 234
2 1 Tissue-Specific Classification 234
2 2 IF Types Based on Amino Acid Sequence Homologies 235
Contents *v
2 3 Classification According to Competency for in Vitro Self-Assembly
orCoassembly 235
2 4 Polymorphism of IF That Contain the Same Subunits 236
2 5 Other Differences: Immunological Specificity, Interspecies
Variation, and Distinctions Conferred by Associated Proteins 236
3 Structure of Oligomers of IF Proteins 237
4 Axial Repeats in IF Structure 240
4 1 Regular Distribution of Particular Types of Amino Acid Residues in
IF Sequences 240
4 2 Axial Repeats from Meridional X-Ray Diffraction 241
4 3 Axial Repeats Detected by Electron Microscopy 241
4 4 Axial Repeats in Paracrystals 244
4 5 Proportionality between the Linear Densities of IF and the Molecular
Weights of Their Constituent Subunits 245
5 Width and Radial Organization of IF 247
5 1 Traditional Estimates of IF Diameter 247
5 2 Evaluation of Transverse Traces of Projected Density from Electron
Micrographs of Negatively Stained, Rotary-Shadowed, and
Unstained IF 248
5 3 Radial Density Profiles of IF 252
5 4 Filaments within Filaments 253
5 5 Interpretation of Images of Negatively Stained IF with and without
Proteolytic Modification 256
5 6 In Vitro Assembly Properties of Proteolytically Modified IF 256
5 7 Other Pertinent Observations 257
5 8 Current Frame of Reference 258
References 260
III Differential Expression of Intermediate Filament Genes
10 Hard Keratin IF and Associated Proteins 267
Barry C Powell and George E Rogers
1 Introduction 267
2 The Proteins and Genes of Wool 269
2 1 Hard Keratin IF 269
2 2 Hard Keratin IFAP 277
2 3 Hard Keratin IFAP Gene Structure and Organization 285
2 4 Evolutionary Expression of Hard Keratin IF and IFAP 287
2 5 Trichohyalin in the IRS and Hair Medulla 288
3 Differentiation 289
3 1 The Structure of Hairs 289
3 2 Hair Developmental Program 291
3 3 Gene Expression during Differentiation in the Hair Follicle 292
References 295
xvi Contents
11 Differentiation-Specific Expression of Keratin Pairs 301
W Michael O Guin, Alexander Schermer, Marion Lynch,
and Tung-Tien Sun
1 Introduction 301
2 Keratin Subfamilies 304
3 Keratin Pairs Defined by Frequent Coexpression 307
4 Patterns of Keratin Pair Expression 311
5 Localization of Various Keratin Pairs 318
6 Structural/Functional Significance of Keratin Pairs 326
7 Conclusions and Perspectives 328
References 330
12 Keratins and Their Genes in Xenopus laevis: Structural and
Developmental Aspects 335
Thomas D Sargent, Erzsebet Jonas, Milan Jamrich, George S Michaels,
Seiji Miyatani, Jeffrey A Winkles, and Igor B Dawid
1 Introduction 335
2 Cytokeratin Gene Sequences from Xenopus 336
2 1 Type I Cytokeratin Sequences 336
2 2 Type II Cytokeratin Sequences 337
2 3 Cytokeratin Gene Structure 337
3 Family Relationships among Type I Cytokeratins 340
4 Developmental Aspects 341
4 1 Distinct Groups of Cytokeratin Genes Are Expressed in
Embryonic/Larval and Adult Stages in Xenopus 341
4 2 Correlation between Type I and Type II Cytokeratin Expression 342
4 3 Developmental Regulation of Cytokeratin Gene Expression 343
5 Conclusions 343
References 343
13 Neural Intermediate Filament (Neurofilament) Genes 345
Linda M Parysek
1 Distinctions among NIFP 345
2 NIFP Amino Acid Sequences 346
3 Sequences Related to the Neural IF Multiphosphorylation Site 347
4 NIFP mRNAs 347
5 Introns in NIFP Genes 348
6 NIFP Gene Promoters 349
References 349
14 The Structure, Complexity, and Evolution of Intermediate Filament
Genes 353
Peter M Steinert and Dennis R Roop
1 Introduction 353
2 Structure of IF Genes 354
Contents xvii
2 1 Complexity 354
2 2 IF Gene Linkage and Chromosomal Localization 354
2 3 IF Gene Structure 356
3 Models for the Evolution of IF Genes 356
3 1 Evolution of the Rod Domain 356
3 2 Evolution of the End Domains 359
3 3 Evolution of Lamin Genes 363
4 Conclusions and Future Perspectives 363
References 364
IV Accessory Proteins Involved in Regulating the Organization of
Intermediate Filaments
15 Intermediate Filament-Associated Proteins 371
Hsi-Yuan Yang, Norman Lieska, and Robert D Goldman
1 Introduction 371
2 IFAP in BHK-21 Cells 372
2 1 Criteria for Identification of IFAP in BHK-21 Cells 373
2 2 IFAP-300k 373*
2 3 IFAP-70-280k 379
3 Other IFAP 380
3 1 Plectin 380
3 2 Synemin 380
3 3 Paranemin 381
3 4 Epinemin 382
3 5 p50 382
3 6 NAPA-73 383
3 7 p230 and Spectrin-Related Proteins 383
3 8 MAP-2 384
3 9 Desmoplakin 1 and 2 385
3 10 Cellular Expression of the IFAP: A Summary 385
4 Speculations Regarding the Possible Functional Significance of IFAP 386
References 77 387
16 Filaggrins 393
Beverly A Dale, Katheryn A Resing, and Paul V Haydock
1 Introduction 393
2 Isolation and Properties of Filaggrin and Profilaggrin 394
2 1 Extraction and Purification 394
2 2 Properties of Profilaggrin and Filaggrin 395
2 3 Profilaggrin Protein Structure 396
2 4 Aggregation with Keratin IF 397
3 Profilaggrin mRNA and Gene Structure 398
3 1 Use of cDNA Clones 398
3 2 Selection and Characterization of Profilaggrin cDNA Clones 399
xviii Contents
3 3 Size and Expression of Profilaggrin mRNA 399
3 4 Repetitive Structure of the Profilaggrin Gene 399
3 5 Predicted Sequence of the Profilaggrin Repeat Unit 402
4 Filaggrin Synthesis and Relation to Epidermal Cell Differentiation 402
4 1 Introduction 402
4 2 Profilaggrin Phosphorylation 403
4 3 Profilaggrin Phosphatase 403
4 4 Proteolytic Processing 404
5 Synthesis of Profilaggrin and Filaggrin during Fetal Development 405
5 1 Expression in Rodent 405
5 2 Expression in Human Fetal Skin Development 405
6 Filaggrin Alterations Associated with Disorders of Keratinization 407
7 Concluding Remarks and Future Directions 409
References 409
V Pathological Conditions Relating to Intermediate Filaments
17 Expression, Organization, and Involvement of Intermediate Filaments in
Disease Processes 415
Omar Skalli and Giulio Gabbiani
1 Introduction 415
2 IF as Differentiation Markers of Neoplastic and Nonneoplastic Cells 416
3 Pathological Situations Characterized by Altered IF Expression and/or
Organization 421
3 1 Myopathies and Cardiomyopathies 421
3 2 Alcoholic Liver Disease 422
3 3 Atheromatosis 425
3 4 Sarcoidosis 428
3 5 Tumors and Transformed Cells 429
3 6 Aging 431
4 Autoantibodies against IF 431
5 IF as Activators of Inflammatory Reactions 433
6 Conclusions 777 „ 435
References 436
18 The Cytoskeleton in Neurological Disease 451
Michael L Shelanski and Carol M Troy
1 Introduction 451
2 Neurofibrillary Degeneration 451
2 1 Neurofibrillary Proliferations Composed of 10-nm IF 452
2 2 Biochemical Composition of Neurofibrillary Tangles 452
2 3 Mechanism of Formation of Neurofibrillary Tangles 453
3 Alzheimer s Disease 456
3 1 The Alzheimer Neurofibrillary Tangle 457
3 2 Nonneural Changes in Alzheimer s Disease 458
Contents xix
4 Other Fibrillar Structures 459
5 Inclusions Containing Cytoskeletal Elements 459
5 1 Pick Bodies 459
5 2 Lewy Bodies 460
5 3 Hirano Bodies 460
5 4 Other Inclusions 460
6 Conclusion 461
References 461
Index 467
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV004140830 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:08:59Z |
| institution | BVB |
| isbn | 0306433176 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002583532 |
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| physical | XIX, 479 S. Ill. |
| publishDate | 1990 |
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| spelling | Cellular and molecular biology of intermediate filaments ed. by Robert D. Goldman ... New York u.a. Plenum Pr. 1990 XIX, 479 S. Ill. txt rdacontent n rdamedia nc rdacarrier Filaments intermédiaires Cytoplasmic filaments Intermediate Filaments Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Intermediärfilament (DE-588)4162026-4 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Intermediärfilament (DE-588)4162026-4 s Cytologie (DE-588)4070177-3 s DE-604 Molekularbiologie (DE-588)4039983-7 s Goldman, Robert D. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002583532&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cellular and molecular biology of intermediate filaments Filaments intermédiaires Cytoplasmic filaments Intermediate Filaments Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd Intermediärfilament (DE-588)4162026-4 gnd Cytologie (DE-588)4070177-3 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)4162026-4 (DE-588)4070177-3 (DE-588)4143413-4 |
| title | Cellular and molecular biology of intermediate filaments |
| title_auth | Cellular and molecular biology of intermediate filaments |
| title_exact_search | Cellular and molecular biology of intermediate filaments |
| title_full | Cellular and molecular biology of intermediate filaments ed. by Robert D. Goldman ... |
| title_fullStr | Cellular and molecular biology of intermediate filaments ed. by Robert D. Goldman ... |
| title_full_unstemmed | Cellular and molecular biology of intermediate filaments ed. by Robert D. Goldman ... |
| title_short | Cellular and molecular biology of intermediate filaments |
| title_sort | cellular and molecular biology of intermediate filaments |
| topic | Filaments intermédiaires Cytoplasmic filaments Intermediate Filaments Molecular Biology Molekularbiologie (DE-588)4039983-7 gnd Intermediärfilament (DE-588)4162026-4 gnd Cytologie (DE-588)4070177-3 gnd |
| topic_facet | Filaments intermédiaires Cytoplasmic filaments Intermediate Filaments Molecular Biology Molekularbiologie Intermediärfilament Cytologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002583532&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT goldmanrobertd cellularandmolecularbiologyofintermediatefilaments |