Transgenic mice and mutants in MHC research: proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
1990
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XV, 317 S. Ill., graph. Darst. |
| ISBN: | 3540522018 0387522018 |
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Record in the Search Index
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| adam_text |
I K Egorov and C S David (Eds )
Transgenic Mice
and Mutants
in MHC Research
With 91 Figures and 80 Tables
Springer-Verlag Berlin Heidelberg New York
London Paris Tokyo HongKong
Contents
I Mutant Models of MHC Antigen Expression and Function (H-2)
Spontaneous Frequency of H-2 Mutations
R W MELVOLD and H I KOHN (With 8 Tables) 3
Microgene Conversion in the Evolution of the MHC Class I
Multigene Family
C WHEELER, D MALONEY, S WATTS, J VOGEL, J TOWNER,
D BALDWIN, J RUFER, M ARBEITMAN, H CHAN, S FOGEL, and
R S GOODENOW (With 1 Figure and 2 Tables) 14
Random Mutagenesis by Oligonucleotides: A Probe for MHC Structure and
Function
K KATOH, R MURRAY, D MULLER, and J A FRELINGER (With 1 Figure
and 2 Tables) 26
Altered Recognition of LCMV Antigen Presented on Mutant
Class I Molecules
D MULLER, M M HOBBS, R MURRAY, K PEDERSON, R AHMED, and
J A FRELINGER 33
Relationship Between Class II Structure and B Cell Signaling
G A BISHOP and J A FRELINGER (With 1 Figure and 1 Table) 36
Multivalent Requirement for the Stimulation of Alloreactive T Cells:
Studies with Engineered Soluble MHC Class I Proteins In Vitro and
In Vivo -'
D H MARGULIES, L F BOYD, S KOZLOWSKI, L KJER-NIELSEN, R LOPEZ,
J MCCLUSKEY, J SCHNECK, and R HUNZIKER (With 4 Figures) 39
Novel MHC Variants Spliced by Overlap Extension
H D HUNT, J K PULLEN, Z CAI, R M HORTON, S N Ho, and
L R PEASE (With 4 Figures and 3 Tables) 47
The Functional Significance of Amino Acid Polymorphisms in Class I
MHC Molecules
J K PULLEN, H D HUNT, R M HORTON, and L R PEASE
(With 1 Figure and 1 Table) 56
Products of Separate Genes Encoded Within Minor Histocompatibility Loci
Stimulate Class I and Class II MHC-Restricted T Cells
D C ROOPENIAN and A P DAVIS (With 1 Figure and 1 Table) 59
VIII
Determination of Distinction Odortypes by Mutation of Class I and
Class II MHC Genes
K YAMAZAKI, G K BEAUCHAMP, L THOMAS, J BARD, and E A BOYSE
(With 1 Table) 62
II Mutants of MHC Genes as Probes of Immunological Function (HLA)
Analysis of HLA-B27-Specific T-Cell Epitopes with Site-Directed Mutants
Mimicking HLA-B27 Polymorphism
S ROJO, V CALVO, D LOPEZ, B GALOCHA, and J A LOPEZ DE CASTRO
(With 3 Figures and 3 Tables) 67
The Role of Amino Acid Position and Side Chain Structure in Serological
and CTL-Defined Epitopes on the HLA-A2 1 Molecule
K T HOGAN, C CLAYBERGER, N SHIMOJO, W E BIDDISON,
A M KRENSKY, and V H ENGELHARD (With 1 Figure and 4 Tables) 77
Two Amino Acids on the a Helical Region of the a 1 Domain Form
Multiple Epitopes Recognized by HLA-Bw52 Specific Human Cytotoxic T
Cell
M TAKIGUCHI, J YAMAMOTO, H HAYASHI, and K KANO
(With 2 Figures) 89
III Regulation of MHC Gene Expression
Mouse Mammary Tumor Virus-Directed Gene Expression in
Transgenic Mice
S R Ross, Y CHOI, C -L L HSU, and J DUDLEY
(With 5 Figures and 3 Tables) 93
Regulation of Class I MHC Expression: In Vivo Function of Regulatory
DNA Sequence Elements in Transgenic Mice
J E MAGUIRE, R EHRLICH, W I FRELS, and D S SINGER
(With 4 Figures) 102
Expression of a Non-Classical Class I Gene in Transgenic Mice
C BORDALLO, W I FRELS, J LUNNEY, A ROSENBERG, S RUDIKOFF, and
D S SINGER (With 2 Figures and 2 Tables) 109
Regulation of Expression of Human MHC Class I Heavy (HLA-B7) and
Light (h/72-m) Chain Genes in Transgenic Mice
J W CHAMBERLAIN, P J CONRAD, and S M WEISSMANN
(With 8 Figures and 1 Table) 114
Cloned Trans-Acting Factors that Bind to the Regulatory Elements of the
Major Histocompatibility Complex Class I Gene
K OZATO, S L GLEASON, B -Z LEVI, S HIRSCHFELD, P H DRIGGERS,
J R FLANAGAN, D L ENNIST, K HAMADA, and E APPELLA
(With 5 Figures) 125
IX
Transcriptional Regulation of MHC Class II Gene Expression: Are MHC
Class II Genes Coordinately Regulated?
H -C Liou, L R IVASHKIV, C J KARA, and L H GLIMCHER
(With 1 Figure and 2 Tables) 133
The Effect of Copy Number on mRNA and Cell Surface Expression of an
A/3k Transgene
S GILFILLAN, S Also, S A MICHIE, and H O MCDEVITT
(With 1 Figure and 3 Tables) 143
Construction of Retroviral Vectors for the Study of Tissue-Specific
Regulation of Human MHC Class II Genes
G DEL POZZO, A MAFFEI, C PERFETTO, N OMBRA, and J GUARDIOLA
(With 1 Figure and 1 Table) 155
IV Expression and Function of Class I Genes in Transgenic Mice
Male Sterility in HLA-B27-Trahsgenic Mice
P IVANYI and W LOKHORST (With 1 Figure and 1 Table) 161
The Lyt-2 Accessory Molecule is Responsible for the Weak Mouse
Anti-HLA Xeno-Response
G J HAMMERLING, U KALINKE, and B ARNOLD (With 4 Figures) 165
Human HLA-B27 Antigen in Transgenic Mice can Function as a Major
Histocompatibility Antigen
M PLA, A SAMAAN, D GILLET, M REBOUL, B FRANGOULIS,
A OPOLSKI, M CHOPIN, and L DEGOS (With 4 Figures) 173
Cytotoxic T Cell Responses Against Human Class I Molecules in Normal
and HLA-A2 1 Transgenic Mice
V H ENGELHARD, E J BERNHARD, M J HOLTERMAN, A -X T LE,
R HENDERSON, J P RIDGE, S STRUB, J BARBOSA, and E LACY
(With 9 Tables) 179
Analysis of the HLA-Cw3 Specific CTL Response of HLA-B7x Human fi2
Microglobulin Transgenic Mice
C BARRA, B PERARNAU, P GERLINGER, M LEMEUR, A GILLET,
P GIBIER, and F A LEMONNIER (With 2 Figures and 2 Tables) 191
H-2-Restricted Recognition of Xeno-MHC Antigens by Primary Mouse
Cytotoxic T Cells is the Exception Rather than the Rule
F KlEVITS, J WlJFFELS, W LOKHORST, W J BOERENKAMP, and P IVANYI
(With 2 Figures) 198
Copy Number and the Presence of Human /?2-Microglobulin Control Cell
Surface Expression of HLA-B27 Antigen in Transgenic Mice with a 25 kb
B27 Gene Fragment
E H WEISS, G SCHLIESSER, W KUON, M LANG, G RIETHMULLER,
F KIEVITS, P IVANYI, and G BREM (With 5 Figures) 205
Expression and Function in a Transgenic Mouse of an H-2Kb Variant Gene
Obtained by Site-Directed Mutagenesis in a Kbml Mutant Mouse
M GENDRON, M NAKAGAWA, K HASENKRUG, S NATHENSON, and
A W SEITZ (With 3 Tables) 214
V Expression and Function of Class II Genes in Transgenic Mice
Clonal Anergy in Transgenic Mice with Pancreatic Expression of MHC
Class II I-E
L C BURKLY, D Lo, O KANAGAWA, R L BRINSTER, and R A FLAVELL
(With 2 Figures and 3 Tables) 219
Role of la Antigens in Clonal Deletion of T Cells: Studies with
Recombinant and Transgenic Mice
C S DAVID and G ANDERSON (With 4 Figures and 8 Tables) 229
Transgenic Mice with MHC Class II Genes: The Use in the Study of Allelic
a/fi Chain Pairing and the Production of Engineered Mice with Mutant I-A
Genes
B -Y WEI, J MARTIN, S SAVARIRAYAN, R LITTLE, and C S DAVID
(With 2 Tables) 237
T Cell Recognition of Major Histocompatibility Complex Antigens in HLA
Class II Transgenic Mice
S K LAWRANCE, L KARLSSON, J PRICE, V QUARANTA, Y RON,
J SPRENT, and P A PETERSON (With 7 Figures) 247
VI Transgenic and Mutant Models of Disease
HLA-B27 and Arthritis
H S LUTHRA, C L NICKERSON, S SAVARIRAYAN, and C S DAVID
(With 2 Figures and 2 Tables) 259
HLA-B27 Transgenic Mice as Potential Models of Human Disease
J D TAUROG, R E HAMMER, S D MAIKA, K L SAMS,
FAK EL-ZAATARI, S A STIMPSON, and J H SCHWAB (With 4 Figures) 268
Mouse Mutants Affecting Growth and Metastasis of a Syngeneic Tumor
O S EGOROV, E SARGENT, G A CARLSON, and I K EGOROV
(With 5 Tables) 276
Transgene Induced MHC Mismatch Results in Rapid Natural Killer Cell
Dependent Elimination of Lymphoma Cells
P HOGLUND, H G LJUNGGREN, C OHLEN, and K KARRE
(With 1 Figure and 2 Tables) 282
Highly Immunogenic Transformed Tumor Clones Expressing Allogeneic
Class I Histocompatibility Gene Demonstrate a Specific Immunotherapeutic
Affect Against the Parental Tumor
K M Hui, T SIM, T T FOO, and A A OEI (With 4 Figures and 2 Tables) 285
XI
Graft Specific MHC Class II Gene Expression During Allograft Response
D S KITTUR, R Xu, J F BURDICK, and W ADLER (With 1 Figure) 296
Influence of MHC and Non-MHC Genes on Tumorigenesis and the Use of
the Recombinant Congenic Strains as a Novel Tool for the Genetic Analysis
of Tumor Susceptibility
P DEMANT, LCJM OOMEN, CJA MOEN, M A VAN DER VALK,
AAM HART, and LFM VAN ZUTPHEN (With 2 Figures and 3 Tables) 299
Subject Index 309 |
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| spelling | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 I. K. Egorov (ed.) ... Berlin [u.a.] Springer 1990 XV, 317 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Maus (DE-588)4169148-9 gnd rswk-swf MHC (DE-588)4169760-1 gnd rswk-swf Genmutation (DE-588)4156638-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1989 Bar Harbor Me. gnd-content Maus (DE-588)4169148-9 s Genmutation (DE-588)4156638-5 s MHC (DE-588)4169760-1 s DE-604 Egorov, Igor K. Sonstige oth Jackson Laboratory (Bar Harbor, Me.) Sonstige (DE-588)2040010-X oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001690357&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 Maus (DE-588)4169148-9 gnd MHC (DE-588)4169760-1 gnd Genmutation (DE-588)4156638-5 gnd |
| subject_GND | (DE-588)4169148-9 (DE-588)4169760-1 (DE-588)4156638-5 (DE-588)1071861417 |
| title | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 |
| title_auth | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 |
| title_exact_search | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 |
| title_full | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 I. K. Egorov (ed.) ... |
| title_fullStr | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 I. K. Egorov (ed.) ... |
| title_full_unstemmed | Transgenic mice and mutants in MHC research proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 I. K. Egorov (ed.) ... |
| title_short | Transgenic mice and mutants in MHC research |
| title_sort | transgenic mice and mutants in mhc research proceedings of a conference held at the jackson laboratory bar harbor june 24 28 1989 |
| title_sub | proceedings of a conference held at the Jackson Laboratory, Bar Harbor, June 24 - 28, 1989 |
| topic | Maus (DE-588)4169148-9 gnd MHC (DE-588)4169760-1 gnd Genmutation (DE-588)4156638-5 gnd |
| topic_facet | Maus MHC Genmutation Konferenzschrift 1989 Bar Harbor Me. |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001690357&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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