Gene regulation: a eukaryotic perspective
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London u.a.
Unwin Hyman
1990
|
| Ausgabe: | 1. publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XVII, 269 S. Ill., graph. Darst. |
| ISBN: | 004445242X 0044452438 |
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| 245 | 1 | 0 | |a Gene regulation |b a eukaryotic perspective |c David S. Latchman |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London u.a. |b Unwin Hyman |c 1990 | |
| 300 | |a XVII, 269 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturangaben | ||
| 650 | 7 | |a Eucaryotes |2 ram | |
| 650 | 7 | |a Régulation génétique |2 ram | |
| 650 | 7 | |a Transcription génétique |2 ram | |
| 650 | 4 | |a Eukaryotic Cells | |
| 650 | 4 | |a Eukaryotic cells | |
| 650 | 4 | |a Gene Expression Regulation | |
| 650 | 4 | |a Genetic regulation | |
| 650 | 4 | |a Genetic transcription | |
| 650 | 4 | |a Transcription, Genetic | |
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| 650 | 0 | 7 | |a Genregulation |0 (DE-588)4122166-7 |2 gnd |9 rswk-swf |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-002550218 | ||
Datensatz im Suchindex
| _version_ | 1804118308505518080 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE PAGE IX
ACKNOWLEDGEMENTS XI
LIST OF TABLES XVII
1 TISSUE-SPECIFIC EXPRESSION OF PROTEINS AND MESSENGER RNAS 1 1.1
INTRODUCTION 1
1.2 TISSUE-SPECIFIC EXPRESSION OF PROTEINS 1
1.2.1 GENERAL METHODS FOR STUDYING THE PROTEIN COMPOSITION OF TISSUES 2
1.2.2 SPECIFIC METHODS FOR STUDYING THE PROTEIN COMPOSITION OF TISSUES 4
1.3 TISSUE-SPECIFIC EXPRESSION OF MESSENGER RNAS 6
1.3.1 GENERAL METHODS FOR STUDYING THE MRNAS EXPRESSED IN DIFFERENT
TISSUES 7
1.3.2 SPECIFIC METHODS FOR STUDYING THE MRNAS EXPRESSED IN DIFFERENT
TISSUES 9
1.4 CONCLUSIONS 12
REFERENCES 12
2 THE DNA OF DIFFERENT CELL TYPES IS SIMILAR IN BOTH AMOUNT AND TYPE 13
2.1 INTRODUCTION 13
2.2 DNALOSS 13
2.2.1 DNA LOSS AS A MECHANISM OF GENE REGULATION 13
2.2.2 CHROMOSOMAL STUDIES 14
2.2.3 FUNCTIONAL STUDIES 19
2.2.4 MOLECULAR STUDIES 22
2.3 DNA AMPLIFICATION 24
2.3.1 DNA AMPLIFICATION AS A MECHANISM OF GENE REGULATION 24
2.3.2 CHROMOSOMAL STUDIES 25
2.3.3 MOLECULAR STUDIES 28
2.4 DNA REARRANGEMENT 30
2.5 CONCLUSIONS 43
REFERENCES 44
XLLL
IMAGE 2
CONTENTS
3 REGULATION AT TRANSCRIPTION 46
3.1 LEVELS OF GENE REGULATION 46
3.2 EVIDENCE FOR TRANSCRIPTIONAL REGULATION 48
3.2.1 EVIDENCE FROM STUDIES OF NUCLEAR RNA 48
3.2.2 EVIDENCE FROM PULSE-LABELLING STUDIES 53
3.2.3 EVIDENCE FROM NUCLEAR RUN-ON ASSAYS 56
3.2.4 EVIDENCE FROM POLYTENE CHROMOSOMES 59
3.3 REGULATION AT TRANSCRIPTIONAL ELONGATION 61
3.4 CONCLUSIONS 65
REFERENCES 65
4 POST-TRANSCRIPTIONAL REGULATION 67
4.1 REGULATION AFTER TRANSCRIPTION? 67
4.2 REGULATION OF RNA SPLICING 68
4.2.1 RNA SPLICING 68
4.2.2 ALTERNATIVE RNA SPLICING 69
4.2.3 MECHANISM OF ALTERNATIVE RNA SPLICING 78
4.2.4 GENERALITY OF ALTERNATIVE RNA SPLICING 81
4.3 REGULATION OF RNA TRANSPORT 82
4.4 REGULATION OF RNA STABILITY 83
4.4.1 CASES OF REGULATION BY ALTERATIONS IN RNA STABILITY 83 4.4.2
MECHANISMS OF STABILITY REGULATION 85
4.4.3 ROLE OF STABILITY CHANGES IN REGULATION OF GENE EXPRESSION 89
4.5 REGULATION OF TRANSLATION 90
4.5.1 CASES OF TRANSLATIONAL CONTROL 90
4.5.2 MECHANISM OF TRANSLATIONAL CONTROL 91
4.5.3 SIGNIFICANCE OF TRANSLATIONAL CONTROL 96
4.6 CONCLUSIONS 97
REFERENCES 97
5 TRANSCRIPTIONAL CONTROL - CHROMATIN STRUCTURE 100
5.1 INTRODUCTION 100
5.2 COMMITMENT TO THE DIFFERENTIATED STATE AND ITS STABILITY 103 5.3
CHROMATIN STRUCTURE 106
5.4 CHANGES IN CHROMATIN STRUCTURE IN ACTIVE OR POTENTIALLY ACTIVE GENES
112
5.4.1 ACTIVE DNA IS ORGANIZED IN A NUCLEOSOMAL STRUCTURE 112 5.4.2
SENSITIVITY OF ACTIVE CHROMATIN TO DNASEL DIGESTION 113 5.4.3 MECHANISM
OF INCREASED DNASEL SENSITIVITY 116
5.5 OTHER CHANGES IN DNA AND ITS ASSOCIATED PROTEINS IN ACTIVE OR
POTENTIALLY ACTIVE GENES 118
5.5.1 DNA METHYLATION 118
5.5.2 HISTONE MODIFICATIONS 125
XIV
IMAGE 3
CONTENTS
5.6 DNASEL HYPERSENSITIVE SITES IN ACTIVE OR POTENTIALLY ACTIVE GENES
126
5.6.1 DETECTION OF DNASEL HYPERSENSITIVE SITES 126
5.6.2 NATURE AND SIGNIFICANCE OF HYPERSENSITIVE SITES 131 5.7
CONCLUSIONS 134
REFERENCES 135
6 TRANSCRIPTIONAL CONTROL - DNA SEQUENCE ELEMENTS 138
6.1 INTRODUCTION 138
6.1.1 RELATIONSHIP OF GENE REGULATION IN PROKARYOTES AND EUKARYOTES 138
6.1.2 COMPLEXITY OF THE EUKARYOTIC SYSTEM 138
6.1.3 THE BRITTEN AND DAVIDSON MODEL FOR THE CO-ORDINATE REGULATION OF
UNLINKED GENES 141
6.2 SHORT SEQUENCE ELEMENTS LOCATED WITHIN OR ADJACENT TO THE GENE
PROMOTER 142
6.2.1 SHORT REGULATORY ELEMENTS 142
6.2.2 THE HEAT-SHOCK RESPONSE ELEMENT 143
6.2.3 OTHER RESPONSE ELEMENTS 148
6.2.4 MECHANISM OF ACTION OF PROMOTER REGULATORY ELEMENTS 151
6.3 ENHANCERS 153
6.3.1 REGULATORY SEQUENCES THAT ACT AT A DISTANCE 153
6.3.2 TISSUE-SPECIFIC ACTIVITY OF ENHANCERS 155
6.3.3 MECHANISM OF ACTION OF ENHANCERS 158
6.3.4 POSITIVE AND NEGATIVE ACTION OF ENHANCER ELEMENTS 161
6.4 ROLE OF REPEATED SEQUENCES 164
6.4.1 REPEATED DNA 164
6.4.2 ROLE OF REPEATED SEQUENCES IN GENE EXPRESSION 165 6.5 REGULATION
OF TRANSCRIPTION BY RNA POLYMERASES I AND III 170
6.5.1 RNA POLYMERASE I 170
6.5.2 RNA POLYMERASE III 170
6.6 CONCLUSIONS 176
REFERENCES 176
7 TRANSCRIPTIONAL CONTROL - TRANSCRIPTION FACTORS 180
7.1 INTRODUCTION 180
7.2 DNA BINDING BY TRANSCRIPTION FACTORS 185
7.2.1 INTRODUCTION 185
7.2.2 THE HELIX-TURN-HELIX MOTIF 185
7.2.3 THE ZINC FINGER MOTIF 194
XV
IMAGE 4
CONTENTS
7.2.4 THE LEUCINE ZIPPER AND THE BASIC DNA-BINDING DOMAIN 204
7.2.5 OTHER DNA-BINDING DOMAINS 207
7.3 ACTIVATION OF TRANSCRIPTION 207
7.3.1 INTRODUCTION 207
7.3.2 ACTIVATION DOMAINS 208
7.3.3 HOW IS TRANSCRIPTION ACTIVATED? 213
7.4 WHAT ACTIVATES THE ACTIVATORS? 217
7.4.1 INTRODUCTION 217
7.4.2 REGULATED SYNTHESIS OF TRANSCRIPTION FACTORS 219
7.4.3 REGULATED ACTIVITY OF TRANSCRIPTION FACTORS 221
7.5 CONCLUSIONS 225
REFERENCES 227
8 GENE REGULATION AND CANCER 231
8.1 INTRODUCTION 231
8.2 PROTO-ONCOGENES 231
8.3 ELEVATED EXPRESSION OF ONCOGENES 237
8.4 TRANSCRIPTION FACTORS AS ONCOGENES 243
8.4.1. FOS, TUN, AND API 243
8.4.2 V-ERBA AND THE THYROID HORMONE RECEPTOR 246
8.4.3 OTHER TRANSCRIPTION-FACTOR-RELATED ONCOGENES 251 8.5 CONCLUSIONS
252
REFERENCES 254
9 CONCLUSIONS AND FUTURE PROSPECTS 257
REFERENCES 259
INDEX 260
X VI
|
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.87/3223 |
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| discipline | Biologie |
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| isbn | 004445242X 0044452438 |
| language | English |
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| physical | XVII, 269 S. Ill., graph. Darst. |
| publishDate | 1990 |
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| publisher | Unwin Hyman |
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| spelling | Latchman, David S. 1956- Verfasser (DE-588)120416859 aut Gene regulation a eukaryotic perspective David S. Latchman 1. publ. London u.a. Unwin Hyman 1990 XVII, 269 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Eucaryotes ram Régulation génétique ram Transcription génétique ram Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten (DE-588)4070991-7 gnd rswk-swf Genregulation (DE-588)4122166-7 gnd rswk-swf Eukaryoten (DE-588)4070991-7 s Genregulation (DE-588)4122166-7 s DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002550218&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Latchman, David S. 1956- Gene regulation a eukaryotic perspective Eucaryotes ram Régulation génétique ram Transcription génétique ram Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten (DE-588)4070991-7 gnd Genregulation (DE-588)4122166-7 gnd |
| subject_GND | (DE-588)4070991-7 (DE-588)4122166-7 |
| title | Gene regulation a eukaryotic perspective |
| title_auth | Gene regulation a eukaryotic perspective |
| title_exact_search | Gene regulation a eukaryotic perspective |
| title_full | Gene regulation a eukaryotic perspective David S. Latchman |
| title_fullStr | Gene regulation a eukaryotic perspective David S. Latchman |
| title_full_unstemmed | Gene regulation a eukaryotic perspective David S. Latchman |
| title_short | Gene regulation |
| title_sort | gene regulation a eukaryotic perspective |
| title_sub | a eukaryotic perspective |
| topic | Eucaryotes ram Régulation génétique ram Transcription génétique ram Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten (DE-588)4070991-7 gnd Genregulation (DE-588)4122166-7 gnd |
| topic_facet | Eucaryotes Régulation génétique Transcription génétique Eukaryotic Cells Eukaryotic cells Gene Expression Regulation Genetic regulation Genetic transcription Transcription, Genetic Eukaryoten Genregulation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002550218&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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