Purines in cellular signaling: targets for new drugs
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Springer
1990
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XV, 448 S. Ill., graph. Darst. |
| ISBN: | 3540972447 0387972447 |
Staff View
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Record in the Search Index
| _version_ | 1804118283780096001 |
|---|---|
| adam_text | K.A. JACOBSON J.W. DALY V. MANGANIELLO EDITORS PURINES IN CELLULAR
SIGNALING TARGETS FOR NEW DRUGS WITH 95 ILLUSTRATIONS SPRINGER-VERLAG
NEW YORK BERLIN HEIDELBERG LONDON PARIS TOKYO HONG KONG CONTENTS PREFACE
V CONTRIBUTORS XI SECTION 1: ADENOSINE RECEPTORS AND EFFECTOR SYSTEMS 1
1 ADENOSINE AGONISTS AND ANTAGONISTS 3 J.W. DALY 2 INTRACELLULAR AND
EXTRACELLULAR METABOLISM OF ADENOSINE AND ADENINE NUCLEOTIDES 13 D.
PEARSON AND L.L. SLAKEY 3 ADENOSINE DEAMINASE AND ADENOSINE TRANSPORT
SYSTEMS IN THE CNS 20 J.D. GEIGER, R.A. PADUA, AND J.I. NAGY 4 TRANSPORT
SYSTEMS FOR ADENOSINE IN MAMMALIAN CELL MEMBRANES 26 A.S. CLANACHAN AND
EE. PARKINSON 5 FORMATION OF ADENOSINE IN THE HEART FROM EXTRACELLULAR
ADENINE NUCLEOTIDES 33 J. SCHRADER, M.M. BORST, M. KELM, B. BADING, AND
K.F. BILRRIG 6 CENTRAL NERVOUS SYSTEM EFFECTS OF ADENOSINE 41 J.W.
PHILLIS 7 ADENOSINE RECEPTOR SUB-TYPES IN ISOLATED TISSUES: ANTAGONIST
STUDIES 48 M.G. COLLIS 8 MOLECULAR PROBES FOR ADENOSINE RECEPTORS 54
K.A. JACOBSON 9 PURIFICATION OF AI ADENOSINE RECEPTOR OF RAT BRAIN
MEMBRANES BY AFFINITY CHROMATOGRAPHY 65 H. NAKATA 10 CHARACTERISTICS OF
AI ADENOSINE RECEPTORS AND GUANINE NUCLEOTIDE BINDING PROTEINS
CO-PURIFIED FROM BOVINE BRAIN 69 J. LINDEN, R. MUNSHI, M.L. ARROYO, AND
A. PATEL 11 ANTAGONIST RADIOLIGAND BINDING TO SOLUBILIZED PORCINE ATRIAL
AI ADENOSINE RECEPTORS 73 M. LEID, P.H. FRANKLIN, AND T.F. MURRAY 12
ISOLATION OF AN ADENOSINE BINDING PROTEIN WHICH HAS PROPERTIES EXPECTED
OF THE AI ADENOSINE RECEPTOR 78 K. RAVID AND J.M. LOWENSTEIN VII 13
IDENTIFICATION OF THE A2 ADENOSINE RECEPTOR BINDING SUBUNIT BY
PHOTOAFFINITY CROSSLINKING 82 W.W. BARRINGTON, K.A. JACOBSON, AJ.
HUTCHISON, M. WILLIAMS, AND G.L. STILES 14 HUMAN PLACENTAL ADENOSINE
A2-LIKE BINDING SITES PROPERTIES AND HOMOLOGY WITH MAMMALIAN AND AVIAN
STRESS PROTEINS 86 K.A. HUTCHISON, B. NEVINS, F. PERINI, AND I.H. FOX 15
CARDIAC INTERSTITIAL FLUID ADENOSINE IN NORMOXIA AND HYPOXIA 90 R.M.
BERNE 16 RATIONALE FOR THE USE OF ADENOSINE IN THE DIAGNOSIS AND
TREATMENT OF CARDIAC ARRHYTHMIAS 95 L. BELARDINELLI AND A. PELLEG 17 THE
CENTRAL ADENOSINE SYSTEM AS A THERAPEUTIC TARGET IN STROKE 100 PJ.
MARANGOS, D. VON LUBITZ, L.P. MILLER, J.L. DAVAL, AND J. DECKERT 18
ADENOSINE-MEDIATED VASOCONSTRICTION IN THE SKIN MICROCIRCULATION 108
K.G. PROCTOR AND I. STOJANOV 19 ADENOSINE IS AN ANTIINFLAMMATORY
AUTOCOID: ADENOSINE RECEPTOR OCCUPANCY PROMOTES NEUTROPHIL CHEMOTAXIS
AND INHIBITS SUPEROXIDE ANION GENERATION 114 B.N. CRONSTEIN, L.
ANGAW-DUGUMA, D. NICHOLLS, A. HUTCHISON, AND M. WILLIAMS 20 BETA
ADRENERGIC RECEPTOR MEDIATED STIMULATION OF ADENINE NUCLEOTIDE
CATABOLISM AND PURINE RELEASE IN HUMAN ADIPOCYTES 120 H. KATHER 21
STRUCTURE ACTIVITY RELATIONSHIPS FOR ADENOSINE ANTAGONISTS 126 R.F.
BRUNS 22 STRUCTURE ACTIVITY RELATIONSHIPS FOR ADENOSINE AGONISTS 136 B.K
TRIVEDI 23 THE DESIGN OF A SERIES OF HIGHLY A2 SELECTIVE ADENOSINE
AGONISTS 146 AJ. HUTCHISON, H. OEI, M. JARVIS, M. WILLIAMS, AND R.L.
WEBB 24 ADENOSINE AGONISTS. CHARACTERIZATION OF THE N6-SUBREGION OF THE
ADENOSINE A2 RECEPTOR VIA MOLECULAR MODELING TECHNIQUES 152 D.F.
ORTWINE, AJ. BRIDGES, C. HUMBIET, AND B.K. TRIVEDI 25 PHYSIOLOGICAL AND
BIOCHEMICAL ASPECTS OF P -SITE-MEDIATED INHIBITION OF ADENYLYL CYCLASE
158 R.A. JOHNSON, S.-M.H. YEUNG, M. BUSHFIELD, D. STUBNER, AND I.
SHOSHANI 26 ADENOSINE RECEPTORS MEDIATING INHIBITION OF PERIPHERAL AND
CENTRAL NEURONS 166 J.A. RIBEIRO AND A.M. SEBASTIAO 27 ADENOSINE
RECEPTORS AS DRUG TARGETS: FULFILLING THE PROMISE? 174 M. WILLIAMS 28
MECHANISMS OF ADENOSINE ACTION 184 B.B. FREDHOLM, J. FASTBOM, M.
DUNDR-ENGSTROM, P.-S. HU, I. VAN DER PLOEG, N. ALTIOK, P. GERWINS, A.
KVANTA, AND C. NORDSTEDT 29 FUNCTIONAL ROLES OF AI AND A2 RECEPTORS IN
RAT HIPPOCAMPUS ANDSTRIATUM 194 TV. DUNWIDDIE, C.R. LUPICA, W.A. CASS,
N.R. ZAHNISER, AND M. WILLIAMS 30 SUBCLASSIFICATION OF NEURONAL
ADENOSINE RECEPTORS 200 L.E. GUSTAFSSON, C.U. WIKLUND, N.P. WIKLUND, AND
L. STELIUS VM 31 EFFECTS OF ADENOSINE ON MAST CELLS 206 M J. LOHSE,
K.-N. KLOTZ, K. MAURER. I. OTT, AND U. SCHWABE 32 THE ROLE OF ADENOSINE
ON THE GASTRIC ACID SECRETORY RESPONSE 213 J.G. GERBER AND N.A. PAYNE 33
ADENOSINE RECEPTORS AND SIGNALING IN THE KIDNEY 220 W.S. SPIELMAN, LJ.
AREND, K.-N. KLOTZ, AND U. SCHWABE 34 INHIBITION OF THE FUNCTION OF
GUANINE NUCLEOTIDE BINDING PROTEINS BY THE NEW POSITIVE INOTROPES 226 V.
RAMKUMAR AND G.L. STILES 35 BLOCKADE OF ANTIGEN ACTIVATED SIGNALS BY
XANTHINE ANALOGS IN RBL-2H3 CELLS:EVIDENCE FOR A NOVEL ADENOSINE
RECEPTOR 233 H. ALI, D. COLLADO-ESCOBAR, D. O REILLY, AND M. BEAVEN
SECTION 2: ADENINE NUCLEOTIDE RECEPTORS AND EFFECTOR SYSTEMS 239 36
CLASSIFICATION AND CHARACTERIZATION OF PURINOCEPTORS 241 G. BURNSTOCK 37
STRUCTURE ACTIVITY RELATIONSHIPS FOR ADENINE NUCLEOTIDE RECEPTORS ON
MAST CELLS, HUMAN PLATELETS, AND SMOOTH MUSCLE 254 N J. CUSACK AND
S.M.O. HOURANI 38 MODULATION OF NOREPINEPHRINE RELEASE BY ATP AND
ADENOSINE 260 D.P. WESTFALL, K. SHINOZUKA, AND R.A. BJUR 39 THE
PHOSPHOLIPASE C LINKED P2Y-PURINERGIC RECEPTOR 266 J.L. BOYER, C.L.
COOPER, M.W. MARTIN, G.L. WALDO, AJ. MORRIS, R.A. JEFFS, H.A. BROWN, AND
TK. HARDEN 40 ROLES OF AN ADP RECEPTOR ON THE PLATELET SURFACE IN
MEDIATING AGGREGATION AND FIBRINOGEN BINDING 272 R.W. COLMAN SECTION 3:
PHOSPHODIESTERASE ENZYMES AND INHIBITORS 279 41 STRUCTURAL AND
FUNCTIONAL CHARACTERIZATION OF CYCLIC GMP-STIMULATED PHOSPHODIESTERASES
AND THEIR ROLE IN INTRACELLULAR SIGNAL TRANSDUCTION 281 R.T MACFARLAND,
S.D. STROOP, AND J.A. BEAVO 42 PHOSPHODIESTERASE GENES FROM FLIES TO
MAMMALS 290 R.L. DAVIS, J. HENKEL-TIGGES, Y. QIU, AND A. NIGHORN 43
STRUCTURE AND FUNCTION OF THE HIGH AFFINITY, ROLIPRAM AND RO 2-1724
SENSITIVE, CAMP PHOSPHODIESTERASES 297 J.V. SWINNEN, K.E. TSIKALAS, AND
M. CONTI 44 CORRELATION OF 3H-ROLIPRAM BINDING TO A CEREBRAL CAMP
PHOSPHODIESTERASE WITH ANTIDEPRESSANT ACTIVITY 303 H.H. SCHNEIDER AND H.
WACHTEL 45 MECHANISM FOR DUAL REGULATION OF THE PARTICULATE
CGMP-INHIBITED CAMP PHOSPHODIESTERASE IN RAT ADIPOCYTES BY ISOPROTERENOL
AND INSULIN 309 CJ. SMITH, E. DEGERMAN, V. VASTA, H. TBRNQVIST, P.
BELFRAGE, AND V.C. MANGANIELLO 46 EXPRESSION OF CALMODULIN-DEPENDENT
CYCLIC NUCLEOTIDE PHOSPHODIESTERASE IN DEVELOPING AND ADULT RAT BRAIN
315 M.L. BILLINGSLEY, J.W. POLLI, CD. BALABAN, AND R.L. KINCAID IX 47
REGULATION OF CAMP METABOLISM IN PC12 CELLS BY TYPE II
(CGMP-ACTIVATABLE) CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 323 M.W. WHALIN,
S J. STRADA, J.G. SCAMMELL, AND WJ. THOMPSON 48 CGMP-BINDING
PHOSPHODIESTERASE: NOVEL EFFECTS OF CGMP BINDING ON THE INTERACTION
BETWEEN FUNCTIONAL DOMAINS IN THE ENZYME 329 S.H. FRANCIS, M.K. THOMAS,
AND J.D. CORBIN 49 CLINICAL INVESTIGATIONS WITH PHOSPHODIESTERASE
INHIBITORS 336 R.E. WEISHAAR 50 CHEMICAL PROBES OF TYPE IV
PHOSPHODIESTERASE: DESIGN, SYNTHESIS, AND CHARACTERIZATION OF
(3H)-2Y186126 AS A RADIOLIGAND FOR SITES WITHIN CARDIAC MEMBRANES 347
D.W. ROBERTSON AND R.F. KAUFFMAN 51 PURIFICATION OF A CGMP-INHIBITED
CAMP PHOSPHODIESTERASE FROM VASCULAR SMOOTH MUSCLE 353 A. RASCON, P.
BELFRAGE, E. DEGERMAN, S. LINDGREN, K.E. ANDERSSON, A. NEWMAN, V.C.
MANGANIELLO, AND L. STAVENOW 52 LOW KMCAMP PHOSPHODIESTERASE ISOZYMES
AND MODULATION OF TONE IN VASCULAR, AIRWAY AND GASTROINTESTINAL SMOOTH
MUSCLE 358 PJ. SILVER, A.L. HARRIS, R.A. BUCHHOLZ, M.S. MILLER, R J.
GORDON, R.L. DUNDORE, AND E.D. PAGANI 53 STRUCTURE ACTIVITY
RELATIONSHIPS OF XANTHINES AS INHIBITORS OF CYCLIC NUCLEOTIDE
PHOSPHODIESTERASES AND AS ANTAGONISTS OF ADENOSINE RECEPTORS 365 J.N.
WELLS, L. NIEVES, AND T. KATSUSHIMA 54 MECHANISMS OF XANTHINE ACTIONS IN
MODELS OF ASTHMA 370 R.E. HOWELL, R.F. GAUDETTE, M.C. RAYNOR, A.T
WARNER, W.T MUEHSAM, J.A. SCHENDEN, J. PERUMATTAM, R.N. HINER, AND WJ.
KINNIER SECTION 4: ABSTRACTS 377 A INTRACELLULAR AND EXTRACELLULAR
METABOLISM OF ADENOSINE AND ADENINE NUCLEOTIDES 379 B MOLECULAR PROBES
FOR PURINOCEPTORS 390 C PHOSPHODIESTERASES - MULTIPLES FORMS AND
REGULATION 395 D THE PHYSIOLOGICAL EFFECTS OF ADENOSINE AND ADENINE
NUCLEOTIDES 399 E STRUCTURE ACTIVITY RELATIONSHIPS AT ADENOSINE AND ATP
RECEPTORS 412 F EFFECTOR SYSTEMS FOR MODULATION OF BIOLOGICAL RESPONSE
BY PURINES 418 G PHOSPHODIESTERASE INHIBITORS - MECHANISMS AND STRUCTURE
ACTIVITY RELATIONSHIPS 427 AUTHOR INDEX 429 SUBJECT INDEX 434
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| genre | (DE-588)1071861417 Konferenzschrift 1989 Rockville Md. gnd-content |
| genre_facet | Konferenzschrift 1989 Rockville Md. |
| id | DE-604.BV004051885 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T16:07:46Z |
| institution | BVB |
| isbn | 3540972447 0387972447 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-002534257 |
| oclc_num | 21080102 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-188 |
| physical | XV, 448 S. Ill., graph. Darst. |
| publishDate | 1990 |
| publishDateSearch | 1990 |
| publishDateSort | 1990 |
| publisher | Springer |
| record_format | marc |
| spelling | Purines in cellular signaling targets for new drugs K. A. Jacobson ... ed. New York u.a. Springer 1990 XV, 448 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Adénosine - Récepteurs Nucléotides puriques Seconds messagers (Biochimie) Adenine Nucleotides physiology Congresses Adenosine Receptors Adenosine physiology Congresses Purine nucleotides Receptors, Purinergic physiology Congresses Second Messenger Systems physiology Congresses Second messengers (Biochemistry) Purinderivate (DE-588)4176396-8 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Regulation (DE-588)4049075-0 gnd rswk-swf Purinozeptor (DE-588)4176398-1 gnd rswk-swf Biosignalverarbeitung (DE-588)4006899-7 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1989 Rockville Md. gnd-content Purinderivate (DE-588)4176396-8 s Zelle (DE-588)4067537-3 s Regulation (DE-588)4049075-0 s Arzneimittelentwicklung (DE-588)4143176-5 s DE-604 Purinozeptor (DE-588)4176398-1 s Pharmakologie (DE-588)4045687-0 s Biosignalverarbeitung (DE-588)4006899-7 s Jacobson, Kenneth A. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002534257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Purines in cellular signaling targets for new drugs Adénosine - Récepteurs Nucléotides puriques Seconds messagers (Biochimie) Adenine Nucleotides physiology Congresses Adenosine Receptors Adenosine physiology Congresses Purine nucleotides Receptors, Purinergic physiology Congresses Second Messenger Systems physiology Congresses Second messengers (Biochemistry) Purinderivate (DE-588)4176396-8 gnd Pharmakologie (DE-588)4045687-0 gnd Zelle (DE-588)4067537-3 gnd Regulation (DE-588)4049075-0 gnd Purinozeptor (DE-588)4176398-1 gnd Biosignalverarbeitung (DE-588)4006899-7 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4176396-8 (DE-588)4045687-0 (DE-588)4067537-3 (DE-588)4049075-0 (DE-588)4176398-1 (DE-588)4006899-7 (DE-588)4143176-5 (DE-588)1071861417 |
| title | Purines in cellular signaling targets for new drugs |
| title_auth | Purines in cellular signaling targets for new drugs |
| title_exact_search | Purines in cellular signaling targets for new drugs |
| title_full | Purines in cellular signaling targets for new drugs K. A. Jacobson ... ed. |
| title_fullStr | Purines in cellular signaling targets for new drugs K. A. Jacobson ... ed. |
| title_full_unstemmed | Purines in cellular signaling targets for new drugs K. A. Jacobson ... ed. |
| title_short | Purines in cellular signaling |
| title_sort | purines in cellular signaling targets for new drugs |
| title_sub | targets for new drugs |
| topic | Adénosine - Récepteurs Nucléotides puriques Seconds messagers (Biochimie) Adenine Nucleotides physiology Congresses Adenosine Receptors Adenosine physiology Congresses Purine nucleotides Receptors, Purinergic physiology Congresses Second Messenger Systems physiology Congresses Second messengers (Biochemistry) Purinderivate (DE-588)4176396-8 gnd Pharmakologie (DE-588)4045687-0 gnd Zelle (DE-588)4067537-3 gnd Regulation (DE-588)4049075-0 gnd Purinozeptor (DE-588)4176398-1 gnd Biosignalverarbeitung (DE-588)4006899-7 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | Adénosine - Récepteurs Nucléotides puriques Seconds messagers (Biochimie) Adenine Nucleotides physiology Congresses Adenosine Receptors Adenosine physiology Congresses Purine nucleotides Receptors, Purinergic physiology Congresses Second Messenger Systems physiology Congresses Second messengers (Biochemistry) Purinderivate Pharmakologie Zelle Regulation Purinozeptor Biosignalverarbeitung Arzneimittelentwicklung Konferenzschrift 1989 Rockville Md. |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=002534257&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT jacobsonkennetha purinesincellularsignalingtargetsfornewdrugs |